New depression drug moves to Long-Term safety check in 1,000 patients

NCT ID NCT06029439

Recruiting now Disease control Sponsor: Neumora Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Oct 01, 2025 · Last updated May 15, 2026 · Updated 27 times

Summary

This study is for adults with major depressive disorder who have already completed a shorter trial of the investigational drug NMRA-335140. Over 52 weeks, researchers will monitor safety and how well the drug continues to work. The goal is to see if this medication can be a safe, long-term treatment option for depression.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

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Locations

Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Phoenix, Arizona, 85012, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Bentonville, Arkansas, 72712, United States
Neumora Investigator Site
COMPLETED

Rogers, Arkansas, 72758, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Cerritos, California, 90703, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Encino, California, 91316, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Garden Grove, California, 92845, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Glendale, California, 91206, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Imperial, California, 92251, United States
Neumora Investigator Site
RECRUITING

Irvine, California, 92614, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Lafayette, California, 94549, United States
Neumora Investigator Site
RECRUITING

Los Angeles, California, 90015, United States
Neumora Investigator Site
RECRUITING

Newport Beach, California, 92660, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Oceanside, California, 92056, United States
Neumora Investigator Site
COMPLETED

Orange, California, 92868, United States
Neumora Investigator Site
COMPLETED

Riverside, California, 92506, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

San Diego, California, 92103, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

San Francisco, California, 94107, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

San Jose, California, 95124, United States
Neumora Investigator Site
COMPLETED

Santa Ana, California, 92704, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Sherman Oaks, California, 91403, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Temecula, California, 92591, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Torrance, California, 90504, United States
Neumora Investigator Site
COMPLETED

Colorado Springs, Colorado, 80910, United States
Neumora Investigator Site
RECRUITING

New Haven, Connecticut, 06520, United States
Neumora Investigator Site
COMPLETED

Norwalk, Connecticut, 06851, United States
Neumora Investigator Site
RECRUITING

Bradenton, Florida, 34205, United States
Neumora Investigator Site
RECRUITING

Brandon, Florida, 33511, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Gainesville, Florida, 32607, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Hallandale, Florida, 33009, United States
Neumora Investigator Site
RECRUITING

Hialeah, Florida, 33012, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Hialeah, Florida, 33016, United States
Neumora Investigator Site
RECRUITING

Hollywood, Florida, 33024, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Jacksonville, Florida, 32256, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Lauderhill, Florida, 33319, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Maitland, Florida, 32751, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Miami, Florida, 33122, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Miami, Florida, 33126, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Miami, Florida, 33133, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Miami, Florida, 33137, United States
Neumora Investigator Site
RECRUITING

Miami, Florida, 33143, United States
Neumora Investigator Site
RECRUITING

Miami, Florida, 33165, United States
Neumora Investigator Site
RECRUITING

Miami, Florida, 33174, United States
Neumora Investigator Site
RECRUITING

Miami Beach, Florida, 33140, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Miami Springs, Florida, 33166, United States
Neumora Investigator Site
RECRUITING

Orlando, Florida, 32803, United States
Neumora Investigator Site
RECRUITING

Orlando, Florida, 32807, United States
Neumora Investigator Site
RECRUITING

Pembroke Pines, Florida, 33024, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Pompano Beach, Florida, 33060, United States
Neumora Investigator Site
COMPLETED

Saint Augustine, Florida, 32086, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Tampa, Florida, 33607, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Tampa, Florida, 33613, United States
Neumora Investigator Site
RECRUITING

Atlanta, Georgia, 30318, United States
Neumora Investigator Site
RECRUITING

Atlanta, Georgia, 30328, United States
Neumora Investigator Site
COMPLETED

Atlanta, Georgia, 30338, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Decatur, Georgia, 30030, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Marietta, Georgia, 30060, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Savannah, Georgia, 31405, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Chicago, Illinois, 60634, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Warrenville, Illinois, 60555, United States
Neumora Investigator Site
COMPLETED

Marrero, Louisiana, 70072, United States
Neumora Investigator Site
RECRUITING

New Orleans, Louisiana, 70115, United States
Neumora Investigator Site
RECRUITING

Baltimore, Maryland, 21208, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Boston, Massachusetts, 02116, United States
Neumora Investigator Site
RECRUITING

Boston, Massachusetts, 02131, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Watertown, Massachusetts, 02472, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Mankato, Minnesota, 56001, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Flowood, Mississippi, 39232, United States
Neumora Investigator Site
COMPLETED

Saint Charles, Missouri, 63304, United States
Neumora Investigator Site
RECRUITING

St Louis, Missouri, 63141, United States
Neumora Investigator Site
COMPLETED

Las Vegas, Nevada, 89102, United States
Neumora Investigator Site
RECRUITING

Berlin, New Jersey, 08009, United States
Neumora Investigator Site
RECRUITING

Toms River, New Jersey, 08755, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Albuquerque, New Mexico, 87109, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Brooklyn, New York, 11224, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Buffalo, New York, 14215, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Cedarhurst, New York, 11516, United States
Neumora Investigator Site
RECRUITING

Inwood, New York, 11096, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

New York, New York, 10017, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

New York, New York, 10029, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

New York, New York, 10036, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Staten Island, New York, 10310, United States
Neumora Investigator Site
COMPLETED

Staten Island, New York, 10314, United States
Neumora Investigator Site
RECRUITING

The Bronx, New York, 10461, United States
Neumora Investigator Site
RECRUITING

Charlotte, North Carolina, 28211, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Monroe, North Carolina, 28112, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Columbus, Ohio, 43210, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Dayton, Ohio, 45417, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

North Canton, Ohio, 44720, United States
Neumora Investigator Site
RECRUITING

Edmond, Oklahoma, 73013, United States
Neumora Investigator Site
RECRUITING

Oklahoma City, Oklahoma, 73118, United States
Neumora Investigator Site
RECRUITING

Allentown, Pennsylvania, 18104, United States
Neumora Investigator Site
COMPLETED

Media, Pennsylvania, 19063, United States
Neumora Investigator Site
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Memphis, Tennessee, 38119, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Austin, Texas, 78737, United States
Neumora Investigator Site
RECRUITING

Dallas, Texas, 75243, United States
Neumora Investigator Site
RECRUITING

DeSoto, Texas, 75115, United States
Neumora Investigator Site
RECRUITING

Fort Worth, Texas, 76104, United States
Neumora Investigator Site
COMPLETED

Houston, Texas, 77030, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Houston, Texas, 77090, United States
Neumora Investigator Site
COMPLETED

Wichita Falls, Texas, 76309, United States
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Bellevue, Washington, 98007, United States
Neumora Investigator Site
RECRUITING

Curitiba, Paraná, 80240280, Brazil
Neumora Investigator Site
RECRUITING

Botafogo - Rio de Janeiro, Rio de Janeiro, 22270-060, Brazil
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Porto Alegre, Rio Grande do Sul, 90610-001, Brazil
Neumora Investigator Site
RECRUITING

Santa Cecília, São Paulo, 01228-000, Brazil
Neumora Investigator Site
RECRUITING

São Bernardo do Campo, São Paulo, 09726150, Brazil
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

São José do Rio Preto, São Paulo, 15090-000, Brazil
Neumora Investigator Site
RECRUITING

São Paulo, 01236030, Brazil
Neumora Investigator Site
COMPLETED

Cherven Bryag, Pleven, 5980, Bulgaria
Neumora Investigator Site
RECRUITING

Sofia, Sofia-Grad, 1408, Bulgaria
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Sofia, Sofia-Grad, 1463, Bulgaria
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Sofia, Sofia-Grad, 1680, Bulgaria
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Varosha, Targovishte, 7700, Bulgaria
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Kardzhali, 6600, Bulgaria
Neumora Investigator Site
COMPLETED

Pleven, 5800, Bulgaria
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Varna, 9020, Bulgaria
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Kelowna, British Columbia, V1Y 1Z9, Canada
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Hamilton, Ontario, L8S 1B7, Canada
Neumora Investigator Site
COMPLETED

Markham, Ontario, L3R 1A3, Canada
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Mississauga, Ontario, L5L 1W8, Canada
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Toronto, Ontario, M5S 1M2, Canada
Neumora Investigator Site
RECRUITING

Santiago, Santiago Metropolitan, 7500710, Chile
Neumora Investigator Site
RECRUITING

Santiago, Santiago Metropolitan, 7560356, Chile
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Santiago, Santiago Metropolitan, 7561282, Chile
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Santiago, Santiago Metropolitan, 8330034, Chile
Neumora Investigator Site
RECRUITING

Antofagasta, 1270244, Chile
Neumora Investigator Site
RECRUITING

Pilsen, Plzeň, 301 00, Czechia
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Prague, Prague, 186 00, Czechia
Neumora Investigator Site
COMPLETED

Kladno, South Bohemian, 272 01, Czechia
Neumora Investigator Site
RECRUITING

Kladno, 272 01, Czechia
Neumora Investigator Site
COMPLETED

Prague, 109 00, Czechia
Neumora Investigator Site
RECRUITING

Helsinki, Etelä-Suomen Lääni, 00100, Finland
Neumora Investigator Site
COMPLETED

Turku, Etelä-Suomen Lääni, 20520, Finland
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Oulu, Oulun Lääni, 90100, Finland
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Clermont-Ferrand, Auvergne-Rhône-Alpes, 63000, France
Neumora Investigator Site
RECRUITING

Douai, Hauts-de-France, 59500, France
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Montpellier, Hérault, 34295, France
Neumora Investigator Site
RECRUITING

La Roche-sur-Yon, Vendée, 85000, France
Neumora Investigator Site
COMPLETED

Poitiers, Vienne, 86000, France
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Berlin, 10117, Germany
Neumora Investigator Site
RECRUITING

Berlin, 10629, Germany
Neumora Investigator Site
RECRUITING

Berlin, 13187, Germany
Neumora Investigator Site
COMPLETED

Hamburg, 20253, Germany
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Suchy Las, Greater Poland Voivodeship, 62-002, Poland
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-133, Poland
Neumora Investigator Site
RECRUITING

Wroclaw, Lower Silesian Voivodeship, 50-414, Poland
Neumora Investigator Site
COMPLETED

Lublin, Lublin Voivodeship, 20-109, Poland
Neumora Investigator Site
COMPLETED

Lublin, Lublin Voivodeship, 20-582, Poland
Neumora Investigator Site
RECRUITING

Białystok, Podkarpackie Voivodeship, 15-879, Poland
Neumora Investigator Site
COMPLETED

Gdansk, Pomeranian Voivodeship, 80-438, Poland
Neumora Investigator Site
RECRUITING

Lund, Skåne County, 222 22, Sweden
Neumora Investigator Site
ACTIVE_NOT_RECRUITING

Stockholm, Stolkholm Ian, 113 29, Sweden
Neumora Investigator Site #1
COMPLETED

Little Rock, Arkansas, 72211, United States
Neumora Investigator Site #1
RECRUITING

Long Beach, California, 90807, United States
Neumora Investigator Site #1
ACTIVE_NOT_RECRUITING

Orange, California, 92868, United States
Neumora Investigator Site #1
COMPLETED

Miami Lakes, Florida, 33016, United States
Neumora Investigator Site #1
RECRUITING

Orlando, Florida, 32801, United States
Neumora Investigator Site #1
RECRUITING

Pompano Beach, Florida, 33060, United States
Neumora Investigator Site #1
ACTIVE_NOT_RECRUITING

Tampa, Florida, 33613, United States
Neumora Investigator Site #1
ACTIVE_NOT_RECRUITING

Atlanta, Georgia, 30328, United States
Neumora Investigator Site #1
RECRUITING

Houston, Texas, 77030, United States
Neumora Investigator Site #1
ACTIVE_NOT_RECRUITING

Everett, Washington, 98201, United States
Neumora Investigator Site #1
COMPLETED

Berlin, 10117, Germany
Neumora Investigator Site #2
RECRUITING

Miami Lakes, Florida, 33016, United States
Neumora Investigator site
RECRUITING

Huntsville, Alabama, 35801, United States
Neumora Investigator site
ACTIVE_NOT_RECRUITING

Little Rock, Arkansas, 72211, United States
Neumora Investigator site
ACTIVE_NOT_RECRUITING

Bellflower, California, 90706, United States
Neumora Investigator site
ACTIVE_NOT_RECRUITING

Long Beach, California, 90807, United States
Neumora Investigator site
ACTIVE_NOT_RECRUITING

Miami, Florida, 33183, United States
Neumora Investigator site
ACTIVE_NOT_RECRUITING

Miami Lakes, Florida, 33014, United States
Neumora Investigator site
ACTIVE_NOT_RECRUITING

Orlando, Florida, 32801, United States
Neumora Investigator site
RECRUITING

Towson, Maryland, 21204, United States
Neumora Investigator site
COMPLETED

Methuen, Massachusetts, 01844, United States
Neumora Investigator site
RECRUITING

Springfield, Massachusetts, 01103, United States
Neumora Investigator site
COMPLETED

Bloomfield Township, Michigan, 48302, United States
Neumora Investigator site
RECRUITING

Princeton, New Jersey, 08540, United States
Neumora Investigator site
RECRUITING

Austin, Texas, 78759, United States

Conditions

Explore the condition pages connected to this study.

MAJOR DEPRESSIVE DISORDER