New depression drug tested for long-term safety in 1,000 patients

NCT ID NCT06029439

Ongoing Disease control Sponsor: Neumora Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at the long-term safety and effectiveness of an experimental drug called NMRA-335140 for people with major depressive disorder. About 1,000 adults who completed earlier studies of this drug will take it for 52 weeks. Researchers will track side effects and changes in depression symptoms to see if the drug remains safe and helpful over time.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER

Contacts and locations

Show contact details

Locations

Neumora Investigator Site

Phoenix, Arizona, 85012, United States
Neumora Investigator Site

Bentonville, Arkansas, 72712, United States
Neumora Investigator Site

Rogers, Arkansas, 72758, United States
Neumora Investigator Site

Cerritos, California, 90703, United States
Neumora Investigator Site

Encino, California, 91316, United States
Neumora Investigator Site

Garden Grove, California, 92845, United States
Neumora Investigator Site

Glendale, California, 91206, United States
Neumora Investigator Site

Imperial, California, 92251, United States
Neumora Investigator Site

Irvine, California, 92614, United States
Neumora Investigator Site

Lafayette, California, 94549, United States
Neumora Investigator Site

Los Angeles, California, 90015, United States
Neumora Investigator Site

Newport Beach, California, 92660, United States
Neumora Investigator Site

Oceanside, California, 92056, United States
Neumora Investigator Site

Orange, California, 92868, United States
Neumora Investigator Site

Riverside, California, 92506, United States
Neumora Investigator Site

San Diego, California, 92103, United States
Neumora Investigator Site

San Francisco, California, 94107, United States
Neumora Investigator Site

San Jose, California, 95124, United States
Neumora Investigator Site

Santa Ana, California, 92704, United States
Neumora Investigator Site

Sherman Oaks, California, 91403, United States
Neumora Investigator Site

Temecula, California, 92591, United States
Neumora Investigator Site

Torrance, California, 90504, United States
Neumora Investigator Site

Colorado Springs, Colorado, 80910, United States
Neumora Investigator Site

New Haven, Connecticut, 06520, United States
Neumora Investigator Site

Norwalk, Connecticut, 06851, United States
Neumora Investigator Site

Bradenton, Florida, 34205, United States
Neumora Investigator Site

Brandon, Florida, 33511, United States
Neumora Investigator Site

Gainesville, Florida, 32607, United States
Neumora Investigator Site

Hallandale, Florida, 33009, United States
Neumora Investigator Site

Hialeah, Florida, 33012, United States
Neumora Investigator Site

Hialeah, Florida, 33016, United States
Neumora Investigator Site

Hollywood, Florida, 33024, United States
Neumora Investigator Site

Jacksonville, Florida, 32256, United States
Neumora Investigator Site

Lauderhill, Florida, 33319, United States
Neumora Investigator Site

Maitland, Florida, 32751, United States
Neumora Investigator Site

Miami, Florida, 33122, United States
Neumora Investigator Site

Miami, Florida, 33126, United States
Neumora Investigator Site

Miami, Florida, 33133, United States
Neumora Investigator Site

Miami, Florida, 33137, United States
Neumora Investigator Site

Miami, Florida, 33143, United States
Neumora Investigator Site

Miami, Florida, 33165, United States
Neumora Investigator Site

Miami, Florida, 33174, United States
Neumora Investigator Site

Miami Beach, Florida, 33140, United States
Neumora Investigator Site

Miami Springs, Florida, 33166, United States
Neumora Investigator Site

Orlando, Florida, 32803, United States
Neumora Investigator Site

Orlando, Florida, 32807, United States
Neumora Investigator Site

Pembroke Pines, Florida, 33024, United States
Neumora Investigator Site

Pompano Beach, Florida, 33060, United States
Neumora Investigator Site

Saint Augustine, Florida, 32086, United States
Neumora Investigator Site

Tampa, Florida, 33607, United States
Neumora Investigator Site

Tampa, Florida, 33613, United States
Neumora Investigator Site

Atlanta, Georgia, 30318, United States
Neumora Investigator Site

Atlanta, Georgia, 30328, United States
Neumora Investigator Site

Atlanta, Georgia, 30338, United States
Neumora Investigator Site

Decatur, Georgia, 30030, United States
Neumora Investigator Site

Marietta, Georgia, 30060, United States
Neumora Investigator Site

Savannah, Georgia, 31405, United States
Neumora Investigator Site

Chicago, Illinois, 60634, United States
Neumora Investigator Site

Warrenville, Illinois, 60555, United States
Neumora Investigator Site

Marrero, Louisiana, 70072, United States
Neumora Investigator Site

New Orleans, Louisiana, 70115, United States
Neumora Investigator Site

Baltimore, Maryland, 21208, United States
Neumora Investigator Site

Boston, Massachusetts, 02116, United States
Neumora Investigator Site

Boston, Massachusetts, 02131, United States
Neumora Investigator Site

Watertown, Massachusetts, 02472, United States
Neumora Investigator Site

Mankato, Minnesota, 56001, United States
Neumora Investigator Site

Flowood, Mississippi, 39232, United States
Neumora Investigator Site

Saint Charles, Missouri, 63304, United States
Neumora Investigator Site

St Louis, Missouri, 63141, United States
Neumora Investigator Site

Las Vegas, Nevada, 89102, United States
Neumora Investigator Site

Berlin, New Jersey, 08009, United States
Neumora Investigator Site

Toms River, New Jersey, 08755, United States
Neumora Investigator Site

Albuquerque, New Mexico, 87109, United States
Neumora Investigator Site

Brooklyn, New York, 11224, United States
Neumora Investigator Site

Buffalo, New York, 14215, United States
Neumora Investigator Site

Cedarhurst, New York, 11516, United States
Neumora Investigator Site

Inwood, New York, 11096, United States
Neumora Investigator Site

New York, New York, 10017, United States
Neumora Investigator Site

New York, New York, 10029, United States
Neumora Investigator Site

New York, New York, 10036, United States
Neumora Investigator Site

Staten Island, New York, 10310, United States
Neumora Investigator Site

Staten Island, New York, 10314, United States
Neumora Investigator Site

The Bronx, New York, 10461, United States
Neumora Investigator Site

Charlotte, North Carolina, 28211, United States
Neumora Investigator Site

Monroe, North Carolina, 28112, United States
Neumora Investigator Site

Columbus, Ohio, 43210, United States
Neumora Investigator Site

Dayton, Ohio, 45417, United States
Neumora Investigator Site

North Canton, Ohio, 44720, United States
Neumora Investigator Site

Edmond, Oklahoma, 73013, United States
Neumora Investigator Site

Oklahoma City, Oklahoma, 73118, United States
Neumora Investigator Site

Allentown, Pennsylvania, 18104, United States
Neumora Investigator Site

Media, Pennsylvania, 19063, United States
Neumora Investigator Site

Philadelphia, Pennsylvania, 19104, United States
Neumora Investigator Site

Memphis, Tennessee, 38119, United States
Neumora Investigator Site

Austin, Texas, 78737, United States
Neumora Investigator Site

Dallas, Texas, 75243, United States
Neumora Investigator Site

DeSoto, Texas, 75115, United States
Neumora Investigator Site

Fort Worth, Texas, 76104, United States
Neumora Investigator Site

Houston, Texas, 77030, United States
Neumora Investigator Site

Houston, Texas, 77090, United States
Neumora Investigator Site

Wichita Falls, Texas, 76309, United States
Neumora Investigator Site

Bellevue, Washington, 98007, United States
Neumora Investigator Site

Curitiba, Paraná, 80240280, Brazil
Neumora Investigator Site

Botafogo - Rio de Janeiro, Rio de Janeiro, 22270-060, Brazil
Neumora Investigator Site

Porto Alegre, Rio Grande do Sul, 90610-001, Brazil
Neumora Investigator Site

Santa Cecília, São Paulo, 01228-000, Brazil
Neumora Investigator Site

São Bernardo do Campo, São Paulo, 09726150, Brazil
Neumora Investigator Site

São José do Rio Preto, São Paulo, 15090-000, Brazil
Neumora Investigator Site

São Paulo, 01236030, Brazil
Neumora Investigator Site

Cherven Bryag, Pleven, 5980, Bulgaria
Neumora Investigator Site

Sofia, Sofia-Grad, 1408, Bulgaria
Neumora Investigator Site

Sofia, Sofia-Grad, 1463, Bulgaria
Neumora Investigator Site

Sofia, Sofia-Grad, 1680, Bulgaria
Neumora Investigator Site

Varosha, Targovishte, 7700, Bulgaria
Neumora Investigator Site

Kardzhali, 6600, Bulgaria
Neumora Investigator Site

Pleven, 5800, Bulgaria
Neumora Investigator Site

Varna, 9020, Bulgaria
Neumora Investigator Site

Kelowna, British Columbia, V1Y 1Z9, Canada
Neumora Investigator Site

Hamilton, Ontario, L8S 1B7, Canada
Neumora Investigator Site

Markham, Ontario, L3R 1A3, Canada
Neumora Investigator Site

Mississauga, Ontario, L5L 1W8, Canada
Neumora Investigator Site

Toronto, Ontario, M5S 1M2, Canada
Neumora Investigator Site

Santiago, Santiago Metropolitan, 7500710, Chile
Neumora Investigator Site

Santiago, Santiago Metropolitan, 7560356, Chile
Neumora Investigator Site

Santiago, Santiago Metropolitan, 7561282, Chile
Neumora Investigator Site

Santiago, Santiago Metropolitan, 8330034, Chile
Neumora Investigator Site

Antofagasta, 1270244, Chile
Neumora Investigator Site

Pilsen, Plzeň, 301 00, Czechia
Neumora Investigator Site

Prague, Prague, 186 00, Czechia
Neumora Investigator Site

Kladno, South Bohemian, 272 01, Czechia
Neumora Investigator Site

Kladno, 272 01, Czechia
Neumora Investigator Site

Prague, 109 00, Czechia
Neumora Investigator Site

Helsinki, Etelä-Suomen Lääni, 00100, Finland
Neumora Investigator Site

Turku, Etelä-Suomen Lääni, 20520, Finland
Neumora Investigator Site

Oulu, Oulun Lääni, 90100, Finland
Neumora Investigator Site

Clermont-Ferrand, Auvergne-Rhône-Alpes, 63000, France
Neumora Investigator Site

Douai, Hauts-de-France, 59500, France
Neumora Investigator Site

Montpellier, Hérault, 34295, France
Neumora Investigator Site

La Roche-sur-Yon, Vendée, 85000, France
Neumora Investigator Site

Poitiers, Vienne, 86000, France
Neumora Investigator Site

Berlin, 10117, Germany
Neumora Investigator Site

Berlin, 10629, Germany
Neumora Investigator Site

Berlin, 13187, Germany
Neumora Investigator Site

Hamburg, 20253, Germany
Neumora Investigator Site

Suchy Las, Greater Poland Voivodeship, 62-002, Poland
Neumora Investigator Site

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-133, Poland
Neumora Investigator Site

Wroclaw, Lower Silesian Voivodeship, 50-414, Poland
Neumora Investigator Site

Lublin, Lublin Voivodeship, 20-109, Poland
Neumora Investigator Site

Lublin, Lublin Voivodeship, 20-582, Poland
Neumora Investigator Site

Białystok, Podkarpackie Voivodeship, 15-879, Poland
Neumora Investigator Site

Gdansk, Pomeranian Voivodeship, 80-438, Poland
Neumora Investigator Site

Lund, Skåne County, 222 22, Sweden
Neumora Investigator Site

Stockholm, Stolkholm Ian, 113 29, Sweden
Neumora Investigator Site #1

Little Rock, Arkansas, 72211, United States
Neumora Investigator Site #1

Long Beach, California, 90807, United States
Neumora Investigator Site #1

Orange, California, 92868, United States
Neumora Investigator Site #1

Miami Lakes, Florida, 33016, United States
Neumora Investigator Site #1

Orlando, Florida, 32801, United States
Neumora Investigator Site #1

Pompano Beach, Florida, 33060, United States
Neumora Investigator Site #1

Tampa, Florida, 33613, United States
Neumora Investigator Site #1

Atlanta, Georgia, 30328, United States
Neumora Investigator Site #1

Houston, Texas, 77030, United States
Neumora Investigator Site #1

Everett, Washington, 98201, United States
Neumora Investigator Site #1

Berlin, 10117, Germany
Neumora Investigator Site #2

Miami Lakes, Florida, 33016, United States
Neumora Investigator site

Huntsville, Alabama, 35801, United States
Neumora Investigator site

Little Rock, Arkansas, 72211, United States
Neumora Investigator site

Bellflower, California, 90706, United States
Neumora Investigator site

Long Beach, California, 90807, United States
Neumora Investigator site

Miami, Florida, 33183, United States
Neumora Investigator site

Miami Lakes, Florida, 33014, United States
Neumora Investigator site

Orlando, Florida, 32801, United States
Neumora Investigator site

Towson, Maryland, 21204, United States
Neumora Investigator site

Methuen, Massachusetts, 01844, United States
Neumora Investigator site

Springfield, Massachusetts, 01103, United States
Neumora Investigator site

Bloomfield Township, Michigan, 48302, United States
Neumora Investigator site

Princeton, New Jersey, 08540, United States
Neumora Investigator site

Austin, Texas, 78759, United States