New injection shows promise for severe eczema relief

NCT ID NCT06224348

Completed Disease control Sponsor: Sanofi Source: ClinicalTrials.gov ↗

Summary

This large, late-stage study tested an investigational drug called amlitelimab, given as an injection under the skin, for people aged 12 and older with moderate-to-severe atopic dermatitis (eczema). The goal was to see if adding amlitelimab to standard topical creams could better clear skin, reduce severe itching, and improve quality of life compared to a placebo. Over 600 participants were randomly assigned to receive either the drug or a placebo for 24 weeks while continuing their usual medicated creams.

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Contacts and locations

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Locations

Acevedo Clinical Research Associates- Site Number : 8401088

Miami, Florida, 33142, United States
Allcutis Research - Portsmouth- Site Number : 8401082

Portsmouth, New Hampshire, 03801, United States
Allergy & Immunology Associates of Ann Arbor- Site Number : 8401078

Ypsilanti, Michigan, 48197, United States
Apex Clinical Research Center- Site Number : 8401237

Mayfield Heights, Ohio, 44124, United States
Avita Clinical Research- Site Number : 8401073

Tampa, Florida, 33613, United States
BRCR Global Gretna- Site Number : 8401243

Gretna, Louisiana, 70053, United States
Cahaba Dermatology & Skin Health Center- Site Number : 8401066

Birmingham, Alabama, 35244, United States
Centro de Diagnostico e Pesquisa da Osteoporose do Espirito Santo- Site Number : 0760017

Vitória, Espírito Santo, 29055-450, Brazil
Centro de Pesquisas da Clínica IBIS- Site Number : 0760002

Salvador, Estado de Bahia, 41820-020, Brazil
Cleaver Medical Group- Site Number : 8401138

Dawsonville, Georgia, 30534, United States
Clever Medical Research- Site Number : 8401160

Miami, Florida, 33126, United States
Clinical Research Center of the Carolinas- Site Number : 8401067

Charleston, South Carolina, 29407, United States
Complete Dermatology - Sugar Land- Site Number : 8401061

Sugar Land, Texas, 77479, United States
Cope Family Medicine - Ogden Clinic- Site Number : 8401114

Bountiful, Utah, 84010, United States
Cura Clinical Research- Site Number : 8401141

Palmdale, California, 93551, United States
Dawes Fretzin Clinical Research- Site Number : 8401015

Indianapolis, Indiana, 46256, United States
Dermatology and Skin Cancer Lee's Summit- Site Number : 8401157

Lee's Summit, Missouri, 64064, United States
Discovery Clinical Trials - San Antonio - Stone Oak Parkway- Site Number : 8401026

San Antonio, Texas, 78258, United States
Encino Research Center- Site Number : 8401042

Encino, California, 91436, United States
Equity Medical- Site Number : 8401239

New York, New York, 10023, United States
Essential Medical Research- Site Number : 8401183

Tulsa, Oklahoma, 74137, United States
Faculdade de Medicina do ABC- Site Number : 0760001

Santo André, 09060-650, Brazil
Global Clinical Professionals (GCP)- Site Number : 8401045

St. Petersburg, Florida, 33705, United States
Hospital Alemao Oswaldo Cruz - São Paulo- Site Number : 0760010

São Paulo, 01323-020, Brazil
Hospital São Lucas da PUCRS - Porto Alegre - Avenida Ipiranga- Site Number : 0760024

Porto Alegre, Rio Grande do Sul, 90610-000, Brazil
Hospital das Clinicas FMUSP- Site Number : 0760012

São Paulo, 05403-000, Brazil
Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto- Site Number : 0760015

Ribeirão Preto, São Paulo, 14049-900, Brazil
Icahn School of Medicine at Mount Sinai- Site Number : 8401129

New York, New York, 10029, United States
Integrative Skin Science and Research- Site Number : 8401275

Sacramento, California, 95815, United States
Investigational Site Number : 0320004

Buenos Aires, 1425, Argentina
Investigational Site Number : 0320005

CABA, Buenos Aires F.D., 1427, Argentina
Investigational Site Number : 0320008

Buenos Aires, 1061, Argentina
Investigational Site Number : 0320010

Buenos Aires, 1414, Argentina
Investigational Site Number : 0320011

Buenos Aires, 1035, Argentina
Investigational Site Number : 0320012

Corrientes, 3400, Argentina
Investigational Site Number : 0320013

Mendoza, 5500, Argentina
Investigational Site Number : 0320018

Buenos Aires, 1178, Argentina
Investigational Site Number : 0320019

Buenos Aires, 1056, Argentina
Investigational Site Number : 0320020

San Miguel de Tucumán, 4000, Argentina
Investigational Site Number : 1002004

Pleven, 5800, Bulgaria
Investigational Site Number : 1002006

Sofia, 1592, Bulgaria
Investigational Site Number : 1002007

Dupnitsa, 2600, Bulgaria
Investigational Site Number : 1002009

Sofia, 1431, Bulgaria
Investigational Site Number : 1240004

Peterborough, Ontario, K9J5K2, Canada
Investigational Site Number : 1240006

Québec, Quebec, G1W 4R4, Canada
Investigational Site Number : 1240008

Mississauga, Ontario, L5H 1G9, Canada
Investigational Site Number : 1240012

Toronto, Ontario, M3H 5Y8, Canada
Investigational Site Number : 1240030

Surrey, British Columbia, V3V 0C6, Canada
Investigational Site Number : 1240038

Richmond Hill, Ontario, L4E 4L6, Canada
Investigational Site Number : 1240039

Calgary, Alberta, T2J 7E1, Canada
Investigational Site Number : 1240041

Winnipeg, Manitoba, R3M 3Z4, Canada
Investigational Site Number : 1240045

Red Deer, Alberta, T4P 1K4, Canada
Investigational Site Number : 1240046

Kamloops, British Columbia, V1Y 4N7, Canada
Investigational Site Number : 1240057

Brampton, Ontario, L6Z1Y4, Canada
Investigational Site Number : 1241106

Markham, Ontario, L3P 1X2, Canada
Investigational Site Number : 1241107

Waterloo, Ontario, N2J 1C4, Canada
Investigational Site Number : 1520001

Santiago, Reg Metropolitana de Santiago, 8420383, Chile
Investigational Site Number : 1520002

Santiago, Reg Metropolitana de Santiago, 7580206, Chile
Investigational Site Number : 1520003

Santiago, Reg Metropolitana de Santiago, 7640881, Chile
Investigational Site Number : 1520005

Santiago, Reg Metropolitana de Santiago, 8380465, Chile
Investigational Site Number : 1520006

Viña del Mar, Región de Valparaíso, 2530900, Chile
Investigational Site Number : 1520008

Santiago, Reg Metropolitana de Santiago, 7500588, Chile
Investigational Site Number : 1520009

Osorno, Reg Metropolitana de Santiago, 5311523, Chile
Investigational Site Number : 1520010

Santiago, 8330032, Chile
Investigational Site Number : 1520011

Santiago, Reg Metropolitana de Santiago, 8380456, Chile
Investigational Site Number : 1520012

Talcahuano, 2687000, Chile
Investigational Site Number : 1560003

Wuxi, 214000, China
Investigational Site Number : 1560005

Shanghai, 200443, China
Investigational Site Number : 1560006

Hangzhou, 310009, China
Investigational Site Number : 1560021

Guangzhou, 510018, China
Investigational Site Number : 1560041

Shenyang, 110001, China
Investigational Site Number : 1560043

Fuzhou, 350005, China
Investigational Site Number : 1560044

Hangzhou, 310003, China
Investigational Site Number : 1560047

Tianjin, 300052, China
Investigational Site Number : 1560049

Wuhan, 430022, China
Investigational Site Number : 1560050

Changsha, 410011, China
Investigational Site Number : 1560051

Nanchang, 330001, China
Investigational Site Number : 1560060

Chengdu, 610072, China
Investigational Site Number : 2030008

Prague, 110 00, Czechia
Investigational Site Number : 2030008

Prague, 110 01, Czechia
Investigational Site Number : 2030009

Pilsen, 323 00, Czechia
Investigational Site Number : 2030010

Olomouc, 779 00, Czechia
Investigational Site Number : 2030011

Prague, 150 00, Czechia
Investigational Site Number : 2032104

Ostrava, 702 00, Czechia
Investigational Site Number : 2032105

Nový Jičín, 741 01, Czechia
Investigational Site Number : 2500002

Toulouse, 31059, France
Investigational Site Number : 2500006

Pierre-Bénite, 69495, France
Investigational Site Number : 2500009

Nantes, 44093, France
Investigational Site Number : 2500010

Romans-sur-Isère, 26102, France
Investigational Site Number : 2500011

Bordeaux, 33000, France
Investigational Site Number : 2500012

Rouen, 76031, France
Investigational Site Number : 2500013

Nice, 06202, France
Investigational Site Number : 2500016

Saint-Pierre, 97410, France
Investigational Site Number : 2760009

Bad Bentheim, 48455, Germany
Investigational Site Number : 2760014

Buxtehude, 21614, Germany
Investigational Site Number : 2760016

Mainz, 55128, Germany
Investigational Site Number : 2760017

Hamburg, 20095, Germany
Investigational Site Number : 2760018

Magdeburg, 39104, Germany
Investigational Site Number : 2760019

Witten, 58453, Germany
Investigational Site Number : 2760020

Augsburg, 86150, Germany
Investigational Site Number : 2760021

Hamburg, 20354, Germany
Investigational Site Number : 2762201

Münster, 48149, Germany
Investigational Site Number : 2762208

Kiel, 24105, Germany
Investigational Site Number : 3800003

Milan, Lombardy, 20122, Italy
Investigational Site Number : 3800008

Pisa, 56126, Italy
Investigational Site Number : 3800011

L’Aquila, 67100, Italy
Investigational Site Number : 3800012

Bologna, 40138, Italy
Investigational Site Number : 3800019

Torette, 60020, Italy
Investigational Site Number : 3920001

Tachikawa, Tokyo, 190-0023, Japan
Investigational Site Number : 3920002

Iruma, Saitama, 350-0495, Japan
Investigational Site Number : 3920003

Kyoto, 606-8507, Japan
Investigational Site Number : 3920004

Chūō, Tokyo, 104-0031, Japan
Investigational Site Number : 3920005

Sagamihara, Kanagawa, 252-0315, Japan
Investigational Site Number : 3920006

Kobe, Hyōgo, 653-0836, Japan
Investigational Site Number : 3920008

Sapporo, Hokkaido, 064-0921, Japan
Investigational Site Number : 3920009

Chitose, Hokkaido, 066-0021, Japan
Investigational Site Number : 3920010

Miyagi-gun, Miyagi, 981-0112, Japan
Investigational Site Number : 3920011

Sendai, Miyagi, 981-3133, Japan
Investigational Site Number : 3923102

Kyoto, 602-8566, Japan
Investigational Site Number : 3923106

Mibu, Tochigi, 321-0293, Japan
Investigational Site Number : 3923107

Minato, Tokyo, 108-0014, Japan
Investigational Site Number : 3923108

Kagoshima, 890-0063, Japan
Investigational Site Number : 3923109

Habikino, 583-8588, Japan
Investigational Site Number : 3923110

Sakai, Osaka, 593-8324, Japan
Investigational Site Number : 3923113

Yokohama, Kanagawa, 221-0825, Japan
Investigational Site Number : 3923113

Yokohama, 221-0825, Japan
Investigational Site Number : 3923114

Obihiro, Hokkaido, 080-0013, Japan
Investigational Site Number : 7240008

Bilbao, Bizkaia, 48013, Spain
Investigational Site Number : 7240010

Esplugues de Llobregat, Catalunya [Cataluña], 08950, Spain
Investigational Site Number : 7240013

Madrid, 28031, Spain
Investigational Site Number : 7240014

Vigo, 36206, Spain
Investigational Site Number : 7240015

Pamplona, Navarre, 31008, Spain
Investigational Site Number : 7240019

Granada, Andalusia, 18012, Spain
Investigational Site Number : 7240020

Seville, Andalusia, 41013, Spain
Investigational Site Number : 7240023

Burjassot, Valenciana, Comunidad, 46100, Spain
Investigational Site Number : 7242502

Manises, Valencia, 46940, Spain
Investigational Site Number : 7242505

Alicante, 03010, Spain
Investigational Site Number : 7920001

Antalya, 07070, Turkey (Türkiye)
Investigational Site Number : 7920002

Istanbul, 34098, Turkey (Türkiye)
Investigational Site Number : 7920003

Istanbul, 34010, Turkey (Türkiye)
Investigational Site Number : 7920004

Kayseri, 38039, Turkey (Türkiye)
Investigational Site Number : 7920005

Istanbul, 34093, Turkey (Türkiye)
Investigational Site Number : 7920006

Istanbul, 34093, Turkey (Türkiye)
Investigational Site Number : 7920007

Samsun, 55139, Turkey (Türkiye)
Investigational Site Number : 7920008

Gaziantep, 27310, Turkey (Türkiye)
Investigational Site Number : 7920009

Istanbul, 34662, Turkey (Türkiye)
Investigational Site Number : 7920010

Ankara, 06560, Turkey (Türkiye)
Irmandade da Santa Casa de Misericórdia de Porto Alegre- Site Number : 0760005

Porto Alegre, Rio Grande do Sul, 90020-090, Brazil
Johnson Dermatology- Site Number : 8401076

Fort Smith, Arkansas, 72916, United States
Jubilee Clinical Research- Site Number : 8401054

Las Vegas, Nevada, 89106, United States
LA Universal Research Center- Site Number : 8401064

Los Angeles, California, 90057, United States
Marvel Clinical Research- Site Number : 8401102

Huntington Beach, California, 92647, United States
NorthShore University HealthSystem - Skokie Hospital- Site Number : 8401038

Skokie, Illinois, 60076, United States
Oakland Medical Center- Site Number : 8401116

Troy, Michigan, 48085, United States
OptiSkin- Site Number : 8401163

New York, New York, 10128, United States
PUC Trials- Nucleo de Pesquisa clinica da Escola de Medicina da PUCPR- Site Number : 0760023

Curitiba, Paraná, 80230-130, Brazil
Palm Springs Community Health Center- Site Number : 8401264

Miami Lakes, Florida, 33016, United States
SMS Clinical Research- Site Number : 8401182

Mesquite, Texas, 75149, United States
Sienna Dermatology- Site Number : 8401148

Missouri City, Texas, 77459, United States
Skin Care Research - Hollywood- Site Number : 8401071

Hollywood, Florida, 33021, United States
Skin Specialists- Site Number : 8401068

Omaha, Nebraska, 68144, United States
Southern California Dermatology- Site Number : 8401043

Santa Ana, California, 92701, United States
Tanner Clinic - Layton Antelope A- Site Number : 8401151

Layton, Utah, 84041, United States
Texas Dermatology and Laser Specialists- Site Number : 8401131

San Antonio, Texas, 78218, United States
University of South Florida- Site Number : 8401070

Tampa, Florida, 33612, United States
Velocity Clinical Research - New Orleans- Site Number : 8401155

New Orleans, Louisiana, 70119, United States
Vial Health - DermDox Dermatology- Site Number : 8401031

Camp Hill, Pennsylvania, 17011, United States

Conditions

Explore the condition pages connected to this study.

DERMATITIS, ATOPIC