Depression drug trial halted: what happened?

NCT ID NCT04855747

Terminated Symptom relief Sponsor: Levomecor Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 10, 2026 · Updated 2 times

Summary

This study tested a new drug called REL-1017 (esmethadone) as an add-on treatment for people with major depression who weren't helped enough by their current antidepressant. The trial was a Phase 3, double-blind, placebo-controlled study with 236 participants. However, the study was terminated early, so the full results are not available.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: REL-1017 (esmethadone)
What this could lead to: If successful, this could provide a new add-on option for people with major depression who haven't responded well to standard antidepressants.
What could go wrong: The trial was terminated early, so results are limited. It's unclear if REL-1017 is effective or safe as an add-on treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION MAJOR DEPRESSIVE DISORDER

Contacts and locations

Locations

Relmada Site

Homewood, Alabama, 35209, United States
Relmada Site

Chandler, Arizona, 85226, United States
Relmada Site

Chandler, Arizona, 85286, United States
Relmada Site

Phoenix, Arizona, 85016, United States
Relmada Site

Tucson, Arizona, 85704, United States
Relmada Site

Bryant, Arkansas, 72022, United States
Relmada Site

Anaheim, California, 92805, United States
Relmada Site

Bellflower, California, 90706, United States
Relmada Site

Encino, California, 91316, United States
Relmada Site

Lafayette, California, 94549, United States
Relmada Site

Los Angeles, California, 90015, United States
Relmada Site

Newport Beach, California, 92660, United States
Relmada Site

Orange, California, 92868, United States
Relmada Site

Redlands, California, 92374, United States
Relmada Site

Santa Ana, California, 92705, United States
Relmada Site

Stanford, California, 94305, United States
Relmada Site

Temecula, California, 92591, United States
Relmada Site

Upland, California, 91786, United States
Relmada Site

Denver, Colorado, 80209, United States
Relmada Site

Brandon, Florida, 33511, United States
Relmada Site

Hialeah, Florida, 33015, United States
Relmada Site

Jacksonville, Florida, 32256, United States
Relmada Site

Maitland, Florida, 32751, United States
Relmada Site

Miami, Florida, 33122, United States
Relmada Site

Miami, Florida, 33125, United States
Relmada Site

Miami, Florida, 33133, United States
Relmada Site

Miami, Florida, 33136, United States
Relmada Site

Miami, Florida, 33174, United States
Relmada Site

Miami Springs, Florida, 33166, United States
Relmada Site

Okeechobee, Florida, 34972, United States
Relmada Site

Tampa, Florida, 33607, United States
Relmada Site

West Palm Beach, Florida, 33407, United States
Relmada Site

Savannah, Georgia, 31406, United States
Relmada Site

Boise, Idaho, 83704, United States
Relmada Site

Chicago, Illinois, 60611, United States
Relmada Site

Chicago, Illinois, 60634, United States
Relmada Site

Elgin, Illinois, 60123, United States
Relmada Site

Overland Park, Kansas, 66210, United States
Relmada Site

Marrero, Louisiana, 70072, United States
Relmada Site

Baltimore, Maryland, 21208, United States
Relmada Site

Bel Air, Maryland, 21015, United States
Relmada Site

Gaithersburg, Maryland, 20877, United States
Relmada Site

Boston, Massachusetts, 02131, United States
Relmada Site

Bloomfield Hills, Michigan, 48302, United States
Relmada Site

Mankato, Minnesota, 56001, United States
Relmada Site

Weldon Spring, Missouri, 63304, United States
Relmada Site

Las Vegas, Nevada, 89121, United States
Relmada Site

Toms River, New Jersey, 08755, United States
Relmada Site

Cedarhurst, New York, 11516, United States
Relmada Site

Monroe, North Carolina, 28112, United States
Relmada Site

Beachwood, Ohio, 44122, United States
Relmada Site

Cincinnati, Ohio, 45215, United States
Relmada Site

Cincinnati, Ohio, 45219, United States
Relmada Site

Westlake, Ohio, 44145, United States
Relmada Site

Philadelphia, Pennsylvania, 19104, United States
Relmada Site

State College, Pennsylvania, 16801, United States
Relmada Site

Memphis, Tennessee, 38119, United States
Relmada Site

Austin, Texas, 78737, United States
Relmada Site

Austin, Texas, 78759, United States
Relmada Site

Beaumont, Texas, 77702, United States
Relmada Site

Bellaire, Texas, 77401, United States
Relmada Site

Dallas, Texas, 75243, United States
Relmada Site

Friendswood, Texas, 77546, United States
Relmada Site

Houston, Texas, 77081, United States
Relmada Site

Sherman, Texas, 75092, United States
Relmada Site

Wichita Falls, Texas, 76309, United States
Relmada Site

Draper, Utah, 84020, United States
Relmada Site

Rutland, Vermont, 05701, United States
Relmada Site

Portsmouth, Virginia, 23703, United States
Relmada Site

Everett, Washington, 98201, United States

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