MAJOR DEPRESSIVE DISORDER (MDD)

This study aims to see if a low-carb ketogenic diet can make a type of non-invasive brain stimulation more effective for adults with depression that hasn't responded to standard medications. Participants will follow either the ketogenic diet or a standard healthy diet for several…

This study is testing whether stimulating a specific brain area with magnetic pulses can help reduce depression symptoms. Researchers will compare real magnetic stimulation to a placebo treatment in 80 adults with moderate to severe depression. The goal is to understand if target…

This small, early-stage study is testing whether combining the medication ketamine with talk therapy is safe and helpful for people dealing with both alcohol use disorder and major depression. Twenty participants will receive ketamine doses alongside cognitive-behavioral therapy …

This study aims to determine if using MRI brain scans to target a rapid depression treatment works better than using scalp measurements. Researchers will compare two methods of guiding accelerated transcranial magnetic stimulation (aTMS), a non-invasive brain stimulation treatmen…

This is a small, early-stage study to see if therapy sessions combined with a dose of psilocybin (the active compound in 'magic mushrooms') is safe and feasible for adults who have both major depression and alcohol use disorder. Researchers will compare a group receiving psilocyb…

This study compares how two different skin patches containing the depression medication selegiline affect the skin. Researchers will check for skin irritation and allergic reactions in 230 healthy volunteers by repeatedly applying both patches. The main goal is to see if a new pa…

This study is testing whether an 8-week online therapy program can help reduce symptoms of anxiety and depression in adults. Participants will be randomly assigned to receive either their usual care alone or their usual care plus the online program. The goal is to see if this con…

This study tests whether a computer-based attention training program can help reduce symptoms of depression. The program uses eye-tracking technology to gently guide participants' gaze away from sad images and toward happy ones during four training sessions. Researchers will meas…

This small, early-stage study is testing whether adding a new, slow-release ketamine tablet to a standard antidepressant can help reduce symptoms of major depression more quickly. Twelve adults with moderate to severe depression will take the ketamine tablets for one week while s…

This study aims to understand how ketamine works to rapidly improve depression symptoms. Researchers will use a special brain imaging technique to measure chemical changes in the brains of 10 adults with treatment-resistant depression before and after they receive a single ketami…

This early-stage study aims to understand how two medications—escitalopram (a common antidepressant) and memantine—affect a specific brain function called 'pattern separation,' which helps distinguish similar memories. Researchers will measure brain activity using MRI scans and t…

This study aims to understand how Cognitive Behavioral Therapy (CBT), a type of talk therapy, helps middle-aged adults with depression. Researchers will use brain scans to see if CBT improves mood and thinking skills by changing how the brain works. The study will enroll 30 parti…

This study aims to understand if a person's daily rest and activity patterns, measured by a wrist-worn device, can predict who develops major depression or whose symptoms get worse. Researchers will follow 160 adults in Hong Kong over time, tracking their sleep, mood, and activit…

This study aims to understand how the drug ketamine might help reduce suicidal thoughts in people with major depression. Researchers will use smartphone apps to track daily stress and brain scans to see how ketamine affects specific brain pathways. The goal is to learn more about…

This study aims to understand how brain networks are involved in thinking problems that occur with schizophrenia, bipolar disorder, and major depression. Researchers will use brain scans and cognitive tests in 400 participants (including patients and healthy volunteers) to identi…