MAJOR DEPRESSIVE DISORDER (MDD)

This trial investigates whether adding low-intensity transcranial magnetic stimulation (Li-TMS) to standard antidepressant medication can improve depressive symptoms and sleep disorders in people with major depression. The study involves 40 participants who receive either real Li…

This study looked at whether adding lithium to personalized maintenance ECT can help prevent depression relapse in people who already got better with ECT. 96 adults with major depression took part. The goal was to see if the combination keeps depression away longer than ECT alone…

This study tested whether a speech analysis tool called acceXible can help screen for and monitor major depressive disorder. Researchers analyzed voice recordings from 166 adults as they described images. The goal was to see if changes in speech patterns relate to depression. If …

This study tested whether a combination of dextromethorphan and bupropion works better than standard SSRI antidepressants for major depression. 80 adults with moderate to severe depression were randomly assigned to one of the two treatments for 6 weeks. Researchers measured chang…

This study looked at whether taking magnesium supplements alongside the antidepressant fluoxetine can improve cognitive function in adults with major depression. Forty participants took either fluoxetine plus magnesium or fluoxetine alone for six weeks. Researchers measured chang…

This completed Phase 2b trial tested whether ropanicant, an experimental drug taken twice daily, can reduce symptoms of major depressive disorder. 214 adults with moderate to severe depression received either ropanicant or a placebo for 6 weeks. The main goal was to see if the dr…

This study tested whether a gentle electrical current applied to the scalp (tDCS) can reduce symptoms of major depression, schizophrenia, OCD, generalized anxiety, and insomnia. 320 adults aged 16–65 received multiple sessions over weeks. Researchers measured symptom changes usin…

This study tested whether taking stingless bee honey daily for two months could improve depression symptoms, memory, and stress markers in adults with major depressive disorder. 45 participants either took the honey or nothing (no placebo). Researchers measured mood, blood marker…

This study tested a new medicine, NH102, to see if it helps with major depression. 243 adults with depression took part. The goal was to check if NH102 reduces symptoms like sad mood and sleep problems better than a placebo or an existing drug. The results will help design larger…

This study tested a new drug, levomilnacipran, for treating major depression. It involved 392 adults aged 18 to 65 with moderate to severe depression. The drug was compared to duloxetine, a commonly used antidepressant, over 8 weeks to see how well it eased symptoms and if it was…

This study looked at whether signals from the heart and brain during transcranial magnetic stimulation (TMS) can predict which people with major depression will get better. Thirty-two adults received an accelerated TMS treatment over 5-8 days while their heart rate was monitored …

This early-stage study tested a new oral drug, SEP-380135, in 43 adults with schizophrenia or major depression (including bipolar disorder). The main goal was to check its safety and how the body processes it. Participants took multiple doses and were monitored for side effects, …

This study looked at 163 teens with major depression to see if family factors (like conflict or closeness) and cognitive skills (like attention and planning) could predict how well they respond to a combination of repetitive transcranial magnetic stimulation (rTMS) and group cogn…