New depression pill SP-624 enters Mid-Stage trial

NCT ID NCT06254612

Ongoing Symptom relief Sponsor: Sirtsei Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a daily oral drug called SP-624 can safely reduce depression symptoms in adults with major depressive disorder. About 456 participants will receive either SP-624 or a placebo for several weeks. The main goal is to see if SP-624 leads to a greater improvement in depression scores compared to placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: SP-624 (a drug taken as a daily capsule)
What this could lead to: If successful, this could lead to a new oral medication option for people with major depressive disorder.
What could go wrong: This is a mid-stage (Phase 2) trial, so results are still uncertain. The drug may not prove more effective than placebo, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER

Contacts and locations

Locations

Accel Clinical

Lakeland, Florida, 33803, United States
Accelerated Enrollment Solutions

Atlanta, Georgia, 30328, United States
Alivation Research

Lincoln, Nebraska, 68526, United States
Boston Clinical Trials

Boston, Massachusetts, 02131, United States
CenExel HRI

Marlton, New Jersey, 08053, United States
Center for Emotional Fitness

Cherry Hill, New Jersey, 08002, United States
CiTrials

Riverside, California, 92506, United States
Clinical Innovations

Bellflower, California, 90706, United States
Clinical Neuroscience Solutions

Jacksonville, Florida, 32256, United States
Clinical Neuroscience Solutions

Orlando, Florida, 32801, United States
Clinical Neuroscience Solutions

Memphis, Tennessee, 38119, United States
Coastal Carolina Research Center

North Charleston, South Carolina, 29405, United States
Collaborative Neuroscience Research

Torrance, California, 90504, United States
Core Clinical Research

Everett, Washington, 98201, United States
DMI Research

Pinellas Park, Florida, 33782, United States
Donald J. Garcia, Jr, MD, PA

Austin, Texas, 78737, United States
Excell Research

Oceanside, California, 92056, United States
Future Search Trials of Dallas

Dallas, Texas, 75231, United States
Grayline Research Center

Wichita Falls, Texas, 76309, United States
Haracec Clinical Research

El Paso, Texas, 79902, United States
IMA Clinical Research

Phoenix, Arizona, 85012, United States
IMA Clinical Research

Las Vegas, Nevada, 89102, United States
IMA Clinical Research

Albuquerque, New Mexico, 87109, United States
Integrative Clinical Trials

Brooklyn, New York, 11229, United States
MCB Clinical Research Centers

Colorado Springs, Colorado, 80910, United States
Magnolia Clinical Research

Cary, North Carolina, 27511, United States
Midwest Clinical Research Center

Dayton, Ohio, 45417, United States
Midwest Research Group

Saint Charles, Missouri, 63304, United States
Neurobehavioral Medicine Group

Bloomfield Hills, Michigan, 48302, United States
New Hope Clinical Research

Charlotte, North Carolina, 28211, United States
Next Level Clinical Trials

West Covina, California, 91790, United States
Noble Clinical Research

Tucson, Arizona, 85704, United States
North Star Medical Research

Middleburg Heights, Ohio, 44130, United States
Northwest Clinical Research Center

Bellevue, Washington, 98007, United States
Pillar Clinical Research

Richardson, Texas, 75080, United States
Pioneer Clinical Research

New York, New York, 10016, United States
R and H Clinical Research

Stafford, Texas, 77477, United States
Redbird Research

Las Vegas, Nevada, 89119, United States
Revive Research Institute

Elgin, Illinois, 60123, United States
SanRo Clinical Research Group

Bryant, Arkansas, 72022, United States
Segal Trials

Lauderhill, Florida, 33319, United States
Segal Trials - Miami Lakes

Miami Lakes, Florida, 33016, United States
Summit Headlands

Portland, Oregon, 97210, United States
Sun Valley Research Center

Imperial, California, 92251, United States
Sunwise Clinical Research

Walnut Creek, California, 94596, United States
Synergy San Diego

Lemon Grove, California, 91945, United States
Tandem Clinical Research

Marrero, Louisiana, 70072, United States
UNC Chapel Hill

Chapel Hill, North Carolina, 27599, United States
Velocity Clinical Research

Meridian, Idaho, 83642, United States
Velocity Clinical Research

Beachwood, Ohio, 44122, United States

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