BIPOLAR DEPRESSION
Clinical trials for BIPOLAR DEPRESSION explained in plain language.
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New drug shows promise for Long-Term bipolar depression control
Disease control ENROLLING_BY_INVITATIONThis study tests the long-term safety and effectiveness of azetukalner in 400 adults with bipolar I or II depression who already completed a previous study on the same drug. Participants will take the medication openly (everyone knows they are getting it) for an extended period. …
Matched conditions: BIPOLAR DEPRESSION
Phase: PHASE3 • Sponsor: Xenon Pharmaceuticals Inc. • Aim: Disease control
Last updated May 11, 2026 20:50 UTC
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Gut health may help bipolar depression recovery
Disease control OngoingThis study tests whether taking a daily probiotic supplement can help people with bipolar depression stay well after a hospital stay. Researchers will compare those taking the probiotic to those taking a placebo to see if it reduces the chance of needing to go back to the hospita…
Matched conditions: BIPOLAR DEPRESSION
Phase: PHASE2 • Sponsor: Sheppard Pratt Health System • Aim: Disease control
Last updated May 11, 2026 20:39 UTC
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Can morning light lift the fog of bipolar depression?
Symptom relief OngoingThis study tests whether bright light therapy can help ease depression in people with bipolar disorder who tend to be night owls. 70 adults will receive either bright light or a placebo light for six weeks alongside their usual treatment. The goal is to see if the light improves …
Matched conditions: BIPOLAR DEPRESSION
Phase: NA • Sponsor: Chinese University of Hong Kong • Aim: Symptom relief
Last updated May 17, 2026 07:34 UTC
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Shock vs. magnet: which therapy is kinder to memory?
Symptom relief OngoingThis study compares two treatments for severe depression that hasn't improved with medication: electroconvulsive therapy (ECT) and magnetic seizure therapy (MST). Both use controlled seizures to reset brain activity, but MST uses magnets instead of electricity. Researchers will c…
Matched conditions: BIPOLAR DEPRESSION
Phase: PHASE2, PHASE3 • Sponsor: University of Sao Paulo • Aim: Symptom relief
Last updated May 11, 2026 20:39 UTC
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Can sweat sessions speed up recovery from bipolar depression?
Symptom relief TerminatedThis study is testing if adding supervised aerobic exercise to regular medication helps people with bipolar depression recover faster and prevents future episodes. It will enroll 54 participants who are currently experiencing depression. They will be randomly assigned to either d…
Matched conditions: BIPOLAR DEPRESSION
Phase: NA • Sponsor: Region Stockholm • Aim: Symptom relief
Last updated Apr 20, 2026 16:17 UTC
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Brain scans reveal Lithium's secret workings in bipolar depression
Knowledge-focused OngoingThis study looks at how lithium, a common treatment for bipolar disorder, changes the brain's wiring. Researchers will use MRI scans to track brain connections in 120 people with bipolar depression over 26 weeks. The goal is to understand why lithium works, not to test a new trea…
Matched conditions: BIPOLAR DEPRESSION
Sponsor: Brigham and Women's Hospital • Aim: Knowledge-focused
Last updated May 17, 2026 07:36 UTC
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Brain scans reveal how gentle magnetic pulses affect bipolar depression in seniors
Knowledge-focused OngoingThis study looks at how low field magnetic stimulation changes brain activity in people aged 60 and older with bipolar depression. Forty participants will have brain scans before and after real or fake treatment on two separate days. The goal is to understand the brain effects of…
Matched conditions: BIPOLAR DEPRESSION
Phase: NA • Sponsor: Mclean Hospital • Aim: Knowledge-focused
Last updated May 17, 2026 07:33 UTC
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Brain scans aim to uncover how bipolar depression drug works
Knowledge-focused TerminatedThis study was designed to explore how the medication cariprazine (Vraylar) helps treat depression in people with bipolar I disorder. Researchers planned to use PET brain scans to see how the drug affects a specific brain receptor (D3 dopamine). The study was withdrawn before enr…
Matched conditions: BIPOLAR DEPRESSION
Phase: PHASE4 • Sponsor: New York State Psychiatric Institute • Aim: Knowledge-focused
Last updated May 17, 2026 07:32 UTC