Brain imaging may predict which depression treatment works for you

NCT ID NCT06002100

ENROLLING_BY_INVITATION Knowledge-focused Sponsor: Kernel Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aims to find brain activity patterns that can predict how people with major depression will respond to different treatments. Researchers will use a non-invasive brain imaging device (TD-fNIRS) to measure brain function in 540 adults before they start treatment. The goal is to move toward personalized depression care, where the right treatment is chosen based on individual brain signals.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to

If successful, this could lead to personalized depression treatment plans based on brain activity, improving outcomes.

What could go wrong

This is an observational study, not a treatment trial. It may not identify reliable biomarkers, and results may not apply to all patients.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Acacia Clinics

    Sunnyvale, California, 94087, United States

  • Bespoke Treatment

    Los Angeles, California, 90012, United States

  • Bespoke Treatment

    Los Angeles, California, 90025, United States

  • BrainHealth Solutions

    Costa Mesa, California, 92626, United States

  • Kadima Neuropsychiatry Institute

    La Jolla, California, 92037, United States

  • Kaizen Brain Center, LLC

    La Jolla, California, 92037, United States

  • Metro Psychiatry Inc.

    Columbus, Ohio, 43215, United States

  • Seattle Neuropsychiatric Treatment Center

    Bellevue, Washington, 98004, United States

  • Seattle Neuropsychiatric Treatment Center

    Seattle, Washington, 98104, United States

  • UCLA TMS

    Los Angeles, California, 90024, United States