MAJOR DEPRESSIVE DISORDER

This study tests whether taking fecal transplants (FMT) by mouth can help adults with major depression, with or without irritable bowel syndrome (IBS). About 133 participants will either receive FMT or continue their usual treatment. Researchers will measure changes in depression…

This study tests whether a personalized smartphone app (iTAB-CV) plus self-monitoring helps people with bipolar disorder or major depression and high blood pressure take their medication more regularly and lower their blood pressure. About 176 adults aged 21-80 with both conditio…

This study looks at whether psilocybin, a hallucinogenic drug, can help people who have both major depression and alcohol use disorder. About 90 adults aged 21-65 will receive psilocybin in a controlled setting. Researchers will measure changes in depression symptoms and drinking…

This early-stage study tests a new tablet called LY03021 in 98 healthy adults aged 18 to 45. The main goal is to check the drug's safety and how the body processes it. This is a first step before testing the medicine in people with depression.

This study tests a brain pacemaker (deep brain stimulation) for people with severe depression that hasn't improved with other treatments. About 16 adults aged 22-70 will have electrodes placed in a brain area linked to mood. The goal is to see if this reduces depression symptoms …

This study is testing a home-based program designed to help prevent long-term memory decline in older adults at risk for Alzheimer's disease. The program combines brain-training exercises with a gentle, non-invasive brain stimulation technique called tDCS, which is delivered by a…

This study tests a treatment called SAINT® neuromodulation for people with major depression who haven't gotten better with medication. About 1000 adults will receive 10 sessions a day for 5 days. The goal is to see if this brain stimulation can ease depression symptoms.

This study tests whether giving three TMS sessions in a single day is safe and effective for adults with major depressive disorder. TMS uses magnetic pulses to stimulate the brain without surgery. The trial involves 37 participants aged 22-85 and compares the accelerated approach…

This study aimed to see if online group therapy (CBT with mindfulness) works as well as in-person therapy for adults with major depression. It planned to include about 200 participants and compare changes in depression and anxiety scores. However, the study was withdrawn before e…

This study is testing whether adding nitrous oxide (laughing gas) to standard hospital care can quickly reduce suicidal thoughts in people with severe depression. About 50 adults with major depression and active suicidal thinking will be randomly assigned to receive either nitrou…

This small study tests whether psilocybin, the active ingredient in magic mushrooms, can change how the brain adapts and grows (neuroplasticity) in people with major depression. 18 adults who haven't gotten better with standard antidepressants will receive psilocybin and have the…

This study aimed to see if a single 45-minute dose of inhaled nitrous oxide (laughing gas) could quickly reduce suicidal thoughts and depression in people visiting the emergency department. It was designed for adults aged 18-65 with major depression who were actively suicidal. Ho…

This study looks at whether adding a low dose of Adderall XR (a stimulant) to repetitive transcranial magnetic stimulation (rTMS) can better ease depression symptoms. Thirty adults with treatment-resistant major depression will be randomly assigned to receive either Adderall or a…

This phase 3 study tests an oral medication called MM120 against a placebo in 149 adults with major depressive disorder. Participants take the drug or placebo for 12 weeks, followed by a 40-week period where everyone can receive MM120. The main goal is to see if MM120 reduces dep…

This study tests a new treatment called TEST for people with depression that hasn't improved with standard treatments. TEST uses a weaker electric current than standard electroconvulsive therapy (ECT), aiming to reduce side effects like memory problems. Eight adults aged 25-64 wi…

This study tests a way to make transcranial magnetic stimulation (TMS) work better for older adults with depression. Researchers use brain scans to personalize the treatment for each person. The goal is to improve mood and brain function in people aged 60 to 79.

This study planned to test whether nitrous oxide (laughing gas) could help people with major depression. It was withdrawn before any participants enrolled, so no results are available. The goal was to find the best dose and schedule for future research.

This study looks at the long-term safety and effectiveness of an experimental drug called CYB003 for people with major depression. Participants have already completed an earlier study and received two doses of CYB003. The goal is to see if the drug continues to help with depressi…

This study tests whether adding mindfulness-based therapy (MBT) to usual care helps adults with serious mental illness (like schizophrenia, bipolar disorder, or major depression) feel better and function better. Researchers will enroll 160 patients from a community mental health …

This study tests whether choosing depression treatments based on a patient's specific symptoms and brain imaging (phenotyping) leads to better results than standard care. About 150 adults with major depression will be enrolled. The goal is to see if personalized treatment selecti…

This study tests a non-invasive brain stimulation technique called intermittent theta burst stimulation (iTBS) for people with major depression who still have symptoms despite taking medication. About 30 adults will receive either real or sham (fake) stimulation to see if it help…

This study is for adults aged 18-65 with moderate to severe depression that hasn't responded well to standard treatments. Researchers will use a personalized brain-mapping technique (pBFS) to guide magnetic stimulation (rTMS) and test if different doses can safely improve mood. T…

This study aimed to see if transcranial magnetic stimulation (TMS) combined with cognitive behavioral therapy could help teens aged 13-17 with major depression that didn't improve with standard treatments. Participants would have tapered off their medications, received daily TMS …

This small pilot study tests whether Imagery Rescripting, a therapy that helps people change upsetting mental images, can reduce depression symptoms. Ten adults with major depression will receive weekly sessions after a waiting period. Researchers will track mood and negative bel…

This study compares two treatments for severe depression that hasn't improved with medication: electroconvulsive therapy (ECT) and magnetic seizure therapy (MST). Both use controlled seizures to reset brain activity, but MST uses magnets instead of electricity. Researchers will c…

This study tests whether a drug called psilocybin (found in magic mushrooms) can safely reduce depression in adults who have both cancer and major depressive disorder. About 56 participants will receive up to two doses of psilocybin or a placebo, with therapists present. The goal…

This study tests a new approach for people with depression that hasn't improved with standard treatments. It combines a type of brain stimulation called iTBS with digital mindfulness training to help improve mood and thinking skills. About 70 adults with moderate-to-severe depres…

This study tests whether psilocybin, the active ingredient in magic mushrooms, combined with psychological support can reduce anhedonia (loss of interest or pleasure) in adults with treatment-resistant depression. About 40 participants will receive the drug and therapy, and resea…

This study tests a personalized version of repetitive transcranial magnetic stimulation (TMS) for people with severe major depressive disorder who haven't gotten better with multiple medications or therapy. Researchers will use brain scans to set the right stimulation frequency f…

This study tests an experimental oral drug, NMRA-335140, against a placebo in 332 adults with major depressive disorder. Over 6 weeks, researchers measure changes in depression symptoms using a standard rating scale. The goal is to see if the drug can safely reduce depression sev…

This small pilot study tests whether low intensity focused ultrasound (LIFUP) can safely help people with major depression that hasn't improved with standard treatments. The treatment uses sound waves to gently stimulate a deep brain area linked to mood. The study aims to enroll …

This study tests whether taking D-Cycloserine (a drug originally used for TB) before a non-invasive brain stimulation therapy called iTBS can improve depression symptoms more than the stimulation alone. About 180 adults with treatment-resistant depression will receive either a lo…

This study looks at the long-term safety and effectiveness of a drug called azetukalner for adults with major depressive disorder. Participants must have already completed a previous phase 3 study of the same drug. Researchers will track side effects and changes in depression sym…

This study tests an experimental oral medication, NMRA-335140, against a placebo in 332 adults with major depressive disorder. Over 6 weeks, researchers measure changes in depression symptoms using standard rating scales. The goal is to see if the drug can safely reduce depressio…

This study is gathering data from 350 people with major depression to build an AI tool that helps doctors choose the best antidepressant. Researchers will analyze genetics, gut bacteria, immune markers, and brain activity. The goal is to create a personalized treatment plan, not …

This study looks at how Transcranial Magnetic Stimulation (TMS) changes the brain in people with major depression. Researchers will use MRI scans to track these changes over 6 weeks. The goal is to better understand how TMS works, not to test a new treatment. 40 adults aged 18-65…

This study looks at how transcranial magnetic stimulation (TMS) affects the brains of people with major depression. Researchers will use MRI scans to measure changes in brain connections before and after TMS treatment. About 54 adults aged 18-80 who are already scheduled for TMS …

This study looks at whether brain wave patterns (gamma oscillations) can help predict if ketamine therapy will work for people with treatment-resistant depression. Researchers will measure brain activity before and during treatment in 100 adults. The goal is to find a simple brai…

This study is testing whether a Samsung smartwatch can detect signs of depression and anxiety. About 220 adults (135 with depression and 85 healthy) will wear the watch for 3 months while it tracks heart rate, sleep, and steps. The goal is to see if the watch's 'Mindfulness Index…

This study tests if a smartphone app that tracks how you type (speed, backspace use, autocorrect) can help monitor mood and thinking problems in people with mood disorders like depression or bipolar disorder. About 132 adults aged 25-50 will use the app and have brain scans and t…

This study looks at how the brain processes pain in people with depression who may be at risk for suicide. Researchers will use brain scans (fMRI) while participants experience mild pressure pain. The goal is to find brain patterns linked to suicide capability, which could help i…

This study tests a special deep brain stimulation (DBS) device that can both stimulate the brain and record its electrical signals. Researchers want to find brain signal patterns that show when the treatment is working for people with severe, treatment-resistant depression. Ten p…

This study looks at how a brain area called the subgenual cingulate responds to transcranial magnetic stimulation (TMS) in people with depression. Researchers will use MRI scans to see if TMS activates this region and how it changes over a 6-week treatment course. 50 adults with …

This study aims to find biological markers in the brain that can predict how well a person with major depression will respond to different treatments. Researchers will use a special brain imaging technique (TD-fNIRS) to measure blood flow and other signals in 540 adults before th…

This study was designed to understand why electroconvulsive therapy (ECT) can cause temporary memory and thinking problems. Researchers planned to measure brain activity with EEG in people with depression receiving ECT. However, the study was withdrawn before any participants wer…

This study looks at how a single dose of the antidepressant citalopram, given through an IV, affects brain activity when combined with a type of brain stimulation called theta burst stimulation (TBS). Thirty adults with major depression who haven't gotten better with other treatm…

This study tests whether mild whole body hyperthermia (gentle heating) can reduce depression symptoms, and whether a drug that blocks an immune protein called IL-6 changes that effect. About 35 adults with major depression will receive either the drug or a placebo before the heat…