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New psoriasis pill shows promise in major trial

NCT ID NCT06588738

Disease control Sponsor: Alumis Inc Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 11, 2026 · Updated 2 times

Summary

This study tested a new daily medicine called ESK-001 in 862 adults with moderate to severe plaque psoriasis. The goal was to see if it reduces psoriasis severity and is safe, comparing it to a placebo and an existing drug (apremilast). Participants took the medicine for 24 weeks and had regular checkups, blood tests, and questionnaires.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

862 people

The number who actually took part.

Started

Aug 2024

Finished

Dec 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Males or females, age ≥18 years 2. Diagnosis of plaque psoriasis for ≥6 months 3. Plaques covering ≥10% of BSA 4. PASI ≥12 5. sPGA ≥3 6. Women of childbearing potential (WOCBP) and males who are sexually active with WOCBP must agree to adhere to highly effective methods of contraception Exclusion Criteria: 1. Nonplaque psoriasis or other inflammatory skin conditions 2. Immune-mediated conditions commonly associated with psoriasis (eg inflammatory bowel disease). Patients with psoriatic arthritis may participate 3. Pregnant, lactating, or planning to get pregnant during the study 4. Use of drugs prior to Study Day 1 that treat or may affect psoriasis: * Topical within 2 weeks * Phototherapy or any systemic treatments within 4 weeks * Any biologic agent targeted to IL-12 or IL-23 within 6 months, oral IL-12 or IL-23 or TNFα inhibitor within 2 months, or IL-17 within 4 months * Systemic immunosuppressants or immunomodulatory drugs within 4 weeks * Modulators of B cells within 6 months, or T cells within 3 months * JAK inhibitors or TYK2 inhibitors within 4 weeks * PDE4 inhibitor within 2 months * Any investigational agent, within 30 days or 5 half-lives or is currently enrolled in an investigational study 5. Lack of clinical response to a TYK2, IL-12, or IL-23 targeted psoriasis treatment 6. Patients with QTcF \>450 msec (males) or \>470 msec (females) at Screening 7. Unstable cardiovascular disease, defined as a recent clinical deterioration or a cardiac hospitalization within the last 3 months 8. Evidence of recent or recurrent herpes zoster or herpes simplex viral infection 9. Evidence of active infection or positive test result for hepatitis B, hepatitis C, HIV or TB 10. History of serious bacterial, fungal, or viral infections that led to hospitalization, or any recent serious infection requiring antibiotic treatment 11. Any history of known or suspected congenital or acquired immunodeficiency state or condition that would compromise the patient's immune status 12. Lab abnormalities indicating significant renal, hepatic or bone marrow dysfunction 13. History of any immune-mediated or inflammatory medical condition for which patient requires current systemic corticosteroids

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Conditions

The condition(s) this trial relates to.

psoriasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Plaque psoriasis

Contacts and locations

Locations

  • Alberta DermaSurgery

    Edmonton, Alberta, T6G 1C3, Canada

  • Allergo Derm Bakos Kft

    Szolnok, 5000, Hungary

  • AppleMed Research Group under WCG

    Miami, Florida, 33126, United States

  • Asheville Clinical Trials

    Asheville, North Carolina, 28803, United States

  • Associated Skin Care Specialists - Minnesota Clinical Study Center

    New Brighton, Minnesota, 55112, United States

  • Bacs Kiskun County Teaching Hospital

    Kecskemét, Bács-Kiskun county, 6000, Hungary

  • Beacon Dermatology

    Calgary, Alberta, T3E 0B2, Canada

  • Borgyogyaszati Klinika Debreceni Egyetem Orvos es Egeszsegtudomenyi Centrum

    Debrecen, Hajdú-Bihar, 4032, Hungary

  • CCA Medical Research Corp

    Ajax, Ontario, L1S 7K8, Canada

  • CHU de Rouen

    Rouen, Normandy, 76031, France

  • CaRe Clinic Red Deer

    Red Deer, Alberta, T4P 1K4, Canada

  • Cameron Dermatology

    New York, New York, 10023, United States

  • Care Clinic Katowice

    Katowice, 40-568, Poland

  • Center for Clinical Studies (CCS) - Webster/Clear Lake Location

    Webster, Texas, 77598, United States

  • Center for Clinical and Basic Research AS

    Tallinn, 10128, Estonia

  • Centre Azur Nice

    Nice, 06000, France

  • Centro Reumatologico de Caguas

    Caguas, Puerto Rico, 00725, Puerto Rico

  • Centrum Medyczne Evimed

    Warsaw, Masovian Voivodeship, 02-625, Poland

  • Centrum Medyczne dr Rajzer Spolka Zoo

    Krakow, Malopolska, 30-438, Poland

  • Chandler Clinical Trials

    Chandler, Arizona, 85224, United States

  • Clear Skin Dermatology

    Newmarket, Ontario, L3Y 5G8, Canada

  • Clinical Best Solutions

    Warsaw, Masovian Voivodeship, 00-710, Poland

  • Clinical Partners LLC

    Johnston, Rhode Island, 02919, United States

  • Clinical Research Puerto Rico

    Ponce, Puerto Rico, 00909, Puerto Rico

  • Clinical Science Institute Dermatology Institute

    Santa Monica, California, 90404, United States

  • DERMA B Kft

    Debrecen, Hajdú-Bihar Megye, 4031, Hungary

  • DS Research of Kentucky

    Louisville, Kentucky, 40241, United States

  • DS Research of Southern Indiana

    Clarksville, Indiana, 47129, United States

  • DermResearchCenter of New York

    Stony Brook, New York, 11790, United States

  • DermaMed Research Kf

    Békés, Oroshaza, 5900, Hungary

  • Dermatologische Praxis Dres Quist

    Mainz, Rhinelkand-Palatinate, 55128, Germany

  • Dermatology Research Associates

    Los Angeles, California, 90045, United States

  • Dermoklinika

    Lodz, Łódź Voivodeship, 90-436, Poland

  • Direct Helpers Research Center (DHRC)

    Hialeah, Florida, 33012, United States

  • Empire Clinical Research - Pomona

    Pomona, California, 91767, United States

  • FAX Pharma Clinical Research Inc

    Miami, Florida, 33146, United States

  • FXM Clinical Research - Miami LLC

    Miami, Florida, 33175, United States

  • FXM Clinical Research Ft. Lauderdale LLC

    Fort Lauderdale, Florida, 33308, United States

  • FXM Clinical Research Miramar LLC

    Miramar, Florida, 33027, United States

  • FutureMeds Krakow

    Krakow, Lesser Poland Voivodeship, 31-501, Poland

  • FutureMeds Lodz

    Lodz, Łódź Voivodeship, 91-363, Poland

  • GCM Medical Group PSC Hato Rey Site

    San Juan, PR, 00917, Puerto Rico

  • Grekin Skin Institute

    Warren, Michigan, 48088, United States

  • Guelph Dermatology Research

    Guelph, Ontario, N1L 0B3, Canada

  • Haut Ambulatorium Magdeburg

    Magdeburg, 39104, Germany

  • Hautarztpraxis Dr Niesmann and Dr Othlinghaus

    Bochum, North Rhine-Westphalia, 44793, Germany

  • Henry Ford Medical Center - Farmington Road

    Detroit, Michigan, 48202, United States

  • Hospital Clínico Universitario de Santiago de Compostela

    Santiago de Compostela, A Coruña, 15706, Spain

  • Hospital Universitario 12 de Octubre

    Madrid, Madrid, 28041, Spain

  • Hospital de Manises

    Manises, 46940, Spain

  • Hospital de la Santa Creu i Sant Pau

    Barcelona, Barcelona, 8041, Spain

  • ISA - Interdisciplinary Study Association GmbH

    Berlin, State of Berlin, 10789, Germany

  • Innomedica

    Tallinn, Harju, 10117, Estonia

  • Innovaderm

    Montreal, Quebec, H2X 2V1, Canada

  • Integrative Skin Science and Research

    Sacramento, California, 95815, United States

  • Jordan Valley Dermatology

    South Jordan, Utah, 84095, United States

  • KliFOs Klinische Forschung Osnabruck

    Osnabrück, 49074, Germany

  • Kliiniliste Uuringute Keskus OU

    Tartu, 50106, Estonia

  • Klinik Hietzing

    Vienna, State of Vienna, 1220, Austria

  • Klinika Ambroziak Dermatologia Kliniczna

    Warsaw, 02-953, Poland

  • Klinika Dermatologii Uniwersytecki Szpital Kliniczny im F Chopina

    Rzeszów, Podkarpackie Voivodeship, 50-368, Poland

  • Klinikum Oldenburg

    Oldenburg, Lower Saxony, 26133, Germany

  • Klinische Forschung Dresden GmbH

    Dresden, Saxony, 1069, Germany

  • Klinische Forschung Schwerin GmbH

    Schwerin, Mecklenburg-Vorpommern, 19055, Germany

  • Las Mercedes Medical Research

    Miami, Florida, 33196, United States

  • Las Vegas Clinical Trials

    Las Vegas, Nevada, 89030, United States

  • Long Beach Research Institute

    Long Beach, California, 90805, United States

  • Luxderm

    Lublin, Lublin Voivodeship, 20-573, Poland

  • MTZ Clinical Research Sp z o o

    Warsaw, 02-172, Poland

  • MVZ DermaKiel GmbH

    Kiel, D-24148, Germany

  • Med Art Clinic

    Riga, LV1003, Latvia

  • Mediprobe Research

    London, Ontario, N5X 2P1, Canada

  • Medmare Bt

    Veszprém, 8200, Hungary

  • Michigan Center for Research Company

    Clarkston, Michigan, 48346, United States

  • Modern Research Associates PLLC

    Dallas, Texas, 75231, United States

  • NYC Health and Hospitals Elmhurst

    Elmhurst, New York, 11373, United States

  • Noble Clinical Research

    Tucson, Arizona, 85704, United States

  • North Bay Dermatology Centre

    North Bay, Ontario, P1B 3Z7, Canada

  • Optima Research Boardman

    Boardman, Ohio, 44512, United States

  • Orvostudomanyi Kutato es Fejleszto Kft

    Debrecen, 4027, Hungary

  • Pioneer Clinical Research NY

    New York, New York, 10016, United States

  • Polyclinique de Courlancy

    Reims, 51100, France

  • Ponce Medical School Foundation Inc

    Ponce, Puerto Rico, 00716, Puerto Rico

  • Pratia Gdynia

    Gdynia, Pomeranian Voivodeship, 81-338, Poland

  • Pratia Katowice

    Katowice, Silesian Voivodeship, 40-018, Poland

  • Praxis fur Dermatologie und Venerologie

    Dresden, Saxony, 01097, Germany

  • Progressive Clinical Research - San Antonio

    San Antonio, Texas, 78213, United States

  • RCMed Oddział Sochaczew

    Sochaczew, Masovian Voivodeship, 96-500, Poland

  • Raoof MD

    Encino, California, 91436, United States

  • Rejuvination Dermatology Oakville

    Oakville, Ontario, L6H 6P8, Canada

  • Renstar Medical Research

    Ocala, Florida, 34470, United States

  • Research Solutions

    Katowice, Silesian Voivodeship, 40-748, Poland

  • Revival Research Institute

    Troy, Michigan, 48084, United States

  • Riga 1st Hospital

    Riga, LV1001, Latvia

  • Rosenpark Research

    Darmstadt, Hesse, 64283, Germany

  • SIA Veseliba un estetika

    Riga, LV1009, Latvia

  • SKiN Health

    Cobourg, Ontario, K9A 0Z4, Canada

  • SMS Clinical Research

    Mesquite, Texas, 75149, United States

  • Schlessinger MD

    Omaha, Nebraska, 68144, United States

  • Semigallia Ltd

    Kuldīga, Kuldigas, LV3301, Latvia

  • Sheba Tel HaShomer Medical Centre

    Ramat Gan, 526200, Israel

  • SimcoDerm Medical and Surgical Dermatology Center

    Barrie, Ontario, L4M 7G1, Canada

  • SkinSense Medical Research

    Saskatoon, Saskatchewan, S7K 2C1, Canada

  • Skincare Studio

    St. John's, Newfoundland and Labrador, A1E 1V4, Canada

  • Smite Aija Medical Practice in Dermatology Venereology

    Talsi, Talsi, LV3201, Latvia

  • Southern California Clinical Research

    Santa Ana, California, 92701, United States

  • Specderm

    Bialystok, Podlaskie Voivodeship, 15-375, Poland

  • Tartu University Hospital

    Tartu, Tartu, 50411, Estonia

  • The Indiana Clinical Trials Center

    Plainfield, Indiana, 46168, United States

  • Toronto Research Centre

    Toronto, Ontario, M3H 5Y8, Canada

  • Total Skin and Beauty Dermatology Center, PC

    Birmingham, Alabama, 35203, United States

  • UC San Diego

    San Diego, California, 92122, United States

  • Universitaetsklinikum Muenster

    Münster, North Rhine-Westphalia, 48149, Germany

  • Universitatsklinikum Erlangen

    Erlangen, Bavaria, 91054, Germany

  • University General Hospital Dr Balmis

    Alicante, Alicante, 3010, Spain

  • Uno Medical Trials Kft

    Budapest, 1152, Hungary

  • VIDA Dermatology/VIDA Clinical Research

    Edmonton, Alberta, T6H 4J8, Canada

  • Veselibas Centrs 4

    Riga, LV1003, Latvia

  • Veselibas Centrs 4 Filiale Dermatologijas Klinika

    Riga, LV1013, Latvia

  • WDC Cosmetic and Research

    Wilmington, North Carolina, 28405, United States

  • XLR8 Medical Research

    Windsor, Ontario, N8T 1E6, Canada

  • Zanamed Medical Clinic Sp z o o

    Lublin, 20-601, Poland

  • Zenith Research Inc.

    Beverly Hills, California, 90211-1705, United States

  • dermMedica

    Wroclaw, 51-503, Poland

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