Disease by developmental or physiological process

This study tests a hexavalent vaccine that protects against six diseases, including polio, but uses a lower dose of the inactivated polio vaccine (IPV). The goal is to see if this reduced-dose version works as well as the standard full-dose vaccine in infants. Around 1,500 health…

This early-stage study tests a new vaccine called PollenVax for people with moderate to severe mugwort pollen allergy. The main goal is to see if the vaccine is safe and tolerable in 30 adults aged 18 to 65. Participants receive four shots of either the vaccine or a placebo, and …

This study tests a new vaccine called Shigella4V, designed to protect against shigellosis, a severe diarrheal disease. Researchers are giving the vaccine to healthy adults, children, and 9-month-old infants to check its safety and whether it triggers a strong immune response. Dif…

This study investigates whether a daily probiotic supplement containing Lactobacillus bacteria can help reduce alcohol cravings, withdrawal symptoms, and the severity of alcohol use disorder in adult men. Participants take either the probiotic or a placebo for 12 weeks, and resea…

This study compares two treatments for severe shoulder arthritis: total shoulder replacement surgery followed by rehab, versus a 12-week exercise program with a physiotherapist. Researchers want to see if surgery leads to better pain relief and function than exercise alone. The t…

This study tested a new insulin called icodec that is injected just once a week, compared to the standard daily insulin glargine, in 429 adults with type 2 diabetes. Participants received either the weekly or daily insulin for 6 months. The goal was to see if the weekly shot cont…

This study tested whether giving pregnant women a balanced energy and protein supplement (BEP) can improve birth weight and reduce complications like low birth weight and preterm birth. Over 3,300 women in Bangladesh were randomly assigned to receive either BEP or standard prenat…

This study investigates whether a structured, personalized exercise plan—tracked with a smartwatch and supported by regular phone check-ins—can help control blood sugar, blood pressure, and weight gain in pregnant women with gestational diabetes, chronic hypertension, or obesity.…

This study tests whether adding a smartphone-based incentive program to standard counseling helps veterans with alcohol use disorder reduce heavy drinking. Participants use a mobile app to submit breath alcohol readings and earn rewards for abstinence. The trial compares this com…

This trial tests an experimental antibody drug called CM-101 in adults with primary sclerosing cholangitis (PSC), a rare liver disease. The drug targets a protein called CCL24 to potentially reduce inflammation and scarring. Participants receive either CM-101 or a placebo by intr…

This study tests an experimental drug called SHR-1819 in children and adolescents aged 6 to 17 with moderate-to-severe atopic dermatitis (a type of eczema). The main goal is to check the drug's safety and how the body processes it. Researchers will also look at changes in skin-re…

This study tested whether the drug RDX-002 can lower high blood fat levels in people who recently stopped taking weight-loss medications like semaglutide or tirzepatide. Sixty-eight adults who had lost at least 10% of their body weight on those drugs took either RDX-002 or a plac…

This Phase 1 trial tests the safety and how the body handles HRS-9813, an experimental oral drug for idiopathic pulmonary fibrosis (a lung-scarring disease). Healthy volunteers aged 18-45 take multiple doses to measure side effects and drug levels in the blood. The study does not…

This study tests whether a device called BB-02, which delivers pulsed electromagnetic fields, can slow cartilage damage in people with early knee osteoarthritis. Researchers will use MRI scans to measure changes in cartilage and track pain levels. The goal is to find a non-surgic…

This study tests a weekly injection called TransCon CNP in children aged 2 to 10 with achondroplasia, the most common form of dwarfism. The goal is to see if it can safely improve growth over one year. Half the children receive the drug and half receive a placebo, and all childre…

This study tests whether a daily dose of Taiwanese Green Propolis, a natural bee-derived supplement, can improve blood fat levels, reduce fatigue, and enhance quality of life in people who have completed treatment for oral cavity cancer. Participants take either propolis capsules…

This phase 3 trial tests whether a new formulation of dexmethylphenidate (CTx-1301) can improve attention and reduce ADHD symptoms in adults for up to 16 hours. Participants take an optimized dose (25, 37.5, or 50 mg) and complete math tests in a simulated classroom. The study co…

This study tests whether a small social robot named Tessa can help people with disabilities who have trouble planning and remembering daily tasks. Participants use the robot in their home, and researchers track how much professional caregiver support they need. The goal is to see…

This study tested a treatment called CPT-SMART that combines PTSD therapy, smoking cessation counseling, medication, and financial incentives to help veterans quit smoking. 120 veteran smokers with PTSD were randomly assigned to either the full program or a control group. The goa…

This study tested a program to help people with opioid use disorder stay on their medication after being hospitalized for serious infections like endocarditis or bone infections. Forty adults took part to see if the program was practical and helpful. The goal is to improve long-t…

This phase 2 pilot study tests whether adding the investigational drug vidutolimod to the immunotherapy nivolumab can destroy more melanoma tumors in lymph nodes or nearby skin areas before surgery. Participants have stage IIIB/C/D melanoma that has spread but not to distant orga…

This study tests whether spermidine, a natural substance found in foods like soy and aged cheese, can improve heart and muscle health in elderly people with coronary artery disease. 180 participants aged 65 and older will receive either spermidine capsules or a placebo for a peri…

This study tests whether leaving a tooth's root canal unfilled and using a blood clot to trigger natural healing works as well as the standard root canal filling. The trial involves 48 men with infected but still living upper premolars. One group gets the standard gutta-percha fi…

This trial investigates how the Fontan surgery, which reroutes blood flow in children born with a single heart ventricle, affects the liver and heart. Researchers use MRI scans and blood tests to measure fibrosis (scarring) and lymphatic congestion. They also test whether spirono…

This study tests a new antibody drug called 611 in 124 Chinese children and adolescents aged 6 to 18 with moderate to severe atopic dermatitis (eczema). The drug targets a protein involved in inflammation. The main goals are to check safety and how the drug moves through the body…

This study tested whether a gout medication (pegloticase) given every 4 weeks works as well as the standard every-2-week schedule, when both are paired with weekly methotrexate. The goal was to lower uric acid levels in people with severe, hard-to-treat gout. About 262 adults wit…

This study tested whether adding photodynamic therapy (a light-activated treatment) to standard sodium hypochlorite irrigation better kills bacteria in root canals. 64 adults needing root canal treatment were randomly assigned to receive either sodium hypochlorite alone or with p…

This study tested whether brief or in-depth counseling could help people living with HIV in Zambia reduce unhealthy alcohol use and improve HIV treatment. 680 adults who were on HIV medication and had hazardous drinking plus mental health or substance use issues took part. Partic…

This trial tests whether repeatedly adding sterile fluid into the womb can help fetuses with severe kidney failure grow enough lungs to survive after birth. Pregnant women with early pregnancy kidney failure can choose to receive the infusions or just be monitored. Babies who sur…

This study tests an experimental drug called X842 in people with severe erosive esophagitis caused by GERD (chronic acid reflux). Participants have either severe esophagus damage (grades C or D) or milder damage that hasn't healed after 8 weeks of standard treatment. The trial co…

This study tests whether giving the antibiotic vancomycin directly into the bone (intraosseous) during diabetic foot amputation works better than the standard IV method to prevent surgical site infections. It includes 40 adults with diabetes who need a below-knee amputation. Rese…

This trial investigates whether a blood-filtering procedure called immunoadsorption (IA), combined with the drug rituximab, can improve neurological function in children aged 0-18 with severe anti-NMDAR encephalitis. Participants receive 10 IA sessions over 28 days plus weekly ri…

This study tests whether special breathing techniques called neurophysiological facilitation of respiration can improve oxygen levels and shorten hospital stays in children aged 6 months to 2 years with pneumonia. The techniques involve gentle stretches and co-contraction of the …

This trial investigates whether non-surgical gum treatment can improve early signs of blood vessel dysfunction in people with periodontitis who have no known heart disease. Sixty participants will receive one of two types of deep cleaning procedures. Researchers will measure chan…

This early-phase trial tests whether MIB-626, a drug that activates sirtuin-NAD pathways, can reach the brain and affect aging-related markers in people with mild Alzheimer's. 22 participants will take either MIB-626 or a placebo for 90 days. The study primarily checks if the dru…

This phase 3 trial tested whether giving preterm babies a drug called darbepoetin weekly could improve their brain development and reduce the need for blood transfusions. 650 infants born between 23 and 28 weeks of pregnancy were treated until they reached 35 weeks or went home. …

This study tests a 10-week nutrition program in 61 older adults (ages 55-85) from rural North Florida, some with mild cognitive impairment and some without. Participants follow either a Mediterranean diet or a modified Mediterranean-ketogenic diet. The goal is to see if the progr…

This study tested the drug larotrectinib in 215 adults with various solid cancers that have a specific change in the NTRK gene. The drug is taken orally and works by blocking the action of the altered gene. The main goal was to see how many patients had their tumors shrink or dis…

This study tests two approaches to reduce the overuse of broad-spectrum antibiotics in adults hospitalized with community-acquired pneumonia. Researchers will compare rapid diagnostic testing and pharmacist-led de-escalation, alone or together, against usual care. The goal is to …

This study tests whether using continuous positive airway pressure (CPAP) or positive end-expiratory pressure (PEEP) during resuscitation helps extremely low birth weight infants (born before 28 weeks) breathe better and avoid lung damage. Half of the babies receive standard care…

This early-phase study tested the safety of combining two drugs—pembrolizumab (an immunotherapy) and AMG386 (which targets blood vessel growth)—in 62 people with advanced solid tumors like melanoma, ovarian, renal, or colorectal cancer. The main goals were to find the safest dose…

This study tests whether a 12-week occupational therapy program based on the Model of Human Occupation (MOHO) can improve life skills and quality of life in mentally ill offenders. Twelve male offenders from a prison in Chennai, India, will attend 24 structured therapy sessions o…

This trial investigates whether doxercalciferol, a form of vitamin D, can prevent bone loss in the spine and thigh bone in postmenopausal women with low bone density. Participants take either doxercalciferol or a placebo daily for two years, with bone density measured at the star…

This study tested two ways to offer HIV treatment, hepatitis C treatment, and substance use disorder medications to people who inject drugs. One group received a telehealth-enhanced program with on-demand services like mobile blood draws and counseling, while the other group got …

This study tests an experimental drug called NT-0796 in 176 obese adults, some with type 2 diabetes. Participants take the drug or a placebo alongside a reduced-calorie diet and increased physical activity for 6 months. The goal is to see if the drug helps with weight loss and re…

This study tests whether a wide-spectrum nutritional supplement can improve mitochondrial function in children with autism spectrum disorder (ASD). Mitochondria are the energy factories in cells, and some children with ASD have abnormal mitochondrial activity. The trial enrolls c…

This study tests whether a mobile-friendly gamified app, called Game-App-KNEE, can improve functional outcomes and recovery for people who have had total knee replacement surgery. Participants use the app daily for three months after discharge, while a control group receives only…

This study tested an ointment called tirbanibulin (Klisyri®) on adults with actinic keratosis, a common precancerous skin condition caused by sun exposure. The trial included 280 participants and applied the ointment to larger skin areas (up to 100 cm²) on the face or balding sca…

This trial investigates whether eating 100 grams of curd cheese daily as part of a personalized diet for 8 weeks can improve cholesterol levels, blood sugar, and body measurements in overweight adults aged 40 to 64. Participants are randomly assigned to either a curd cheese-suppl…

This study tests a program called Project YES+ for youth aged 15-21 living with HIV in Zambia. The program combines peer mentoring with mental health support to reduce stigma, violence, and depression. Researchers will enroll 400 participants to see if the program is feasible and…

This study tests whether a nasal spray containing adelmidrol can reduce inflammation and shrink nasal polyps in people with chronic sinusitis. Participants are adults aged 18 to 70 who are scheduled for sinus surgery. Half receive standard care plus the adelmidrol spray, while th…

This completed phase 2 trial tested whether adding alpha interferon to standard surgery helps prevent skin melanoma from returning. 278 participants with stage I-IV melanoma were assigned to one of six groups, including surgery alone, low or high dose interferon, chemotherapy, or…

This study tests the long-term safety of an experimental oral drug called orforglipron in adults with type 2 diabetes whose blood sugar is not well controlled by diet, exercise, or other diabetes pills. Participants take the drug once daily for about a year, and researchers monit…

This early-phase trial tests whether a daily vitamin B3 supplement called nicotinamide riboside can improve brain energy and reduce stress in people with mild cognitive impairment or mild Alzheimer's disease. Fifty participants will take the supplement for 12 weeks while research…

This trial investigates whether cardiac resynchronization therapy (CRT) — a special type of pacing — can improve how far people can walk in six minutes. It includes adults with congenital heart disease where the right ventricle pumps blood to the body (systemic right ventricle). …

This study tests whether whole-body vibration therapy, alone or combined with exercise, can improve bone health and physical function in women with low bone density who have had a total knee replacement. Forty-eight women will be randomly assigned to vibration only, vibration plu…

This study tests whether the immunotherapy drug durvalumab can be safely given to people with advanced liver cancer who also have an active hepatitis B infection. All participants receive an antiviral drug (entecavir) to control the hepatitis B virus. The main goal is to see if d…

This completed trial tested whether daily omega-3 fish oil supplements can help maintain healthy blood vessels in the eyes of adults with type 1 diabetes. 82 participants took either a 1000 mg omega-3 capsule or a placebo for the study, with regular eye exams to monitor retinal c…

This study explores whether combining a high-protein Mediterranean diet with resistance exercise can help people with heart disease build muscle and lower their risk of future heart problems. The trial enrolls adults who have completed cardiac rehab and may have low muscle mass w…

This study tests whether a single intravenous dose of ferumoxytol raises hemoglobin more effectively than daily oral ferrous sulfate in pregnant women with iron deficiency anemia. Participants are between 24 and 34 weeks pregnant with a single baby. The trial measures hemoglobin …

This study compares a new drug, HRS-7535, to an existing diabetes medication, dapagliflozin, in adults with type 2 diabetes whose blood sugar is not well controlled with metformin alone. The goal is to see if HRS-7535 works better at lowering blood sugar and body weight over 32 w…

This study tests whether newborns with neonatal abstinence syndrome (NAS) who receive a high-calorie formula for two weeks gain weight better than those on standard formula. The babies are managed using the Eat, Sleep, Console approach. The main goal is to see how much weight the…

This study compares two common substances—hydrogen peroxide and adrenaline—for controlling bleeding during tonsillectomy in children and teens aged 5 to 18. Surgeons apply one of the two to the surgical site and measure how quickly bleeding stops and how much blood is lost. The g…

This early-phase study tested the drug baricitinib in 17 people with Alzheimer's disease, ALS, or mild cognitive problems. The goal was to see if the drug reaches the brain and lowers inflammation linked to these diseases. Participants took baricitinib pills for 24 weeks, and res…

This study tests whether a combination of a special omega-3 supplement (LIPINOVA®) and a home-based exercise and education program can improve quality of life for people with lingering post-COVID symptoms. About 146 adults aged 18–70 who have had symptoms for more than 12 weeks w…

This trial tests whether a structured family support program helps relatives of critically ill patients in intensive care units (ICUs). The program includes a specialist nurse who supports families from admission through discharge and follow-up, plus better communication between …

This study looks at how well the SAGITTA EVL R hip implant works over the long term—7 to 10 years after surgery. Researchers are checking how many implants survive without needing another revision, how satisfied patients are, and what complications arise. The study includes adult…

This study tested an artificial version of the LCAT enzyme (ACP-501) in one person with familial LCAT deficiency, a rare genetic condition that leads to low 'good' cholesterol and kidney failure. The participant received several infusions of the drug over weeks, with regular bloo…

This phase 1 trial tests a single injection of TV-44749, an extended-release form of olanzapine, in Chinese adults with stable schizophrenia. The study aims to check safety, tolerability, and how the drug moves through the body. Participants receive one of three doses of the inje…

This study tests a family-based behavioral program for youth aged 6-17 with type 1 diabetes who are overweight or obese, along with an overweight parent. The program focuses on healthy meal planning, food literacy, and family habits to improve weight and diabetes control. Twenty …

This pilot study tests whether dialectical behavioural therapy (DBT) — a type of talk therapy that teaches skills like mindfulness and emotion regulation — can help Indigenous youth with type 2 diabetes improve their quality of life and diabetes control. The study enrolls 20 yout…

This study tests a 5-week community-based program that teaches protective behavioral strategies to reduce alcohol use in men aged 35–44 with hazardous drinking habits in rural Vietnam. Participants learn to set safe drinking limits, choose nonalcoholic drinks, and plan ahead, wit…

This study compares a fully automated digital screening and brief intervention (e-SBI) to the traditional in-person approach for reducing harmful alcohol consumption. Researchers will enroll over 500 adults from Brazilian public health clinics to see which method works better at …

This study tested two lifestyle programs for overweight or obese pregnant women to help them manage weight gain during pregnancy. One group received weekly group sessions on diet and activity, while the other got extra health information and classes. Researchers tracked weight ga…

This study tests a small ear device that gently stimulates nerves to see if it helps people with both PTSD and opioid use disorder stay on buprenorphine therapy. Twenty participants will use either the active device or a placebo for 12 weeks. Researchers will check if they keep t…

This study tested fecal microbiota transplantation (FMT) from different donors to treat ulcerative colitis, a type of inflammatory bowel disease. Researchers gave 102 patients a one-time colonoscopic infusion of fresh fecal bacteria from healthy donors. The goal was to see if don…

This study tests whether a daily capsule containing fragments of a probiotic bacterium (L. rhamnosus) can reduce liver fat and improve blood markers in adults with metabolic dysfunction-associated steatotic liver disease (MASLD). Participants take either the supplement or a place…

This trial investigates whether changing how often and when people with type 2 diabetes eat can improve weight, blood sugar, and cholesterol. Over 12 weeks, participants follow one of three eating plans: a standard 6-meal diet, a 3-meal diet, or time-restricted eating (eating all…

This study tested whether adding Naderin (sodium nucleinate) to standard treatment could reduce complications in 75 patients with cancer, tuberculosis, or hepatitis C. The main group received Naderin plus standard therapy, while the control group received standard therapy alone. …

This phase II trial tests whether giving two targeted drugs (dabrafenib and trametinib) before and after surgery can improve outcomes for people with stage IIIB-C melanoma that has a BRAF V600 mutation. 35 participants will take the drugs for 12 weeks before surgery, then continu…

This study investigates whether changing diet can reduce disease activity in people with psoriatic arthritis. Participants are randomly assigned to one of two diets: one focusing on which foods are eaten, and another limiting daily calorie intake. The trial lasts 24 weeks and inc…

This Phase 2 trial tested whether oral cimetidine (Tagamet), a common heartburn drug, can reduce light sensitivity in people with erythropoietic protoporphyria (EPP) and X-linked protoporphyria (XLP). These genetic conditions cause severe pain from sunlight exposure. The study en…

This study compares two minimally invasive treatments for deep gum disease bone defects: a non-surgical approach (MINST) and a surgical one (MIST). Researchers want to see if the non-surgical method can achieve similar bone and gum attachment improvements as surgery, but with les…

This trial tests a package of services called TASKPEN, which combines HIV care with screening and treatment for high blood pressure, diabetes, and tobacco use. It involves over 5,700 adults living with HIV in Lusaka, Zambia. The goal is to see if this integrated approach helps mo…

This study tests a new procedure called ReCET that uses gentle electrical pulses to regenerate the lining of the small intestine. Combined with a diabetes drug (semaglutide), the goal is to help people with type 2 diabetes stop using insulin. The study involves 32 adults and comp…

This study investigates whether drinking galactose before cycling can prevent low blood sugar (hypoglycemia) in people with type 1 diabetes. Fourteen participants will try four different drinks—dextrose, galactose, lactose, or a sweetened placebo—on separate days, then cycle for …

This study investigates whether giving vitamin D supplements to adults with inflammatory bowel disease (Crohn's disease or ulcerative colitis) who also have low vitamin D levels can improve their iron status. Participants take high-dose vitamin D3 weekly for 8 weeks, then a lower…

This study looks at whether the shape of a person's face influences how Botox injections change bite force in people who grind their teeth (bruxism). Participants with different facial structures receive Botox into the jaw muscle, and bite force is measured before and after treat…

This study tests whether a three-month smartphone-supported walking program can improve daily step counts, psychological well-being, and body composition in adults with cardiovascular disease or type 2 diabetes. Participants use the Walk15 app to set personalized step goals and t…

This study tests whether giving patients their own stool bacteria through a temporary stoma can reduce inflammation in the unused part of the colon, a condition called diversion colitis. Sixty-six people with rectal cancer who have a temporary ileostomy will receive either a dail…

This study tested an experimental drug called XPro1595 in 208 people with early Alzheimer's disease who also had signs of brain inflammation. The goal was to see if the drug could improve memory, thinking, and daily function compared to a placebo over 24 weeks. Researchers also c…

This study tests a 6-week online group program designed to help African American women with type 2 diabetes reduce diabetes-related distress and improve blood sugar control. The program combines diabetes education, motivational interviewing, and cognitive behavioral therapy, deli…

This study tested a family-focused diabetes education program delivered in Marshallese faith-based organizations. Over 300 adults with type 2 diabetes and their family members took part. The goal was to see if group education in a familiar community setting could improve blood su…

This study tests a new, minimally invasive surgical technique to repair open neural tube defects (spina bifida) in unborn babies. Instead of opening the uterus, surgeons use a tiny camera and tools inserted through small incisions. The goal is to close the spinal defect effective…

This study compares a new probiotic gel to a standard steroid gel for treating minor recurrent canker sores—painful mouth ulcers that make eating and talking difficult. Adults with these sores will apply either the probiotic or steroid gel four times daily for up to two weeks. Re…

This study looked at two drugs, mirabegron and oxybutynin, in 52 children over age 3 who had surgery for posterior urethral valves. The goal was to see which drug better improves bladder and kidney function and reduces urinary tract infections. Researchers also checked safety by …

This study tested a new approach for people with advanced melanoma that can be surgically removed. Participants received a combination of two immunotherapies: one injected directly into the tumor (Tavo) and one given through a vein (nivolumab). After 12 weeks, they had surgery to…

This study tested a long-acting injectable (LAI) form of the drug lumateperone in 52 adults with stable schizophrenia or schizoaffective disorder. Participants received a single injection of one of several LAI formulations, along with oral capsules, to see how the drug behaves in…

This early-phase trial tested an experimental drug called BW-20507 in 32 people. First, healthy volunteers received a single dose to check safety. Then, people with chronic hepatitis B received multiple doses to see how the drug behaves in the body and whether it fights the virus…

This phase 3 study tested the drug bimekizumab in 133 Chinese adults with moderate to severe plaque psoriasis. Participants received either bimekizumab or a placebo for 16 weeks. The main goals were to see if bimekizumab could clear at least 90% of psoriasis (PASI90) and achieve …

This large Phase 3 trial tested whether the diabetes drug semaglutide, taken as a daily pill, can slow cognitive decline in people with early Alzheimer's disease. About 1,840 participants received either semaglutide or a placebo for up to 3 years and 4 months. The study measured …

This study tested whether offering smokers more frequent and personalized outreach, plus more treatment choices like nicotine patches and text support, helps more people quit compared to standard care. Over 12,000 adult smokers from 10 primary care clinics took part. The goal was…

This phase 3 study tested a drug called rocatinlimab in 726 adults with moderate-to-severe atopic dermatitis (eczema) that wasn't well controlled by creams. Participants received either the drug or a placebo as a shot under the skin for 24 weeks. The main goals were to see if the…

This completed study tested whether a customizable texting program could help veterans with type 2 diabetes improve their blood sugar control. 366 veterans were randomly assigned to receive either standard daily diabetes texts or a more interactive version with check-ins, medicat…

This completed pilot study tested whether transferring gut bacteria from lean donors or from people who had gastric bypass surgery could improve metabolism in 29 obese adults with prediabetes or diabetes. Participants received fecal transplants, and researchers measured changes i…

This study looked at whether using a soft hip brace (abduction splint) for two months in one-month-old babies with mild hip dysplasia (stable hips but abnormal ultrasound) improves hip development. 90 infants were enrolled. The goal was to see if the brace makes hip ultrasound me…

This completed Phase 2 study tested whether a combination of two experimental drugs, K-877-ER and CSG452, can improve liver health in adults with nonalcoholic steatohepatitis (NASH) and liver fibrosis. The 228 participants received either the combination or a placebo. The main go…

This trial tests whether giving intravenous thiamine (vitamin B1) alongside standard treatment helps people with diabetic ketoacidosis recover faster. Diabetic ketoacidosis is a serious condition where the blood becomes too acidic. The study includes adults hospitalized with this…

This study tests whether an artificial intelligence system can safely and effectively adjust insulin doses for people with type 2 diabetes while they are in the hospital. About 144 participants will be randomly assigned to have their insulin doses set either by the AI system or b…

This trial tests whether a personalized physical activity plan can help children aged 5–18 with congenital heart disease increase their exercise capacity and daily activity levels. The plan is designed with input from parents, teachers, and a pediatric cardiologist to address saf…

This study examines how well a biosimilar (a lower-cost copy) of the drug ranibizumab works for diabetic macular edema, a condition that causes vision loss in people with diabetes. Researchers will review medical records of 60 adults who received at least one injection of the bio…

This phase 2 trial tests whether OSE-127, an antibody that blocks a key immune signal, can reduce disease activity in people with moderate to severe ulcerative colitis who have not responded to or cannot tolerate previous treatments. Participants are randomly assigned to receive …

This study tests the long-term safety of maralixibat, an oral medication, in children with progressive familial intrahepatic cholestasis (PFIC), a rare liver disease that causes intense itching. Participants who completed a prior study will receive maralixibat twice daily. Resear…

This study tests whether deep brain stimulation (DBS) can help people with severe depression that hasn't improved with other treatments. Participants have a device surgically implanted to stimulate a specific brain area, then receive active stimulation for six months along with b…

This study tests whether certolizumab pegol (Cimzia), a drug already used for arthritis, can reduce flares of anterior uveitis—a painful eye inflammation—in people with axial spondyloarthritis who have had uveitis before. About 89 adults with active axial spondyloarthritis and a …

This trial investigates whether structured exercise—either aerobic cycling or resistance training—can improve health-related biomarkers in women with breast cancer undergoing neoadjuvant therapy (chemotherapy or endocrine therapy before surgery). The main focus is on changes in K…

This trial investigates whether replacing red or processed meat with pulses (like beans, lentils, and chickpeas) can improve markers of heart health and change the gut microbiome. Participants are adults aged 18-65 with unhealthy, sedentary lifestyles who eat at least three servi…

This study tests whether giving doctors a reminder and providing patients with a one-page handout can help women who had gestational diabetes or high blood pressure during pregnancy get a primary care visit within six months of delivery. The goal is to prevent future diabetes and…

This study compares three dietary approaches—intermittent fasting (16:8 schedule), a clean ketogenic diet (20g carbs per day from whole foods), and a combination of both—in healthy adults. Researchers measure changes in body composition, cholesterol, triglycerides, and blood suga…

This study tests an oral capsule called AK0901 (AZSTARYS) in children aged 6 to 12 with attention deficit hyperactivity disorder (ADHD). The trial compares the drug against a placebo to see if it reduces ADHD symptoms like inattention and hyperactivity. Researchers measure sympto…

This trial tests whether a family-centered diabetes education program helps people with type 2 diabetes manage their blood sugar better than standard education. About 1,100 adults with type 2 diabetes and their family members take part. Participants are randomly assigned to eithe…

This study tests whether a graft made from a patient's own or donor stem cells can repair the cornea's surface in people with limbal stem cell deficiency, a condition that causes pain, scarring, and vision loss. A small biopsy of limbal tissue is taken from a healthy eye or donor…

This trial tests whether a nurse-led education program, based on the Health Belief Model, can improve treatment adherence in people with inflammatory bowel disease (Crohn's disease or ulcerative colitis) who are receiving anti-TNF therapy. The program aims to address patients' co…

This trial investigates whether bosentan, a drug that blocks endothelin and relaxes blood vessels, can help people who suddenly lose vision from giant cell arteritis (Horton's disease). Standard steroid treatment often fails to restore sight once blindness occurs. The study enrol…

This study tests whether virtual reality exposure therapy (VRET) can help men with alcohol use disorder reduce their psychological dependence on alcohol and prevent relapse. Eighty men who have completed detox will be randomly assigned to either VRET or standard treatment. VRET u…

This study tests whether adding a probiotic (Lactobacillus reuteri) to standard deep-cleaning treatment for gum disease can improve gum health and blood sugar levels in adults with diabetes. Participants receive either the probiotic or a placebo (salt water) applied directly into…

This study looks at whether using a continuous glucose monitor (CGM) alongside standard nutrition and activity advice can improve metabolic health in young people aged 11 and older who have prediabetes and are overweight. Participants wear the CGM intermittently to see how daily …

This trial tests whether CardiolRx, a pharmaceutical cannabidiol, can improve heart recovery in adults with acute myocarditis (heart muscle inflammation). Participants receive either CardiolRx or a placebo for 12 weeks. The study uses heart MRI scans to measure changes in heart t…

This trial compares two ways to deliver rehabilitation for women with knee osteoarthritis: in-person clinic visits versus tele-rehabilitation using a smartphone, tablet, or computer. Both groups receive hot packs and strengthening exercises. The study measures knee function, musc…

This trial tests a smartphone app called Tappt that uses smart tags to help people with hepatitis C stick to their daily oral medication. Participants scan tags each time they take a dose, and the app tracks adherence. The study compares their results to historical data from simi…

This study tests a drug called faricimab (VABYSMO) in people with diabetic macular edema, a condition where diabetes causes fluid buildup in the center of the retina, leading to vision loss. Participants receive injections of faricimab into the eye every four weeks. The goal is t…

This study tests whether a gel made from spirulina (a type of algae) can improve the treatment of stage II gum disease when used alongside standard deep cleaning. Researchers will compare different ways of preparing the spirulina gel and measure gum health and inflammation levels…

This study tests whether a 15-week aerobic exercise program at the YMCA can help smokers who are highly sensitive to stress quit smoking. Participants work with a personal trainer three times a week and also receive support from a national quitline. The goal is to see if exercise…

This trial investigates whether a single 4 mg dose of the steroid dexamethasone, given intravenously before hip fracture surgery, can lower the risk and severity of postoperative delirium in adults aged 60 and older. Delirium is a sudden state of confusion that often occurs after…

This study investigates whether clascoterone cream 1%, an FDA-approved acne medication, works by reducing sebum (skin oil) production. Researchers will measure forehead oil levels and changes in skin bacteria in 40 participants aged 12 and older with mild to moderate acne. The go…

This study tests whether a therapeutic education program helps teenagers and young adults with congenital heart disease transition from pediatric to adult medical care. Participants aged 13 to 25 will either receive the education program or standard follow-up. Researchers will me…

This phase 2 trial investigates whether lenalidomide, a drug that calms inflammation, can slow cognitive decline in people with mild cognitive impairment due to Alzheimer's disease. Participants take lenalidomide or a placebo for up to 12 months, followed by a 6-month washout per…

This study tests whether a computer-assisted tool helps mental health providers in rural VA clinics deliver cognitive behavioral therapy (CBT) more effectively for depression and anxiety. About 34 therapists and 167 veterans will take part. Therapists are randomly assigned to use…

This trial investigates whether adding low-intensity transcranial magnetic stimulation (Li-TMS) to standard antidepressant medication can improve depressive symptoms and sleep disorders in people with major depression. The study involves 40 participants who receive either real Li…

This trial tests whether a team-based approach, including a dedicated nurse care manager, can help primary care clinics provide medication treatment for opioid use disorder. The study involves 12 clinics across five U.S. states, with half using the new approach and half continuin…

This study compares a smartphone app (iPhone Level) to a specialized device (BROM) for measuring how much the lower back can bend forward, backward, and sideways. Researchers will enroll 120 healthy male university students aged 18–25 with normal body weight. If the app works wel…

This study tests a new, less invasive way to measure stomach acid using a small wireless capsule (SmartPill) that patients swallow. It compares the capsule's accuracy to the standard method, which involves a tube placed through the nose into the stomach. The study includes health…

This study is working to create a reliable imaging test to find and measure problem areas in muscle and fascia tissue, known as myofascial pain. Researchers will use ultrasound and MRI to identify unique 'biosignatures' in 120 people with plantar fasciitis, Achilles tendinopathy,…

This study tested a new, low-cost device called Apne-Scan to see if it can accurately detect sleep apnoea compared to standard home tests. Forty adults referred to a sleep clinic wore the Apne-Scan mask alongside their usual test overnight. The goal was to see if the simpler, che…

This study tests whether a smartphone-based camera can accurately screen for eye diseases such as diabetic retinopathy, glaucoma, and age-related macular degeneration. About 550 patients will have photos taken with both the smartphone camera and standard equipment. Ophthalmologis…

This study uses machine learning to tell apart diabetic kidney disease from other kidney diseases in people with type 2 diabetes. Researchers analyzed data from over 2,200 patients across 14 medical centers to build a model that uses routine clinical and lab information. The goal…

This study looks at whether substances in the blood from a tooth's pulp can help dentists tell the difference between reversible pulpitis (a mild inflammation that can heal) and irreversible pulpitis (severe damage needing a root canal). Researchers will collect a small sample of…

This study tests a special SPECT imaging agent that seeks out a protein called LRRC15, found on many aggressive cancers like pancreatic, breast, lung, and brain tumors. The goal is to see if this scan can help doctors diagnose and stage these cancers more accurately. Healthy volu…

This trial tests whether a magnetic sensor placed on the skin can accurately measure blood pressure in the jugular vein and radial artery, compared to standard invasive methods using catheters. The study involves 10 adults with complex congenital heart disease or chronic right he…

This study is testing a portable, non-invasive breath analyzer that measures tiny particles in exhaled breath to screen for conditions like type 2 diabetes, liver disease, kidney disease, and lung disease. Researchers will enroll healthy volunteers and people with known diagnoses…

This study is adapting and testing a French version of the Athletic Disordered Eating (ADE) scale, a 17-question screening tool designed specifically for athletes. Researchers will enroll 229 athletes aged 15 to 70 who exercise more than 6 hours per week. Participants complete th…

This study tested a phone-based health coaching program for pregnant women with a higher body mass index. The goal was to help them gain a healthy amount of weight during pregnancy and prevent problems like gestational diabetes and later obesity in both mothers and children. Over…

This trial evaluates whether a hospital-based remedial vaccination strategy can improve Tdap-IPV (tetanus, diphtheria, pertussis, polio) vaccination rates in adults aged 65 and older in the Sarthe region of France. Participants are randomly assigned to receive either the remedial…

This trial investigates whether a low-level diode laser can prevent or reduce severe mouth sores (mucositis) caused by radiation and chemotherapy in people with advanced head and neck cancer. Participants receive either real laser therapy or a non-functional placebo laser during …

This study tested a digital program designed to prevent teens from starting to misuse opioids. About 533 high school students who had never misused opioids but were at higher risk took part. The program aimed to increase their understanding of the serious risks of misusing prescr…

This study analyzes health records from over 2 million adults across five continents to see if GLP-1 receptor agonists (like semaglutide and liraglutide) can lower the risk of developing Alzheimer's disease. It focuses on people aged 40 and older with type 2 diabetes or obesity, …

This study tests whether an 8-week program combining gentle yoga and tai chi with acceptance-based techniques can lower the risk of developing anorexia nervosa in female college students who already have elevated body shape concerns. Participants are randomly assigned to the mind…

This study tests a program called FLARE that teaches families how to protect children from the sun. It includes children ages 8 to 17 who have a parent who survived melanoma and who have had at least one sunburn in the past year. Families are randomly assigned to either the FLARE…

This study tests whether a computer program called pronia.ai can help doctors identify young people at high risk for psychosis and offer them early, tailored treatment. Participants aged 16 to 40 with early warning signs will either receive standard care or the AI-guided approach…

This study tests a program called 'Thoughts and Health' designed to prevent depression in adolescents. The program is delivered in 12 sessions in a school setting. Researchers will see if it helps students' mental health and their ability to finish junior high with passing grades…

This trial investigates whether a structured educational program led by nurses can reduce anxiety and improve outcomes for adults undergoing their first heart surgery. Participants are randomly assigned to receive either the nurse-led program or usual care. The program covers pre…

This study tested a non-invasive brain stimulation technique called HD-tDCS in 269 people with mild cognitive impairment or early Alzheimer's. The goal was to see if different doses could improve brain connectivity and memory. Participants received the stimulation while researche…

This study tests whether shining a specific type of near-infrared light on the front of the brain can safely help people with major depressive disorder. The light is thought to boost energy production in brain cells, which may improve mood. Researchers will measure changes in dep…

This study compares two ultrasound-guided injection treatments for adhesive capsulitis, also known as frozen shoulder. One group receives a steroid and numbing medicine injected directly into the shoulder joint, while the other group gets the same medicine injected near the supra…

This study tests whether a non-invasive brain stimulation device, used at home, can safely and effectively ease symptoms of major depression in people who have not improved with medication. Participants use the device for 30 minutes a day, five days a week, for four weeks. The tr…

This study tests whether using a virtual reality headset during a scheduled cesarean section can help reduce pain and anxiety. Twenty women will be offered the headset at different stages of care, from admission to after birth. Researchers will measure how many accept and use it,…

This study tested a behavioral sleep program for 16 depressed teenagers who slept less than 7 hours on school nights or had irregular sleep schedules. The program included one session with a provider and used smartphone tools to help teens create a plan for longer and more regula…

This study tested whether a 3-month home exercise program on an elliptical machine and 3 months of bright light therapy could improve movement, balance, and mood in adults with traumatic brain injury. Thirty-four participants (including healthy volunteers) were enrolled. The goal…

This clinical trial tests a gel called ABIO3419, injected into the knee joint, to see if it safely reduces pain and improves function in people with knee osteoarthritis. The study compares ABIO3419 to another treatment and measures pain relief over three months. Participants are …

This trial investigates whether a non-invasive technique called transcranial direct current stimulation (tDCS) can help with fatigue, depression, anxiety, and cognitive problems in people with multiple sclerosis (MS). tDCS uses a weak electrical current applied to the scalp to ge…

This study tested whether taking hydrocortisone (a cortisol-like hormone), melatonin, or both could reduce jet lag symptoms after long eastward flights. Fifty-seven healthy adults aged 18-65 who flew across 6-8 time zones took the pills for 4 days after arrival and reported their…

This study tested a combination of two drugs, atomoxetine and oxybutynin (called AtoOxy), as a potential pill-based treatment for obstructive sleep apnea (OSA). 117 adults with OSA who were not using CPAP took the medication for one month. The goal was to see if the drug combo co…

This trial explores whether a group-based psychomotor therapy—using breathing, relaxation, and body awareness exercises—can be a practical and acceptable way to help young adults (ages 18-35) with anxiety. The study focuses on whether people will join and stick with the program, …

This study tests whether a personalized teaching method called 'Touch-to-Teach' helps people with stage II periodontitis clean between their teeth better than standard instructions. Forty participants will be split into two groups: one gets standard care, the other gets the new m…

This study tested whether bright light therapy could help people with multiple sclerosis who have trouble sleeping. 27 participants used a light box at home. The goal was to see if it was safe and if it improved sleep and daily function.

This study tests whether a specific type of talk therapy called cognitive behavioral therapy (CBT) can help people with body dysmorphic disorder (BDD). Participants receive 22 weekly one-on-one CBT sessions that teach them to challenge negative thoughts and behaviors about their …

This study tests whether a wheelchair-mounted robotic arm called Jaco helps people with tetraplegia perform daily tasks like grasping and reaching at home. Participants use the device for two months after training. Researchers measure changes in performance and satisfaction with …

This study tests whether a 6-week mindfulness program (MBSR) can reduce PTSD symptoms and improve quality of life in people who have been in a road traffic accident. About 110 adults aged 18-60 with PTSD will be randomly assigned to either MBSR or standard care. Researchers will …

This study tests whether a brief, telehealth-delivered therapy called Written Exposure Therapy (WET) can help autistic adults who have experienced trauma. Participants complete five weekly writing sessions and wear a Fitbit to track sleep, activity, and heart rate. The goal is to…

This study tested whether giving teens with ADHD and their parents a question list or a short video before a doctor visit helps them talk more openly and get better care. About 126 English-speaking teens aged 11-17 with ADHD took part. The goal was to see if these tools improve s…

This study tests whether preserving the cystic artery during laparoscopic gallbladder removal can reduce complications like bleeding. Two hundred patients with symptomatic gallstones will be split into two groups: one where the artery is preserved and one where it is clipped or b…

This study tests whether writing about imagined future scenarios (worst-case, best-case, or neutral) can reduce social anxiety symptoms. 270 adults with elevated social anxiety will complete three online writing sessions over three weeks. Researchers will measure changes in anxie…

This study tests whether a self-help app called MyDiaMate can reduce diabetes distress in adults with type 1 diabetes. Researchers are enrolling 660 participants across the Netherlands, UK, Spain, and Germany. The app aims to support mental health alongside usual care.

This study looked at whether quercetin, a natural substance found in foods like apples and onions, can change how the body absorbs sugar. Researchers gave 24 obese adults (some with type 2 diabetes) either quercetin or a placebo during a sugar-drink test. They measured blood suga…

This study looks at whether people with diabetes experience more pain after a second root canal treatment compared to those without diabetes. About 50 adults with a single-rooted tooth needing retreatment will take part. Pain levels and painkiller use will be tracked for a week a…

This study tests whether a 6-week online self-help program can help people with psychotic disorders who hear voices at least once a week. The program combines metacognitive training and mindfulness techniques to reduce the frequency and distress of auditory hallucinations. Partic…

This study tests whether adding task-oriented training—like walking on different surfaces, climbing stairs, and reaching for objects—to standard aerobic and strength exercises can improve functional mobility, balance, and fatigue in people with relapsing-remitting multiple sclero…

This pilot study in Pakistan tests a culturally adapted psychological therapy (Y-CMAP) for autistic young people aged 14-24 who have a history of self-harm. The therapy is based on cognitive behavioral therapy and includes 8-10 sessions over three months. The study will check if …

This study tests whether watching an augmented reality (AR) educational video on a tablet can lower anxiety in people about to undergo cardiac catheterization, a common heart procedure. Participants in the experimental group view the AR video in addition to receiving standard pap…

This study tests an experimental drug called EVO756 in 160 adults with moderate to severe chronic spontaneous urticaria (CSU), also known as chronic hives. Participants must have had hives for at least 3 months and not gotten enough relief from standard antihistamines. The goal i…

This trial tests whether a program called MyRAKAN Autism, which combines video modeling with virtual reality, can help autistic young adults improve their social communication skills. Participants attend eight sessions over five weeks, practicing skills like eye contact, conversa…

This study tested whether adding thalidomide to glutamine can delay the onset of severe mouth sores caused by radiation therapy. 138 oral cancer patients were randomly assigned to receive either the combination or glutamine alone during their radiation treatment. The main goal wa…

This trial investigates whether inhaling a 50/50 mix of nitrous oxide (laughing gas) and oxygen can reduce pain when a nasogastric tube is placed in children aged 3 months to 3 years. The study includes children with mild to moderate dehydration from conditions like gastroenterit…

This study tested whether using a stress ball during a routine fetal checkup (non-stress test) helps pregnant women feel less anxious and more comfortable. 70 pregnant women participated. The goal was to see if this simple, drug-free tool can improve the testing experience for mo…

This completed pilot study tested whether shining a low-level laser into the blood (intravenous laser therapy) can improve sleep and reduce pain in people with chronic sciatica. Sixty-six adults with sciatica and poor sleep received either electroacupuncture alone or electroacupu…

This study tests whether adding hypnosis to standard care helps control pain and anxiety during a knee lavage procedure for people with knee osteoarthritis. About 100 participants will be randomly assigned to receive either usual care alone or usual care plus hypnosis. The main g…

This study tests a personalized approach to giving the steroid dexamethasone to hospitalized adults with pneumonia. Instead of a standard dose, the amount is adjusted daily based on a blood marker called C-reactive protein (CRP). The goal is to reduce steroid side effects while s…

This pilot study tested a word game-based workbook to help people with diabetes learn about managing their condition, focusing on diet and carbohydrate control. 25 participants used the workbook during clinic visits or at home, completing puzzles and goal-setting exercises. The s…

This study tests whether a headset that delivers tiny electrical pulses to nerves behind the ear can reduce anxiety in teens aged 12-17 with Generalized Anxiety Disorder. Sixty participants will use either the active device or a sham (fake) device for 30 minutes a day, 5 days a w…

This study tests a non-invasive brain stimulation technique called tACS in 50 children and teens aged 6-18 with ADHD. The goal is to see if a mild electrical current applied to the scalp can improve attention and executive function. Participants will receive both real and sham st…

This pilot study tested whether adding structured supportive psychotherapy to the antipsychotic risperidone could improve cognitive function and reduce inflammation in 44 hospitalized adults with schizophrenia. Participants received either risperidone plus 12 weekly talk therapy …

This study looked at four different ways to activate the cleaning solution used during root canals: laser, sonic, ultrasonic, and simple needle irrigation. The goal was to see which method causes the least pain after the procedure and how much debris gets pushed out of the tooth.…

This study tested whether a plant-based melatonin supplement (phytomelatonin) from tomatoes can improve sleep quality better than synthetic melatonin or a placebo. 244 adults with poor sleep took one capsule nightly for 28 days. Sleep was tracked with a wearable ring and question…

This study tests whether time-restricted eating (fasting for 16 hours each day) can improve memory, thinking, and overall well-being in overweight adults aged 65 and older who are worried about their memory. Over 24 weeks, participants either follow the fasting plan or join a hea…

This study tests whether injecting a concentrated sugar-water solution (dextrose) into the knee joint can reduce pain and improve function in people with knee osteoarthritis. Participants receive either the dextrose injection or a placebo (salt-water injection) under ultrasound g…

This study tests whether combining two sedatives, dexmedetomidine and esketamine, can lower the chance of delirium (sudden confusion) in older patients (60+) after surgery in the ICU. Delirium is common and can lead to worse outcomes. The trial will involve 100 participants and t…

This study tests an oral drug called SDX (serdexmethylphenidate) to see if it safely reduces excessive daytime sleepiness in adults with idiopathic hypersomnia, a condition where people feel extremely sleepy during the day despite getting enough sleep at night. Participants will …

This study tests two behavioral therapies—imagery rehearsal therapy (IRT) and targeted dream control (TDC)—to reduce nightmares in adults with narcolepsy. Participants attend therapy sessions, keep a daily sleep log, and complete questionnaires. Some Chicago-area participants als…

This study tests whether using a virtual reality headset during placement of a cervical ripening balloon can reduce pain and anxiety for women undergoing labor induction. Sixty pregnant women will either receive standard care or standard care plus a VR experience. The goal is to …

This study is testing a device called the CORI™ KNEE TENSIONER, which helps surgeons balance the knee during total knee replacement surgery. Fifty adults who need a knee replacement will have the surgery using this device, and their recovery and quality of life will be tracked fo…

This study looked at whether giving fewer antibiotics after appendicitis surgery could lower the risk of antibiotic side effects without compromising patient safety. Over 650 adults who had surgery for simple or complicated appendicitis took part. The goal was to find the right b…

This study looked at whether extra family support helps children with Down syndrome and obstructive sleep apnea use their positive airway pressure (PAP) machine more regularly. 27 children aged 6-18 were split into two groups: one received standard care, the other got a family-in…

This study compares two final rinses inside the tooth after root canal treatment for people with severe tooth pain from irreversible pulpitis. One rinse is a cold saline solution (cryotherapy), the other is a steroid solution (dexamethasone). The goal is to see which better reduc…

This study tests whether ALIDYA, a gel injected into the skin, can improve the appearance of cellulite on the back of the thighs. Thirty women aged 20 to 45 with mild to moderate cellulite received six weekly treatments. Researchers used photos, ultrasound, and other imaging to m…

This phase 3 study tests whether YZJ-1139 tablets help adults with insomnia fall asleep faster and sleep more efficiently. Participants receive either 20 mg, 40 mg, or a placebo daily for two weeks. Sleep is measured using both sleep diaries and overnight lab tests.

This study tests a wearable device that delivers low-intensity ultrasound to the knee for 1-4 hours daily, combined with a diclofenac pain patch, to reduce pain and improve function in people with mild-to-moderate knee osteoarthritis. Participants aged 50-85 with frequent knee pa…

This study tests whether watching short telenovela-style videos can reduce anxiety and boost confidence in African-American and Hispanic family caregivers of hospice patients. 62 caregivers will either watch the videos during telehealth visits or receive usual hospice care. The g…

This trial tests whether rhythmic electrical pulses delivered to the wrist (median nerve stimulation) can reduce tics and the urge to tic in people with Tourette syndrome or chronic tic disorder. Participants wear a portable device for 15 minutes at a time over four weeks. The st…

This study tested whether using special lasers during root canal treatment can lower pain afterward compared to standard methods. Forty-five adults with infected front teeth were split into three groups: one got standard cleaning, another got a combination of two lasers, and the …

This trial tests whether a type of talking therapy called CBT-AR can help young people aged 12 to 25 with avoidant/restrictive food intake disorder (ARFID). ARFID is an eating disorder where people avoid certain foods or eat very little, not because of body image concerns but due…

This completed study looked at whether extracorporeal shockwave therapy can improve quality of life and reduce pain in people with plantar fasciitis, a common cause of heel pain. Researchers enrolled 175 adults aged 25 to 59 who had heel pain for at least three months. The therap…

This study tests whether a mindfulness app called Headspace can help low-income parents reduce stress, anxiety, and depression. Participants use the app on their own schedule for guided meditations. Researchers measure changes in stress and mood over time to see if the app provid…

This study tests whether adding foot massage to standard cold therapy can reduce pain and improve satisfaction in people who have had knee replacement surgery. Sixty participants will be randomly assigned to receive either cold therapy alone or cold therapy plus foot massage for …

This study investigates whether acupuncture can relieve symptoms and improve quality of life in women diagnosed with treatment-resistant interstitial cystitis/bladder pain syndrome. Participants receive eight sessions of acupuncture over four weeks at specific points on the body.…

This trial investigates whether jaw exercises (Rocabado programme) work better when guided by a physiotherapist through online video sessions versus doing them at home with written instructions alone. Adults aged 18-60 with jaw-joint pain and teeth grinding are randomly assigned …

This study looks at whether berberine, a natural compound, can improve cognitive problems like memory and attention in people with schizophrenia. One hundred adults aged 18-60 will take either berberine or a placebo pill for 12 weeks, in addition to their regular antipsychotic me…

This study tested a new type of leg brace designed to help children with cerebral palsy and other movement disorders walk more easily. The brace was custom-made for each child and could be adjusted to provide different kinds of support. Researchers measured how well children walk…

This study tested whether a sensory mindfulness technique could help mothers of babies in the neonatal intensive care unit (NICU) produce more breast milk and feel better. 60 mothers who were pumping milk for their hospitalized infants took part. The approach involved mindfulness…

This study tested custom-made insoles for people with diabetic foot to see if they improve balance and walking. Twenty-five participants aged 40 to 65 with early-stage diabetic foot issues were included. The insoles were designed using pressure measurements to offload high-pressu…

This study explores whether virtual reality goggles and noise-cancelling headphones can make ketamine/esketamine treatment for depression more tolerable and effective. Participants receive a single treatment while immersed in a relaxing virtual environment. The goal is to see if …

This study tested whether using a virtual reality headset showing calming scenery for 20-30 minutes could lower anxiety in parents whose children were in the hospital. 485 parents participated, and their anxiety levels were measured and compared to standard care without any tech-…

This study tests whether inhaling medical cannabis three times a day can safely reduce pain in people with diabetic peripheral neuropathy. 122 adults will receive either a low, medium, or high dose of THC or a placebo using a special inhaler. The main goal is to see if pain score…

This pilot study tests whether a special cream (KeraStat) and a mobile app (MyCap) can help manage skin rashes caused by radiation therapy in head and neck cancer patients. Sixteen participants will apply the cream at least twice daily during radiation and use the app to report t…

This study tests four virtual coaching sessions to help veterans with chronic pain use their own cannabis products more effectively. Participants will learn strategies to manage pain and related symptoms. The goal is to see if this coaching improves pain relief and satisfaction.

This study tests whether a prescription pain cream called Multiprofen-CC™ can help control pain and reduce the need for opioid painkillers after total knee replacement. About 288 adults having knee surgery will use either the cream or a placebo along with standard pain care. The …

This pilot study tests whether a short, evidence-based therapy called Written Exposure Therapy (WET) can help reduce PTSD symptoms in adults who are in residential treatment for substance use disorders. Participants complete five guided writing sessions about their trauma. The st…

This study tests a group program that combines mindfulness and art therapy for adolescents with a history of abuse. The program aims to improve how teens see their bodies and reduce feelings of shame. Participants attend sessions that include meditation, creative art activities, …

This study tests whether adding passive sensing technology (like smartphone data) to a standard counseling program helps community health workers better treat postpartum depression in low-resource settings. The trial compares the digital-enhanced approach to standard counseling a…

This study tests whether adding shock wave therapy to a specific trigger point in the forearm muscle can improve grip strength and reduce pain in people with tennis elbow. Fifty-two adults with tennis elbow will receive standard shock wave treatment to the elbow, plus either real…

This study looks at whether adding a physical activity education program to adapted exercise helps people with mild memory or thinking problems more than exercise alone. Thirty-four participants will be followed for six months to measure changes in activity level, thinking skills…

This trial tests whether a brief online group therapy called EMDR Flash can help adults who survived the 2023 Kahramanmaraş earthquakes in Türkiye. Participants receive two 60-90 minute group sessions via Zoom and are compared to a waitlist group. The study measures changes in PT…

This clinical trial tests whether a new drug called YZJ-1139 can help people with insomnia sleep better than the commonly used medication zolpidem. Adults aged 18 to 64 with insomnia disorder take either YZJ-1139 or zolpidem daily for 28 days. Researchers measure sleep quality us…

This study explores whether a 9-month online mind-body exercise program is practical and acceptable for people with multiple sclerosis (MS) living in Portugal and Spain. The program combines physical fitness, Pilates, Tai-Chi, mindfulness, and relaxation in small group sessions v…

This study is testing a mobile app that gives weekly suggestions to help people with binge eating and obesity. The goal is to see which suggestions work best and in what order. About 300 adults who binge eat regularly and have a BMI of 30 or higher are taking part. The app tracks…

This pilot study tested the Atlas Knee System, a device implanted outside the knee joint to reduce pressure on the inner knee, in 50 people with medial knee osteoarthritis. The goal was to see if it safely relieves pain and improves function over 24 months. Participants were foll…

This study tested whether ear acupressure (small pellets on specific ear points) plus basic breast care can reduce pain and blocked milk ducts in women after cesarean delivery. 72 new mothers with blocked ducts received either real ear acupressure or a sham version for 3 days, al…

This study tested a 5-month early time-restricted eating plan (eating only between 7 AM and 3 PM) in 100 highly trained young male judo athletes. Researchers measured changes in body composition, muscle damage markers, and psychological factors like anxiety and self-confidence. T…

This pilot study tested a six-session culturally adapted cognitive behavioral therapy (Ca-CBT) for depression and anxiety in 50 people living with HIV in Pakistan. The therapy was delivered by trained HIV health workers and included culturally relevant stories and materials. The …

This study tested three different skin glues (Dermabond, Swiftset, and Liquiband) used to close small incisions after laparoscopic or robotic abdominal surgery. 180 adults each received two different glues on opposite sides of their incisions. The main goal was to see which glue …

This study tested whether an extended-release form of nalbuphine, a pain medication, can reduce chronic coughing in people with idiopathic pulmonary fibrosis (IPF). 165 participants received either different doses of the drug or a placebo for 6 weeks. The main goal was to see if …

This study tested a counseling program called Youth Friendship Bench SA for young women aged 18-25 in South Africa who had symptoms of depression, anxiety, or stress. The program included individual and group counseling sessions, plus optional text reminders. The goal was to see …

This study tested whether a supplement containing L-histidine, along with a topical oil or lotion and unscented soap, could improve mild-to-moderate eczema in children. Forty children ages 1 to 12 were split into two groups: one received a powder supplement and the other a gummy …

This study tests whether adding neural gliding exercises—gentle movements that help nerves slide smoothly—to standard shock wave therapy and home exercises can further reduce pain and improve foot function in people with plantar fasciitis. About 56 adults with this common cause o…

This trial investigates whether a double-reading animated film, watched by both children and their parents before surgery, can reduce anxiety in children aged 3 to 7. The film uses avatars to walk the child through their hospital journey, from room to operating room. Researchers …

This study tests whether a special flickering light (40 Hz) can improve sleep and thinking in people with mild cognitive impairment or early Alzheimer's disease. Participants will sit under the light for one hour while researchers measure brain activity and memory. The goal is to…

This study tests whether a mobile app providing education based on the Life Model can help reduce anxiety and improve daily living activities in people who have had their thyroid gland removed for benign disease. About 68 participants will either receive standard discharge instru…

This trial investigates whether applying a heated pack to the arm for 5 or 10 minutes before inserting a dialysis needle can reduce pain in people with an arteriovenous fistula. About 51 adults on hemodialysis will be randomly assigned to receive heat for 5 minutes, 10 minutes, o…

This study investigates whether a beetroot powder jelly candy can help competitive swimmers swim faster and feel less tired. Beetroot is rich in nitrate, which the body converts to nitric oxide, a compound that may improve blood flow and muscle efficiency. The trial involves 21 s…

This study tests whether watching virtual reality videos of mountains, beaches, and waterfalls before coronary angiography can lower anxiety, boost comfort, and improve patient satisfaction. Researchers will compare first-time angiography patients who use VR goggles to those who …

This study tests whether giving magnesium during and after spinal surgery can reduce pain and the need for morphine. Adults undergoing multi-level back surgery are randomly assigned to receive either magnesium or a placebo (saline) infusion for 12 hours after surgery. Pain levels…

This study tests two short behavioral therapies delivered over video calls for adults with chronic orofacial (jaw or face) muscle pain and insomnia. One therapy focuses on sleep habits and routines; the other uses jaw relaxation and breathing exercises. The goal is to see which a…

This study tests whether cognitive behavioural therapy for insomnia (CBT-I) can improve sleep and ADHD symptoms in adolescents aged 12 to 18 who have both ADHD and insomnia. Participants receive either CBT-I plus usual care or usual care alone. The goal is to see if addressing in…

This study tests whether a probiotic gummy containing Weizmannia coagulans BC99 can reduce symptoms of allergic rhinitis (hay fever) in children aged 4 to 14. Over 8 weeks, half the children receive the probiotic gummy and half receive a placebo. Researchers track changes in nasa…

This study tests whether a new dental anesthesia pen causes less pain and anxiety than a traditional syringe in children aged 6 to 12 who need a filling. Each child will try both methods (with a two-week break in between) so they can compare the experience directly. The goal is t…

This study investigates whether an online Pilates program designed for people with hypermobile Ehlers-Danlos syndrome or hypermobility spectrum disorder can reduce pain and improve function. Participants follow 25-minute guided videos three times a week for eight weeks. Researche…

This study tests whether wearing virtual reality glasses during femoral sheath removal — a routine step after a heart catheterization — can lower pain, anxiety, and changes in vital signs. About 60 adults undergoing this procedure will be randomly assigned to either use VR glasse…

This study investigates whether laughter yoga can lower stress and improve quality of life for pregnant women diagnosed with gestational diabetes. Participants will practice laughter yoga sessions that combine breathing exercises, clapping, and playful activities. The trial measu…

This study tests whether Snoezelen multisensory therapy — a calming, personalized experience using lights, sounds, textures, and scents — can reduce agitation, depression, and anxiety in older adults with dementia. Sixty participants with mild to moderate dementia will receive ei…

This study tests whether an 8-week choral singing program can improve the well-being of nursing home residents with dementia. Participants attend one 75-minute group singing session each week, plus a dress rehearsal and final concert. Researchers measure changes in stress hormone…

This study investigates whether an 8-week yoga program can help female smokers manage stress and nicotine withdrawal when trying to quit. Participants attend two 60-minute yoga sessions per week and provide hair and saliva samples to measure stress hormones. The goal is to see if…

This trial tests whether a program combining education with high-intensity interval training (HIIT) can improve knee osteoarthritis symptoms and reduce heart disease risk better than a standard neuromuscular exercise program. About 150 adults with knee osteoarthritis and at least…

This study tests whether adding the blood pressure medication propranolol to cognitive processing therapy (a type of talk therapy) helps people with both post-traumatic stress disorder (PTSD) and alcohol use disorder. About 48 adults aged 18 to 70 with both conditions will receiv…

This trial investigates whether using an electronic apex locator to determine the exact stopping point during root canal treatment can reduce pain afterward. Participants with a single-rooted tooth needing a root canal are randomly assigned to one of three groups: two groups use …

This study compares two ways to manage pain after total knee replacement: a continuous nerve block using a catheter near the femoral triangle versus tissue infiltration with a local anesthetic. The goal is to see which method better prevents long-term chronic pain and improves kn…

This study tests whether cognitive behavioral therapy (CBT) can reduce anxiety and depression in people with inflammatory bowel disease (Crohn's disease or ulcerative colitis). Participants receive either psychologist-led or self-administered CBT over 8 weeks. The goal is to see …

This study tests a 10-week visual rehabilitation program for children with autism spectrum disorder who also have vision problems. The program uses games and activities to improve how children use their eyes and process visual information. Researchers want to see if better vision…

This trial tests whether applying platelet-rich fibrin (PRF) — a wound dressing made from a patient's own blood — to the roof of the mouth after gum graft surgery improves pain, sleep, and overall quality of life compared to standard dressings. About 78 adults needing gum surgery…

This study tests whether a daily skincare routine using Cetaphil cleansers and moisturizers can improve skin symptoms and quality of life for people with mild-to-severe plaque psoriasis. Participants apply the products to one side of their body while continuing their usual prescr…

This study tests whether pediatric massage can improve behavior and social skills in children aged 3 to 10 with autism spectrum disorder (ASD). Children receive massage twice a week for 12 weeks from a professional, plus at-home massage from trained parents. Researchers also use …

This study tests whether repeated acupressure can help reduce agitation, pain, and sleep disturbances in intensive care unit (ICU) patients who are on mechanical ventilators. Participants receive either real acupressure or a light touch (sham) twice daily for four days. Researche…

This study compares core stabilization exercises to a daily physical activity program in children aged 10-18 with juvenile spondyloarthropathy, a type of arthritis. The goal is to see if targeted core training can reduce pain, fatigue, and improve quality of life better than gene…

This study explores whether locally adapted nature-based health interventions can help people with mild to moderate anxiety, depression, or stress. Around 120 adults will take part in weekly outdoor group sessions for at least 10 weeks, focusing on nature interaction, social conn…

This completed study from the National Institute of Neurological Disorders and Stroke aimed to better understand how the brain controls movement and what goes wrong in movement disorders like Parkinson's disease, Tourette's syndrome, and dystonia. Over 1,200 adults—both patients …

This study used PET scans to measure blood flow in the frontal lobe while participants performed thinking tasks. It included healthy volunteers and people with schizophrenia or Parkinson's disease. The goal was to understand how the frontal lobe works during cognitive activities …

This study tested how different warning labels (pictorial vs. text-only) and flavor descriptors (sweet vs. none) on little cigar and cigarillo packages affect people's attention and emotional reactions. Researchers used eye tracking and skin sensors on 90 adult tobacco users. The…

This study looks at people with a rare inherited condition that causes extremely high cholesterol and early heart disease. Researchers used special tests to measure artery hardening before it becomes life-threatening. The goal was to gather information to help develop future trea…

This study looked at 137 people with Chronic Granulomatous Disease (CGD), a rare immune disorder. It compared those who received a stem cell transplant with those who got standard care. The goal was to see which patients benefit most from transplant and what type of transplant wo…

This study looks at how good or poor sleep quality influences quality of life, depression, and fatigue in people with multiple sclerosis. Researchers will survey about 121 adults with MS to measure their sleep patterns and link them to these health outcomes. The goal is to better…

This study looks at families where one sibling has a rheumatic disease (like rheumatoid arthritis or lupus) and the other does not. Researchers compare their blood, genes, and environmental exposures to find clues about why one got sick. Over 1,000 participants are involved, incl…

This study explored how family members share health information about genetic diseases like sickle cell, diabetes, and cancer. Over 1,000 adults completed surveys or interviews about their family health history and support. The goal was to understand social and relational factors…

This completed study looked at how a person's neighborhood environment might influence drug use, addiction, and whether they seek treatment. Over 1,600 adults from Baltimore took part, including people who never used drugs, past users, and current users. Researchers collected hea…

This study looks at rare genetic disorders where the body can't make cholesterol properly, which can cause birth defects and learning problems. Researchers collect blood, urine, and tissue samples from affected people and their families to learn more about these conditions. The g…

This study looked at 23 adults going through alcohol detox to see how the bacteria in their mouth and gut change over time. Researchers collected stool and mouth samples along with diet and mood questionnaires. The goal was to better understand the link between gut bacteria, anxi…

This completed early-phase study looked at how opioid use disorder changes the way people make decisions. Twelve adults with moderate to severe opioid use disorder completed gambling tasks and had brain scans while receiving oxycodone, placebo, or remifentanil. The goal was to un…

This study follows 31 people with progressive fibrosing interstitial lung disease (PF-ILD) for one year. Researchers compare imaging scans (CT and MRI) with standard breathing tests to see which method best tracks lung damage over time. The goal is to find better ways to measure …

This early-phase study tested whether ferumoxytol, an iron-based contrast agent, can help MRI scans better detect inflammation in the brains of people with multiple sclerosis (MS). Fourteen participants (some with MS, some healthy) received a single IV dose of ferumoxytol and had…

This study looked at people with suspected bone-related connective tissue disorders (like brittle bone disease) and their healthy family members. The goal was to learn more about these conditions, train doctors, and collect samples for future research. Participants received stand…

This study follows adults in Zambia who have both HIV and chronic hepatitis B to track liver health over up to 10 years. Researchers aim to understand how current HIV treatments affect hepatitis B and liver damage, and to identify factors that lead to serious outcomes like liver …

This completed study from the National Institute of Mental Health looked at nearly 5,000 people with schizophrenia or related disorders, along with their siblings. The goal was to find genes linked to the illness and see how they affect brain function. This research helps scienti…

This study followed 17 adults with neurofibromatosis type 1 (NF1) over two years to learn how their skin tumors (dermal neurofibromas) grow and change. Researchers used special cameras and skin biopsies to measure tumor growth and look for genes that might influence it. The goal …

This study aims to create and improve cognitive tasks used during functional MRI scans to better understand how drugs affect the brain. It involves 525 healthy volunteers, including both drug users and non-users, aged 18 to 65. Participants perform tasks like memory tests or reac…

This study created a registry of medical records from women with inborn errors of metabolism—rare conditions that affect how the body turns food into energy. Researchers collected data from past or current pregnancies and followed babies for one year after birth. The goal was to …

This study looked at nearly 1,400 people with rare conditions like PPNAD, Carney Complex, and Peutz-Jeghers syndrome. The goal was to find the genetic causes and link them to specific symptoms. Researchers used clinical exams and genetic testing to better understand how these dis…

This study aimed to understand the brain and genetics behind autism spectrum disorders (ASD). Researchers compared brain scans, thinking tests, and DNA from 678 people with ASD, healthy volunteers, and their parents. The goal was to find links between brain activity, behavior, an…

This completed study followed 945 people, mostly children and young adults with severe eczema or related allergic conditions, along with their relatives. Researchers observed how these diseases progress over up to a year, using tests like allergy skin pricks, blood draws, and lun…

This study aims to reduce the number of people with depression who do not receive treatment. It compares two approaches: one where people only get a brief psychological therapy at a health center, and another where they also receive community support to encourage them to seek and…

This completed study looked at how genes influence addiction and related behaviors. Researchers collected blood samples and had 847 adults (healthy volunteers, smokers, drug users, and people with psychiatric disorders) complete questionnaires and computer tasks. The goal was to …

This study looked at Smith-Lemli-Opitz syndrome (SLOS), a rare genetic condition that affects cholesterol production and causes birth defects and intellectual disabilities. Researchers enrolled 130 patients and their mothers to learn more about the disease's progression, genetic …

This study tested whether portable devices like PDAs and GPS units can give a more accurate picture of stress and drug use as it happens. About 373 adults in treatment for heroin addiction carried these devices for 16 weeks, recording drug use and stress levels. The goal was to s…

This study looks at whether a smartphone-based program can help veterans with depression begin and continue mental health treatment. Researchers will analyze medical records to find out who struggles to engage in care, then test an eHealth tool that lets veterans track their mood…

This study aimed to find new gene changes that cause rare lipid disorders. Researchers used advanced genetic testing to look at many genes at once in 140 people and their relatives. The goal was to discover causes that older methods missed.

This study looked at whether the diabetes drug metformin can slow aging in people without diabetes. Researchers wanted to see if the drug's effects depend on whether a person is insulin sensitive or insulin resistant. Over 12 weeks, 101 adults aged 40-75 took either metformin or …

This completed study looked at 386 adults with psoriasis to understand how skin inflammation might be linked to heart and blood vessel diseases. Participants had up to seven visits over four years, including blood tests, heart scans, and optional skin biopsies. The goal was to se…

This study follows thousands of pregnant women in France who had or likely had COVID-19 during pregnancy or shortly after giving birth. Researchers track health problems in both mothers and newborns up to 12 weeks after delivery, using medical records and questionnaires about men…

This study looked at whether emergency department pharmacists can safely reduce the use of certain brain-active medications in people with dementia or mild cognitive impairment. Researchers worked with 300 participants to see if pharmacists could communicate medication changes to…

This study tests how well a dummy patch pump (with no electronics or medicine) sticks to the skin of 175 adults with insulin-requiring diabetes. The goal is to see if the adhesive can stay on for 5 to 7 days in different body locations. The results will help design a future comme…

This study looks at how the brains of children aged 9 to 12 with anxiety disorders respond to making mistakes. Researchers measure two types of brain activity: one after an error and one after a balance disturbance. Half of the children will use a 45-minute computer program desig…

This completed study from Minia University looked at 200 patients with autoimmune thyroiditis (an inflamed thyroid) who had thyroid surgery. The goal was to see how often thyroid cancer is found by accident when examining the removed tissue. Researchers checked for cancer in pati…

This study investigates how different language treatments affect both language skills and brain function in people with aphasia, a condition that impairs the ability to speak, understand, read, or write after a stroke. Participants will receive therapy targeting naming, spelling,…

This study looked at how schizophrenia affects physical activity, balance, muscle strength, and thinking skills. Researchers measured these abilities in 35 adults diagnosed with schizophrenia. The goal was to better understand the challenges patients face, which could help improv…

This study tests whether an 8-hour digital learning program using virtual reality (VR) and augmented reality (AR) can improve dementia care knowledge, attitudes, and teamwork among long-term care professionals. About 150 staff from 12 care institutions in Taiwan take part, with s…

This study adapts an existing advocacy program, called ASSIST, for Latinx families of autistic youth aged 12 and older. The program teaches parents how to advocate for adult disability services, aiming to improve access to care. Researchers will test the adapted program with 48 S…

This study tests whether suvorexant (Belsomra), a sleep medication, can lower brain activity linked to cannabis cravings. Twenty adults who use cannabis daily will take the drug for 14 days and undergo brain scans before and after. The goal is to see if the medication reduces the…

This study looked at how vaping and traditional smoking affect gum healing after a deep dental cleaning in people with stage II gum disease. Researchers measured gum pocket depth, bleeding, and inflammation markers in 117 participants. The goal was to see if vaping is less harmfu…

This study investigates whether type 2 diabetes changes the levels of key growth factors and inflammatory markers in Albumin Platelet-Rich Fibrin (Alb-PRF) membranes—a blood-derived material used to support wound healing and dental tissue repair. Researchers will compare Alb-PRF …

This study looks at whether people with dyssynergic defecation—a condition where the pelvic muscles don't relax properly during bowel movements—are more likely to have psychiatric disorders like anxiety or depression. Researchers will compare 148 patients to healthy volunteers us…

This study looks at how isotretinoin, a vitamin A-based acne medication, affects eye structures and tear production in people with severe cystic acne. Participants receive standard treatment and undergo eye exams, including dry eye tests and advanced imaging, before and during th…

This study followed 69 people in Taiwan with lupus nephritis who were newly prescribed the drug Myfortic (mycophenolate sodium). Researchers tracked side effects and reasons for stopping the drug over 12 months. The goal was to understand the drug's safety in this specific popula…

This study examines whether ticagrelor, a heart medication, changes how the body absorbs and processes YZJ-1139, an experimental insomnia treatment. Healthy volunteers aged 18 to 45 will take YZJ-1139 alone and then with ticagrelor to compare drug levels and safety. The goal is t…

This study looks at whether a 90-minute afternoon nap, a moderate dose of caffeine, and a short recovery routine (stretching plus a snack) can improve evening athletic performance. Sixty elite university athletes (30 men, 30 women) will try different combinations of these strateg…

This completed study looked at how genetic differences might change the way immune cells in the lungs respond to environmental triggers like dust and germs. Researchers collected blood and lung samples from 20 healthy adults to compare cell function between people with different …

This study examines whether a new insomnia drug, YZJ-1139, can be safely taken with the antidepressant escitalopram. Healthy adults aged 18 to 45 will receive both drugs and be monitored for side effects, drug levels in the blood, and changes in eye movements, balance, and thinki…

This study followed 88 children and young adults with types III and IV osteogenesis imperfecta (brittle bone disease) to track how the condition changes over time. Researchers measured bone density, lung and heart function, hearing, and movement abilities. The goal was to better …

This completed study looked at how the social networks of caregivers affect their stress and health when caring for someone with an inherited disease. Researchers surveyed over 680 participants, including family members and formal caregivers, to understand caregiving burden and s…

This trial compares two high-intensity training programs—CrossFit and running-based HIIT—in elite male distance runners who live and train at moderate altitude. Over six weeks, participants train five days per week and undergo tests for aerobic fitness, strength, and blood marker…

This study followed 1,771 adults and children who received blood transfusions to check how safe the blood supply is. Researchers tested patients' blood for viruses like HIV and hepatitis before and after transfusion, and stored samples for future testing. The goal was to keep blo…

This study tested a harm reduction program designed specifically for Black adults who misuse opioids or stimulants. 63 participants completed surveys before and after the program to see if their knowledge, confidence, and willingness to use overdose prevention techniques improved…

This study looked at how people with and without non-alcoholic fatty liver disease (NAFLD) process food. Researchers monitored 53 adults over two days, measuring metabolism, blood, and urine after meals. The goal was to find differences that might explain why fat builds up in the…

This study tested a new risk score that combines genetic and environmental factors to predict multiple sclerosis (MS). Researchers studied 181 people, including MS patients and their close relatives. The goal was to see if this score could identify who might develop MS in the fut…

This study creates a registry for people with familial hypercholesterolemia (FH) in Greece, a genetic condition that causes very high cholesterol and early heart disease. Researchers will screen adults aged 18 to 80 to learn how common FH is and describe the health of those affec…

This study examined how Mexican-American families discuss their risk for diabetes, heart disease, breast cancer, and colon cancer. Researchers interviewed 498 adults from Mexican-American households in Houston to understand how culture and family history influence health communic…

This study tested a document called Voicing My CHOiCES, designed to help young adults (ages 18-39) with serious illnesses like cancer or HIV discuss their care preferences. Participants filled out questionnaires about anxiety, social support, and communication, then reviewed the …

This study examines how the sleep aid YZJ-1139 behaves in people with severe kidney impairment compared to those with normal kidney function. Sixteen adults will receive a single 20 mg dose, and researchers will measure drug levels in the blood and urine, as well as any side effe…

This study is looking at how nutrition affects disease activity in people with rheumatic diseases like rheumatoid arthritis, lupus, and psoriatic arthritis. Researchers will measure the nutritional status of 460 participants using several different tools and compare it to how act…

This study looked at how dopamine receptors in the brain work in people with schizophrenia compared to healthy volunteers. Researchers used special PET and MRI scans to measure two types of dopamine receptors. The goal was to better understand what causes schizophrenia, which cou…

This study examines whether two specific ultrasound measurements—the ratio of the transverse cerebellar diameter to abdominal circumference and the ratio of mid-thigh circumference to femur length—can more accurately estimate gestational age in both healthy and growth-restricted …

This study is the first time Leucettinib-21 is being tested in humans. It aims to check the drug's safety and how the body processes it. The trial includes healthy volunteers and people with Down syndrome or Alzheimer's disease. No treatment benefit is expected at this early stag…

This study looked at the natural bacteria in the gut of 131 adults with and without uveitis, an inflammatory eye disease. Researchers collected stool and blood samples and performed eye exams to see if differences in gut bacteria are linked to eye inflammation. No treatment was g…

This study tested whether doctors can use simple decision guides to better manage opioid misuse behaviors in patients on long-term opioid therapy for chronic pain. Researchers worked with 49 clinicians at community clinics to see if the guides were easy to use and helpful. The go…

This study looked at people with neurofibromatosis type 1 (NF1) to better understand how harmless tumors (plexiform neurofibromas) turn into a rare cancer called MPNST. Ten participants had MRI, PET scans, and tumor biopsies. Researchers tested whether a special PET scan (FLT PET…

This study looks at a nerve in the neck called the ansa cervicalis, which controls muscles that help keep the airway open. Researchers will measure the nerve's size and shape in 50 adults having neck surgery for head and neck cancer. They will also test how stimulating the nerve …

This study tests whether wearable sensors and digital home tasks can track changes in movement, speech, and falls in people with ALS. About 20 participants will wear neck and wrist sensors and complete speech and handwriting tests over 48 weeks. The goal is to see if these digita…

This study investigates how a specific strain of pneumococcus bacteria (serotype 3) colonizes the nose of healthy adults. Researchers will give volunteers nose drops containing the bacteria to see what dose leads to colonization and how long the bacteria stay before the immune sy…

This study surveys medical students to understand their attitudes toward tattoos and piercings and measure their awareness of related skin risks, such as infections, allergic reactions, and scarring. Researchers aim to see if students have adequate knowledge and how their views d…

This study uses advanced heart imaging to understand how blood flows inside the heart in people with cardiac amyloidosis, a condition where abnormal proteins build up in heart tissue. Researchers will compare these images with those from healthy volunteers to find unique patterns…

This study looks at how the womb lining heals after different types of womb-sparing surgery for placenta accreta, a serious pregnancy condition where the placenta grows too deeply into the womb wall. Researchers will use a small camera (hysteroscopy) three months after surgery to…

This study looked at two specific proteins in the blood of people with bipolar disorder during a manic episode and compared them to healthy volunteers. The goal was to see if these proteins, which are linked to inflammation and brain cell communication, could help explain the con…

This study looks at whether certain antibiotics given before surgery are linked to postoperative delirium in adults over 65 having elective non-cardiac surgery. Researchers will track antibiotic use and check for delirium twice daily. The goal is to provide safety evidence to gui…

This study looked at levels of a specific enzyme, α-N-acetylgalactosaminidase, in the blood of people with panic disorder who had never taken medication. Researchers compared these levels to healthy individuals and checked for connections with symptom severity and inflammation. T…

This study investigates whether exercising in the morning versus the afternoon changes how the body handles blood sugar and burns fat in people with type 1 diabetes. Twelve adults with type 1 diabetes will do one hour of moderate exercise at 9 AM and another session at 4 PM on se…

This study looks at whether computer models can predict if local anesthetic (numbing) will work for people with a painful tooth condition called symptomatic irreversible pulpitis. Researchers analyzed records from 4,390 adult patients to compare three different machine learning a…

This study investigates why athletes with type 1 diabetes often experience higher blood sugar during competitions compared to regular training. Researchers will monitor 12 athletes with type 1 diabetes and 12 healthy athletes during a 5K race and a 5K training session, measuring …

This study examines whether levels of a blood enzyme called α-N-acetylgalactosaminidase differ between people with schizoaffective disorder during acute episodes and those in remission, compared to healthy individuals. The goal is to better understand the biological processes beh…

This study looked at how children with cerebral palsy, their parents, and healthcare professionals experience sleep disordered breathing and its management. Researchers interviewed 24 participants to understand the challenges and what helps or hinders treatment. The goal was to g…

This study looked at how adults with autism spectrum disorder (ASD) form emotional attachments to others. Researchers used questionnaires to measure social responsiveness and attachment styles in 32 adults with ASD. The goal was to better understand the link between autism and at…

This study tested whether training healthcare providers to prescribe continuous glucose monitors (CGMs) increases their use among patients with type 2 diabetes. Researchers trained clinic staff at three community health centers serving a mostly Hispanic/Latino population. They th…

This study enrolled 800 adults undergoing upper endoscopy to find risk factors and blood markers that could help diagnose and monitor eosinophilic esophagitis (EoE), a chronic allergic condition of the esophagus. Researchers compared people with and without EoE, collecting blood,…

This study looked at whether asking people with multiple sclerosis (MS) to do two things at once — like walking while thinking — can uncover balance problems that standard tests miss. Researchers studied 24 people with mild MS and low disability. The goal was to see if this dual-…

This study followed 55 people with dental implants for 5 years to see if their history of gum disease (aggressive, chronic, or none) affected implant health. Participants received regular dental cleanings. Researchers measured bone loss, gum inflammation, and implant survival. Th…

This study enrolled 500 skin cancer patients in China and analyzed over 1.2 million of their social media posts using artificial intelligence. The goal was to see if AI could detect signs of psychological distress and suicidal thoughts. Researchers hope this approach could lead t…

This study looks at how regular winter swimming—bathing in cold open water during winter—affects blood cells, blood flow, and stress-fighting enzymes in healthy men. Researchers compare winter swimmers to a control group who never swim in cold water and have a sedentary lifestyle…

This observational study investigates whether a substance in the blood called nociceptin is linked to overactive nerves in people who have both type 2 diabetes and metabolic fatty liver disease. Researchers will compare 50 patients with both conditions to 50 healthy volunteers, m…

This study looks at whether children with ADHD are more likely to have very flexible joints (benign joint hypermobility) and if a certain blood marker differs. Researchers will compare 171 children aged 6 to 12—some with ADHD and some without—using physical exams and blood tests.…

This study follows people newly diagnosed with psoriatic arthritis (PsA) to see how a 'treat to target' approach works in everyday clinics. Participants receive standard care, often starting with methotrexate, and their disease activity is tracked over time. The goal is to unders…

This study investigates how often people with lateral epicondylitis (tennis elbow) also have posterolateral rotatory instability, a ligament problem that causes similar pain but requires different treatment. Researchers will check the elbow's lateral collateral ligament during sc…

This study creates a registry of adults with pancreatic exocrine insufficiency (PEI), a condition where the pancreas does not produce enough enzymes to digest food properly. Researchers at eight specialist centers across Europe will track how doctors prescribe pancreatic enzyme r…

This study looks at how common pneumococcus bacteria are in the noses and throats of healthy Vietnamese children aged 6 months to 5 years. Researchers will take a simple swab and interview parents about factors like vaccination history, antibiotic use, and living environment. The…

This study tests a tool called the Cultural Formulation Interview-Engagement Aid (CFI-EA), designed to help clinicians and patients from different cultural backgrounds communicate better. The goal is to see if using this tool improves patient satisfaction and keeps people in trea…

This study looks at how getting too little sleep and not putting weight on one leg affects muscle strength and balance. Healthy adults who exercise regularly will walk on one leg and sleep either 5 or 9 hours for three days. Researchers will measure muscle size, strength, and how…

This study investigates whether stress hormone activity is linked to depression and brain changes in children with type 1 diabetes. Researchers will measure cortisol levels and use brain scans in children aged 6–12 who have had diabetes for at least a year, comparing them to thei…

This study investigates whether gut microorganisms and their byproducts play a role in triggering severe flare-ups of ulcerative colitis. Researchers will compare patients hospitalized with severe colitis to those with milder symptoms, analyzing stool and blood samples over three…

This study investigates why people develop obstructive sleep apnea (OSA) and whether the underlying cause affects how they respond to different treatments. Researchers will test three approaches—CPAP, a sleep medication (eszopiclone), and supplemental oxygen—in adults with OSA. T…

This observational study investigates the role of hormonal and metabolic disorders in the development of gestational diabetes mellitus (GDM). Researchers are analyzing data from over 600 pregnant women to identify risk factors and markers that could predict adverse outcomes for b…

This study investigates how a medication called lorazepam, which boosts the calming brain chemical GABA, changes emotional brain activity in people with psychosis. Participants aged 16–60 with conditions like schizophrenia or bipolar disorder, along with healthy volunteers, will …

This study looks at whether a specific gene variant (ApoE4) is more common in people with certain brain MRI patterns that suggest cerebral amyloid angiopathy (CAA), a condition where proteins build up in brain blood vessels. Researchers will analyze genetic samples from 100 patie…

This study investigates people with oculocutaneous albinism who have no known genetic cause for their condition. Researchers use advanced DNA analysis techniques to search for new or hidden mutations. The goal is to improve diagnosis and understanding of this inherited condition.

This study examines the patient profiles and treatment patterns of adults with melanoma in Japan who were prescribed either dabrafenib with trametinib or encorafenib with binimetinib. Researchers are looking at data from 2012 to 2021 to understand patient characteristics and how …

Sleep problems affect up to 90% of people with alcohol dependence and often lead to relapse. This study tests whether a short questionnaire called the Short Sleep Index (SSI) can reliably measure sleep quality compared to a longer, standard sleep questionnaire. Researchers will a…

This study follows 150 people with bicuspid aortic stenosis—a narrowed heart valve present from birth—who receive a transcatheter aortic valve replacement (TAVI) using the Evolut Pro or Evolut R XL device. Researchers will measure how well the valve works over time, including blo…

This study surveys anesthesiologists to explore whether feelings of being a fraud (impostor phenomenon) are linked to everyday memory and attention lapses. Participants complete online questionnaires about impostor feelings, cognitive failures, anxiety, depression, sleep quality,…

This study looks at how eating a high-fat meal changes levels of certain fats in the blood called ceramides, and whether those changes affect blood vessel function. Healthy adults aged 18 to 40 will eat either a meal rich in long-chain fatty acids (which raise ceramides) or mediu…

This study looks at whether women who had a cervical procedure called LEEP (loop electrosurgical excision procedure) before age 25 face higher risks in future pregnancies, such as preterm labor or early rupture of membranes. Researchers reviewed records of 115 women who had LEEP …

This study looks at how certain genetic changes (mutations) in the hepatitis B virus (HBV) affect the amount of virus in the blood of people with chronic infection. Researchers analyzed blood samples from 92 patients not on antiviral treatment. They found that specific mutations …

This study tests whether pharmacists using a generative AI tool (ChatGPT) can provide more accurate and complete medication counseling compared to standard practice. The trial involves 136 adults with chronic conditions like diabetes, high blood pressure, or asthma who are pickin…

This study screens women who gave birth in four French hospitals for postpartum depression and anxiety during the COVID-19 pandemic. Participants fill out three questionnaires shortly after delivery and again about a month later. The goal is to measure how common postpartum depre…

This study follows people with idiopathic normal pressure hydrocephalus (iNPH) who are already scheduled for shunt surgery. Researchers measure changes in thinking skills and frailty one year after the procedure to identify which patients are most likely to improve. The goal is t…

This study explores whether a special type of MRI called flow MRI can improve the diagnosis and management of normal pressure hydrocephalus, a condition where excess fluid builds up in the brain's cavities. Researchers will measure how cerebrospinal fluid and blood move through t…

This study follows couples who gave birth in either a midwifery-led birth unit or a standard obstetric unit in France. Researchers want to see if the type of care affects parents' mental health, especially post-traumatic stress, and the child's development up to two years later. …

This study investigates whether chronic cannabis use impairs contrast sensitivity — the ability to see objects clearly against their background, especially when they are moving. Researchers will compare three groups: cannabis addicts, tobacco-only smokers, and non-smokers. Partic…

This study looks at proteins that help parts of cells communicate—specifically mitochondria and the endoplasmic reticulum—in people with healthy gums, gingivitis, or advanced gum disease. Researchers measure these proteins in saliva and gum fluid to see if they relate to inflamma…