MAJOR DEPRESSIVE DISORDER

This study tests whether nitrous oxide, commonly known as laughing gas, can reduce symptoms of depression in people whose depression has not improved with standard treatments. About 120 adults aged 18 to 65 with treatment-resistant depression will receive either the gas or a plac…

This study tests whether daridorexant, a sleep medication, can improve insomnia and depression in people with major depressive disorder. 134 adults will receive either the drug or a placebo for three months. Researchers will measure sleep quality and mood changes using questionna…

This study tests whether placing small needles under the skin (intradermal acupuncture) can help adults with major depression reduce or stop their antidepressant medication (SSRIs) with fewer side effects. About 114 participants who are already planning to lower their dose will b…

This study tests whether using a mild electrical brain stimulation device (tDCS) at home, twice a day for three weeks, can reduce depression symptoms. It involves 30 adults with depression who have never taken antidepressant medication. Participants are randomly assigned to recei…

This study tests whether two anti-inflammatory drugs, celecoxib or minocycline, can reduce depression symptoms in people with major depressive disorder or bipolar depression. About 42 adults aged 18-65 with moderate to severe depression will take one of the drugs for 8 weeks. Res…

This early-phase study tests an experimental drug called PDC-1421 to see if it is safe and can help relieve depression in people with cancer. About 12 adults with stage I-III cancer and moderate to severe depression will take the drug for up to 5 weeks. Researchers will measure m…

This study tests whether a single oral dose of CYB003, a drug related to psilocybin, can help ease symptoms of depression and anxiety in 40 adults with major depressive disorder. Participants will receive either the drug or a placebo, and researchers will use brain scans and ques…

This study tests whether bupropion hydrobromide, a medication already used in adults, can safely reduce symptoms of major depression in children and teenagers aged 7 to 17. About 246 participants will receive either the drug or a placebo (a pill with no active medicine) to compar…

This study tests whether low-dose laser acupuncture can safely improve sleep in 120 adults with major depression and insomnia. Participants will receive 30 laser sessions over six weeks while continuing their usual depression medication. The study compares real laser acupuncture …

This study looks at how the brain controls impulses in people with bipolar disorder or major depression. Researchers will use brain scans while participants perform tasks with emotional faces. The goal is to find differences that could help doctors tell these two conditions apart…

This study aims to improve how doctors diagnose bipolar disorder and predict future mood episodes. Researchers will use smartwatches to track sleep and activity, and simple computer tasks to measure decision-making in 600 people with bipolar disorder, major depression, or no mood…

This study tests whether a non-invasive brain stimulation technique called tDCS, used at home, can improve sleep quality in adults with moderate depression. Researchers will track changes in sleep efficiency and mood over time. The goal is to understand if better sleep leads to f…

This study looks at how different types of brain stimulation affect brain activity in 250 military Veterans with major depression. Researchers will use transcranial magnetic stimulation (TMS) and EEG to measure brain changes. The goal is to develop more personalized brain stimula…

This study looks at whether simple eye tests (electroretinography) can predict how well antidepressants work in people with major depression. About 108 adults starting a common antidepressant will have eye tests and depression questionnaires before treatment and again at 6 and 12…

This study tests whether a brain stimulation treatment for depression can be improved by customizing it to each person. Researchers will use brain wave measurements (EEG) to find the best stimulation settings for each participant. The study involves 80 adults with treatment-resis…

This study tests a new way to monitor muscle activity during electroconvulsive therapy (ECT) for people with depression, bipolar disorder, or schizophrenia. It compares a standard arm tourniquet method with a newer, potentially less painful approach. The goal is to see if the new…

This study tests whether data from your smartphone (like activity and usage patterns) can warn doctors when depression symptoms are about to return. Researchers will track 320 adults who have been treated for depression and are currently well. If successful, this could lead to an…

This study looks at whether S-ketamine changes the function of mitochondria (the energy centers of cells) in people with treatment-resistant depression. Researchers will take blood samples from 30 adults before, shortly after, and six weeks after treatment to see if these changes…

This study tests a group program to help veterans with serious mental illness feel more comfortable and confident working with their doctors and therapists. About 119 veterans from three VA centers will take part. The goal is to see if the program improves teamwork between vetera…

This study looks at how different types of non-invasive brain stimulation change mood and brain activity in 200 adults with major depression. Participants will receive three types of stimulation (including a placebo-like sham) and undergo MRI scans while taking antidepressants. T…

This study explores whether generative AI can support people who are already in therapy for generalized anxiety disorder or major depressive disorder. Researchers will enroll 204 adults in the U.S. who are currently in individual therapy. Participants will use an AI tool alongsid…