MAJOR DEPRESSIVE DISORDER (MDD)

This study is testing whether a non-invasive brain stimulation treatment, called deep Transcranial Magnetic Stimulation (dTMS), can help hospitalized teenagers with severe depression. Researchers will give 60 teens either the real treatment or a sham (fake) version during their h…

This study is testing whether a new drug called CYB003 helps reduce depression symptoms when added to a person's current antidepressant medication. It will involve 330 adults with moderate to severe depression who are already taking a stable dose of antidepressants. Participants …

This study aims to see if non-drug approaches like physical activity, brain training games, and dietary supplements can help people with depression. Researchers want to find out if these lifestyle changes can reduce depressive symptoms and also help prevent or slow down memory an…

This study is testing if a medication called suvorexant, which affects brain chemicals related to sleep and alertness, is safe and tolerable for veterans with major depression and a high risk of suicide. Over four weeks, 30 participants will take the drug and complete various com…

This study is testing if using a non-invasive magnetic brain stimulator (TMS) right before electroconvulsive therapy (ECT) can make the ECT treatment work with less electrical energy. Researchers want to see if this combination helps people with severe, hard-to-treat depression g…

This study is testing whether a faster, 5-day schedule of non-invasive brain stimulation can help reduce depression in older adults (ages 60-85) who haven't gotten better with standard antidepressant medications. Researchers will use a magnetic coil placed on the head to stimulat…

This study is testing whether adding a new drug called milsaperidone to standard antidepressants helps people with major depression who aren't getting enough relief. It will involve 500 adults whose current depression treatment isn't working well enough. Researchers will compare …

This UK trial is testing whether a home-use brain stimulation device can help people with depression. The device, called tDCS, delivers a mild electrical current through a headset. Researchers want to see if using it at home for 10 weeks, along with a person's usual care, is bett…

This study is testing whether adding an investigational drug called SPN-821 to a person's current antidepressant helps reduce symptoms of major depression more effectively. It will involve about 230 adults whose depression hasn't improved enough on their current medication alone.…

This small pilot study is testing whether adding a structured exercise program before and during a brain stimulation treatment makes it work better for people with difficult-to-treat depression. Researchers will compare the effects of exercise plus brain stimulation against brain…

This study is testing if adding a low dose of aripiprazole to a common antidepressant helps people with depression who get stuck in loops of negative, repetitive thinking. 108 adults with depression will take either the antidepressant alone or the antidepressant plus aripiprazole…

This study is testing an investigational drug called SPT-300 to see if it can help reduce symptoms in adults with major depression, including those who also feel anxious. About 360 participants will be randomly assigned to receive either the real drug or a placebo (inactive subst…

This study is testing whether a type of gentle brain stimulation, called tDCS, can be safely done at home by people with depression that hasn't improved with standard treatments. Ten participants will self-administer the 20-minute stimulation sessions at home, five times a day fo…

This study is testing two new group talk therapies for major depression. One therapy focuses on changing rigid negative thoughts, while the other aims to boost motivation and enjoyment of positive experiences. Researchers will compare these new approaches to a waiting list to see…

This study is testing whether an experimental drug called ACP-211 can help adults with major depression who haven't gotten better with standard antidepressant treatments. Researchers will compare ACP-211 against a placebo (inactive pill) to see if it reduces depression symptoms m…

This study aims to find out if an experimental medication called DT-101 can help reduce symptoms of major depression. Researchers will compare DT-101 against a placebo (inactive treatment) in 300 adults with recurrent depression over about 6 weeks. Participants will visit the cli…

This study is testing a new monthly injection of a medication called cariprazine for people with schizophrenia, bipolar disorder, or major depression. It aims to see if the injection is safe, how the body processes it, and if it helps control symptoms. The study will enroll 24 ad…

This study is testing whether a fecal microbiota transplant (FMT) can help people with major depression who don't get better enough after starting a standard antidepressant. About 214 participants will take either FMT capsules or placebo pills for four weeks while continuing thei…

This study is testing whether a safe, non-invasive brain stimulation device can help treat major depression when used at home. For 10 weeks, 200 participants will use the device, with half receiving a fake version for comparison, all while being monitored remotely by video. The g…

This study is testing whether a new smartphone app called EMOCARE can reliably track depression symptoms compared to standard paper questionnaires. Researchers will enroll 104 adults with mild to severe depression who will use the app for 6 weeks while also completing traditional…

This study is testing whether a simple, non-invasive eye-tracking test using a VR headset can help detect early signs of cognitive decline. It will compare the eye responses of 140 adults, including people with Alzheimer's disease, mild memory problems, depression-related impairm…

This study is testing whether lifestyle changes can help prevent memory and thinking problems in adults aged 50-80 who have depression or depressive symptoms. Participants will try different 12-week programs involving supervised exercise, brain training games, or Mediterranean di…

This study is testing whether a home-based brain stimulation treatment can help reduce depression in people with borderline personality disorder (BPD). Researchers will compare real brain stimulation to a sham (fake) treatment in 60 participants over two weeks. The main goal is t…

This study is testing a new therapy that uses real-time brain scans to help people with depression. While inside an MRI machine, participants see their own brain activity and try to change negative thought patterns. Researchers want to see if this high-tech brain training can red…

This study tests whether a 5-day brain stimulation treatment called TMS can help reduce depression and suicidal thoughts in teens and young adults. The non-invasive treatment uses MRI scans to target specific brain areas and aims to provide a fast-acting alternative to traditiona…

This study is testing if adding a physical therapy program to standard depression treatment can improve quality of life for hospitalized adults. The program includes gentle exercises and education about physical activity's benefits for mental health. Researchers will also ask pat…

This study is testing whether a nasal spray containing a form of ketamine can quickly reduce severe depression symptoms and suicidal thoughts in adults. About 98 participants with major depression and active suicidal thoughts will receive either the spray or a placebo. The main g…

This large study in Pakistan is testing a flexible, three-step care plan to treat depression in women who have survived breast cancer. It will involve over 26,000 participants and compare the new plan to usual care to see if it better reduces depression and improves quality of li…

This study aims to understand how an online sleep improvement program helps reduce depression. Researchers will measure changes in a specific brain receptor and sleep patterns in 42 adults with depression before and after the therapy. The goal is to learn the biological reason wh…

This study is investigating whether a gentle, non-invasive stimulation of a nerve in the ear can improve motivation and mood in people with depression. Researchers will recruit 120 people, half with depression and half without, to see if the stimulation works and if a person's in…

This study aims to understand how depression affects different types of thinking, especially those related to emotions, in adults. Researchers will compare brain scans and thinking tests from 120 people with depression to 120 healthy volunteers. The goal is to map how depression …

This study aims to find objective biological markers in the brain to help diagnose and track treatment for severe mental disorders like depression, schizophrenia, and bipolar disorder. Researchers will use a powerful 7T MRI scanner and vision tests to compare brain chemistry and …

This study aims to see if using a visual life history calendar helps people in Hong Kong remember their mental health history more accurately. Researchers will compare the standard mental health interview with and without the calendar tool. The goal is to improve how we measure h…

This study uses special brain scans to understand how people with depression respond to magnetic stimulation therapy. Researchers will scan 100 adults—some receiving depression treatment and some healthy volunteers—to look for brain activity patterns. The goal is to gather resear…

This study aims to find biological signs in the brain and genes that can predict if a person's depression will return after they stop taking antidepressant medication. Researchers will follow 204 people with depression and healthy volunteers, measuring brain activity and taking b…

This study aims to better understand depression in teenagers by closely observing them. Researchers will track 1000 teens with moderate to severe depression using wearable devices, brain scans, and blood tests. The goal is to find patterns that could help predict how well treatme…