MAJOR DEPRESSIVE DISORDER

This study is testing an experimental brain implant for people with severe depression that hasn't improved with medications or therapy. Ten participants will have a device surgically placed in their brain to deliver mild electrical stimulation, aiming to reduce symptoms. Research…

This study is testing whether adding a drug called D-Cycloserine makes a non-invasive brain stimulation therapy more effective for treating depression. Adults with moderate-to-severe depression that hasn't responded well to other treatments will receive either the drug or a place…

This study is testing how a non-invasive brain stimulation technique, called TMS, affects a specific brain area linked to depression. Researchers will use MRI scans to see how this brain area responds during six weeks of daily TMS treatments. The goal is to better understand how …

This study is testing whether deep brain stimulation (DBS), a surgical treatment sometimes called a 'brain pacemaker,' can help people with severe depression that hasn't improved with other treatments like multiple medications, therapy, or electroconvulsive therapy (ECT). Researc…

This study is testing a more precise way to use transcranial magnetic stimulation (TMS), an FDA-approved depression treatment, for people over 60. Researchers are using individual brain scans to try to find the best spot to stimulate for each person, hoping to make the treatment …

This study is testing a new, gentler form of brain stimulation called TEST for people with severe depression that hasn't improved with standard treatments. It aims to see if TEST can safely reduce depression symptoms without the memory problems sometimes caused by stronger therap…

This study is testing if personalized text message reminders can help people who have both high blood pressure and a mood disorder (like depression or bipolar disorder) remember to take their blood pressure medicine. Researchers are comparing two groups: one gets text reminders p…

This study is testing whether a 5-day brain stimulation treatment called SAINT can help people with major depression who haven't improved with standard antidepressant medications. About 1000 adults will receive 10 brief stimulation sessions per day for 5 consecutive days. Researc…

This study is testing a faster version of a non-invasive brain stimulation treatment called TMS for adults with depression that hasn't improved with medication. Instead of the usual 6-week schedule, the new approach delivers three short treatment sessions in a single day. Researc…

This study is testing whether matching depression treatments to a person's specific symptoms works better than standard care. Researchers will first sort 150 adults with major depression into one of five subtypes, like trouble feeling pleasure or high anxiety. Then, half will get…

This study aims to understand how a single session of mild whole-body heating might help reduce symptoms of major depression. Researchers are testing 35 adults with depression to see if the treatment works and to learn more about how it affects the body's immune system. The study…

This study follows adults with major depressive disorder who previously participated in related research to see how safe and effective the experimental drug azetukalner is over a longer period. About 460 participants will continue taking the medication while researchers monitor s…

This small, early-stage study from Yale University is investigating whether psilocybin, the active compound in 'magic mushrooms,' can change brain activity in a way that helps treat major depression. The study involves 18 adults with depression who haven't gotten better with stan…

This study follows up on earlier trials to see how safe and effective the investigational treatment CYB003 is over the long term for people with major depressive disorder. It includes 468 participants who have already completed one of two previous CYB003 studies. The main goal is…

This small pilot study is testing whether a new, non-invasive brain stimulation technique called low-intensity focused ultrasound (LIFUP) is safe and helpful for people with severe depression that hasn't improved with standard medications. The treatment aims to target a specific …

This study tested whether a non-invasive brain stimulation technique called intermittent Theta Burst Stimulation (iTBS) could help people with major depression who still have symptoms despite taking medication. Participants received either real or fake stimulation sessions over t…

This early-stage study is testing a new tablet called LY03021 for depression. Researchers are checking how safe it is and how the body processes it in 98 healthy volunteers. They're also seeing if taking the pill with food makes a difference in how it works.

This study is testing whether adding a low dose of Adderall XR makes brain stimulation therapy work better for people with depression that hasn't improved with standard medications. It will involve 30 adults who will be randomly assigned to take either Adderall or a placebo pill …

This study is testing whether a non-invasive brain stimulation technique called TMS, combined with talk therapy, can help teenagers with depression that hasn't improved with standard treatments. Researchers will enroll 80 teens aged 13-17 who have tried at least three other depre…

This study is testing whether a single dose of psilocybin, the active compound in 'magic mushrooms,' can help people who have both major depression and alcohol use disorder. Researchers at Johns Hopkins are comparing the effects of psilocybin to a placebo in 90 participants. The …

This study is testing an oral medication called MM120 for adults with major depressive disorder. About 140 participants will be randomly assigned to receive either the drug or a placebo for 12 weeks, followed by a 40-week period where all participants may receive the drug. The ma…

This study is testing a new, personalized method for magnetic brain stimulation to treat severe depression. It aims to see if finding a person's unique 'brain rhythm' for treatment is safe and practical, rather than using a standard one-size-fits-all frequency. The study will inv…

This study aimed to test if a single 45-minute dose of inhaled nitrous oxide (laughing gas) could quickly reduce severe suicidal thoughts and depression in people arriving at the emergency room. It planned to compare the gas to a placebo, given alongside standard emergency care, …

This study is testing whether mindfulness-based therapy can help people with serious mental illnesses like schizophrenia, depression, and bipolar disorder. Researchers are working with 160 patients at community mental health centers to see if adding mindfulness therapy to regular…

This study is testing whether psilocybin, the active compound in 'magic mushrooms,' combined with psychological support, can help people with treatment-resistant depression who struggle with anhedonia—the inability to feel pleasure. The trial involves 40 adults who have not respo…

This study is testing whether inhaling nitrous oxide (laughing gas) can quickly reduce suicidal thoughts in hospitalized patients with severe depression. Fifty patients will receive either the gas or a placebo during up to six sessions while continuing their standard depression t…

This study aims to create a tool to help doctors choose the right antidepressant for each patient with major depression. Researchers will collect blood, stool, and saliva samples, along with brainwave data and mood tracking from 350 participants over two years. They will use arti…

This study aimed to understand why some people experience temporary memory problems after electroconvulsive therapy (ECT), a treatment for severe depression. Researchers planned to measure brain activity in people receiving ECT to see how it affects the brain's memory system. The…

This study uses brain scans to understand how TMS (transcranial magnetic stimulation) treatment affects brain connections in people with depression. Researchers will scan participants' brains before and after they receive standard TMS treatment for their depression. The goal is t…

This study aims to find a brain signal that can predict whether ketamine treatment will work for people with hard-to-treat depression. Researchers will measure specific brain wave patterns (called gamma oscillations) in 100 participants before and after ketamine therapy. The goal…

This study is investigating how a gentle electrical stimulation device placed on the ear might affect the brain circuits involved in stress for people with major depression. Researchers are testing the device during a brain scan to see if it changes brain activity and heart rate …

This study aims to understand how the brain's pain and opioid systems might be linked to a person's capability for suicide. Researchers will use brain scans (fMRI) on 90 adults with major depression and suicidal thoughts, as well as healthy volunteers, while they perform a pain t…

This study aims to find brain signals that predict which depression treatments work best for individual patients. Researchers will use a special light-based brain scanner on 540 people receiving different treatments like ketamine, TMS, or antidepressants. The goal is to help doct…

This study is testing whether a smartphone app can detect early signs of mood changes in people with depression or bipolar disorder by analyzing how they type. Researchers are comparing typing patterns—like speed and error rates—with brain scans and standard mood questionnaires. …

This study aims to understand how a brain stimulation treatment works for major depression. Researchers will give 30 participants either a single dose of an antidepressant or a placebo, along with brain stimulation sessions, while measuring brain activity with scans and recording…

This study is a phase 2/3 open-label controlled trial (CT) in which adults with Major Depressive Disorder (MDD) and adults who have MDD plus comorbid Inflammatory Bowel Syndrome (IBS) will be assigned to either receive oral Fecal Microbiota Transplantation (FMT) or to continue wi…