MAJOR DEPRESSIVE DISORDER

This study tests a special deep brain stimulation (DBS) device that can both stimulate and record brain activity in people with treatment-resistant depression. Ten participants will have electrodes implanted in a brain region called the subcallosal cingulate. The goal is to ident…

This study looks at the long-term safety and effectiveness of an experimental drug called NMRA-335140 for people with major depressive disorder. About 1,000 adults who completed earlier studies of this drug will take it for 52 weeks. Researchers will track side effects and change…

This study looks at the long-term safety and effectiveness of azetukalner in adults with major depressive disorder. Participants must have successfully completed a previous phase 3 study of this drug. The goal is to monitor side effects and track changes in depression symptoms ov…

This study tests whether using MRI to guide transcranial magnetic stimulation (TMS) works better than the usual scalp-based method for treating depression. It involves 54 participants, including those with treatment-resistant depression and others with COVID-related distress. The…

This study tests whether a home-based program combining cognitive exercises (like puzzles) with mild brain stimulation can improve thinking and memory in older adults with mild cognitive impairment or late-life depression. About 40 participants will use the program at home with h…

This study tests a new approach for people with depression that hasn't responded to medication. It combines an FDA-approved brain stimulation technique called rTMS with digital mindfulness exercises. The goal is to see if this combination can improve both mood and cognitive funct…

This study tests whether taking fecal microbiota transplantation (FMT) pills can improve symptoms of major depressive disorder (MDD) and irritable bowel syndrome (IBS). About 133 adults with MDD, with or without IBS, will either receive FMT or continue their usual treatment. Rese…

This study is a long-term follow-up for people with major depressive disorder who already completed a previous trial with CYB003, a drug similar to psilocybin. It will test how safe and effective CYB003 is over time, with optional extra doses. About 468 participants will be monit…

This study tests whether psilocybin, the active ingredient in magic mushrooms, can help people with both major depression and alcohol use disorder. Researchers at Johns Hopkins will give 90 adults either psilocybin or a placebo and track changes in mood and drinking habits. The g…

This study tests whether deep brain stimulation (DBS) can help people with severe depression that hasn't improved with other treatments. Sixteen adults aged 22 to 70 will have electrodes implanted in a brain region called the medial forebrain bundle. The device delivers mild elec…

This study tests whether choosing depression treatments based on a person's specific symptoms (like anhedonia or anxious distress) works better than the usual trial-and-error method. 150 adults with major depressive disorder will receive either standard care or a treatment matche…

This study explores whether a taste test can serve as a diagnostic tool for depression. Participants with untreated major depressive disorder will take a taste test before and after starting an antidepressant prescribed by their doctor, and again six to eight weeks later. The goa…

This study tests whether a Samsung smartwatch can detect signs of depression by analyzing heart rate, sleep, and step count. About 220 adults with and without depression will wear the watch for 3 months and complete daily mood surveys. The goal is to see if the watch's 'Mindfulne…

This study tests whether an accelerated form of transcranial magnetic stimulation (TMS) can safely and effectively reduce depression symptoms in people with major depressive disorder. About 50 participants aged 15 and older will receive the treatment in an open-label design. The …

This study tests an oral medication called MM120 against a placebo in adults with major depressive disorder. The trial has two parts: a 12-week blinded phase followed by a 40-week open-label extension where everyone gets MM120. The main goal is to see if MM120 reduces depression …

This study looks at whether Behavioral Activation (BA) therapy can change the habit of repetitive negative thinking (rumination) in people with major depression. Up to 120 adults will receive 12 sessions of BA over 11 weeks. Researchers will measure symptom changes and explore wh…

This small study tests a new treatment called TEST for people with depression that hasn't improved with standard treatments. TEST uses a lower electric current than standard electroconvulsive therapy (ECT), aiming to avoid memory and thinking problems. Eight adults aged 25-64 wil…

This early-phase trial tests whether inhaling a low dose of xenon gas can quickly improve depressive symptoms in 20 people with treatment-resistant major depression or bipolar depression. Participants receive either xenon or a placebo gas added to their usual treatment, and resea…

This study tests a behavioral program called SWITCH that teaches people with serious mental illness (like depression, schizophrenia, or bipolar disorder) to set goals, use rewards, and build habits to do more activities outside the home. 52 participants will attend weekly online …

This study tests whether a wearable headband that shines near-infrared light can improve depression and sleep in adults aged 60 and older with major depression. Participants will wear the device for up to 8 weeks, and researchers will track sleep, mood, and daily activity using a…

This study aimed to see if a web-based self-help program called Deprexis could help orthopedic patients with major depressive disorder. The plan was to offer the 8-week online program to patients with depression and see if they would use it and if their mood and physical function…

This study tests whether real-time brain scans (fMRI) can help people with depression learn to reduce rumination—repetitive negative thinking. 80 participants will receive either real or sham neurofeedback while in a powerful 7T MRI machine. The goal is to strengthen a specific b…

This study looks at whether nicotine patches can safely improve mood and thinking in adults aged 60 and older with depression. Participants who completed a previous blinded trial will wear a patch daily for up to 12 weeks, then taper off. The goal is to see if nicotine helps the …

This study tests whether nicotine patches can improve cognitive control (like focus and memory) and mood in adults aged 60 and older with depression. Sixty participants will wear either a nicotine or placebo patch daily for 12-15 weeks. Researchers will measure changes in depress…

This study tests whether a device that sends mild electrical pulses to facial muscles can help treat major depression. Twenty adults with depression will use the device at home for 45 minutes daily over four weeks. The main goal is to see if the approach is feasible and safe, wit…

This study tests a program called Omnis Salutis for recent veterans with PTSD, depression, anxiety, or substance use disorders. The program teaches veterans to identify their health goals and communicate them to doctors and family. Researchers want to see if it improves social an…

This study tests whether a daily oral drug called SP-624 can safely reduce depression symptoms in adults with major depressive disorder. About 456 participants will receive either SP-624 or a placebo for several weeks. The main goal is to see if SP-624 leads to a greater improvem…

This study looks at how a fast form of brain stimulation called iTBS affects the brains of 22 adults with major depression. Participants receive both real and fake stimulation in a blinded setup, followed by 6 weeks of daily treatment. The goal is to understand how iTBS changes b…

This study aimed to see if nitrous oxide (laughing gas) could help people with major depression, especially those who hadn't improved with other treatments. Participants would have received four weekly sessions of the gas or a placebo. However, the study was withdrawn before any …

This study tests whether giving different numbers of daily brain stimulation sessions (rTMS) can safely improve symptoms in people with moderate to severe depression that hasn't responded to other treatments. One hundred adults will receive 4, 6, 8, or 10 sessions per day for 5 d…

This study tests whether up to two doses of psilocybin (the active ingredient in magic mushrooms) can safely reduce depression in adults who have both cancer and major depressive disorder. About 56 participants will receive either psilocybin or a placebo in a first session, and t…

This small pilot study tests whether Imagery Rescripting, a therapy that helps people change negative mental images, can reduce depression and negative beliefs. Ten adults with major depressive disorder will receive weekly sessions after a waiting period. The study tracks depress…

This pilot study tests whether a type of brain stimulation called accelerated continuous theta-burst stimulation (acTBS) can reduce suicidal thoughts in people hospitalized for depression. Forty inpatients will receive either real or sham (fake) stimulation up to 5 times a day fo…

This study aimed to see if transcranial magnetic stimulation (TMS) combined with talk therapy could help teens aged 13–17 whose depression didn't improve with standard treatments. Participants would have daily TMS sessions for two weeks and weekly therapy. However, the study was …

This study compares two brain stimulation treatments—electroconvulsive therapy (ECT) and magnetic seizure therapy (MST)—for people with severe depression that hasn't improved with standard medications. About 100 adults with major depression or bipolar depression will receive one …

This study tests whether short, computer-based cognitive training sessions can enhance or extend the rapid antidepressant effects of ketamine or esketamine. Researchers will enroll 600 adults with depression who are already receiving ketamine treatment. Participants will do eithe…

This study tests an experimental oral medication, NMRA-335140, against a placebo in 332 adults with major depressive disorder. The goal is to see if the drug reduces depression symptoms over 6 weeks. Participants are randomly assigned to receive either the drug or a placebo, and …

This study tests an experimental oral medication, NMRA-335140, against a placebo in 332 adults with major depressive disorder. Over 6 weeks, researchers measure changes in depression symptoms using standard rating scales. The goal is to see if the drug can safely reduce depressio…

This study aimed to compare online group cognitive behavioral therapy (CBT) with in-person group CBT for adults with major depression. The goal was to see if online therapy is just as effective and more cost-effective. However, the trial was withdrawn before enrolling any partici…

This study tests an accelerated version of a brain stimulation treatment called TMS for people with depression and anxiety. Researchers want to find the best dose to reduce symptoms. About 70 adults will take part, and the study measures changes in mood using standard questionnai…

This pilot study tests whether a personalized form of transcranial magnetic stimulation (TMS) is feasible and safe for people with severe major depressive disorder who haven't improved with multiple medications or therapy. Ten participants will receive up to 30 TMS sessions over …

This study explores whether low intensity focused ultrasound (LIFU) can safely change brain activity linked to depression and anxiety in 25 veterans. Participants receive LIFU during MRI scans, and researchers monitor for side effects and brain changes. The goal is to see if this…

This phase 2 trial tests whether adding magnesium to a standard SSRI antidepressant works better than the SSRI alone for adults with major depressive disorder. Fifty participants will be randomly assigned to receive either the combination or just the SSRI. The main goal is to see…

This study aimed to see if a single 45-minute dose of inhaled nitrous oxide (laughing gas) could quickly reduce suicidal thoughts and depression in people visiting the emergency department. It was designed for adults aged 18-65 with major depressive disorder who were actively sui…

This study tests two non-invasive brain stimulation methods to help people with major depression who haven't gotten better with medication. Ninety adults will receive either standard or deep brain stimulation daily for four weeks. Researchers will check if the deep method reduces…

This early-stage study is testing a smartphone app called NEAT-O that provides cognitive behavioral therapy (CBT) to adults with opioid use disorder who also have anxiety or depression. The goal is to see if the app is easy to use and acceptable to patients. If successful, it wil…

This study tests a new way of doing electroconvulsive therapy (ECT) for people with treatment-resistant depression. The goal is to target the brain more precisely to reduce side effects like memory loss while still helping with depression. Twenty participants will receive the new…

This study tests whether adding group mindfulness-based therapy to usual treatment helps people with serious mental illnesses like schizophrenia, bipolar disorder, or major depression. Researchers will randomly assign 160 patients to either usual care alone or usual care plus min…

This study tests a program that combines mood management with health and wellness coaching to help pregnant smokers who are depressed quit smoking and stay smoke-free after their baby is born. About 26 participants will take part during pregnancy and after birth. The goal is to s…

This early study tests whether adding Adderall XR (a stimulant) to repetitive transcranial magnetic stimulation (rTMS) can improve depression symptoms more than rTMS plus a placebo. Thirty adults with treatment-resistant major depressive disorder will take either Adderall or a su…

This study tests whether a faster version of transcranial magnetic stimulation (TMS) can safely treat major depressive disorder. Instead of the usual 30 sessions over six weeks, participants receive three 19-minute sessions in a single day. The trial includes 37 adults aged 22-85…

This early-stage study tests a new tablet called LY03021 in 98 healthy adults aged 18 to 45. The main goal is to check safety and how the body processes the drug. It is a first step before testing the drug in people with depression.

This small pilot study tested whether low-intensity focused ultrasound can safely ease symptoms in people with treatment-resistant depression. The device targets a brain region linked to mood. Only 1 person was enrolled, and the trial is currently suspended, so results are very l…

This study tests a new way to deliver an FDA-approved treatment called TMS (transcranial magnetic stimulation) for depression in adults aged 60 to 79. Researchers use fMRI brain scans to personalize the treatment target. The goal is to improve depression symptoms and brain connec…

This study is testing a device called SAINT® that delivers a special type of brain stimulation (accelerated TMS) to treat major depression. It involves 1000 adults who haven't gotten enough relief from standard antidepressants. Participants get 10 treatments each day for 5 days, …

This study tests whether inhaling nitrous oxide (laughing gas) can quickly reduce suicidal thoughts in people hospitalized for depression. Fifty adults with major depression and active suicidal ideas will receive either nitrous oxide or a placebo gas, plus their usual treatment. …

This study tests whether a smartphone app based on cognitive behavioral therapy (CBT) can help adults who are already taking antidepressants feel better. 150 participants in Sweden will use the app for 9 weeks, with extra online materials and therapist support available. The goal…

This study tests whether taking D-cycloserine (a drug originally used for TB) before a non-invasive brain stimulation therapy called iTBS can improve depression symptoms more than the stimulation alone. About 180 adults with treatment-resistant depression will receive daily iTBS …

This small pilot study tests whether psilocybin, the active ingredient in magic mushrooms, can change brain connections to improve depression. 18 adults with major depression who didn't get better with standard treatments will receive psilocybin. Researchers will measure brain ac…

This study tests whether a type of brain stimulation called intermittent theta burst stimulation (iTBS) can help people with major depression who are already on medication but still have symptoms. About 30 adults will receive either real or sham stimulation to see if it improves …

This early-phase study tests whether giving a single intravenous dose of the antidepressant citalopram together with 10 sessions of theta burst stimulation (a form of transcranial magnetic stimulation) can quickly improve depression symptoms. Thirty adults with major depressive d…

This study looks at how vagus nerve stimulation (VNS) affects the nervous system, heart, immune system, and metabolism in people who already have a VNS device for epilepsy or depression. Researchers will measure things like nerve activity, blood pressure, and heart rate during di…

This study explores how anxiety contributes to treatment-resistant depression. Researchers will follow 37 adults with depression to see if anxiety levels can predict who will have a harder time recovering. The goal is to better identify at-risk patients and develop more targeted …

This study uses PET and MRI scans to measure brain cell connections in people with major depression or PTSD. Researchers will give ketamine to see if it can reverse synaptic loss linked to these conditions. The goal is to understand brain changes, not to provide treatment. About …

This study looks at how internet habits, cyberbullying, and emotional coping skills relate to mental health in young people aged 15 to 24. Researchers will survey 50 participants about their internet use, depression, anxiety, and self-harm thoughts. The goal is to better understa…

This study aims to find which patients with treatment-resistant depression are most likely to get relief from a single low dose of IV ketamine. Researchers will use interviews, questionnaires, brain wave tests, and computer tasks to look for clues. The goal is to make this treatm…

This study looks at how transcranial magnetic stimulation (TMS) affects a brain area called the subgenual cingulate, which is linked to depression. Researchers will give 54 adults with depression daily TMS sessions for 4-6 weeks, along with MRI scans, to see how this brain region…

This study gives ketamine to 120 people with major depression and suicidal thoughts who are not on other psychiatric medications. Researchers use brain scans and a gentle nose swab to see how ketamine changes brain connections and neuron activity. The goal is to understand why ke…

This study looks at how stress influences long-term mood and thinking in 75 older adults with depression. Participants receive standard antidepressant treatment while researchers track their depression severity, memory, and brain activity using MRI scans. The goal is to understan…

This study is collecting data from 350 people with major depression to build an AI tool that helps doctors choose the best antidepressant for each patient. Researchers are analyzing blood, gut bacteria, brain activity, and genetics to find patterns that predict treatment success.…

This study aimed to see if electronic cigarettes could help people with depression smoke less or quit. It planned to follow smokers for 12 months, measuring how many cut down or stopped. However, the study was withdrawn before enrolling anyone, so no results were collected.

This study tests whether low intensity focused ultrasound can change negative thought patterns in people with depression. Researchers will target a key brain network involved in mind-wandering and self-judgment. 80 participants will receive both real and sham ultrasound sessions …

This study was designed to test the safety and feasibility of a focused ultrasound device called Exablate Neuro with a new Echo-Focusing feature for people with treatment-resistant brain disorders like essential tremor or depression. However, the trial was withdrawn before enroll…

This study looks at how Transcranial Magnetic Stimulation (TMS) changes the brain in people with major depression. Researchers will use MRI scans to track these changes over 6 weeks. The goal is to better understand how TMS works, not to test a new treatment. 40 adults aged 18-65…

This study looks at whether specific brain wave patterns (gamma oscillations) can help predict how well ketamine therapy works for people with treatment-resistant depression. Researchers will measure brain activity using EEG before and during ketamine treatment and track depressi…

This study aims to understand how the brain's pain-processing systems relate to a person's ability to attempt suicide. Researchers will use fMRI scans to measure brain activity in 90 adults with depression while they experience pressure pain. The goal is to identify neural patter…

This study was designed to understand why electroconvulsive therapy (ECT) sometimes causes temporary memory problems. Researchers planned to measure brain waves in people with severe depression or bipolar disorder receiving ECT. The study was withdrawn before any participants wer…

This study looks at whether brain scans can help predict which veterans with hard-to-treat depression will get better with a treatment called transcranial magnetic stimulation (TMS). Researchers will use MRI scans to measure brain activity before and during TMS therapy. The goal …

This study will survey 25,000 people in China with mood disorders like bipolar disorder or major depression. Researchers want to understand what factors increase the risk of suicide or self-harm. They will follow 1,000 participants for one year to see if their predictions hold tr…

This study aims to find brain activity patterns that can predict how people with major depression will respond to different treatments. Researchers will use a non-invasive brain imaging device (TD-fNIRS) to measure brain function in 540 adults before they start treatment. The goa…

This study looks at how transcranial magnetic stimulation (TMS) changes brain connections in people with major depression. Researchers will use MRI scans to measure brain activity before and after TMS treatment. The study involves 54 adults aged 18-80 who are already receiving TM…

This study looks at whether mild whole-body hyperthermia (raising body temperature to about 101.3°F) can help treat major depression by affecting the immune system. Researchers will give some participants a drug that blocks IL-6 (tocilizumab) and others a placebo before the heati…

This study explores a personalized form of brain stimulation called resonant frequency rTMS for people with major depression. Researchers will test different stimulation frequencies to see which one best engages brain circuits. The goal is to develop a more targeted treatment app…