MAJOR DEPRESSIVE DISORDER (MDD)

This is a small pilot study to see if therapy sessions combined with a single dose of psilocybin (the active compound in 'magic mushrooms') is safe and feasible for adults who have both major depression and alcohol use disorder. Researchers will compare a group receiving psilocyb…

This study tests a type of brain stimulation called theta burst stimulation (TBS) in 120 adults and teens with depression that hasn't improved with standard treatments. Participants will receive either real or fake stimulation alongside their usual antidepressants to see if TBS c…

This study tests whether adding a probiotic (Lactobacillus crispatus) to the antidepressant sertraline helps reduce depression symptoms in teens aged 12-18 with major depressive disorder. About 60 participants will receive either the probiotic or a placebo with their medication f…

This study tests whether using a person's brain scan (MRI) to guide transcranial magnetic stimulation (TMS) works better than the standard scalp-measured approach for treating depression. About 160 adults with major depressive disorder will receive accelerated TMS (10 sessions da…

This study looks at whether a drug called ketamine, given through an IV, along with a type of talk therapy (DBT), can help reduce suicidal thoughts in people with borderline personality disorder and depression or bipolar disorder. About 120 adults will get either ketamine or a pl…

This study tests whether a computer task that trains your eye movements can help reduce symptoms of major depression. Sixty adults with depression will either do the gaze training or a control task. The goal is to see if changing how you look at emotional images can improve mood.

This early-stage study tests whether adding ketamine to talk therapy is safe and helpful for people who struggle with both alcohol use disorder and major depression. Twenty participants will receive ketamine alongside cognitive behavioral therapy. The goal is to see if this combi…

This study tests if an online therapy program (ICBT) can help adults with generalized anxiety disorder or major depressive disorder feel better. About 160 participants will either get their usual care or usual care plus an 8-week online program with 12 modules. The goal is to see…

This study tests whether inhaling DMT, a fast-acting psychedelic, can quickly reduce depression and suicidal thoughts in adults with major depressive disorder. 140 participants will receive either a high or low dose, and those not improving after one week can get an extra high do…

This study tests whether adding a low-carb ketogenic diet to a personalized brain stimulation treatment (iTBS) can better reduce depression symptoms in adults with treatment-resistant depression. Sixty participants will follow either a ketogenic diet or a standard healthy diet fo…

This study looks at whether the way doctors explain a sedation treatment can change how well it works for depression. Twenty adults with major depressive disorder will receive a single propofol infusion. Afterward, they will be told about their brain activity in either a 'respons…

This study tests whether a special type of bright light therapy can improve thinking and memory problems in people with major depression. About 120 adults with depression and cognitive issues will either receive the special light or a dim red placebo light for four weeks. Researc…

This study looks at how brain networks relate to thinking and memory problems in people with schizophrenia, bipolar disorder, or major depression. Researchers will use brain scans and cognitive tests to build models that could help diagnose these conditions and predict treatment …

This study looks at how two treatments for severe depression—electroconvulsive therapy (ECT) and magnetic seizure therapy (MST)—change brain activity. Researchers will use a special brain imaging technique (fNIRS) to measure blood flow in the front and side parts of the brain bef…

This study looks at how things like air pollution, noise, and lack of green spaces in cities may affect mental health. Researchers will track 680 people with depression, anxiety, or alcohol use disorder, plus healthy volunteers, using wearable devices and a smartphone app. The go…

This study looks at how ketamine might help reduce suicidal thoughts in people with major depressive disorder by targeting stress-related brain pathways. Researchers will use smartphone tracking and PET brain scans to monitor real-time responses to stress and ketamine. The study …

This study tests whether a conversational AI that collects medical history can make people with major depression feel more understood by their doctors. About 130 adults with moderate to severe depression will try both the AI system and standard care, then rate their experience. T…

This study follows 160 adults in Hong Kong to see if their daily rest-activity patterns can predict who develops major depressive disorder. Researchers will track sleep, activity, and mood over time to find distinctive rhythm profiles linked to depression. No treatment is given; …

This study looks at how two medications, escitalopram (a common antidepressant) and memantine (usually for Alzheimer's), affect memory and brain scans in 30 adults with major depression. Participants take escitalopram plus either memantine or a placebo. The goal is to understand …

This study looks at how cognitive behavioral therapy (CBT) affects the brains of people aged 40-60 with major depression. Researchers will use MRI scans to measure changes in brain structure and function before and after CBT. The goal is to understand why CBT helps some people mo…

This study tests whether a new selegiline skin patch causes less irritation or allergic reactions than an existing patch. About 230 healthy adults will wear both patches repeatedly to see how their skin reacts. The goal is to check skin safety and how well the patches stick, not …