New depression drug shows promise but study halted early

NCT ID NCT04634669

Terminated Symptom relief Sponsor: Axsome Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at the long-term safety and symptom relief of an experimental drug called AXS-05 in 181 adults with treatment-resistant depression (depression that hasn't improved with other treatments). Participants took the drug and were monitored for side effects and mood changes. The study was stopped early, so results are limited, but the goal was to see if AXS-05 could be a safe option for people who have not found relief from other antidepressants.

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Conditions

The condition(s) this trial relates to.

Depression Depressive Disorder, Treatment-Resistant major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER TREATMENT RESISTANT DEPRESSION

Contacts and locations

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Locations

Clinical Research Site

Little Rock, Arkansas, 72209, United States
Clinical Research Site

Redlands, California, 92374, United States
Clinical Research Site

Sherman Oaks, California, 91403, United States
Clinical Research Site

Upland, California, 91786, United States
Clinical Research Site

Miami, Florida, 33122, United States
Clinical Research Site

Miami Lakes, Florida, 33016, United States
Clinical Research Site

Orlando, Florida, 32081, United States
Clinical Research Site

Chicago, Illinois, 60634, United States
Clinical Research Site

Boston, Massachusetts, 02131, United States
Clinical Research Site

Berlin, New Jersey, 08009, United States
Clinical Research Site

Rochester, New York, 14618, United States
Clinical Research Site

Staten Island, New York, 10312, United States
Clinical Research Site

Hickory, North Carolina, 28601, United States
Clinical Research Site

Raleigh, North Carolina, 27609, United States
Clinical Research Site

Cincinnati, Ohio, 45215, United States
Clinical Research Site

Middleburg Heights, Ohio, 44130, United States
Clinical Research Site

Media, Pennsylvania, 19063, United States
Clinical Research Site

Dallas, Texas, 75243, United States
Clinical Research Site

Friendswood, Texas, 77546, United States
Clinical Research Site

Everett, Washington, 98201, United States

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