Could a diabetes drug lift depression? new trial explores semaglutide's mood effects

NCT ID NCT07136714

Recruiting now Symptom relief Sponsor: Nordsjaellands Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether semaglutide, a drug used for diabetes and weight loss, can help improve mood in people with major depression who are also overweight or obese. Over 26 weeks, 116 participants will receive either semaglutide or a placebo added to their usual depression treatment. The main goal is to see if depressive symptoms decrease more with semaglutide.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Depression major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Mental Health Centre North Zealand
RECRUITING

Hillerød, Denmark, 3400, Denmark

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••