Magic mushroom compound tested for Long-Term depression relief

NCT ID NCT06605105

ENROLLING_BY_INVITATION Disease control Sponsor: Cybin IRL Limited Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 14, 2026 · Updated 3 times

Summary

This study is a long-term follow-up for people with major depressive disorder who already completed a previous trial with CYB003, a drug similar to psilocybin. It will test how safe and effective CYB003 is over time, with optional extra doses. About 468 participants will be monitored using a standard depression rating scale.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: CYB003 (a deuterated psilocin analog, similar to the active compound in magic mushrooms)
What this could lead to: If successful, this could provide a new, long-term treatment option for people with major depressive disorder that may reduce symptoms with fewer doses than current antidepressants.
What could go wrong: This is an extension study, so participants already responded well in earlier trials. It is not a standalone test, and long-term side effects or loss of effectiveness are still possible. The drug is investigational and not yet approved.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depression major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER

Contacts and locations

Locations

Adams Clinical

Watertown, Massachusetts, 02472, United States
Adams Clinical Boston

Boston, Massachusetts, 02116, United States
Adams Clinical Bronx

The Bronx, New York, 10461, United States
Adams Clinical Harlem

New York, New York, 10029, United States
Atlanta Center For Medical Research

Atlanta, Georgia, 30331, United States
Cedar Clinical Research

Draper, Utah, 84020, United States
CenExel iResearch

Savannah, Georgia, 31405, United States
Cenexel iResearcvh Atlanta, LLC

Atlanta, Georgia, 30030, United States
Charter Research

Orlando, Florida, 32803, United States
Clinical Neuroscience Solutions, CNS Healthcare

Memphis, Tennessee, 38119, United States
Clinical Neuroscience Solutions, Inc

Orlando, Florida, 32801, United States
Combined Research Orlando

Phoenix, Arizona, 85022, United States
InSite Clinical Research, LLC

DeSoto, Texas, 75115, United States
Inland Psychiatric Medical Group Inc (IPMG Research)

San Juan Capistrano, California, 92675, United States
K2 Medical Research

Lady Lake, Florida, 32159, United States
K2 Medical Research

Maitland, Florida, 32751, United States
Monash University - Notting Hill

Notting Hill, Victoria, 3168, Australia
Mountain View Clinical Research

Denver, Colorado, 80209, United States
Neurobehavioral Clinical Research

Canton, Ohio, 44720, United States
Neurocentrix Research

Carlton, Victoria, 3053, Australia
Open Mind Collective / UCSF Medical Center - Mount Zion

San Francisco, California, 94114, United States
Psychiatric Medicine Associates

Skokie, Illinois, 60076, United States
Psychiatric Medicine Associates, LLC

Skokie, Illinois, 60076, United States
Ramsay Clinic

Melbourne, Victoria, 3004, Australia
Redbird Research

Las Vegas, Nevada, 89119, United States
Research Centers of America

Hollywood, Florida, 33024, United States
Segal Trials Center for Psychedelic Research

Lauderhill, Florida, 33319, United States
Starlight Clinical Research

Evergreen, Colorado, 80439, United States
Sunstone Medical, PC

Rockville, Maryland, 20850, United States
Sydney Local Health District

Camperdown, New South Wales, 2050, Australia
Thompson Brain & Mind Healthcare

Maroochydore, Queensland, 4558, Australia
Uptown Research Institute

Chicago, Illinois, 60640, United States
Zillan Clinical Research

Houston, Texas, 77082, United States

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