Nasal spray could rapidly ease depression and suicidal urges

NCT ID NCT07193901

Recruiting now Symptom relief Sponsor: Sichuan Purity Pharmaceutical Technology Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a nasal spray containing (R)-Ketamine, a fast-acting drug, in 98 adults with major depression who are currently having suicidal thoughts. Participants receive either the spray or a placebo twice a week for 4 weeks. The goal is to see if the spray can quickly reduce depression symptoms and suicidal behavior, and to check its safety.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: (R)-Ketamine hydrochloride nasal spray
What this could lead to: If it works, this could provide a fast-acting treatment to quickly reduce severe depression and suicidal thoughts, potentially saving lives.
What could go wrong: This is an early Phase 2 trial with only 98 participants, so results may not apply broadly. The drug may cause side effects or fail to outperform placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER (MDD)

Contacts and locations

Locations

BEIjing AnDing hospital capital medical university
RECRUITING

Beijing, China
Beijing AnDing hospital capital medical university
RECRUITING

Beijing, China
Beijing Huilongguan Hospital
RECRUITING

Beijing, China
Hangzhou Seventh People's Hospital
RECRUITING

Hangzhou, China
Suzhou Guangji Hospital
RECRUITING

Suzhou, China
The Fourth People's Hospital of Chengdu
RECRUITING

Chengdu, China
The affiliated Kangning Hospital of Ningbo University
RECRUITING

Ningbo, China
The fourth affiliated hospital of Anhui medical university
RECRUITING

Hefei, China

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