Depression and heat: new study explores body temperature control

NCT ID NCT06805851

Recruiting now Knowledge-focused Sponsor: Penn State University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how adults with depression respond to heat stress compared to those without depression. Researchers will measure skin blood flow, sweating, and core temperature during passive heating. The goal is to understand if depression or antidepressant medications like SSRIs and SNRIs change how the body cools itself.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could help explain why some people with depression have trouble regulating body temperature, potentially guiding future treatments.
What could go wrong: This is an early observational study with only 64 participants. It does not test a treatment, so results may not lead to direct medical changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder Heat Stress Disorders major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION SELECTIVE SEROTONIN REUPTAKE INHIBITOR

Contacts and locations

Locations

Noll Laboratory
RECRUITING

University Park, Pennsylvania, 16802, United States

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