Zapping the Brain's fear center: a new hope for depression?

NCT ID NCT07059143

Completed Symptom relief Sponsor: Ruijin Hospital Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 10, 2026 · Updated 4 times

Summary

This study tests a non-invasive device that uses gentle electrical currents to stimulate the right amygdala, a brain area linked to emotion. Fifty adults with major depression will receive either real or sham stimulation for six weeks. Researchers will measure changes in mood, thinking, and daily function to see if this approach can rapidly ease depressive symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Nervio-X transcranial temporal interference stimulation (TIS) device
What this could lead to: If it works, this could offer a fast, non-drug option to relieve depression symptoms by targeting a specific brain area.
What could go wrong: This is a small early-stage trial with only 50 people, so results may not apply broadly. The device is experimental and its long-term safety and effectiveness are not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER (MDD)

Contacts and locations

Locations

Anding Hospital (Mental Health Center of Tianjin Medical University)

Tianjin, China
Ruijin Hospital

Shanghai, China
The Affiliated Brain Hospital Of Guangzhou Medical University

Guangdong, China

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