MAJOR DEPRESSIVE DISORDER

This study is testing whether a type of acupuncture can help adults with depression safely reduce or stop their antidepressant medication (SSRIs). Participants who are already planning to lower their dose will be randomly assigned to receive real acupuncture, fake acupuncture, or…

This study aims to find out if bupropion, an antidepressant medication, is effective and safe for treating major depression in children and adolescents aged 7 to 17. About 246 young people with depression will receive either the real medication or a placebo (inactive pill) for se…

This study is testing a 10-session group program designed to help Veterans with serious mental illnesses like schizophrenia or bipolar disorder work more effectively with their treatment teams. The goal is to help Veterans gain the skills and confidence to collaborate on their ow…

This study is testing whether nitrous oxide, commonly known as laughing gas, can help people whose depression hasn't improved with standard antidepressants. 120 adults with treatment-resistant depression will receive either laughing gas or a control treatment once a week for four…

This study aims to understand how a single dose of a drug related to psilocybin (the psychedelic compound in 'magic mushrooms') might help people with depression and anxiety. Researchers will give 40 participants either the drug or a placebo and use brain scans and questionnaires…

This study aims to see if people recovering from mental health or substance use problems, when trained, can effectively help others with depression and addiction. It will test a talk-based therapy called Behavioral Activation, delivered by these 'peer recovery specialists', in 25…

This study aims to see if one of two different medications works better to treat depression and mild memory problems in people living with HIV. Researchers will compare pramipexole, a drug that affects dopamine, to escitalopram, a common antidepressant. They will check how well t…

This study is testing whether a non-invasive, needle-free laser acupuncture treatment can help improve sleep and ease depression symptoms. It will involve 120 adults with major depression and insomnia, comparing the laser treatment to a fake laser and standard medication. Researc…

This study aims to see if using an AI chatbot (like ChatGPT) as a supplement to regular therapy can help people feel better. It will enroll 204 adults in the US who are already seeing a therapist for anxiety or depression. Participants will use the chatbot for four weeks, and res…

This study is testing whether a home-based brain stimulation treatment called tDCS, given twice daily for three weeks, can help reduce symptoms of depression. It will involve 30 adults with depression who are not currently taking antidepressant medication. Participants will be ra…

This research aims to better understand and predict mood episodes in bipolar disorder. Researchers will track 600 participants' sleep, activity, and decision-making using smartwatches and computer tasks. The goal is to find patterns that can help distinguish bipolar disorder from…

This study aims to understand how different patterns of non-invasive brain stimulation affect mood and brain function in adults with major depression. Researchers will compare three stimulation types and use brain scans to see how they work with antidepressant treatments. The goa…

This study is testing if data collected from a person's smartphone can predict when their depression symptoms might return. Researchers will enroll 320 adults who have recently recovered from depression. Half will use a special app that collects phone data, while the other half r…

This study aims to understand how the antidepressant drug S-ketamine works by looking at its effects on mitochondria, the energy centers of cells, in people with hard-to-treat depression. Researchers will enroll 30 adults and measure markers related to cell energy in their blood …