BIPOLAR DEPRESSION
Clinical trials for BIPOLAR DEPRESSION explained in plain language.
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Ketamine shows promise for stubborn bipolar depression
Disease control CompletedThis study tested whether regular ketamine infusions could help maintain relief from severe bipolar depression in people who initially responded to the treatment. Forty-one adults with treatment-resistant bipolar depression received flexible-dose ketamine infusions every 2-4 week…
Matched conditions: BIPOLAR DEPRESSION
Phase: PHASE2 • Sponsor: Joshua Rosenblat • Aim: Disease control
Last updated Apr 01, 2026 14:41 UTC
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Ketamine shows promise for stubborn bipolar depression in new trial
Disease control CompletedThis study tested whether repeated low-dose ketamine infusions could help people with treatment-resistant bipolar depression. 71 participants who hadn't responded to standard medications received either ketamine or a sedative placebo over two weeks. Researchers measured changes i…
Matched conditions: BIPOLAR DEPRESSION
Phase: PHASE2 • Sponsor: Joshua Rosenblat • Aim: Disease control
Last updated Mar 30, 2026 14:29 UTC
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New hope for bipolar depression? major trial tests promising drug
Disease control CompletedThis large, completed study tested whether a medication called ITI-007 (lumateperone) could safely help reduce depressive symptoms in adults with bipolar disorder. Over 550 participants with bipolar I or II disorder who were experiencing a major depressive episode were randomly a…
Matched conditions: BIPOLAR DEPRESSION
Phase: PHASE3 • Sponsor: Intra-Cellular Therapies, Inc. • Aim: Disease control
Last updated Mar 27, 2026 12:39 UTC
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Natural compound tested as potential mood booster for bipolar depression
Symptom relief CompletedThis study tested whether a supplement called palmitoylethanolamide (PEA) could help reduce depression symptoms in people with bipolar disorder. Thirty-four participants who were already taking mood stabilizer medication received either PEA or a placebo. Researchers measured chan…
Matched conditions: BIPOLAR DEPRESSION
Phase: PHASE2 • Sponsor: The University of Texas Health Science Center, Houston • Aim: Symptom relief
Last updated Mar 23, 2026 15:16 UTC
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Scientists scan brains to unlock Ketamine's secrets for severe depression
Knowledge-focused CompletedThis study aimed to understand how ketamine treatment affects the brain in people with bipolar depression that hasn't responded to other medications. Twenty participants received ketamine infusions and had their brains scanned before and after treatment. Researchers compared brai…
Matched conditions: BIPOLAR DEPRESSION
Phase: PHASE2 • Sponsor: Brian Barnett • Aim: Knowledge-focused
Last updated Mar 24, 2026 12:02 UTC