MAJOR DEPRESSIVE DISORDER
Clinical trials for MAJOR DEPRESSIVE DISORDER explained in plain language.
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Depression drug trial halted: what happened with AXS-05?
Disease control TerminatedThis study looked at the long-term safety and effectiveness of an experimental drug called AXS-05 for people with major depression that didn't improve with other treatments. About 181 adults who had already tried other antidepressants without success took part. The study was stop…
Matched conditions: MAJOR DEPRESSIVE DISORDER
Phase: PHASE2 • Sponsor: Axsome Therapeutics, Inc. • Aim: Disease control
Last updated May 14, 2026 12:03 UTC
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Depression drug trial halted mid-study
Symptom relief TerminatedThis study tested whether adding a daily pill called REL-1017 to a person's usual antidepressant could better relieve major depression symptoms. About 236 adults with depression that wasn't fully controlled by their current medication took either REL-1017 or a placebo. The trial …
Matched conditions: MAJOR DEPRESSIVE DISORDER
Phase: PHASE3 • Sponsor: Levomecor Inc. • Aim: Symptom relief
Last updated May 11, 2026 20:38 UTC
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New depression pill shows promise in early trial
Symptom relief TerminatedThis study tested a new drug called REL-1017 as an add-on treatment for adults with major depression who did not get enough help from standard antidepressants. The trial was stopped early after enrolling only 27 participants. The main goal was to measure changes in depression sym…
Matched conditions: MAJOR DEPRESSIVE DISORDER
Phase: PHASE3 • Sponsor: Levomecor Inc. • Aim: Symptom relief
Last updated May 07, 2026 18:41 UTC
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Psilocybin depression study Follow-Up cut short
Knowledge-focused TerminatedThis study was designed to observe 26 people with major depressive disorder for one year after they received a single dose of psilocybin or niacin in a previous trial. Researchers planned to track depression symptoms through surveys and phone interviews at 3, 6, 10, and 12 months…
Matched conditions: MAJOR DEPRESSIVE DISORDER
Sponsor: Usona Institute • Aim: Knowledge-focused
Last updated May 16, 2026 23:51 UTC
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Brain test to predict PTSD drug success falls short
Knowledge-focused TerminatedThis study aimed to see if a simple brain-wave test could predict which veterans with PTSD or depression would get the most relief from common antidepressants called SSRIs. Researchers planned to enroll 94 participants over 5 years, but the study was stopped early after only 26 p…
Matched conditions: MAJOR DEPRESSIVE DISORDER
Phase: PHASE4 • Sponsor: VA Office of Research and Development • Aim: Knowledge-focused
Last updated May 11, 2026 20:47 UTC
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Smartphone study aims to curb veteran suicide by boosting emotional awareness
Knowledge-focused TerminatedThis study tested a smartphone-based program to help veterans with serious mental illness (like PTSD, bipolar disorder, or schizophrenia) who struggle to recognize their own emotions—a condition called alexithymia. The goal was to see if improving emotion awareness could lower su…
Matched conditions: MAJOR DEPRESSIVE DISORDER
Phase: PHASE1 • Sponsor: VA Office of Research and Development • Aim: Knowledge-focused
Last updated May 06, 2026 16:13 UTC