New brain zapping method aims to lift depression in just 5 days

NCT ID NCT05819021

Ongoing Symptom relief Sponsor: Magnus Medical Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing a device called SAINT® that delivers a special type of brain stimulation (accelerated TMS) to treat major depression. It involves 1000 adults who haven't gotten enough relief from standard antidepressants. Participants get 10 treatments each day for 5 days, with the goal of quickly improving their symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: SAINT® Neuromodulation System (accelerated TMS device)
What this could lead to: If successful, this could offer a faster, more personalized treatment option for people with depression who haven't responded to medication.
What could go wrong: This is an observational study, not a randomized controlled trial, so results may be less conclusive. The treatment is intensive (10 sessions daily for 5 days) and may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depression Depressive Disorder, Treatment-Resistant major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER

Contacts and locations

Locations

Acacia Research Center

Sunnyvale, California, 94087, United States
Boston Precision Neurotherapeutics

Natick, Massachusetts, 01760, United States
BrainHealth Solutions

Costa Mesa, California, 92626, United States
Fermata

Brooklyn, New York, 11249, United States
Integral TMS

Sunnyvale, California, 94085, United States
LA TMS

Los Angeles, California, 90025, United States
Seattle Neuropsychiatric Treatment Center

Seattle, Washington, 98104, United States

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