Forecasting depression relapse: new study aims to predict the unpredictable

NCT ID NCT06746155

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study follows 252 people whose major depression is in remission to find early warning signs of relapse. Researchers will track symptoms, physical activity, sleep, thinking skills, and brain activity. The goal is to build a model that tells doctors who is likely to relapse and when, so they can step in early to prevent a full depressive episode.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to

If successful, this could lead to a practical tool that helps doctors predict and prevent depression relapse, improving long-term management.

What could go wrong

This is an observational study, not testing a treatment. The model may not be accurate enough for widespread use, and results may not apply to all patients.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

major depressive disorder Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Centre for Addiction and Mental Health (CAMH)

    RECRUITING

    Toronto, Ontario, Canada

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • McMaster University

    RECRUITING

    Hamilton, Ontario, Canada

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Nova Scotia Health

    RECRUITING

    Halifax, Nova Scotia, Canada

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Ontario Shores Centre for Mental Health Sciences

    RECRUITING

    Whitby, Ontario, Canada

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Queen's University

    RECRUITING

    Kingston, Ontario, Canada

    Contact Email: •••••@•••••

  • University Health Network

    RECRUITING

    Toronto, Ontario, Canada

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of British Columbia

    RECRUITING

    Vancouver, British Columbia, Canada

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of Calgary

    RECRUITING

    Calgary, Alberta, Canada

    Contact Phone: •••-•••-•••• Email: •••••@•••••