Gut feeling: can probiotics lift depression in metabolic syndrome?

NCT ID NCT06765057

Recruiting now Symptom relief Sponsor: Roaa Ahmed Alkreadees Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether a daily probiotic blend (called psychobiotics) can help ease depression and improve metabolic health in adults with pre-metabolic or metabolic syndrome. Sixty participants will take either the probiotic or a placebo for 12 weeks. Researchers will measure changes in depression, anxiety, waist size, blood sugar, blood pressure, and cholesterol.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: a multi-strain probiotic supplement (Ecologic® Barrier) containing 9 bacterial strains
What this could lead to: If it works, this could point toward a simple, safe add-on treatment for depression in people with metabolic problems.
What could go wrong: This is a small, early-phase trial with only 60 participants, so results may not apply widely. The effect may be small or no better than placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

abdominal obesity-metabolic syndrome major depressive disorder mixed anxiety and depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION ANXIETY DISORDER

Contacts and locations

Locations

King Saud University Medical City
RECRUITING

Riyadh, Riyadh Region, Saudi Arabia

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