Disease by developmental or physiological process

This trial tests an experimental oral vaccine, WRSs2, designed to protect against Shigella sonnei, a common cause of severe diarrhea. Healthy adults aged 18-49 receive either the vaccine or a placebo, then are later exposed to the live bacteria in a controlled setting to see if t…

This study tested a new vaccine called Shigella4V2 to protect infants against shigellosis, a severe diarrheal disease. Researchers gave the vaccine to 110 healthy 9-month-old babies to check its safety and how well it triggers an immune response. The goal is to find the best dose…

This trial investigates whether non-surgical gum treatment can improve early signs of blood vessel dysfunction in people with periodontitis who have no known heart disease. Sixty participants will receive one of two types of deep cleaning procedures. Researchers will measure chan…

This study follows over 14,000 adults with sleep apnea who are prescribed positive airway pressure (PAP) therapy. It investigates whether using telemonitoring—where the device sends usage data to their doctor remotely—helps people use the therapy more consistently and effectively…

This trial tests whether online group dialectical behavioral therapy (DBT) is as effective as traditional face-to-face group DBT for women with bulimia nervosa. Participants will be randomly assigned to either 12 weeks of online or in-person group therapy, and researchers will co…

This study tested a combination of three immunotherapy drugs (INCMGA00012, INCAGN02385, and INCAGN02390) in 61 people with advanced melanoma or other solid tumors that had stopped responding to standard treatments. The goal was to find the safest dose and see if the drugs could s…

This study looked at whether tiny plastic particles (microplastics) we encounter daily might contribute to obesity and gut problems. Researchers gave 96 overweight or obese adults either a probiotic supplement or a placebo to see if the probiotic could reduce the harmful effects …

This study tests whether the nicotine concentration in vape pods affects how well smokers can quit. 312 adult smokers who want to quit will use either low or high nicotine salt e-liquids for three months, plus receive counseling. The goal is to see if higher nicotine levels lead …

This phase 2 trial is testing whether combining two chemotherapy drugs, gemcitabine and oxaliplatin, can shrink tumors in children and adolescents with certain solid cancers that have come back or not responded to standard treatment. The study includes patients with medulloblasto…

This trial tests whether rinsing with coconut oil can reduce plaque and gum inflammation as effectively as a standard chlorhexidine mouthwash. Eighty adults with plaque-induced gingivitis will be split into two groups: one using coconut oil daily and the other using chlorhexidine…

This Phase 3 trial is testing whether a once-daily 50 mg semaglutide tablet can help East Asian adults with overweight or obesity lose weight. Participants will take either the active tablet or a placebo for 68 weeks, alongside lifestyle counseling on diet and physical activity. …

This pilot study is testing whether a dietary supplement made from the tinder fungus can safely ease gut symptoms in adults with mild-to-moderate ulcerative colitis or Crohn's disease. Participants will drink the supplement and be monitored for changes in symptoms, inflammation m…

This study tested a new way to stimulate the brain in people addicted to amphetamines. Nine adults received closed-loop transcranial alternating current stimulation (tACS), which adjusts the stimulation based on their real-time brain activity. The goal was to improve executive co…

This trial tests whether insulin eye drops can improve the ocular surface in people with moderate-to-severe dry eye disease. Participants will receive either insulin eye drops or artificial tears for up to a year. The study measures changes in dry eye symptoms and tear production…

This trial tests whether Masgutova Neurosensorimotor Reflex Integration (MNRI) therapy can improve fine motor skills in children aged 2-6 with developmental delays. Participants receive either MNRI sessions or standard care for four weeks. The study measures changes in hand funct…

This trial tests whether letting smokers adjust their own nicotine patch dose—based on their smoking history and withdrawal symptoms—helps them stay smoke-free longer than the standard fixed-dose patch. Adult smokers who smoke at least 10 cigarettes a day and are motivated to qui…

This study looks at whether allowing a slightly higher blood sugar range (70-110 mg/dL) during labor in mothers with diabetes can reduce the number of newborns with low blood sugar. Researchers will compare this approach to standard care in 169 pregnant women planning a vaginal d…

This study tested cyclosporin 0.1% eye drops in 25 adults with moderate to severe dry eye disease that didn't get better with artificial tears. The goal was to see if the drops reduce eye dryness and redness. Participants used the drops alongside their usual tear substitutes for …

This trial tests an experimental medicine called BI 1569912 in adults aged 18 to 65 with major depressive disorder whose current antidepressants aren't working well enough. Participants take a single dose of the drug or a placebo, in addition to their usual antidepressant, and ar…

This study tested an investigational drug called VRDN-001 in 143 people with thyroid eye disease who did not improve in earlier studies. The drug aims to reduce inflammation and eye bulging by blocking a specific receptor. Researchers measured how many participants had at least a…

This trial tests whether taking oral sodium bicarbonate to correct metabolic acidosis can slow the buildup of calcium in the blood vessels of people on long-term hemodialysis. The study will include 40 adults who have been on dialysis for over six months and have low bicarbonate …

This study tests whether the oral drug upadacitinib works better than the injected drug adalimumab for adults with moderate to severe rheumatoid arthritis who still have symptoms after trying one TNF blocker. About 480 participants will be randomly assigned to receive either upad…

This study will follow about 1,000 adolescents and adults in China who are prescribed upadacitinib for moderate to severe atopic dermatitis (eczema). Researchers will track how patients use the medication, any dose changes, and how well they stick to their treatment over 12 month…

This trial tests whether herbal mouthwashes containing tea tree oil, thyme hydrosol, or essential oils can reduce the plaque and gum inflammation seen in gingivitis. About 52 adults with gingivitis will use one of these mouthwashes or a placebo twice daily for three months, along…

This study tests whether a new tablet formulation of semaglutide (oral semaglutide D) works as well as the approved version in Japanese adults with type 2 diabetes. About 264 participants will take either the new or approved tablet once daily for 27 weeks. Researchers will compar…

This study tests whether a supplement made from brown algae and chromium picolinate, when added to a calorie-controlled Mediterranean diet, can reduce fat buildup in the liver. Adults with metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic syndrome wil…

This study looked at whether aspirin or a diabetes drug called an SGLT2 inhibitor (like dapagliflozin) can improve liver health in people with type 2 diabetes and non-alcoholic fatty liver disease. Researchers measured liver enzymes, cholesterol, and liver stiffness (using FibroS…

This study tests whether adding DIR/Floortime—a child-led, relationship-based therapy—to standard care helps children aged 4-12 with mild-to-moderate autism improve emotional, social, communication, and daily living skills. Half the children receive the 10-week Floortime program …

This trial tests a new, less invasive surgical approach for treating advanced periodontitis (stage III). Instead of lifting the gum, doctors access the damaged bone through a small pinhole, clean the area, and place a bone graft to encourage regeneration. The study includes adult…

This study tests whether a single low dose of ketamine can quickly reduce obsessive-compulsive disorder (OCD) symptoms. Adults with OCD will receive either ketamine or a comparison drug, and researchers will measure symptom changes using a standard OCD scale. The trial also uses …

This study compares two popular mouthwashes, Listerine and Chlorhexidine, to see which better controls gum inflammation and plaque in people undergoing orthodontic treatment with braces. Sixty participants aged 13-40 will use one of the rinses and be checked at 2 and 4 weeks. The…

This trial compares two surgical strategies for managing placenta accreta, a condition where the placenta grows too deeply into the uterine wall and can cause severe bleeding during delivery. One approach is a caesarean hysterectomy, which removes the uterus after the baby is bor…

This study tested a new drug called amlitelimab, given as a shot under the skin, for people aged 12 and older with moderate-to-severe atopic dermatitis (eczema) that wasn't controlled by creams. The trial included 643 participants and compared amlitelimab to a placebo, while ever…

This study tests whether the steroid hydrocortisone, added to usual care, can help ICU patients with severe hospital-acquired pneumonia. Researchers will compare hydrocortisone against a placebo in 180 adults. The goal is to see if the drug reduces early death or worsening of bre…

This study tests a drug called hydronidone in 300 adults with liver scarring (fibrosis or cirrhosis) from chronic hepatitis B. Participants take the drug three times daily for 28 days to see if it is safe. The main goal is to track any side effects.

This trial tests a digital health program designed to help young adults with type 1 diabetes improve their blood sugar control. Participants use the SweetGoals app to set and track behavioral goals, and some also receive financial incentives for meeting those goals or access to w…

This study tests a drug called hydronidone in 200 adults with liver fibrosis caused by chronic hepatitis B or fatty liver disease. Participants take three capsules three times daily for 28 days. The main goal is to check for side effects, not to measure how well the drug works.

This Phase 3 study tests amlitelimab, an injected drug, in 589 people aged 12 and older with moderate-to-severe atopic dermatitis (eczema) that hasn't responded well to topical treatments. The goal is to see if amlitelimab can clear or nearly clear the skin and reduce eczema seve…

This Phase 3 trial tested an investigational drug called veligrotug (VRDN-001) in 188 people with chronic thyroid eye disease. The drug is an antibody that blocks a protein involved in the disease. The main goal was to see if it could reduce eye bulging (proptosis) compared to a …

This study tests a drug called TQH2722, a lab-made antibody that blocks inflammation, for people with severe chronic sinusitis (with or without nasal polyps). About 120 adults who completed a prior TQH2722 study will receive either 300mg or 600mg injections over a long period. Re…

This Phase 2 study tested an experimental oral drug called TTI-101 in 100 people with idiopathic pulmonary fibrosis (IPF), a disease that causes lung scarring and breathing difficulty. Participants took either TTI-101 or a placebo daily for 12 weeks. The main goal was to check sa…

This study tested a drug called batoclimab in 35 adults with Graves' disease whose thyroid hormone levels were still high despite taking standard antithyroid drugs. The goal was to see if batoclimab could help bring those levels back to normal or below over 24 weeks. Batoclimab w…

This study tested a special program to help people with both bipolar disorder and substance use problems stick to their treatment after leaving the hospital. 178 adults were split into two groups: one received extra counseling and support, while the other got enhanced safety moni…

This trial tests whether a 'learning health system'—a structured partnership between juvenile justice agencies and community mental health centers—can improve the full continuum of substance use care for youth involved in the justice system. The approach uses local data to identi…

This study tested a gel called SGX302, which is activated by visible light, on 15 people with mild-to-moderate plaque psoriasis. The goal was to see if it could clear or nearly clear skin lesions over 18 weeks. The treatment is applied to the skin and then exposed to light, aimin…

This virtual trial tests whether a daily prebiotic and probiotic supplement can relieve symptoms of bacterial vaginosis and yeast infections, such as itching, odor, and abnormal discharge. Women aged 25 and older with these concerns will take two capsules daily for 30 days. The s…

This study will follow about 470 adults with type 2 diabetes who are starting oral semaglutide as part of their normal care. Researchers will track changes in blood sugar (HbA1c) and body weight over 5 to 7 months. The goal is to see how well the medication works when prescribed …

This study tests a drug called hydronidone in 150 adults with liver scarring caused by chronic hepatitis B. Participants take the capsules three times daily for 28 days. The main goal is to check for side effects and ensure the drug is safe. This is an early-phase trial, so it fo…

This completed Phase 3 trial tested a drug called VRDN-001 in 231 people with thyroid eye disease (TED). The drug works by blocking a receptor involved in inflammation and swelling. The main goal was to check safety and tolerability, with secondary goals including measuring chang…

This trial tests whether veligrotug, an antibody that blocks a receptor involved in inflammation, can reduce eye bulging and swelling in people with active thyroid eye disease. Participants receive five infusions of the drug or a placebo. The study measures how many people see a …

This trial is testing whether combining the immunotherapy drug pembrolizumab with other experimental agents can help people with advanced melanoma whose cancer has stopped responding to standard anti-PD-1 treatment. The study includes several treatment arms, each pairing pembroli…

This trial tests whether injecting a specially processed form of a patient's own fat tissue, called nanofat, can improve repigmentation in stable vitiligo when combined with standard narrowband UVB light therapy. In each of 20 adults, one vitiligo patch receives nanofat plus ligh…

This study tested a remote video monitoring system to help people with opioid use disorder safely take their methadone at home. Fifteen adults already on methadone treatment used a smartphone or computer camera to record each dose. The goal was to see if this method could track a…

This study tested a new medicine called NNC0487-0111 in 448 adults with type 2 diabetes. Participants received either a once-weekly injection, a daily pill, or a placebo for about 43 weeks. The goal was to see how well different doses lower blood sugar and body weight.

This study tested a new medicine called NNC0519-0130 in 299 adults with type 2 diabetes. The goal was to see if a once-weekly injection can lower blood sugar and body weight. Participants received up to 7 different doses for about 40 weeks. The results will help find the best dos…

This study tests whether gabapentin, an FDA-approved medication, can help restore the balance of key brain chemicals (GABA and glutamate) in people with bipolar disorder who also use cannabis. Participants are randomly assigned to receive either gabapentin or a placebo for 17 day…

This trial tests whether giving anti-VEGF injections 3, 7, or 14 days before surgery makes a difference for people with proliferative diabetic retinopathy, a complication of diabetes that causes abnormal blood vessels in the eye. Participants are randomly assigned to one of three…

This trial tests an experimental oral drug called HTD1801 in adults with nonalcoholic steatohepatitis (NASH), a serious liver condition, along with liver fibrosis and type 2 diabetes or prediabetes. Participants receive either HTD1801 or a placebo to see if the drug can improve l…

This phase 2 trial tests whether adding nicorandil, a drug typically used for heart conditions, can improve blood sugar control and reduce body weight in obese people with type 2 diabetes who are already taking sulfonylureas. About 46 adults with a BMI over 30 will receive nicora…

This study tests whether a gel containing a human growth factor (rhPDGF-BB) can help wounds heal faster after skin cancer removal on the head or neck. About 40 adults whose surgical wounds are too large to stitch closed will receive either the gel or a placebo. The goal is to see…

This trial tests whether eating oat-based porridge daily, alongside standard prenatal calcium and vitamin D supplements, can improve calcium and vitamin D levels in pregnant women with mild to moderate hypocalcemia. Researchers will measure blood levels at weeks 8 and 33 of pregn…

This study tests an updated version of the BRITE app, called ViraBrite, which sends suicide safety planning materials and coping skills to teens when they are feeling high emotional distress. Twenty teens who have recently attempted suicide or had suicidal thoughts with a plan wi…

This phase 2 trial is testing whether two investigational drugs, AD109 and AD504, taken as a pill at bedtime, can reduce the number of breathing pauses in people with obstructive sleep apnea. The study compares these drugs against atomoxetine (an existing medication) and a placeb…

This trial compares two surgical approaches for total hip replacement: the minimally invasive SuperPATH technique and the conventional posterior approach. Adults with hip arthritis or related conditions are randomly assigned to one of the two procedures. The study tracks recovery…

This trial follows women with polycystic ovary syndrome (PCOS) who take metformin, a standard diabetes medication, for six months. Researchers track changes in insulin resistance, iron levels, erythropoietin, cholesterol, and blood counts at three and six months. The goal is to s…

This study tested a drug called sonelokimab, given as a shot under the skin, in 422 adults with moderate to severe hidradenitis suppurativa (a painful skin condition causing boils and abscesses). Participants were randomly assigned to receive either the drug or a placebo for up t…

This trial investigates whether a sterile gauze infused with natural plant extracts can reduce bacteria on the eyelid margin in people with bilateral anterior blepharitis. Each participant receives the plant-based gauze on one eye and a standard gauze on the other, allowing direc…

This trial compares giving zoledronate, a yearly intravenous bone-strengthening drug, within 5 days of hip fracture surgery versus waiting 3 months. The goal is to see if early treatment is as safe and effective at reducing bone turnover and preventing future fractures. Participa…

This study aims to find the most effective amount of exercise to reduce liver fat in people with NASH, a serious liver disease. Researchers will compare different exercise doses in 45 sedentary adults aged 18-69 with NASH and early-stage liver scarring. The goal is to provide cle…

This pilot study tests whether combining ketamine injections with talk therapy is a safe and acceptable way to treat moderate-to-severe methamphetamine use disorder in 17 publicly insured patients, some of whom have or are at risk for HIV. Participants receive three monitored ket…

This trial evaluates an experimental drug called HTD1801 in overweight or obese adults with high cholesterol. The study aims to see if the drug is safe and tolerable when taken daily at different doses, and how the body processes it. Participants are randomly assigned to receive …

This early-stage trial is testing an experimental drug called AMG 355, given alone or together with the immunotherapy Keytruda, in 77 adults with advanced solid tumors (like lung, colon, stomach, or melanoma) that have not responded to standard treatments. The main goals are to c…

This trial tests whether propolis, a natural resin from bees, can control bleeding during a tooth-saving procedure called full pulpotomy for adults with painful, inflamed molars. Participants are randomly assigned to receive propolis or the standard sodium hypochlorite as a hemos…

This study compares two different mandibular advancement devices—oral appliances that hold the jaw forward during sleep—to see which works better for people with mild-to-moderate obstructive sleep apnea. Participants will wear each device for three months, with a two-week break i…

This trial tests whether using artificial intelligence and computer guidance to lift the sinus floor and place dental implants immediately, along with a graft made from the patient's own tooth, improves outcomes compared to the traditional free-hand method. The study includes peo…

This study tested a drug called TOUR006 in 143 adults with chronic kidney disease and high levels of a protein linked to inflammation (hs-CRP). The goal was to see if monthly or quarterly shots could safely lower inflammation. The study is complete, and results will show if the d…

This pilot study looks at whether a daily low-dose iron supplement (27 mg for three months) can improve iron status, gut health, and endurance in young female elite football players. Researchers will track diet, blood markers like hemoglobin and ferritin, gut leakage indicators, …

This study tested whether N-acetylcysteine (NAC), an over-the-counter supplement, can help people who use both tobacco and cannabis quit both substances. Fifty-nine regular smokers who also used cannabis took either NAC or a placebo for 8 weeks. Researchers tracked how often they…

This trial investigates whether a topical clobetasol gel can change the levels of microRNAs in the gum fluid of people with oral lichen planus, a chronic inflammatory condition. Participants will apply either the active gel or a placebo to their lesions, and researchers will comp…

This trial tests whether a mouthwash containing chlorhexidine and sodium DNA can better control bacterial biofilm in people with advanced periodontitis (stage III or IV). Participants will receive standard non-surgical gum treatment plus one of two mouthwashes or a placebo, and r…

This trial tests whether different intensities of breathing exercises (inspiratory muscle training) can improve diaphragm function, thinking, sleep, and mood in young adults aged 18-25 who have low muscle mass. Participants will be randomly assigned to high-intensity, moderate-in…

This trial tests a smart insulin pump algorithm designed to automatically adjust insulin delivery during the night to keep blood sugar levels in a safe range. The algorithm predicts when blood sugar might drop too low and pauses insulin, and when it might rise too high, it gives …

This phase 2 trial is testing the drug ibrutinib in 18 people with stage IV melanoma that has not responded to previous treatments. Ibrutinib works by blocking certain enzymes that help cancer cells grow. The study aims to see if the drug can shrink tumors and how long it keeps t…

This trial tests an 8-week online coaching program that teaches parents of preschool autistic children how to use everyday interactions to boost their child's social communication. Families are randomly assigned to either the coaching program or a waitlist, and the study measures…

This study tested a new insulin called icodec that is injected just once a week, compared to standard daily insulin shots, in over 1,000 adults with type 2 diabetes who had never used insulin before. The goal was to see if the weekly shot controls blood sugar just as well as dail…

This trial tests a Family Mental Health Navigator (FMHN) program for publicly insured youth aged 6-17 who are already receiving services at a San Francisco hospital. The program pairs families with a navigator who uses mobile health tools to help them get referrals and start trea…

This study is testing whether a subcutaneous (under the skin) injection of ocrelizumab works as well as the standard intravenous (IV) infusion for people with relapsing or primary progressive multiple sclerosis. The trial will compare how the drug is absorbed, its safety, and its…

This study tested a new insulin called icodec that is injected just once a week, compared to the standard daily insulin glargine, in 429 adults with type 2 diabetes. Participants received either the weekly or daily insulin for 6 months. The goal was to see if the weekly shot cont…

This trial tests whether an automated oxygen delivery system, called FreeO2, can help patients with pneumonia recover faster and leave the hospital sooner. The device automatically adjusts oxygen flow based on continuous monitoring of blood oxygen levels, aiming to keep patients …

This trial tests whether inhaled insulin (Exubera) can control blood sugar as well as insulin glargine (Lantus) injections in adults with type 2 diabetes who are not well controlled on two or more oral medications. Participants will receive either inhaled insulin before meals or …

This Phase 3 trial tested whether HTD1801 (berberine ursodeoxycholate) can help people with type 2 diabetes who aren't well controlled on metformin alone. Over 500 participants received either the drug or a placebo for 24 weeks. The main goal was to see if the drug lowered blood …

This trial tests whether a motor rehabilitation program using mixed reality games can improve postural stability (balance) in children and adults with neurological impairments, such as cerebral palsy, Parkinson's disease, multiple sclerosis, or stroke. Participants will be random…

This study looked at whether a custom-made hip spacer can help people with infected hip replacements. 25 patients had their infected hip implant removed and replaced with a temporary custom spacer, followed by antibiotics. After the infection cleared, they received a new permanen…

This trial tests whether eating dairy products can improve how the body uses insulin in overweight and obese adults with prediabetes. Participants will be randomly assigned to eat either limited dairy (1 serving or less per day), reduced-fat dairy, or regular-fat dairy for 12 wee…

This trial tests whether an inhaled form of insulin (Exubera) can control blood sugar as effectively as a daily insulin injection (Lantus) in adults with type 2 diabetes who are not well controlled on two or more oral medications. Participants are randomly assigned to add either …

This trial tests whether levetiracetam, a drug used for seizures, can reduce overactivity in the hippocampus—a brain area linked to memory—and improve cognitive function in people with schizophrenia or schizoaffective disorder. Participants receive either levetiracetam or a place…

This completed study tested Igalmi, a fast-dissolving film placed under the tongue, for managing frequent agitation in people with schizophrenia or bipolar disorder. 29 adults received the drug as needed for 7 days in a clinic. Researchers looked for signs that the drug might sto…

This trial tests whether obinutuzumab, a next-generation antibody, can help people with membranous nephropathy—a kidney disease that causes protein leakage and swelling—who haven't responded well to the standard drug rituximab or who can't take it due to allergic reactions. About…

This study tests whether a mobile app can help people with type 1 diabetes adjust their insulin doses better than standard care. About 50 participants over age 15 will use the app or receive usual care for 3 months. The main goal is to see if the app improves blood sugar control,…

This trial compares two psychological treatments for obsessive-compulsive disorder (OCD): metacognitive therapy, which focuses on changing unhelpful thinking patterns, and exposure and response prevention, the current standard behavioral therapy. The study aims to see if metacogn…

This trial tests a new atherectomy device that uses a diamond-coated rotating crown to grind away calcium buildup in heart arteries. It aims to see if this device can safely and effectively prepare the artery for stent placement in people with calcified coronary artery disease. T…

This trial investigates whether a blood-filtering procedure called immunoadsorption (IA), combined with the drug rituximab, can improve neurological function in children aged 0-18 with severe anti-NMDAR encephalitis. Participants receive 10 IA sessions over 28 days plus weekly ri…

This trial is testing an investigational drug called OPT101 in adults with type 1 diabetes. The goal is to see if it is safe and how it affects the immune system. Participants will receive multiple doses of the drug, and researchers will monitor for side effects and measure drug …

This trial tests whether repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, can help adults with alcohol use disorder when added to their usual treatment. Nine adults will receive 10 sessions of stimulation over the right frontal brai…

This trial tests a new device that uses sound waves to break up calcium deposits in the heart's arteries, which can harden and narrow them. The study includes adults with coronary artery calcification who are eligible for a procedure to open blocked arteries. The goal is to see i…

This study tested a new daily medicine called ESK-001 in 862 adults with moderate to severe plaque psoriasis. The goal was to see if it reduces psoriasis severity and is safe, comparing it to a placebo and an existing drug (apremilast). Participants took the medicine for 24 weeks…

This trial tests whether a daily bioactive collagen peptide supplement can improve knee pain, stiffness, and physical function in adults with mild to moderate knee osteoarthritis. Participants are randomly assigned to take either the collagen supplement or a glucosamine and chond…

This study tested whether a new daily pill, ESK-001, can safely reduce psoriasis severity in adults with moderate to severe plaque psoriasis. Over 900 participants took either ESK-001, a placebo (dummy pill), or an approved psoriasis drug (apremilast) for 24 weeks. Researchers me…

This completed study compared the effectiveness of once-daily oral semaglutide (Rybelsus) to other oral diabetes medications in 1020 adults with type 2 diabetes who were already taking metformin. Participants were randomly assigned to receive either Rybelsus or another diabetes p…

This trial asks whether one way of setting a breathing machine is better than another for children born with a hole in the heart who are having surgery to close it. The hole lets extra blood flow to the lungs, which can make them stiff and harder to inflate. During surgery, a mac…

This phase 2 trial tests whether a low dose of everolimus, a drug used in cancer, can safely improve signs of aging in 106 adults aged 55-80 who have insulin resistance or prediabetes. Participants take the drug daily or weekly for 24 weeks, and researchers measure changes in met…

This study tests whether adding the sleep medication suvorexant to standard buprenorphine treatment can improve sleep and medication adherence in people with opioid use disorder who have recently used fentanyl. Participants first stay in a residential setting for five days to sta…

This trial tests whether a series of allergy shots, called PURETHAL Mites, can reduce symptoms like sneezing, runny nose, and congestion in adults with moderate to severe house dust mite allergies, with or without asthma. Participants receive either the active treatment or a plac…

This study looks at people who undergo laparoscopic surgery for suspected appendicitis but are found to have a normal appendix. It compares two approaches: removing the appendix anyway (routine appendectomy) or leaving it in place. The goal is to see which approach leads to fewer…

This phase 2 trial is testing an experimental drug called TransCon CNP in children with achondroplasia, a common form of dwarfism. The study aims to see if a once-weekly injection under the skin can safely improve growth, measured by height velocity over a year. Participants will…

This trial investigates whether a traditional herbal drug, NOSHIN SHAHD, can improve insulin resistance and reduce inflammation and oxidative stress in people with type 2 diabetes. Participants will take the herbal drug or a placebo for about six weeks, and researchers will measu…

This pilot study tests whether having older Black men with diabetes lead support groups can help other older Black men better manage their type 2 diabetes. All 48 participants receive standard diabetes education, and half also get 6 months of monthly peer-led support sessions. Th…

This first-in-human study tested a new drug called IBC-Ab002 in 40 people with early Alzheimer's disease. The drug is an antibody that targets PD-L1, a protein involved in immune regulation. The main goal was to check safety and how the drug moves through the body, not yet to pro…

This study tests an investigational drug called HZBio1 in people with gout. The goal is to see if it is safe and how well it lowers uric acid levels. Participants receive multiple injections of HZBio1 over several weeks. The trial includes adults aged 18 to 70 with gout and eleva…

This study tests whether a simple salt-water mouth rinse can detect pneumocystis, a lung infection that can be life-threatening in people with weak immune systems. Current diagnosis requires coughing up sputum or a tube inserted into the lungs, which can be uncomfortable. Researc…

This study is testing whether a new urine analysis device, the Sysmex UF-5000, can accurately measure inflammation markers in healthy men. The goal is to establish a baseline for what's normal, which could help develop a quick, non-invasive test for urethritis, a common infection…

This study looks at whether the weight of the placenta, and its size relative to the baby's birth weight, can help predict low blood sugar (hypoglycemia) in newborns during the first 24 hours after birth. The study will include about 98 infants born at 35 weeks or later to mother…

This study tests a voice-analysis device designed to help clinicians screen for moderate to severe depression. Adults aged 22 and older will record their voice, and the device's assessment will be compared to a standard clinical interview. The goal is to see if the device can acc…

This study tests a voice-analysis device designed to help clinicians screen for moderate to severe depression in adults. About 1,600 English-speaking adults aged 22 and older will record their voices, and the device's screening results will be compared with a standard clinical in…

This study tests whether tissue taken during routine carpal tunnel release surgery can help diagnose amyloidosis, a condition where abnormal proteins build up in organs. People with bilateral carpal tunnel syndrome and certain risk factors—like age, heart issues, or family histor…

This trial is testing whether 3D ultrasound can diagnose placenta accreta spectrum more accurately than the standard 2D ultrasound with color Doppler. Placenta accreta is a serious pregnancy condition where the placenta grows too deeply into the uterine wall, which can cause seve…

This study tests a new MRI technique called ENRAGED FLAIR that aims to capture two types of brain images (T2-FLAIR and T1-weighted) in a single sequence, instead of the usual two separate scans. Researchers will compare the image quality and time savings against standard MRI in 1…

This pilot study tests whether a special MRI contrast agent called ferumoxytol can highlight areas of active inflammation in the brains of people with secondary progressive multiple sclerosis (SPMS). The goal is to see if this imaging method can distinguish chronic-active lesions…

This study is testing whether a simple blood test can help doctors tell apart two main causes of intrauterine growth restriction (IUGR) — a condition where a baby grows slower than expected in the womb. The test measures the ratio of two proteins, sFlt-1 and PlGF, which are linke…

This study tests a telemedicine tool called the TAP, designed to assess autism symptoms in toddlers aged 18-42 months. Researchers will compare diagnoses made via video call with traditional in-person evaluations to see how accurate the tool is. The goal is to make autism diagnos…

This study tests whether intestinal ultrasound can accurately detect pouchitis—inflammation of the internal pouch created after ulcerative colitis surgery. Adults who have had this surgery will receive an ultrasound, and the results will be compared to the standard pouchoscopy wi…

This trial evaluates a new blood test (ELISPOT) that looks for immune cells in a newborn's cord blood that produce antibodies against the Toxoplasma parasite. The goal is to see if this test can diagnose congenital toxoplasmosis—an infection passed from mother to baby during preg…

This study investigates whether hearing problems are an under-recognized complication of diabetes. Researchers will screen 172 adults with type 1 or type 2 diabetes using hearing tests and a questionnaire. If a hearing issue is found, a more detailed assessment will be done to de…

This trial tests a wearable device called CAVA that records eye and head movements for 30 days in people with dizziness conditions like Meniere's disease and BPPV. The goal is to see if the device can accurately detect episodes of nystagmus, an eye movement linked to dizziness, a…

This study tests whether a 12-week Bhangra dance program can improve metabolic health, physical function, and mental well-being in women aged 40-70 from the Indian diaspora. Participants will attend dance classes twice a week and undergo health assessments before and after. The g…

This trial tests whether a group prenatal care model that includes social services can improve maternal mental health and reduce preterm birth compared to standard individual care with added services. Pregnant women eligible for Medi-Cal in central California are randomly assigne…

This study tests whether a specially designed probiotic, Streptococcus salivarius eK12, can prevent repeated strep throat infections in children aged 3 to 10. The probiotic is given as a daily supplement and aims to crowd out the harmful bacteria without antibiotics. Researchers …

This study tests whether screening women for type 2 diabetes while they are still in the hospital after giving birth can help catch the disease early and prevent it. About 116 women who had gestational diabetes will be randomly assigned to either early testing or usual care. The …

This trial tests whether a one-day online workshop based on cognitive behavioural therapy (CBT) can reduce the risk of postpartum depression and anxiety. Pregnant women in their third trimester who have a history of depression but are not currently depressed will be randomly assi…

This study in Addis Ababa, Ethiopia, tests whether giving protein supplements only to pregnant women who are undernourished can prevent problems like low birth weight and stillbirth. Over 6,700 pregnant women are randomly assigned to receive supplements either universally or only…

This study tested whether a lifestyle physical activity program, using a Fitbit tracker and coaching calls, could help pregnant women at risk for cannabis use reduce their use. Sixteen women who used cannabis at least weekly before pregnancy and had mild depression or anxiety too…

This trial is testing the safety of the Menhycia® vaccine in about 3,000 healthy 3-month-old infants who have not yet received any epidemic meningitis vaccine. The infants will receive three doses of the vaccine at least one month apart, with an optional booster at 12 months of a…

This study tested a program to prevent type 2 diabetes in Chinese immigrants with prediabetes. Participants received weekly videos on diabetes prevention and fresh, culturally appropriate produce. The goal was to see if this approach could help people lose weight and build health…

This trial tests whether short, equipment-free exercise sessions in the classroom can ease anxiety, depression, and stress while boosting physical activity in medical students. Around 105 students will be split into groups receiving either two, one, or no exercise sessions per we…

This completed study looked at whether lupus patients already taking hydroxychloroquine long-term had a lower risk of catching COVID-19 or developing severe symptoms. Researchers compared 552 patients who either took the drug or did not, using blood tests and questionnaires. The …

This study tests whether computer-based training that targets emotional memory or attention can prevent major depression in young people who have depressive symptoms or have recovered from a depressive episode. Participants are randomly assigned to one of three active training pr…

This trial tests whether a structured lifestyle program—combining exercise, healthy eating, cognitive training, and social activities—can slow cognitive decline in older adults at risk of dementia. Participants aged 60-80 with modifiable risk factors will be randomly assigned to …

This trial tests whether a three-dose hepatitis B vaccine can protect healthcare workers in Zambia from infection. The vaccine is given at 0, 1, and 6 months, and blood tests measure the immune response. The goal is to see if the vaccine produces protective antibodies and cellula…

This study tests whether a new high-intensity exercise program is feasible and can improve dynamic balance and physical activity in adolescents with cerebral palsy or spina bifida. Participants will perform a series of exercises twice a week, with researchers measuring walking sp…

This trial tests whether different combinations of cannabinoids—THC, CBN, CBG, CBD, and melatonin—taken as gummies can improve sleep quality in adults aged 21 to 55 who report poor sleep. Participants will be randomly assigned to receive one of several active gummy formulas or a …

This trial tests whether therapeutic touch or foot reflexology can improve sleep quality and ease menopausal symptoms in postmenopausal women who lived through the 2023 Kahramanmaraş earthquakes. About 155 women will be randomly assigned to receive one of the two therapies or to …

This study tests whether low-cost virtual reality (VR) tools, like 360° video and a new VR Photoscan process, can help people with post-traumatic stress disorder (PTSD) engage more easily with trauma-focused therapy. Participants will receive standard therapy (TF-CBT) either alon…

This study tests whether a non-ablative radiofrequency treatment can improve vaginal tissue health and reduce symptoms of Genitourinary Syndrome of Menopause (GSM), such as dryness and discomfort, in postmenopausal women. Participants will be randomly assigned to receive either t…

This study tests whether chair-supported yoga can improve sleep quality and reduce pain in people aged 65 and older who live in nursing homes. Participants will be randomly assigned to either attend chair yoga sessions twice a week for 8 weeks or receive routine care only. The tr…

This trial tests whether TECAR therapy, a non-invasive device that delivers energy to painful areas, can reduce pain in people with fibromyalgia. About 46 adults with fibromyalgia will receive either real or sham TECAR sessions twice a week for three weeks. Researchers will measu…

This trial tests whether an online psychiatric nursing program based on the Tidal Model can improve psychological resilience and self-compassion in adults diagnosed with anxiety disorder. Participants are randomly assigned to either receive eight one-on-one online nursing session…

This study tests whether a special silk dressing (SYLKE®) causes fewer skin problems like rashes, blisters, or redness compared to standard skin glue (Dermabond®) after ACL knee surgery. About 100 people aged 14 to 60 having ACL reconstruction will be randomly assigned to one of …

This trial tests whether online educational modules or live webinars, completed before hip replacement surgery, can reduce anxiety and improve outcomes like pain, function, and quality of life. It involves adults aged 50 and older with advanced hip osteoarthritis who are schedule…

This trial tests three different approaches to help people with bipolar disorder become more physically active. Participants are randomly assigned to receive brief advice alone, or brief advice plus supervised and home-based exercise with either health education or cognitive-beha…

This pilot study tests a mobile app called Brain CareNotes designed to reduce the burden on unpaid caregivers of people with Alzheimer's or related dementias who live in rural areas. About 60 caregivers will use either the Brain CareNotes app or a basic education app for six mont…

This study tests an online Emergency Preparedness Toolkit for caregivers of people with dementia. The toolkit helps caregivers find a backup caregiver so they can focus on their own health needs during an emergency. About 68 caregivers aged 55 and older who live with their partne…

This study tested a fractional carbon dioxide laser treatment for women with vaginal and urinary symptoms like dryness, burning, pain during sex, and incontinence. One hundred women received three laser sessions about six weeks apart. The main goal was to see if symptoms improved…

This trial tests whether listening to personalized music during cataract surgery can reduce anxiety and pain. About 100 patients having surgery under local anesthesia will either receive standard care or also listen to their preferred instrumental music (60-100 beats per minute) …

This study tested a daily dietary supplement (DITTO Cycle Supplement) in 40 women aged 18-45 who regularly experience period symptoms like cramps, bloating, fatigue, and mood swings. Over three menstrual cycles, researchers tracked changes in symptom severity and quality of life …

This study tested whether a structured education session led by a nurse could lower anxiety and improve quality of life in 188 adults having their first shock wave lithotripsy for kidney stones. The education covered what to expect during the procedure, pain management, and recov…

This study tests whether a virtual reality (VR) mindfulness app can reduce anxiety before surgery and acute pain after surgery. Adults scheduled for surgery will use the VR headset for up to 25 minutes, and researchers will measure changes in anxiety and pain scores, as well as u…

This study is testing a new eye drop that combines trehalose, sodium hyaluronate, and NAAGA without preservatives. It will enroll 30 adults with dry eye disease who are either new to treatment or unhappy with their current drops. Over 6 months, researchers will track changes in s…

This study tests whether a cream made with L-menthol and balsam copaiba oil can reduce symptoms of arthritis, joint pain, and muscle pain. Adults aged 20 to 65 with mild-to-moderate joint discomfort apply the cream or a placebo to affected areas three times daily for seven days. …

This study looks at whether adding sensory and cognitive activities—like listening to music, gentle touch, or brain exercises—to standard ICU care can help adults recover faster after heart surgery. About 125 patients will be randomly assigned to one of four groups to see which a…

This study tests whether pediatric massage can improve behavior and social skills in children aged 3 to 10 with autism spectrum disorder (ASD). Children receive massage twice a week for 12 weeks from a professional, plus at-home massage from trained parents. Researchers also use …

This study tests whether a 15mg dose of the painkiller ketorolac works as well as a 30mg dose for relieving kidney stone pain in the emergency department. About 86 adults with severe pain will receive one of the two doses, and their pain levels will be tracked over several hours.…

This trial tests whether listening to preferred music or squeezing a stress ball during cataract surgery can reduce patients' pain and anxiety. About 240 adults having their first cataract surgery will be assigned to one of these two simple, drug-free techniques or to standard ca…

This trial tests whether using real-world props, like a kayak paddle or sitting in an actual kayak, can lower anxiety during a virtual reality (VR) kayaking game in adolescents with mild to moderate intellectual disabilities. Participants will be randomly assigned to play the VR …

This study tests an 8-week hybrid physiotherapy program for adults aged 45-75 who live with both chronic pain and depression. The program combines weekly face-to-face sessions on pain science with guided exercises and online videos. Researchers will measure changes in pain intens…

This six-week study tests whether two liquid supplements, BrainJuice Peach Mango and BrainJuice ACTIVE Pomegranate Acai, can improve cognitive function, performance, and mood in healthy adults aged 18-57 who have concerns in these areas. Participants drink one supplement daily fo…

This study explores whether sleep problems in children with ADHD are linked to being overly sensitive to everyday sensations, like touch or sound. It tests a bedtime routine called 'Power Down' that uses gentle massage and calming cues to help children relax before sleep. The stu…

This study tests a program called I2-ART, where trained family navigators support caregivers of minority children with ADHD. The goal is to help families follow through with recommended treatments like medication or behavior therapy. The study involves about 108 participants and …

This study tests whether Emotional Freedom Techniques (EFT) — a therapy that combines tapping on specific body points with focused thoughts — can help people recovering from coronary artery bypass surgery. Researchers will compare 33 patients who receive EFT plus standard care ag…

This study compared two types of ultrasound-guided nerve blocks (caudal block and dorsal penile block) to control pain after hypospadias repair in 62 boys aged 1-6 years. The main goal was to see how long it took before children needed extra pain medicine. The results could help …

This study tested a probiotic (BB-12 with LGG) in 123 children with autism and stomach problems. The goal was to see if different doses are safe and can improve behavior and gut health. Researchers tracked side effects, behavior changes, and gut bacteria over 56 days of treatment…

This study tests a 12-week supervised exercise program for adults with severe mental illness, such as schizophrenia, bipolar disorder, or major depression. The program combines cycling, strength training, and breathing exercises in twice-weekly sessions. Researchers will measure …

This study tests whether a cosmetic serum and cream containing urea, salicylic acid, and collagen can reduce the thickness and pain of foot calluses and corns. Adult women with a single callus or corn will apply the treatment twice daily for two months. High-frequency ultrasound …

This study tests an online program called SAGE LEAF that teaches positive emotion skills to family caregivers of people with dementia. Over 6 weeks, participants learn techniques like gratitude and mindfulness through short lessons and daily practice. The goal is to see if the pr…

This study tests whether adding a sensor-based exergame to regular table tennis practice can help adolescent boys with mild autism react faster and move more quickly during play. Half of the 24 participants will do 20 minutes of light-based reaction training twice a week for 8 we…

This study tested whether a natural compound called palmitoylethanolamide (PEA) can help reduce depression in people with bipolar disorder. 34 adults who were already taking a mood stabilizer took PEA or a placebo. Researchers measured changes in depression scores and looked at h…

This study tests an 8-week online group program that teaches parents of young autistic children (ages 2-6) strategies to support their child's social communication and development. Parents attend weekly sessions and practice techniques at home. Researchers will measure changes in…

This trial tests whether wearing virtual reality goggles that show relaxing nature scenes can reduce pain, anxiety, and sleep problems in people recovering from total knee replacement surgery. Half of the participants will receive standard care plus the virtual reality sessions, …

This study tested short, digital exercises (called micro-interventions) designed to reduce distress and improve well-being in breast cancer survivors. 120 women who had been diagnosed with early-stage breast cancer in the past 5 years and had mild-to-moderate anxiety or depressio…

This study tests whether a low dose of oral ketamine can safely help with anxiety in people with pancreatic cancer. Twenty participants will receive both ketamine and a placebo at different times to compare effects. The main goal is to see if such a study is even possible, not to…

This study tested whether taking hydrocortisone (a cortisol-like hormone), melatonin, or both could reduce jet lag symptoms after long eastward flights. Fifty-seven healthy adults aged 18-65 who flew across 6-8 time zones took the pills for 4 days after arrival and reported their…

This study tests whether a low-carbohydrate diet (under 40 grams of carbs per day) can reduce pain and improve quality of life in women aged 65-75 with knee osteoarthritis. It specifically looks at whether the diet's effects differ between African-American and non-Hispanic white …

This study tested an experimental drug called AXS-05 to see if it can safely reduce agitation in people with Alzheimer's disease. About 408 participants took either the drug or a placebo for several weeks. The goal was to measure changes in agitation using a standard rating scale…

This study tested whether a computerized training program that targets emotional reactions can help relieve obsessive thoughts and compulsive behaviors in people with OCD. Five adults with OCD completed 14 training sessions over three weeks. The goal was to see if this approach c…

This study tests whether listening to music or metronome sounds that match your heart rate can reduce chronic pain in people with multiple sclerosis. 45 participants will be split into three groups: one does motor imagery with a heartbeat-synced metronome, one listens to relaxing…

This trial tests whether a robotic pet or a video can reduce pain, fear, and anxiety in children aged 5-10 during a blood draw (venipuncture). Children are randomly assigned to interact with a robotic pet, watch an animal video, or receive routine care during the procedure. Resea…

This phase 2a trial tests CYB004, a synthetic version of the psychedelic DMT, combined with talk therapy in 36 adults with moderate-to-severe generalized anxiety disorder. The study aims to see if the drug is safe, tolerable, and can reduce anxiety symptoms compared to an active …

This pilot study is testing whether a gentle form of yoga, called restorative flow yoga, can help reduce chronic pain and lower inflammation in women aged 60 and older. Participants will attend yoga sessions designed to relax the body and mind, and researchers will measure change…

This study tests whether watching a virtual reality (VR) video of an electroconvulsive therapy (ECT) session can reduce anxiety and improve knowledge about the procedure. About 64 adults about to have ECT for the first time will be randomly assigned to either a VR education sessi…

This trial tests a new psychoeducation program that teaches military veterans with PTSD how sensory processing affects their stress, emotions, and daily life. Participants learn strategies to better regulate overwhelming situations, improve sleep, and engage socially. The study a…

This study tests whether a gel made from a patient's own blood platelets can help diabetic individuals heal faster after tooth removal. Twelve adults with diabetes who need two similar-sized tooth extractions will receive the gel in one socket and standard care in the other. Rese…

This trial tests whether a mouthwash containing lithium can prevent or reduce oral mucositis (painful mouth sores) and dysgeusia (taste changes) in people receiving radiation for head and neck tumors. Participants will rinse with either a lithium mouthwash or a placebo during the…

This study tests four different vaginal treatments (estrogen, DHEA, estrogen with probiotics, and a moisturizer) in 160 breast cancer patients who have vaginal atrophy due to hormone therapy. The goal is to see which treatment best relieves symptoms like dryness and pain, and imp…

This study tests whether a medically supervised 12-week ketogenic diet is practical for 6 adults with PTSD in Germany. The main goal is to see if people can stick to the diet and complete the study. It is not designed to measure how well the diet works for PTSD symptoms, but it m…

This study tests whether a walking program that uses FitBit tracking and personalized coaching can help people who recently had a leg amputation due to diabetes or peripheral artery disease become more physically active. Participants will use a FitBit to monitor their steps and r…

This study tests whether placing ice inside the rectum before a prostate biopsy can lower pain, anxiety, stress hormone levels, and complications like bleeding. About 84 men having their first prostate biopsy will either receive standard care or ice application. The goal is to se…

This trial tests whether adding virtual reality to cognitive behavioural therapy (CBT) can better reduce persecutory thoughts in people with schizophrenia spectrum disorders compared to traditional CBT alone. About 256 participants will receive either VR-assisted CBT or standard …

This trial tests whether watching a 30-40 minute augmented-reality animation that shows a child's journey through surgery can reduce anxiety in children aged 3-12 before adenotonsillectomy. Half the children will watch the animation before surgery, while the other half receives s…

This trial asks whether letting mothers use their personal cellphones during a planned C-section under spinal anesthesia can lower anxiety and stress and improve satisfaction. About 82 low-risk pregnant women will be randomly assigned to either use their phones freely during surg…

This trial is testing a program called TEAMSS, designed to help fifth graders with elevated anxiety transition more smoothly to middle school. The program includes reading materials, a school tour, group sessions, parent meetings, and teacher consultations. The goal is to see if …

This study tested whether adding a long-acting stimulant (methylphenidate) to regular antipsychotic medication can improve thinking and daily function in people with schizophrenia or schizoaffective disorder. Thirty-five adults who were stable on their current treatment took the …

This pilot trial tests whether pediatric primary care providers can effectively deliver a brief intervention called the Anxiety Action Plan (AxAP) to help children aged 6-17 with elevated anxiety symptoms. Providers receive training and coaching to administer the intervention, wh…

This trial tests whether a daily synbiotic supplement, combining probiotics and a prebiotic fiber, can ease common perimenopause and menopause symptoms like poor sleep, anxiety, and brain fog. Women aged 44–55 experiencing these symptoms will take either the active supplement or …

This study tested whether a specialized swim program (Sensory Enhanced Aquatics) helps autistic children aged 5-9 learn swimming and water safety better than standard lessons. Fifty-one children participated in 16 half-hour lessons. Researchers measured swimming skills before and…

This study tests if using a stress ball can reduce pain, anxiety, and changes in heart rate during chest tube removal after open heart surgery. About 46 adults who have one chest tube after surgery will be split into two groups: one will squeeze a stress ball during the procedure…

This study tested whether lidocaine, a common numbing drug, works as well as remifentanil (an opioid) for pain after laparoscopic gallbladder removal. 138 adults took part. The goal is to find effective pain relief with fewer opioid side effects.

This study compares two types of nerve blocks for pain after hip replacement surgery. Sixty adults will receive either a sacral erector spinae plane block or a fascia iliaca compartment block, both using a numbing medicine through a small tube. The goal is to see which method red…

This study evaluates a new dermocosmetic cream containing 15% azelaic acid in people with mild-to-moderate acne. Researchers will observe how well the cream reduces acne lesions and improves skin discoloration, and how well it is tolerated, compared to standard treatments like or…

This pilot study explores whether adding improv comedy to standard cognitive behavioral therapy (CBT) can help adults with obsessive-compulsive disorder (OCD). Participants will take part in therapist-led group sessions that combine exposure and response prevention (ERP) with imp…

This trial tests whether using an iPhone with interactive rehabilitation software (HappyGoGo) for daily home exercise can improve pain, range of motion, and quality of life in people with frozen shoulder. Thirty participants are randomly assigned to either standard rehab plus the…

This trial tests whether virtual reality exercise games or electrical muscle stimulation can reduce shoulder pain and improve movement in people with chronic kidney disease who are on dialysis. Participants will receive one of the two therapies several times a week for eight week…

This study tested whether sanitary pads containing active oxygen and negative ions can reduce pain and improve healing after an episiotomy (a cut made during childbirth) in first-time mothers. 66 women were randomly assigned to use either the special pads or regular postpartum pa…

This study tested whether online occupational therapy-based parent coaching could improve feeding problems in children aged 3-6 who were born prematurely. 39 mothers participated, with some receiving coaching and others not. The coaching aimed to teach mothers better feeding stra…

This study looks at whether watching a short, AI-created story video at home can help children aged 4 to 10 feel less anxious and scared before their first skin prick test for allergies. About 100 kids will be split into two groups: one watches the video, the other gets standard …

This trial tests whether adding music therapy to standard rehabilitation helps people recover better after serious neurological injuries like stroke, brain injury, or spinal cord damage. About 75 participants aged 16-80 will be randomly assigned to receive either music therapy or…

This Phase 3 trial tested a cream containing ruxolitinib in 204 adults with prurigo nodularis, a skin condition causing intense itching and hard bumps. Participants applied the cream twice daily for 12 weeks. The main goal was to see if it reduced itch by at least 4 points on a 0…

This study tests whether a new physiotherapist-led primary care model can improve function and quality of life for adults with hip or knee pain. About 728 participants in Canada will be assigned to either the new model or usual care. The goal is to see if this approach reduces pa…

This study tests a mobile program called Compass for Care, designed to help people caring for a loved one with Alzheimer's or related dementias. The program delivers 12 weekly modules and tailored messages focusing on five self-care behaviors, such as taking time to recharge and …

This study looked at whether the drug Acthar can reduce inflammation and improve symptoms during a rheumatoid arthritis (RA) flare. Forty adults with RA who were having a flare took part. Researchers used ultrasound and disease activity scores to measure changes after treatment.

This trial tests whether playing with a rainbow parachute can improve upper arm strength and social-emotional skills in children aged 5 to 8 with developmental delays. Half the children will do parachute games for 8 weeks, while the other half does rhyming activities. Researchers…

This study tested a brain stimulation technique called closed-loop tACS in 21 people with methamphetamine addiction. The device uses brain wave patterns to deliver targeted electrical stimulation aimed at reducing cravings. Researchers measured craving levels and impulse control …

This study tested whether repeated doses of ketamine, an FDA-approved anesthetic, could speed up the effects of talk therapy (Prolonged Exposure) for PTSD in 75 veterans. Participants received either ketamine or a placebo alongside therapy. The goal was to see if ketamine could r…

This trial tests whether a structured, nurse-led empowerment program can boost mothers' knowledge and caregiving practices for children with nocturnal enuresis (bedwetting). Around 200 mothers of children aged 6-12 will either receive the program in small group sessions or contin…

This study looks at whether adding deep friction massage to a standard exercise program helps people with bicipital tendinitis (a painful shoulder condition). Researchers will measure pain, movement ability, fear of movement, and quality of life in 42 adults aged 20-55. The goal …

This study tests whether a one-month program of isometric neck exercises and posture advice can reduce cervicogenic headaches, stress, and sleep problems in 44 adolescents aged 13-19 who use smartphones at least 4 hours daily. Participants will be randomly assigned to either the …

This study looks at whether adding cognitive behavioral therapy (CBT) and exercise to knee replacement surgery helps reduce pain and improve function. About 282 adults with knee osteoarthritis are randomly assigned to one of three groups: a non-surgical program with CBT and exerc…

This study tested a new medicine called BXCL501 to see if it can safely reduce the unpleasant symptoms people feel when they stop taking opioids. 225 adults with opioid use disorder took part. The medicine was given as a film under the tongue, and researchers measured withdrawal …

This trial tests a 12-week guided self-help program for parents of young children (ages 2-6) with neurodevelopmental disorders like autism or ADHD. The program combines a workbook, online modules, and group sessions to teach acceptance and mindfulness skills. The goal is to see i…

This study tests an online psychological support program based on Acceptance and Commitment Therapy (ACT) for mothers of children with autism. The program aims to reduce parenting stress and improve mothers' mental health, which may also benefit their children's behavior. Mothers…

This trial tests a 12-week smartphone-based program called PACT, which combines acceptance and commitment training with positive parenting advice, for parents of children with special health care needs. The goal is to see if it can improve parents' mental well-being, psychologica…

This study tested a fast-dissolving film (BXCL501) placed under the tongue to quickly reduce agitation in people with bipolar disorder. About 380 adults with bipolar I or II who were very agitated took part. The goal was to see if the film safely calms agitation better than a pla…

This trial tests whether a traditional Chinese medicine aromatic sachet, placed beside the pillow each night, can improve sleep quality in women aged 45 to 59 experiencing poor sleep during the menopausal transition. One hundred twenty-two women in Macao will use either the herba…

This trial tests whether adding virtual reality (VR) exercises to a standard rehabilitation program can improve pain, balance, and quality of life in people with symptomatic knee osteoarthritis. Adults aged 40-85 with chronic knee pain will either receive conventional rehab alone…

This trial tests whether a dissolvable film placed under the tongue, containing the drug dexmedetomidine (BXCL501), can reduce agitation in people with schizophrenia. Participants are adults aged 18 to 65 who are clinically agitated. The study compares different doses of the film…

This trial tests whether a 6-week virtual Tai Chi and Qigong program can improve sleep quality in adults aged 50 and older. Participants take three 50-minute online classes per week, with some starting immediately and others waiting six weeks. Researchers measure sleep quality an…

This study tested a sublingual film containing dexmedetomidine (BXCL501) to quickly calm agitation in 100 older adults with dementia. Participants received either the drug or a placebo, and researchers measured changes in agitation scores and side effects. The goal was to find a …

This study will test whether foot reflexology—a type of foot massage—can help women aged 18-45 with migraines feel less pain, anxiety, and fear of movement. Twenty women will either receive 10 foot massage sessions over 5 weeks or no massage. Researchers will measure changes in h…

This trial tests whether low-frequency whole body vibration—standing on a gently vibrating platform—can improve motor skills and sensory integration in children aged 5 to 9 with mild to moderate autism. Participants receive vibration sessions alongside routine physical therapy, a…

This study tested a wearable morning light device (Re-Timer) for women with postpartum depression. 95 women wore either bright or dim light glasses for 60 minutes each morning for 5 weeks. Researchers measured changes in depression symptoms, sleep, and body clock timing. The goal…

This Phase 3 trial tested a sublingual film containing dexmedetomidine (BXCL501) to quickly reduce agitation in 380 adults with schizophrenia or related disorders. Participants received either the drug or a placebo film, and researchers measured changes in agitation symptoms over…

This study tested a medicine called BXCL501 for calming sudden episodes of agitation in people with dementia. It involved 151 participants who took the medicine only when needed over 12 weeks. The goal was to see if it safely reduces severe restlessness, tension, or aggression.

This study is testing two new artificial tear formulas to see if they are safe and well-tolerated in people with moderate dry eye disease. Researchers will monitor for side effects and eye health in 148 participants who already use artificial tears. The goal is to find better opt…

This study tests whether haptotherapy, a gentle touch-based therapy, can reduce anxiety and improve bonding in pregnant women who have had a previous abortion. Eighty women between 28 and 32 weeks of pregnancy will receive five 45-minute group sessions. Researchers will measure a…

This study tests a new online program called Tiny Heroes, designed to help parents of anxious children aged 3 to 6. The program teaches parents cognitive behavioral therapy techniques through four online modules. Researchers want to see if it is practical and effective in reducin…

This pilot study is testing whether a one-time, 45-minute virtual reality (VR) session guided by an AI coach can help people with chronic pain who also misuse opioids. The session includes a check-in, pain coping skills training, and a stress reduction exercise. The study involve…

This study looks at how a 3-month program of exercise and education affects pain and quality of life in people with hand osteoarthritis. Researchers will analyze data from 2,000 participants in the Swedish Osteoarthritis Registry. The goal is to see if this first-line treatment h…

This trial tests whether an 8-week mindfulness-based stress reduction program can help first-time pregnant women feel less depressed, improve their psychological well-being, and strengthen their attachment to their unborn baby. About 108 women in their first pregnancy, between 13…

This study tests whether an 8-week mindful self-compassion program can reduce self-harm, improve emotional control, and boost quality of life in 60 adults with borderline personality disorder. Participants learn mindfulness and self-kindness techniques. The goal is to see if this…

This study explores whether listening to music after a cesarean section can help first-time mothers feel less pain and anxiety, and improve their breastfeeding success. Participants will be divided into groups, with one group listening to music and the other receiving standard ca…

This early-stage study tests whether a new medicine called BI 3031185 is safe and well-tolerated in adults with borderline personality disorder (BPD) or attention-deficit/hyperactivity disorder (ADHD). About 96 participants will receive either the drug or a placebo in a crossover…

This pilot study explores whether real-time fMRI neurofeedback can help veterans reduce suicide-specific rumination—the repetitive mental fixation on suicidal thoughts. Sixteen veterans will receive two brain-training sessions, learning to modulate activity in brain regions linke…

This study tests whether a precise type of radiation, called stereotactic radiotherapy, can safely reduce symptoms in people with treatment-resistant depression. Nine adults aged 18 to 50 who have not improved after at least two antidepressant trials will receive the treatment. R…

This study tests a special scalp cream to see if it safely relieves symptoms like flaking and itching in people with mild to moderate seborrheic dermatitis (a common dandruff condition). About 34 adults will use either the cream or a placebo for a set time. Researchers will measu…

This study looked at whether an 8-week group exercise program could improve physical abilities and sleep in adults aged 65 to 90. Eighty participants from community centers in Taiwan either joined the exercise program or continued their usual activities. The program included aero…

This trial asks whether wearing a virtual reality (VR) headset before and during short hand surgeries can help reduce pain and anxiety. Adults undergoing elective hand surgery with local anesthesia and sedation will use the VR headset as a distraction. Researchers will measure se…

This trial tests whether a cream made with mushroom extracts can help protect the skin of women undergoing radiation therapy for breast cancer. Participants use the cream or a standard moisturizer on the treated breast twice daily, starting before radiation and continuing for a m…

This trial tests whether giving patients an educational booklet before total knee replacement surgery improves their knowledge and beliefs about the procedure. Adults aged 55 to 75 scheduled for knee replacement will receive the booklet or standard care. Researchers will measure …

This study tests whether a special therapy using sights, sounds, touch, and other senses can help people with moderate Alzheimer's think clearer, feel calmer, and behave better. It also looks at whether this therapy reduces stress for their caregivers. Twenty-four people aged 65 …

This study looked at how well paracetamol alone or combined with different NSAIDs (ibuprofen, mefenamic acid, or diclofenac) controls pain after root canal treatment. 185 adults with severe tooth pain took part. The goal was to see if combining drugs works better than paracetamol…

This trial is testing whether a bio-natural moisturizing cream, called SaaTwae, can safely ease symptoms of mild-to-moderate atopic dermatitis (eczema) in children and adults. Participants will apply the cream or a placebo to affected skin twice daily, and researchers will track …

This trial tests whether using a virtual reality headset can reduce pain, improve comfort, and ease psychological symptoms in boys aged 6-12 after hypospadias surgery. Half the children will play a car racing game in VR for 15 minutes shortly after surgery, while the other half r…

This study tests a new type of brain training for children with ADHD. It uses a device that measures brain activity and gives feedback, sometimes with virtual reality goggles. The goal is to see if this training can improve attention and reduce hyperactivity. About 110 children a…

This pilot study is testing whether a low-cost, portable driving simulator can help retrain driving skills in people who have had a stroke or who live with Parkinson's disease or multiple sclerosis. Participants will be randomly assigned to train on either the portable simulator …

This study tested a program that combines mindfulness training, music listening, and video counseling to help new mothers manage depression and persistent pain after childbirth. The program was designed for use in outpatient care and includes digital tools. 1,720 healthy women wh…

This study explores whether a single-session sleep training program can improve sleep and reduce symptoms of borderline personality disorder (BPD) in teenagers. Teens aged 13-18 with BPD symptoms will receive a brief intervention based on the TSC-Youth protocol, which teaches hea…

This study tested an investigational medication called BXCL501 (dexmedetomidine) given as a film under the tongue for episodes of agitation in people with schizophrenia, schizoaffective disorder, or bipolar disorder. The trial included 452 adults aged 18-75 and compared the drug …

This study tests whether a gamified physical therapy software, called Yoomi, can help older hospital patients exercise safely in their beds. The goal is to see if this fun, interactive approach can preserve muscle strength and function during a hospital stay, reducing the need fo…

This study looks at whether ethnic minority adolescents who have experienced racial discrimination show stronger biological stress responses when faced with subtle racism. Researchers will measure blood pressure, stress hormones, and other markers while teens take part in a simul…

This study looks at people who have severe allergic reactions (anaphylaxis), especially when the cause is unknown. Researchers will do blood tests and bone marrow biopsies to find genetic or molecular clues. The goal is to understand what goes wrong in the body, not to test a new…

This study looked at Smith-Lemli-Opitz syndrome (SLOS), a rare genetic condition that affects cholesterol production and causes birth defects and intellectual disabilities. Researchers enrolled 130 patients and their mothers to learn more about the disease's progression, genetic …

This completed study looked at 386 adults with psoriasis to understand how skin inflammation might be linked to heart and blood vessel diseases. Participants had up to seven visits over four years, including blood tests, heart scans, and optional skin biopsies. The goal was to se…

This study looked at the natural bacteria in the gut of 131 adults with and without uveitis, an inflammatory eye disease. Researchers collected stool and blood samples and performed eye exams to see if differences in gut bacteria are linked to eye inflammation. No treatment was g…

This completed study used PET and MRI scans to compare brain dopamine function in people with Gaucher disease or Parkinson disease, their family members, and healthy volunteers. Researchers aimed to see if certain genetic mutations cause early changes in dopamine storage. The stu…

This study examined how Mexican-American families discuss their risk for diabetes, heart disease, breast cancer, and colon cancer. Researchers interviewed 498 adults from Mexican-American households in Houston to understand how culture and family history influence health communic…

This completed study looked at risk factors for diabetes and heart disease in 146 healthy African, African-American, and white women who were federal employees or contractors. Researchers compared things like triglyceride levels and insulin resistance to see if the best screening…

This study looked at whether teaching mothers about their family health history can help them encourage healthier eating and exercise in their families. About 310 adults with at least one child took part. Researchers gave them a Family Health Package with personalized risk info a…

This study looked at how nicotine affects brain activity and genes in smokers and non-smokers. Researchers used brain scans and genetic tests to understand why some people find it harder to quit smoking. The goal was to find biological markers that could predict quitting success …

This study followed 1,771 adults and children who received blood transfusions to check how safe the blood supply is. Researchers tested patients' blood for viruses like HIV and hepatitis before and after transfusion, and stored samples for future testing. The goal was to keep blo…

This study looked at how hormone changes during perimenopause (the time around menopause) might affect mood and behavior. Over 1,100 women participated, including those with depression symptoms and healthy volunteers. No treatments were given; instead, researchers used surveys an…

This study explores how transcranial magnetic stimulation (TMS) changes brain activity in people with and without heavy alcohol use. Researchers will use magnetoencephalography (MEG) to measure brain signals before and after TMS. The goal is to gather early data to support future…

This study looked at how nalmefene, a drug that blocks opioid receptors, changes brain activity and drinking behavior in heavy drinkers. Thirteen healthy heavy drinkers took nalmefene or a placebo and had brain scans while seeing alcohol-related cues. They also could self-adminis…

This study looked at 805 blood donors who tested positive for hepatitis C virus (HCV) to learn how the virus spreads and affects health over time. Researchers collected blood samples and health information to track infection and liver disease. The goal was to better understand HC…

This study looked at how fat-carrying particles called lipoproteins work in healthy people and those with high cholesterol or other lipid disorders. Researchers injected tiny, safe amounts of radioactive lipoproteins to track them in the body. The goal was to better understand ho…

This early-phase study tested a single dose of bisnorcymserine (BNC) in 75 healthy volunteers aged 55 and older to see how safe it is and how the body processes it. BNC is designed to block a brain chemical that may affect communication between nerve cells, potentially helping wi…

This study tested whether full-body suits made with far-infrared (FIR) emitting fibers affect body temperature, heart rate, oxygen use, and power output in young competitive cyclists. Nine cyclists rode a stationary bike for 40 minutes at a steady pace, then did a 5-second sprint…

This study looked at 23 adults going through alcohol detox to see how the bacteria in their mouth and gut change over time. Researchers collected stool and mouth samples along with diet and mood questionnaires. The goal was to better understand the link between gut bacteria, anxi…

This study used advanced brain imaging (MRI and MEG) to look for differences in brain structure, chemistry, and activity between people with schizophrenia and healthy volunteers. Over 3,200 adults took part. The goal was to better understand the brain changes linked to schizophre…

This completed study looked at how inflammation might connect heart disease and diabetes. Researchers used PET scans and blood tests to measure inflammation in 150 adults, including healthy volunteers. The goal was to better understand these links, not to test a new treatment.

This completed study by the National Human Genome Research Institute looked at 207 people with Moebius syndrome or similar congenital facial weakness disorders, along with their family members. Researchers aimed to better understand the genetic and clinical features of these cond…

This completed study from the National Institute of Mental Health looked at nearly 5,000 people with schizophrenia or related disorders, along with their siblings. The goal was to find genes linked to the illness and see how they affect brain function. This research helps scienti…

This completed study from the National Institute of Mental Health looked at over 1,500 women to better understand the symptoms of premenstrual syndrome (PMS) and a severe form called PMDD. Researchers used interviews, rating scales, and hormone tests to track mood and behavior ch…

This study follows 1600 adults with opioid use disorder over the long term by collecting monthly online surveys and yearly phone interviews. Researchers will track substance use, mental health, treatment involvement, and daily functioning. The goal is to better understand how peo…

This study looks at how type 2 diabetes affects young people aged 12 to 25. Researchers want to see if giving the pancreas a 2-week rest with insulin shots can improve its ability to make insulin. Participants take metformin, follow a diet, and some also get insulin. The study al…

This study looked for genetic causes of congenital heart disease (heart problems present at birth) in families from Uganda and Nigeria. Over 1,200 people took part, including affected children and their parents. Researchers used advanced DNA testing to find gene changes linked to…

This study is building an international registry of people with GNE myopathy, an ultra-rare muscle disease that causes progressive weakness and often leads to wheelchair use. Participants will complete online questionnaires about their symptoms, medical history, quality of life, …

This study looked at nearly 1,400 people with rare conditions like PPNAD, Carney Complex, and Peutz-Jeghers syndrome. The goal was to find the genetic causes and link them to specific symptoms. Researchers used clinical exams and genetic testing to better understand how these dis…

This study investigated whether environmental exposures during military service increase the risk of developing myositis, a rare autoimmune disease that attacks muscles. Researchers compared 37 military personnel with and without myositis using questionnaires and blood samples. N…

This study aimed to understand the brain and genetics behind autism spectrum disorders (ASD). Researchers compared brain scans, thinking tests, and DNA from 678 people with ASD, healthy volunteers, and their parents. The goal was to find links between brain activity, behavior, an…

This study looked at the genes and lifestyle of over 7,400 people in Nigeria to understand why some develop type 2 diabetes. Researchers compared people with and without diabetes to find genetic differences. The goal is to learn more about diabetes causes in African populations a…

This completed study looked at how opioid use disorder changes dopamine signaling in the brain. Researchers used PET and MRI scans to compare people with opioid use disorder (some on medication, some not) to healthy volunteers. The goal was to understand differences in dopamine r…

This study looked at people with three rare genetic conditions—xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD)—that affect the body's ability to repair DNA. Researchers examined 709 participants to understand how these defects relate to cancer ri…

This study looked at how blood vessel stiffness affects organs like the heart, brain, kidneys, and gut in people with Williams Syndrome (WS) or supravalvular aortic stenosis (SVAS). Researchers compared 159 participants (ages 3–85) with these conditions to healthy volunteers over…

This study explores whether a wrist-worn sensor can identify early signs of delirium in hospitalized adults aged 65 and older. Delirium is a common and serious complication of hospitalization, and early detection is key. Participants wear a consumer-grade sensor on their wrist to…

This study looks at whether a protein in the blood, called soluble CD95 ligand, plays a role in ANCA-associated vasculitis, a rare group of diseases that cause inflammation of blood vessels. Researchers will collect blood and urine samples from 48 adults with the condition and tr…

This study analyzed health records of over 200,000 adults with obesity and type 2 diabetes to see if taking GLP-1 drugs (like Ozempic) before a cancer diagnosis is linked to better survival and fewer complications after cancer. The researchers compared GLP-1 users to those on oth…

This study looks at whether children born with heart defects who need surgery might also have delays in speech and thinking. Researchers will check the children's cognitive and language skills before their operation and again one and two years after. The goal is to see if speech …

This study looks at whether people with mild memory problems change their health habits, make future plans, or join more research after learning about their Alzheimer's-related brain scan results. It includes 100 Black and White adults with amnestic mild cognitive impairment. The…

This completed study looked at how the social networks of caregivers affect their stress and health when caring for someone with an inherited disease. Researchers surveyed over 680 participants, including family members and formal caregivers, to understand caregiving burden and s…

This study follows up to 5,000 people with autoinflammatory diseases (like NOMID, CANDLE, and juvenile dermatomyositis) and their healthy relatives. Researchers will collect medical history, blood samples, and imaging over 2-5 day visits to learn how these diseases work and find …

This large observational study across multiple African sites tracks pregnant women who use antimalarial drugs, especially in the first trimester. The goal is to assess whether these medications are linked to miscarriage, stillbirth, or major birth defects. By following thousands …

This study looked at whether adding folic acid and vitamin B12 to locally made cereals can improve the nutrition, thinking skills, and mood of teenage girls in rural Ethiopia. About 472 girls aged 13-19 took part. The goal was to see if small-scale food fortification can help pre…

This study looks at how smoking affects proteins linked to blood vessel formation in gum disease. Researchers will measure levels of KLF2, FBXW7, and other markers in fluid from around the teeth and in saliva from adults who are smokers or non-smokers, with healthy gums, gingivit…

This study is observing 66 pregnant women at high risk for preeclampsia to see if changes in their platelets (blood cells involved in clotting) can predict pregnancy complications. Researchers will collect blood samples before and after starting daily low-dose aspirin. The goal i…

This study looks at how the heart medication digoxin is processed in infants born with single ventricle heart disease. Researchers will collect blood samples during routine care to measure drug levels. The goal is to better understand dosing, but the study does not change the inf…

This study used MRI and PET scans to examine the glutamate system in people with major depression, PTSD, or bipolar disorder. Researchers aimed to understand how a specific glutamate receptor (mGluR5) relates to these conditions. 180 participants aged 18-70 completed cognitive te…

This study looks at whether smoking and advanced gum disease (Stage III periodontitis) are linked to changes in three saliva markers: TNF-α, FoxO-1, and SIRT-1, which are involved in inflammation and stress responses. Researchers will compare saliva samples from 80 adults divided…

This early-stage trial will test a new drug called hydronidone, which is being developed for liver fibrosis caused by hepatitis B. Since patients often need to take antiviral drugs for hepatitis B, researchers want to see if hydronidone can be taken safely alongside four common a…

This study looked at how pain influences opioid cravings in 89 adults with opioid use disorder and chronic pain. Participants attended a brief education session and then had their pain response and cravings measured. The goal was to better understand the connection between pain a…

This study looked at how depression in mothers affects their interactions with their babies and the child's development. Researchers observed 701 mothers and their infants at home and in a lab when the babies were 5, 12, and 24 months old. The goal was to understand differences i…

This study looks at long-term hormone and metabolic problems in people who survived a childhood brain tumor. Researchers will check survivors for issues like growth, thyroid, and blood sugar problems, and see how these relate to the tumor and its treatment. The goal is to help do…

This study used ultrasound to measure how much fluid remains in the stomach after standard preoperative fasting in 592 adults scheduled for elective surgery. Researchers compared diabetic and non-diabetic patients to see if diabetes affects stomach emptying. The goal is to help t…

This study looks at families where one sibling has a rheumatic disease (like rheumatoid arthritis or lupus) and the other does not. Researchers compare their blood, genes, and environmental exposures to find clues about why one got sick. Over 1,000 participants are involved, incl…

This study investigates whether proteins from the Hippo signaling pathway—known to control cell growth and bone health—are present at different levels in the gum fluid of people with healthy gums, gingivitis, or periodontitis. Researchers will collect fluid samples from 75 partic…

This study looks at whether adrenaline, the body's stress hormone, triggers an immune reaction during low blood sugar (hypoglycemia) in people with and without type 1 diabetes. Researchers will lower participants' blood sugar and then give drugs that block adrenaline's effects to…

This study follows nearly 90,000 farmers and their spouses to track long-term health effects of pesticides, crops, and animals. Participants report new medical conditions, which researchers then confirm through medical records and genetic samples. The goal is to better understand…

This study looks at whether adults aged 70 and older with multiple chronic conditions (but no heart disease) can safely stop taking statins. Researchers are comparing those who continue statins to those who stop, tracking deaths and major heart events over 2-4 years. The goal is …

This completed Phase 1 trial studied how deupirfenidone (LYT-100) and nintedanib interact in 24 healthy adults aged 18-65. Participants took both drugs over several weeks to measure drug levels and check for side effects. The goal was to understand potential drug-drug interaction…

This trial tests whether a mobile exercise app can deliver the same benefits as supervised training. Healthy university students will be randomly assigned to use the 7-Minute Workout® app, follow a supervised high-intensity interval training program, or receive no intervention fo…

This pilot trial is testing whether a program called CRUSH, designed to teach sexual health and relationship skills, is practical and well-received by autistic adults aged 18 to 30. Participants will attend 15-20 group sessions with one-on-one coaching and complete assessments be…

This study looks at how the body processes arginine, a natural nutrient, in teenagers with type 2 diabetes. Researchers will give participants arginine and measure its effect on insulin production. The goal is to better understand the disease and see if arginine could be a safe, …

This study asks whether pioglitazone, a widely used diabetes medication, might reduce bone density in people with type 2 diabetes. Researchers will compare bone mineral density and bone turnover markers in adults aged 30-55 who take pioglitazone versus those who do not. The goal …

This study looks at whether antimuscarinic drugs used for overactive bladder (OAB) affect how long ejaculation lasts and the time before a man can ejaculate again. Researchers will follow men aged 20 to 50 who are prescribed tolterodine or propiverine for OAB. Participants fill o…

This study follows nearly 600 people with Smith-Magenis syndrome (SMS), a rare genetic condition, to track how their health, behavior, and development change over time. Researchers will perform detailed medical exams, genetic tests, and surveys to better understand the syndrome's…

This study looks at whether blood tests called bone turnover markers can quickly show if osteoporosis drugs are working in postmenopausal women. Forty women will receive either bone-strengthening or bone-building medications for six months. The goal is to see if these blood tests…

This study looks at how false or misleading health information found online affects the way people with chronic illnesses like diabetes and high blood pressure take their medications and make treatment decisions. Researchers will survey 300 adults who use social media at least on…

This study compares levels of a protein called VISTA in immune cells from people with multiple sclerosis (MS) or clinically isolated syndrome (CIS) and healthy volunteers. Researchers will take blood samples at the first attack and again at 6 and 12 months to see if VISTA levels …

This study tested whether educational podcasts and videos created by artificial intelligence could improve knowledge about osteoporosis and digital health literacy. Sixty adults aged 45 and older with osteoporosis or at risk for it received either audio or video content based on …

This study looked at how a gentle nerve stimulation device (tVNS) affects stress-related brain activity and body functions in people with major depression. Researchers compared active stimulation to a sham (fake) version in 62 adults, focusing on differences between men and women…

This study uses brain scans to compare how a single dose of two ADHD medications—guanfacine (a non-stimulant) and lisdexamfetamine (a stimulant)—affect brain function in children and teens with ADHD, relative to a placebo. Participants perform tasks of attention, working memory, …

This study looked at how often thiamine (vitamin B1) deficiency occurs in hospitalized veterans who do not abuse alcohol. Thiamine deficiency can cause symptoms like fatigue, confusion, and weakness, and may be more common in veterans due to food insecurity and chronic illness. R…

This study aims to understand the lived experiences of family caregivers who provide unpaid care to people with mental health conditions like depression, anxiety, and trauma in Zambia during the COVID-19 pandemic. Researchers will interview caregivers and mental health experts to…

This trial tests whether a gamified app-based training program can improve intensive care unit (ICU) nurses' understanding of delirium, their confidence in learning about it, and their clinical reasoning skills. Around 100 registered nurses working in adult ICUs will use the app,…

This study looks at whether a fast, automatic eye test can predict delirium (sudden confusion) in intensive care patients who need a breathing machine. Delirium is common and serious, but current screening methods take time and training. Researchers will measure pupil reactions i…

This study investigates the link between gut bacteria and diabetic kidney disease, a common complication of type 2 diabetes. Researchers will analyze blood, urine, and stool samples from 556 adults with the condition to look for bacterial and metabolic markers. The goal is to und…

This study explores the link between gut bacteria and alcohol use disorder (AUD). Researchers compared gut microbiota in three groups: current heavy drinkers with AUD, people with AUD who have been abstinent for at least 4 weeks, and healthy moderate drinkers. Participants provid…

This study tests whether a mild electrical brain stimulation technique called transcranial direct current stimulation (tDCS) can alter brain activity in adults with major depression. Using MRI to guide the stimulation, researchers will measure changes in brain connectivity and al…

This study investigates whether partial sleep deprivation, compared with normal sleep, changes metabolic and cognitive functions related to food intake, hunger, and memory. Healthy young men aged 20-28 will undergo both sleep conditions in a controlled setting, with blood samples…

This completed study worked with 65 African American/Black adults who use cocaine or other illicit substances to develop a manual called I-DREM. The goal was to gather their feedback on how to improve recruitment and retention in substance use disorder clinical trials. Participan…

This study looked at three substances in saliva—Adseverin, 1-alpha defensin, and sRANKL—to see if they differ between people with healthy gums, gingivitis, or periodontitis. Researchers collected saliva from 60 non-smoking, systemically healthy adults and measured these biomarker…

This study looks at whether spending 2 to 3.5 weeks at a device-free summer camp in Maine can improve mental health and brain activity in teens aged 12 to 17. Researchers will measure changes in mental health scores and brain waves (EEG) from the start to the end of camp. The goa…

This study evaluates whether prismaLINE PAP devices accurately count breathing events (apneas and hypopneas) compared to the gold-standard polysomnography (PSG) in people with sleep apnea. Participants will use a full face mask during a titration night, where the device briefly l…

This study used PET scans to measure blood flow in the frontal lobe while participants performed thinking tasks. It included healthy volunteers and people with schizophrenia or Parkinson's disease. The goal was to understand how the frontal lobe works during cognitive activities …

This study looks at how scar tissue (fibrosis) forms in the heart in conditions like aortic stenosis, heart damage from chemotherapy, and carcinoid syndrome. Researchers will use special PET scans to see active scarring early. About 180 adults will take part to help improve detec…

This study investigates how viral infections influence the community of bacteria in the airways of young children with cystic fibrosis. Researchers will collect throat swabs from children under 5 years old over one year, tracking their microbiome, inflammation, and clinical sympt…

This study tests whether teaching Latino patients with type 2 diabetes how to use patient portals and telehealth during a hospital stay helps them manage their care after discharge. 84 adults will receive either one-on-one digital training or standard care. The main goal is to se…

This study tests whether using the wrist (radial artery) instead of the groin (femoral artery) as a second access point during a minimally invasive heart valve replacement (TAVI) reduces bleeding and other complications. About 542 patients will be randomly assigned to one of the …

This early-stage trial tests whether a single dose of HTD1801, an experimental drug for primary sclerosing cholangitis, is safe and tolerable in healthy adults. Researchers will monitor participants for side effects and measure how the drug moves through the body. The goal is to …

This early-stage trial is testing an experimental drug called HTD4010, a synthetic version of a natural peptide that may help the pancreas regenerate insulin-producing cells. The study enrolls healthy, non-diabetic volunteers to receive single ascending doses of the drug or a pla…

This study asks whether a scenario-based simulation, where nursing students interact with an actor portraying a person with schizophrenia, can boost their knowledge, empathy, and caregiving skills. Around 105 students will complete questionnaires before and after the simulation, …

This study investigates the link between the physical structure of the upper airway and its tendency to collapse during sleep, which is a key factor in obstructive sleep apnea. Researchers will measure airway collapsibility using a special pressure device, and assess anatomy via …

This study asks whether a person's ABO/Rh blood type is linked to how well their diabetic kidney disease responds to standard treatment. Researchers will follow 161 adults with type 2 diabetes and kidney disease for one year, measuring kidney function and protein in the urine at …

This study investigates whether disease-modifying medications for relapsing-remitting multiple sclerosis (RRMS) can reduce cognitive fatigue—the tiredness that follows intense mental effort. Researchers will use functional MRI to measure brain activation in people starting either…

This study looks at how gum disease, from mild gingivitis to more severe periodontitis, changes the activity of certain genes and proteins involved in inflammation and cellular cleanup. Researchers will collect small gum tissue samples from people with healthy gums, gingivitis, o…

This trial asks whether the 'first-night effect'—poorer sleep in an unfamiliar place—impairs next-day strength and muscular endurance, and whether men and women respond differently. Thirty-two resistance-trained adults (16 women, 16 men) will sleep 8 hours at home and 8 hours in …

This observational study tests a mobile app that uses a dynamic difficulty adjustment system to personalize cognitive activities for people with mild cognitive impairment or mild Alzheimer's disease, as well as healthy older adults. The goal is to see if the app can reach a stabl…

This study tests whether a family-centered developmental care program, called NIDCAP, can improve brain and behavior outcomes in preterm infants born with severe intrauterine growth restriction. The intervention involves weekly observations of each infant's behavior, with persona…

This completed study from Minia University looked at 200 patients with autoimmune thyroiditis (an inflamed thyroid) who had thyroid surgery. The goal was to see how often thyroid cancer is found by accident when examining the removed tissue. Researchers checked for cancer in pati…

This study looks at how melatonin from lotions and bubble baths enters the body compared to traditional oral tablets. Researchers will measure melatonin levels in saliva after use to see how quickly it is absorbed and how long it stays in the system. The trial involves healthy un…

This study collected DNA, tissue, and medical history from 305 people with Williams syndrome or supravalvar aortic stenosis (SVAS), as well as their family members and healthy volunteers. The goal was to create a resource for future research to understand why symptoms vary so muc…

This study explores whether the medication Tysabri can reduce cognitive fatigue—the tiredness that comes after intense mental effort—in people with relapsing-remitting multiple sclerosis (RRMS). Researchers will compare brain activity, measured with functional MRI, between RRMS p…

This study is testing whether an artificial intelligence system can more accurately classify small bowel Crohn's disease and predict how patients will fare over the next year. Researchers will analyze existing CT or MRI scans from 437 patients, combining imaging features with cli…

This trial tests whether an online training course, called MelaMEd, can improve primary care doctors' ability to detect and manage melanoma, the most serious form of skin cancer. Participants—general practitioners, trainees, and pediatricians—answer questions and review skin lesi…

This study looks at how IgA nephropathy, a kidney disease, is actually treated in the United States. By analyzing medical records from thousands of patients, researchers aim to understand which therapies are used, in what order, and for how long. The goal is to see how current tr…

This study looks at how eating a high-fat meal changes levels of certain fats in the blood called ceramides, and whether those changes affect blood vessel function. Healthy adults aged 18 to 40 will eat either a meal rich in long-chain fatty acids (which raise ceramides) or mediu…

This study looks at what influences sleep quality in patients recovering in the intensive care unit after open-heart surgery. Researchers will measure pain, fatigue, and environmental stressors to see which factors most affect sleep. The goal is to find ways to improve sleep and …

This observational study looks at whether two proteins found in saliva—Gasdermin E and Granzyme B—are present in different amounts in people with periodontitis (a severe form of gum disease) compared to those with healthy gums. Researchers will collect saliva samples and measure …

This completed pilot study in Yomitan Village, Okinawa tested three simple, low-cost approaches to reduce stress and encourage healthy habits in 45 adults with overweight or pre-metabolic syndrome. Participants were randomly assigned to receive health leaflets, wear functional cl…

This study looked at how having fibromyalgia changes body measurements and sleep patterns in people with obstructive sleep apnea. Researchers measured neck, waist, and hip sizes, and used sleep tests and ultrasound to compare 77 participants. The goal was to better understand the…

This study looks at how children over age 3 with pyridoxine-dependent epilepsy, a rare genetic condition, develop cognitively over time. Researchers will use a standardized questionnaire called Vineland II to measure adaptive behaviors like communication and daily living skills. …

This study looks at how oral isotretinoin, a common acne treatment, affects the surface of the eye and the meibomian glands, which produce the oily layer of tears. Researchers will measure tear film stability, gland structure, and dry eye symptoms in 60 acne patients before and a…

This study looked at how well vaccines work in adults with moderate-to-severe eczema who are taking amlitelimab, an experimental drug. About 224 participants received either amlitelimab or a placebo along with tetanus and pneumonia vaccines. The goal was to see if the drug change…

This study tests whether a fast form of brain stimulation (accelerated iTBS) can improve thinking and memory in 30 adults with schizophrenia or schizoaffective disorder who are already taking the medication clozapine. Participants will receive both real stimulation and a sham (fa…

This trial investigates whether combining group and individual educational sessions helps patients with chronic inflammatory rheumatism (like rheumatoid arthritis or spondyloarthritis) learn safety skills better than individual sessions alone. Participants are starting their firs…

This study looks at whether people with type 2 diabetes who eat more dairy products (like milk, cheese, and yogurt) during an intensive lifestyle program have better blood sugar control and weight maintenance. Researchers will track changes in A1C, weight, and cholesterol in abou…

This trial investigates how replacing animal proteins with plant proteins in the diet influences metabolism. Adults with early signs of metabolic syndrome (like high triglycerides or slightly elevated blood pressure) will follow a controlled diet for four weeks, either predominan…

This study investigates whether stress inside gum cells plays a role in periodontal disease, which causes inflammation and damage to the tissues supporting the teeth. Researchers measured markers of cell stress and inflammation in fluid and tissue samples from 72 non-smoking adul…

This completed study looked at how a person's neighborhood environment might influence drug use, addiction, and whether they seek treatment. Over 1,600 adults from Baltimore took part, including people who never used drugs, past users, and current users. Researchers collected hea…

This study tested a new risk score that combines genetic and environmental factors to predict multiple sclerosis (MS). Researchers studied 181 people, including MS patients and their close relatives. The goal was to see if this score could identify who might develop MS in the fut…

This study is looking at whether a substance in the blood called LRG can help doctors tell how active ulcerative colitis or Crohn's disease is in the gut. Researchers will measure LRG levels in 300 people who might have these conditions and compare them with what is seen during a…

This study examines whether placentas from pregnancies with intrauterine growth restriction (IUGR) have different levels of certain progesterone receptors compared to healthy pregnancies. Researchers will analyze placental tissue collected after delivery from 90 women. The goal i…

This study looked at two common treatments for low blood pressure upon standing in people with autonomic failure: the drug midodrine and an abdominal compression belt. Researchers measured how each affects heart health markers like pulse wave velocity. The trial involved 31 adult…