MAJOR DEPRESSIVE DISORDER (MDD)

This study tested a smartphone tool called acceXible that analyzes how people describe images to screen for depression. Researchers enrolled 166 Spanish-speaking adults to see if changes in speech patterns can help detect and monitor major depressive disorder. The goal is to prov…

This early-stage study tested a new oral drug, SEP-380135, in 43 adults with schizophrenia or major depression (including bipolar disorder). The main goal was to check if the drug is safe and how the body processes it. Participants took multiple doses and were closely monitored f…

This study tested a non-invasive brain stimulation method called tDCS in 320 adults with depression, schizophrenia, OCD, anxiety, or insomnia. Participants received the stimulation while researchers measured changes in symptoms using standard rating scales. The goal was to see if…

This study tested whether a combination of two drugs (dextromethorphan and bupropion) works better than standard antidepressants (SSRIs) for adults with major depression. 80 participants were randomly assigned to one of the two treatments for 6 weeks. The goal was to see if the n…

This study tested a new drug called ropanicant in 214 adults with major depression. Participants received one of two doses or a placebo for 6 weeks. The goal was to see if the drug reduces depression symptoms better than a placebo. The trial is now complete, and results will show…

This study tested a new extended-release capsule called levomilnacipran for treating major depressive disorder. It involved 392 adults aged 18 to 65 and compared the new drug to duloxetine, a standard antidepressant, over 8 weeks. The goal was to see if the new drug works better …

This study looked at whether adding magnesium supplements to standard depression treatment (fluoxetine) could improve cognitive function in adults with major depressive disorder. Forty participants took either fluoxetine alone or fluoxetine plus magnesium for 6 weeks. Researchers…

This study tested whether taking stingless bee honey daily for two months could improve depressive symptoms, memory, and brain health in adults with major depressive disorder. 45 participants either took the honey or nothing extra alongside their usual treatment. The goal was to …

This study tested a new medicine, NH102, for people with major depression. It included 243 adults aged 18 to 65. The goal was to see if NH102 reduces depression symptoms better than a placebo or an existing drug called duloxetine. Researchers measured changes using a standard dep…

This study looked at 163 teens with major depression to see if family environment (like conflict or closeness) and thinking skills (like attention and planning) could predict how well they respond to a treatment combining brain stimulation (rTMS) and group therapy. The goal was t…