MAJOR DEPRESSIVE DISORDER (MDD)

This study tests whether a special flashing light treatment can safely help adults with mild to moderate depression. Thirty participants will receive 10 sessions of light stimulation over two weeks, while continuing their usual medication. The main goal is to check for side effec…

This study looks at the safety of a new drug called SPT-300 for adults with major depressive disorder, with or without anxious distress. It is an extension study for people who already completed a previous trial of the same drug. About 360 participants will take the drug for 6 we…

This study tests an experimental drug called ONO-1110 in 100 Japanese adults with major depressive disorder. Half receive the drug, half receive a placebo, and researchers track changes in depression symptoms over 8 weeks using a standard rating scale. The goal is to see if ONO-1…

This study looks at whether a 12-week physical activity program can improve symptoms in adults with major depression who are already taking antidepressants. 110 participants will be split into two groups: one that exercises plus medication, and one that only takes medication. Res…

This study tests a non-invasive brain stimulation technique called transcranial temporal interference stimulation (TIS) aimed at the right amygdala to quickly reduce depressive symptoms. Fifty adults with major depressive disorder will receive either real or sham stimulation over…

This study tests whether adding aripiprazole to a standard antidepressant (escitalopram) can reduce repetitive, intrusive negative thinking (rumination) in people with major depression. About 108 adults with depression and high rumination will receive either escitalopram alone or…

This study looks at how depression changes the way people process emotions and make decisions. Researchers will compare 120 adults with major depression to 120 healthy volunteers, all aged 21 to 80. Participants will complete thinking tasks and brain scans to understand these dif…

This study looks at brain tissue and lab-grown nerve cells from 150 people who had schizophrenia, depression, bipolar disorder, Alzheimer's, or frontotemporal dementia. Researchers want to find out how the connections between brain cells (synapses) stop working properly in these …

This study looks at how things like social support, income, and habits affect mental health and brain diseases. About 1,310 adults in Europe, including those with depression, schizophrenia, bipolar disorder, Alzheimer's, Parkinson's, or dementia, will answer surveys and have brai…

This study looks at whether giving vitamin D to women with depression and low vitamin D levels can change their brain wave patterns, measured by a non-invasive EEG test. The goal is to understand if vitamin D affects brain activity and mood. The study involves 34 women aged 20-40…

This study looks at how the brain works in adults with autism, depression, or both. Researchers will use brain scans and tests to measure brain activity and inflammation. The goal is to better understand these conditions, not to test a new treatment. About 160 adults aged 20-50 w…

This study looks at whether a natural chemical called oxytocin, measured in saliva during a psychedelic therapy session, can help predict how well people with hard-to-treat depression will respond to treatment. Researchers will track 80 adults with major depressive disorder who a…

This study is analyzing blood samples from 1,799 people with brain diseases (like Alzheimer's, dementia, depression, and schizophrenia) and healthy volunteers. Researchers want to see if certain substances in the blood can help doctors diagnose these conditions more accurately. T…

This study reviewed medical records of 376 people who received LSD or psilocybin therapy for hard-to-treat depression, anxiety, or addiction. Researchers wanted to see if the intensity of the psychedelic experience was linked to better outcomes. No new treatments were given—only …