New brain zapping method aims to lift depression in just 5 days
NCT ID NCT05819021
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is testing a device called SAINT® that delivers a special type of brain stimulation (accelerated TMS) to treat major depression. It involves 1000 adults who haven't gotten enough relief from standard antidepressants. Participants get 10 treatments each day for 5 days, with the goal of quickly improving their symptoms.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
SAINT® Neuromodulation System (accelerated TMS device)
What this could lead to
If successful, this could offer a faster, more personalized treatment option for people with depression who haven't responded to medication.
What could go wrong
This is an observational study, not a randomized controlled trial, so results may be less conclusive. The treatment is intensive (10 sessions daily for 5 days) and may not work for everyone.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Acacia Research Center
Sunnyvale, California, 94087, United States
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Boston Precision Neurotherapeutics
Natick, Massachusetts, 01760, United States
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BrainHealth Solutions
Costa Mesa, California, 92626, United States
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Fermata
Brooklyn, New York, 11249, United States
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Integral TMS
Sunnyvale, California, 94085, United States
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LA TMS
Los Angeles, California, 90025, United States
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Seattle Neuropsychiatric Treatment Center
Seattle, Washington, 98104, United States