BIPOLAR DEPRESSION

This pilot study is testing whether one 25 mg dose of psilocybin, given alongside psychotherapy, can ease depression in people with bipolar II disorder who haven't responded to at least two prior treatments. Using brain scans (fMRI), researchers will look at how the drug affects …

This Phase 3 study tests the long-term safety and effectiveness of azetukalner, a daily pill, in 400 adults with bipolar I or II depression who previously completed a related study. Participants take the drug for 52 weeks, and researchers track side effects, mood changes, and qua…

This study tests whether taking a daily probiotic supplement can help people who were recently hospitalized for bipolar depression avoid another episode. 80 adults aged 18-65 will be randomly assigned to receive either the probiotic or a placebo pill for several months. Researche…

This pilot study asks whether the antibiotic minocycline, the supplement N-acetylcysteine (NAC), or both together can ease depression in people with bipolar disorder. Participants continue their usual mood stabilizer while receiving one of the treatments or a placebo. The goal is…

This early-phase trial tests whether inhaling a low dose of xenon gas can quickly improve depressive symptoms in 20 people with treatment-resistant major depression or bipolar depression. Participants receive either xenon or a placebo gas added to their usual treatment, and resea…

This study compares two brain stimulation treatments—electroconvulsive therapy (ECT) and magnetic seizure therapy (MST)—for people with severe depression that hasn't improved with standard medications. About 100 adults with major depression or bipolar depression will receive one …

This study tests whether sitting under a bright light for 30 minutes each day for six weeks can improve mood in people with bipolar depression who also tend to be evening types. Seventy adults will be randomly assigned to either the bright light or a placebo device. The goal is t…

This study looks at whether moderate-to-vigorous aerobic exercise, called Braining, can help people with bipolar depression recover faster and prevent future depressive episodes. Fifty-four participants will be split into three groups: one doing supervised aerobic exercise three …

This study investigates whether changes in brain chemicals (GABA and glutamate) can predict who will respond to ketamine for treatment-resistant depression. Researchers will give two intravenous ketamine infusions to 18 adults and measure chemical levels in the brain and blood. T…

This study was designed to explore how cariprazine (Vraylar) might help people with bipolar depression by looking at its effect on a specific brain receptor (D3 dopamine). Participants would have taken cariprazine for six weeks and undergone PET scans to see how the drug works in…

This study looks at how low field magnetic stimulation changes brain activity in older adults (age 60+) with bipolar depression. Forty participants receive both real and sham (fake) stimulation on separate days, with brain scans taken before and after each session. The goal is to…

This study looks at whether brain wave patterns recorded during and after electroconvulsive therapy (ECT) can predict how much depression symptoms improve. About 31 adults with treatment-resistant depression will have their brain activity measured with a wearable EEG device. The …