Gut health for mental health? probiotics join antidepressant in teen trial
NCT ID NCT07645157
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether adding multi-strain probiotics to the antidepressant sertraline helps teenagers aged 12-18 with major depression feel better than sertraline alone. Over 8 weeks, 120 participants will take either the combination or sertraline with a placebo. Researchers will track changes in depression scores and safety.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
sertraline and multi-strain probiotics
What this could lead to
If it works, this could point toward a simple, safe add-on treatment to better manage depression in teenagers.
What could go wrong
This is a small, early-phase trial (120 participants) testing a combination therapy, so results may not apply broadly. Probiotics may not provide additional benefit over placebo.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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The Affiliated Hospital of Chongqing Medical University
RECRUITINGChongqing, Yuzhong, 400010, China
Contact Phone: •••-•••-•••• Email: •••••@•••••