Gut health for mental health? probiotics join antidepressant in teen trial

NCT ID NCT07645157

Recruiting now Symptom relief Sponsor: First Affiliated Hospital of Chongqing Medical University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding multi-strain probiotics to the antidepressant sertraline helps teenagers aged 12-18 with major depression feel better than sertraline alone. Over 8 weeks, 120 participants will take either the combination or sertraline with a placebo. Researchers will track changes in depression scores and safety.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: sertraline and multi-strain probiotics
What this could lead to: If it works, this could point toward a simple, safe add-on treatment to better manage depression in teenagers.
What could go wrong: This is a small, early-phase trial (120 participants) testing a combination therapy, so results may not apply broadly. Probiotics may not provide additional benefit over placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER (MDD) PROBIOTIC INTERVENTION

Contacts and locations

Locations

The Affiliated Hospital of Chongqing Medical University
RECRUITING

Chongqing, Yuzhong, 400010, China

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