MAJOR DEPRESSIVE DISORDER (MDD)
Clinical trials for MAJOR DEPRESSIVE DISORDER (MDD) explained in plain language.
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New hope for depression? experimental drug enters Mid-Stage testing
Disease control OngoingThis study is testing whether a new drug called ONO-1110 can help reduce symptoms of major depression. It will involve about 100 Japanese adults with moderate to severe depression. Participants will be randomly assigned to receive either the new drug or a placebo for 8 weeks to s…
Matched conditions: MAJOR DEPRESSIVE DISORDER (MDD)
Phase: PHASE2 • Sponsor: Ono Pharmaceutical Co. Ltd • Aim: Disease control
Last updated Mar 31, 2026 12:11 UTC
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New depression treatment enters next safety check
Disease control ENROLLING_BY_INVITATIONThis study continues testing an experimental medication called SPT-300 for adults with major depression. It follows 360 people who completed a previous trial to gather more safety information over 6 weeks. The main goal is to see how well people tolerate the drug and monitor for …
Matched conditions: MAJOR DEPRESSIVE DISORDER (MDD)
Phase: PHASE2 • Sponsor: Seaport Therapeutics • Aim: Disease control
Last updated Mar 30, 2026 14:32 UTC
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Geneva hospital reviews 'Magic Mushroom' and LSD therapy for depression
Disease control OngoingThis study is looking back at medical records to understand how supervised therapy using substances like LSD or psilocybin (from 'magic mushrooms') worked for people with severe depression, anxiety, or addiction. It involves about 376 people in Switzerland who had already receive…
Matched conditions: MAJOR DEPRESSIVE DISORDER (MDD)
Sponsor: University Hospital, Geneva • Aim: Disease control
Last updated Mar 27, 2026 12:41 UTC
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New depression drug enters Mid-Stage testing
Disease control OngoingThis study is testing whether an experimental drug called Ropanicant can help reduce symptoms of major depression. About 195 adults with moderate to severe depression will receive either one of two doses of the drug or a placebo pill for 6 weeks. Researchers will measure changes …
Matched conditions: MAJOR DEPRESSIVE DISORDER (MDD)
Phase: PHASE2 • Sponsor: Suven Life Sciences Limited • Aim: Disease control
Last updated Mar 27, 2026 12:41 UTC
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Could flashing lights ease depression? new study investigates
Symptom relief OngoingThis small, early-stage study is testing whether a non-invasive light therapy is safe and might help people with moderate to severe depression. Thirty participants will receive ten 30-minute sessions of flashing white light over two weeks, with follow-up checks. The main goal is …
Matched conditions: MAJOR DEPRESSIVE DISORDER (MDD)
Phase: NA • Sponsor: University of Sao Paulo • Aim: Symptom relief
Last updated Mar 30, 2026 14:35 UTC
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Can a 12-Week workout plan rewire the brain to fight depression?
Symptom relief OngoingThis study is testing whether a structured 12-week exercise program can help reduce symptoms in adults diagnosed with major depression. It will compare 110 participants, half doing the exercise program while taking antidepressants and half just taking antidepressants. Researchers…
Matched conditions: MAJOR DEPRESSIVE DISORDER (MDD)
Phase: NA • Sponsor: IRCCS Centro San Giovanni di Dio Fatebenefratelli • Aim: Symptom relief
Last updated Mar 30, 2026 14:30 UTC
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Scientists hunt for the Brain's 'Love Hormone' clue in psychedelic depression treatment
Knowledge-focused ENROLLING_BY_INVITATIONThis study is trying to find a simple biological signal that can predict who will benefit most from psychedelic-assisted therapy for hard-to-treat depression. Researchers will measure levels of oxytocin, sometimes called the 'love hormone,' in the saliva of 80 participants during…
Matched conditions: MAJOR DEPRESSIVE DISORDER (MDD)
Sponsor: University of Geneva, Switzerland • Aim: Knowledge-focused
Last updated Apr 01, 2026 14:41 UTC
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Blood test breakthrough could speed up brain disease diagnosis
Knowledge-focused ENROLLING_BY_INVITATIONThis study is looking at whether simple blood tests can help doctors diagnose brain diseases like Alzheimer's, dementia, depression, and schizophrenia more quickly and accurately. Researchers will analyze blood samples from about 1,800 people who already have these conditions, al…
Matched conditions: MAJOR DEPRESSIVE DISORDER (MDD)
Sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau • Aim: Knowledge-focused
Last updated Apr 01, 2026 14:41 UTC
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Groundbreaking study connects life circumstances to brain changes in mental illness
Knowledge-focused ENROLLING_BY_INVITATIONThis large European study aims to understand how social and economic factors—like income, education, and social support—affect mental health and brain biology. Researchers will follow over 1,300 adults, including people with conditions like depression, schizophrenia, Alzheimer's,…
Matched conditions: MAJOR DEPRESSIVE DISORDER (MDD)
Sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau • Aim: Knowledge-focused
Last updated Mar 20, 2026 14:48 UTC
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Scientists scan brains to unlock secrets of depression and autism
Knowledge-focused ENROLLING_BY_INVITATIONThis study aims to understand how brain activity differs in adults with depression, autism, or both conditions. Researchers will use brain scans and stimulation tests to measure brain inflammation and electrical patterns in 160 participants. The goal is to learn how these brain d…
Matched conditions: MAJOR DEPRESSIVE DISORDER (MDD)
Sponsor: National Taiwan University Hospital • Aim: Knowledge-focused
Last updated Mar 19, 2026 14:56 UTC
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Scientists search for common thread in brain disorders
Knowledge-focused ENROLLING_BY_INVITATIONThis study examines donated brain tissue and lab-grown brain cells to understand how conditions like schizophrenia, depression, bipolar disorder, Alzheimer's, and frontotemporal dementia affect the connections between brain cells (synapses). Researchers will analyze genetic and p…
Matched conditions: MAJOR DEPRESSIVE DISORDER (MDD)
Sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau • Aim: Knowledge-focused
Last updated Mar 18, 2026 14:41 UTC