MAJOR DEPRESSIVE DISORDER (MDD)

This small pilot study will test whether adding ketamine to cognitive behavioral therapy (CBT) is safe and feasible for people with both alcohol use disorder and major depression. Twenty participants will receive three ketamine injections over six weeks along with CBT sessions. T…

This study tests a new non-invasive brain stimulation tool called kTMP to treat anhedonia, the loss of interest or pleasure, in people with major depressive disorder. 104 participants will receive either active or sham stimulation. The main goal is to see if kTMP changes brain ac…

This study compares an AI-delivered digital therapy called Nook to standard cognitive behavioural therapy (CBT) for people with moderate depression and/or anxiety. 400 participants aged 16-64 in the UK will be randomly assigned to either the AI program or human-led therapy. The g…

This study looks at whether aerobic exercise (like brisk walking) and mindful breathing can help adults with major depressive disorder feel better and improve their quality of life. Participants are split into three groups: one does 45 minutes of moderate exercise three times a w…

This study tests a non-invasive brain stimulation technique called tTIS for adults with major depressive disorder. Sixty participants will receive either active stimulation targeting specific brain areas or a sham (fake) treatment over 5 days. Researchers will measure changes in …

This study tests whether combining ketamine infusions with dialectical behavioural therapy (DBT) can reduce suicidal thoughts more effectively than a placebo plus DBT. About 120 adults with borderline personality disorder and treatment-resistant depression or bipolar disorder wil…

This study looks at whether the type of education patients receive about a single propofol sedation session can change how well it works for depression. Twenty adults with moderate to severe major depressive disorder will get one propofol infusion and be randomly assigned to eith…

This study tests a type of brain stimulation called theta burst stimulation (TBS) for people with depression that hasn't improved with medication. About 120 adults and teens will either get real TBS or a fake version first, then real TBS later. Researchers will measure changes in…

This study tests whether using a person's brain scan (MRI) to guide TMS treatment for depression works better than the standard scalp-measurement method. 160 adults with major depression will receive accelerated TMS (10 sessions a day for 5 days) with either MRI or scalp targetin…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with therapy is safe and helpful for people who have both major depression and alcohol use disorder. Thirty adults will receive either psilocybin or a placebo, along with therapy sessions. The…

This study tests whether adding a ketogenic (low-carb) diet to a non-invasive brain stimulation treatment called iTBS helps people with treatment-resistant depression feel better. Sixty adults will follow either a keto diet or a standard healthy diet for three weeks, then receive…

This study tests a new computer task that trains your eye movements to help treat major depression. The task uses a gaze-contingent feedback system to retrain attention patterns. Researchers will enroll 60 adults with depression to see if this approach reduces symptoms. The goal …

This study tests whether an 8-week internet-based cognitive behavioral therapy (ICBT) program can help adults with generalized anxiety disorder or major depressive disorder. Participants in Taiwan will either receive standard care alone or standard care plus the online program, w…

This pilot study will examine whether certain genes related to serotonin are linked to gut bacteria that process tryptophan in adults with depression, anxiety, PTSD, or panic disorder. Thirty participants will provide saliva and stool samples from home. The goal is to gather info…

This study will use advanced brain scans to see how a quick, 3-minute form of magnetic brain stimulation changes the brain in people with major depression. Twenty adults will receive one week of treatment and have PET and MRI scans before and after. The goal is to understand the …

This study looks at 130 people with major depression who have suicidal thoughts. Researchers will use brain scans, genetic tests, and other biological measures to see how rapid treatments like Esketamine and electroconvulsive therapy (ECT) change the brain. The goal is to find ea…

This study will use a brain imaging technique called fNIRS to see how electroconvulsive therapy (ECT) and magnetic seizure therapy (MST) change brain activity in people with major depression. Researchers will compare the two treatments in 60 adults to understand their effects on …

This study looks at whether using a conversational AI to collect medical history can make people with depression feel more understood by their doctors. About 130 adults with moderate to severe depression will try the AI at home before a regular visit and rate how empathetic the e…

This study looks at how ketamine, a drug already used for depression, might reduce suicidal thoughts by affecting stress-related brain pathways. Researchers will give 12 adults with major depressive disorder a single ketamine infusion, then use smartphone tracking and PET brain s…

This study compares a new selegiline skin patch to an existing one (EMSAM®) to see how well the skin tolerates it. Researchers will apply both patches to 230 healthy adults and check for irritation or allergic reactions. The goal is to ensure the new patch is safe for the skin be…

This research looks at how brain networks relate to thinking and memory problems in people with schizophrenia, bipolar disorder, or major depression. The goal is to use brain imaging to better assess cognitive issues, improve diagnosis, and predict how well treatments might work.…

This study will use brain scans to see how cognitive behavioural therapy (CBT) affects the brains of 30 people aged 40-60 with major depression. Participants will receive 12 weeks of CBT, with follow-ups up to 9 months. The goal is to understand how CBT improves mood and thinking…

This study follows 160 adults in Hong Kong over time to see if disruptions in daily activity and sleep (rest-activity rhythms) can predict who develops major depressive disorder. Participants will wear activity monitors and complete questionnaires about mood and sleep. The goal i…