Forecasting depression relapse: new study aims to predict the unpredictable
NCT ID NCT06746155
First seen Jun 24, 2026 · Last updated Jul 10, 2026 · Updated 2 times
Summary
This study follows 252 people whose major depression is in remission to find early warning signs of relapse. Researchers will track symptoms, physical activity, sleep, thinking skills, and brain activity. The goal is to build a model that tells doctors who is likely to relapse and when, so they can step in early to prevent a full depressive episode.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- What this could lead to
- If successful, this could lead to a practical tool that helps doctors predict and prevent depression relapse, improving long-term management.
- What could go wrong
- This is an observational study, not testing a treatment. The model may not be accurate enough for widespread use, and results may not apply to all patients.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Centre for Addiction and Mental Health (CAMH)
RECRUITINGToronto, Ontario, Canada
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McMaster University
RECRUITINGHamilton, Ontario, Canada
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Nova Scotia Health
RECRUITINGHalifax, Nova Scotia, Canada
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Ontario Shores Centre for Mental Health Sciences
RECRUITINGWhitby, Ontario, Canada
Contact Email: •••••@•••••
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Queen's University
RECRUITINGKingston, Ontario, Canada
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The Royal Ottawa Mental Health Centre
NOT_YET_RECRUITINGOttawa, Ontario, K1Z 7K4, Canada
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University Health Network
RECRUITINGToronto, Ontario, Canada
Contact Email: •••••@•••••
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University of British Columbia
RECRUITINGVancouver, British Columbia, Canada
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University of Calgary
RECRUITINGCalgary, Alberta, Canada
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