Exercise as medicine: new study tests if walking away depression works

NCT ID NCT06989944

First seen Feb 06, 2026 · Last updated May 15, 2026 · Updated 16 times

Summary

This study looks at whether a 12-week physical activity program can improve symptoms in adults with major depression who are already taking antidepressants. 110 participants will be split into two groups: one that exercises plus medication, and one that only takes medication. Researchers will track mood, brain activity, and biological changes to understand how exercise might help.

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Contacts and locations

Locations

  • Azienda Sanitaria Locale di Pescara

    Pescara, 65124, Italy

  • IRCCS Centro San Giovanni fi Dio Fatebenefratelli

    Brescia, 25125, Italy

  • IRCCS Ospedale San Raffaele

    Milan, 20132, Italy

  • Istituto Neurologico Mediterraneo Neuromed, NEUROMED

    Isernia, 86077, Italy

Conditions

Explore the condition pages connected to this study.