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Could a single session of brain zaps and talk therapy lift depression?

NCT ID NCT07507370

Recruiting now Symptom relief Sponsor: University of North Carolina, Chapel Hill Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether a single session that combines two types of brain stimulation (TMS and tACS) with psychotherapy can safely and feasibly help people with major depression that hasn't improved with standard treatments. The researchers will enroll 30 adults aged 18-70 with moderate to severe depression. Half will get the real brain stimulation, and half will get a sham (placebo) version, so the study can compare effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Intermittent Theta Burst Stimulation (iTBS) and Transcranial Alternating Current Stimulation (tACS) devices
What this could lead to
If it works, this could point toward a rapid, one-session treatment option for people with depression that hasn't responded to other therapies.
What could go wrong
This is a very early, small feasibility study with only 30 people. It is designed mainly to test safety and whether the session can be completed, not to prove it works. The active and sham groups are small, so results may not be reliable.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depression major depressive disorder mood disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER

Contacts and locations

Locations

  • Carolina Center for Neurostimulation

    RECRUITING

    Chapel Hill, North Carolina, 27516, United States

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