Could a diabetes pill lift depression? new trial aims to find out
NCT ID NCT07239011
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether dapagliflozin, a drug normally used for diabetes, can help reduce depression symptoms when added to standard antidepressant treatment. Sixty adults with moderate to severe depression will receive either dapagliflozin plus fluoxetine or fluoxetine alone. The goal is to see if the combination leads to greater improvement in mood and quality of life.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Dapagliflozin
What this could lead to
If it works, this could point toward a new, repurposed treatment option for depression, especially for people who don't respond well to current antidepressants.
What could go wrong
This is an early, small Phase 1/2 trial with only 60 participants, so results may not apply broadly. Dapagliflozin is not yet proven for depression and may cause side effects like dehydration or urinary infections.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Mostafa Bahaa
RECRUITINGDamietta, New Damietta, 34518, Egypt
Contact Phone: •••-•••-•••• Email: •••••@•••••