BIPOLAR DEPRESSION
Clinical trials for BIPOLAR DEPRESSION explained in plain language.
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Can a fatty acid lift the fog of bipolar depression?
Symptom relief CompletedThis study tested whether a natural compound called palmitoylethanolamide (PEA) can help reduce depression in people with bipolar disorder. Thirty-four adults who were already taking a mood stabilizer took part. Researchers measured changes in depression scores and looked at whet…
Matched conditions: BIPOLAR DEPRESSION
Phase: PHASE2 • Sponsor: The University of Texas Health Science Center, Houston • Aim: Symptom relief
Last updated May 17, 2026 10:08 UTC
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Ketamine infusions show promise for maintaining relief in stubborn bipolar depression
Symptom relief CompletedThis study looked at whether repeated low-dose ketamine infusions could help people with treatment-resistant bipolar depression keep feeling better over 12 weeks. Forty-one adults who had already responded to an initial course of ketamine received up to six more infusions on a fl…
Matched conditions: BIPOLAR DEPRESSION
Phase: PHASE2 • Sponsor: Joshua Rosenblat • Aim: Symptom relief
Last updated May 14, 2026 12:04 UTC
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Sound waves for the brain: a new way to ease depression and anxiety?
Symptom relief CompletedThis study tested a new, non-invasive treatment for people with depression, anxiety, bipolar disorder, or PTSD. It used low-intensity focused ultrasound to gently stimulate a brain region called the amygdala, which is involved in emotion. 29 adults received daily sessions for thr…
Matched conditions: BIPOLAR DEPRESSION
Phase: NA • Sponsor: University of Texas at Austin • Aim: Symptom relief
Last updated May 04, 2026 16:20 UTC
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New pill shows promise for bipolar depression in major trial
Symptom relief CompletedThis study tested a new medication called ITI-007 (lumateperone) to see if it can safely ease depression in people with bipolar I or II disorder. About 550 adults took either the drug or a placebo for six weeks. Researchers measured mood changes using a standard depression scale.…
Matched conditions: BIPOLAR DEPRESSION
Phase: PHASE3 • Sponsor: Intra-Cellular Therapies, Inc. • Aim: Symptom relief
Last updated Apr 30, 2026 15:50 UTC
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Ketamine shows promise for bipolar depression in new trial
Symptom relief CompletedThis study tested four doses of intravenous ketamine in 71 adults with treatment-resistant bipolar depression. Participants received either ketamine or a sedative (midazolam) over two weeks. The goal was to see if ketamine could safely reduce depression symptoms. Results focused …
Matched conditions: BIPOLAR DEPRESSION
Phase: PHASE2 • Sponsor: Joshua Rosenblat • Aim: Symptom relief
Last updated Apr 24, 2026 16:06 UTC
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Immune booster shows promise for bipolar depression
Symptom relief CompletedThis study tested a low dose of interleukin-2 (IL-2) in 14 people with bipolar disorder who were currently depressed. The goal was to see if the treatment could increase certain immune cells (Tregs) and improve mood. Participants continued their usual mood stabilizers or antidepr…
Matched conditions: BIPOLAR DEPRESSION
Phase: PHASE2 • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Symptom relief
Last updated Apr 24, 2026 16:06 UTC
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Brain scans reveal Ketamine's effects in bipolar depression
Knowledge-focused CompletedThis study looked at how a single dose of ketamine changes brain connections in people with bipolar depression who haven't gotten better with other treatments. Twenty adults received ketamine and had brain scans before and after. The goal was to see if changes in brain activity c…
Matched conditions: BIPOLAR DEPRESSION
Phase: PHASE2 • Sponsor: Brian Barnett • Aim: Knowledge-focused
Last updated May 15, 2026 11:56 UTC