MAJOR DEPRESSIVE EPISODE
Clinical trials for MAJOR DEPRESSIVE EPISODE explained in plain language.
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Ketamine vs. ECT: which stops suicidal thoughts faster?
Disease control ENROLLING_BY_INVITATIONThis study compares two treatments—electroconvulsive therapy (ECT) and intravenous ketamine—for quickly reversing acute suicidal depression in 1,500 adults aged 18 to 90. Participants are randomly assigned to receive either ECT or ketamine twice a week for up to four weeks. The m…
Matched conditions: MAJOR DEPRESSIVE EPISODE
Phase: PHASE4 • Sponsor: Brigham and Women's Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:04 UTC
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Which pill works best for bipolar depression? huge study aims to find out
Disease control OngoingThis large study compares four FDA-approved medications for bipolar depression to see which one helps people feel better. Over 2,700 adults with bipolar I or II disorder and current depression will be randomly assigned to one of the drugs. The goal is to find which treatment lead…
Matched conditions: MAJOR DEPRESSIVE EPISODE
Phase: PHASE4 • Sponsor: Massachusetts General Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:04 UTC
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Bipolar depression study scrapped before it began
Knowledge-focused TerminatedThis study was designed to explore how cariprazine (Vraylar) might help people with bipolar depression by looking at its effect on a specific brain receptor (D3 dopamine). Participants would have taken cariprazine for six weeks and undergone PET scans to see how the drug works in…
Matched conditions: MAJOR DEPRESSIVE EPISODE
Phase: PHASE4 • Sponsor: New York State Psychiatric Institute • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:07 UTC
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Brain scans reveal Lithium's secret workings in bipolar depression
Knowledge-focused OngoingThis study looks at how lithium, a common treatment for bipolar disorder, affects the brain's wiring. Researchers will use MRI scans to track changes in brain connections over 26 weeks in 120 adults with bipolar depression. The goal is to understand why lithium works, not to test…
Matched conditions: MAJOR DEPRESSIVE EPISODE
Sponsor: Brigham and Women's Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:07 UTC