Brain pacemaker trial aims to lift severe bipolar depression
NCT ID NCT06599099
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests deep brain stimulation (DBS) for people with severe bipolar depression that hasn't improved with other treatments. Ten participants will have electrodes surgically placed in their brain and a device implanted in their chest to deliver electrical pulses. The goal is to see if DBS can reduce depression symptoms and help find better ways to target brain circuits.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Deep brain stimulation (DBS) device
What this could lead to
If it works, this could point toward a more reliable way to treat severe bipolar depression that hasn't responded to other treatments.
What could go wrong
This is a very small, early study with only 10 people. Surgery risks include brain bleeding, infection, and seizure. There may be no benefit to participants.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Baylor College of Medicine
RECRUITINGHouston, Texas, 77030, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Massachusetts General Hospital
ACTIVE_NOT_RECRUITINGBoston, Massachusetts, 02114, United States
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Rice University
ACTIVE_NOT_RECRUITINGHouston, Texas, 77030, United States
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University of Washington
ACTIVE_NOT_RECRUITINGSeattle, Washington, 98195, United States