Magnesium pills might sharpen your mind while treating depression
NCT ID NCT07521358
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at whether taking magnesium supplements alongside the antidepressant fluoxetine can improve cognitive function in adults with major depression. Forty participants took either fluoxetine plus magnesium or fluoxetine alone for six weeks. Researchers measured changes in thinking skills and a brain protein called BDNF. The goal is to see if magnesium offers an extra benefit for mental clarity.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Magnesium (dietary supplement)
What this could lead to
If it works, adding magnesium to standard depression treatment could help improve thinking and memory in people with depression.
What could go wrong
This is a very small, completed trial with only 40 people. Results may not apply to everyone, and magnesium might not provide any extra benefit beyond fluoxetine alone.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Dr. Wahidin Sudirohusodo Hospital
Makassar, South Sulawesi, 90245, Indonesia