Scientists trigger immune response to uncover Depression's brain secrets

NCT ID NCT04751331

Recruiting now Knowledge-focused Sponsor: Laureate Institute for Brain Research, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how the immune system and brain talk to each other in people with major depression. Researchers will give a harmless substance (LPS) to temporarily activate the immune system and then measure brain activity and mood changes. The goal is to understand the links between inflammation, brain circuits, and depression symptoms. 180 adults (half with depression, half healthy) will take part.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Laureate Institute for Brain Research
RECRUITING

Tulsa, Oklahoma, 74136, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••