Could a common mineral boost antidepressants? new trial investigates
NCT ID NCT07458022
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This phase 2 trial tests whether adding magnesium to a standard SSRI antidepressant works better than the SSRI alone for adults with major depressive disorder. Fifty participants will be randomly assigned to receive either the combination or just the SSRI. The main goal is to see if depression scores improve more with the added magnesium after 4 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
magnesium
What this could lead to
If it works, this could point toward a simple, low-cost way to boost the effectiveness of standard antidepressants for people with major depression.
What could go wrong
This is a small, early-phase trial with only 50 participants, so results may not apply to everyone. It's also not yet clear if adding magnesium is safe or effective long-term.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for MAJOR DEPRESSIVE DISORDER are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Combined Military Hospital (CMH)
Multan, Punjab Province, 60000, Pakistan