Magnesium pills might sharpen your mind while treating depression

NCT ID NCT07521358

Completed Symptom relief Sponsor: Hasanuddin University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether taking magnesium supplements alongside the antidepressant fluoxetine can improve cognitive function in adults with major depression. Forty participants took either fluoxetine plus magnesium or fluoxetine alone for six weeks. Researchers measured changes in thinking skills and a brain protein called BDNF. The goal is to see if magnesium offers an extra benefit for mental clarity.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Magnesium (dietary supplement)
What this could lead to: If it works, adding magnesium to standard depression treatment could help improve thinking and memory in people with depression.
What could go wrong: This is a very small, completed trial with only 40 people. Results may not apply to everyone, and magnesium might not provide any extra benefit beyond fluoxetine alone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depression major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER (MDD)

Contacts and locations

Locations

Dr. Wahidin Sudirohusodo Hospital

Makassar, South Sulawesi, 90245, Indonesia

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