Eczema drug nemolizumab put to the vaccine test

NCT ID NCT04365387

Completed Disease control Sponsor: Galderma R&D Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether nemolizumab, a drug for moderate-to-severe eczema, interferes with the body's ability to respond to tetanus and meningococcal vaccines. 242 adults and teens with eczema received either nemolizumab or a placebo, plus the vaccines. The goal was to see if the drug dampens the immune response, which could affect how well vaccines protect them.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: nemolizumab
What this could lead to: If successful, this could show that nemolizumab does not weaken vaccine responses, allowing people with eczema to get vaccinated while on treatment.
What could go wrong: This is a small, early-phase study (Phase 2) focused on immune response to vaccines, not on treating eczema itself. Results may not apply to all patients or other vaccines.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atopic eczema Eczema Pruritus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DERMATITIS ATOPIC

Contacts and locations

Locations

Galderma Investigational Site (SIte#8870)

Boca Raton, Florida, 33433, United States
Galderma Investigational Site (Site#8003)

Webster, Texas, 77598, United States
Galderma Investigational Site (Site#8033)

Clinton Township, Michigan, 48038-1137, United States
Galderma Investigational Site (Site#8129)

Fort Gratiot, Michigan, 48059, United States
Galderma Investigational Site (Site#8130)

Los Angeles, California, 90045, United States
Galderma Investigational Site (Site#8142)

Indianapolis, Indiana, 46250, United States
Galderma Investigational Site (Site#8200)

Goodlettsville, Tennessee, 37072, United States
Galderma Investigational Site (Site#8213)

Ormond Beach, Florida, 32174, United States
Galderma Investigational Site (Site#8245)

Dallas, Texas, 75231, United States
Galderma Investigational Site (Site#8329)

San Antonio, Texas, 78229-3409, United States
Galderma Investigational Site (Site#8353)

Yardley, Pennsylvania, 19067, United States
Galderma Investigational Site (Site#8391)

Hialeah, Florida, 33013, United States
Galderma Investigational Site (Site#8420)

Portsmouth, New Hampshire, 03801, United States
Galderma Investigational Site (Site#8428)

Philadelphia, Pennsylvania, 19104, United States
Galderma Investigational Site (Site#8447)

Fort Smith, Arkansas, 72916, United States
Galderma Investigational Site (Site#8532)

Overland Park, Kansas, 66215, United States
Galderma Investigational Site (Site#8578)

Cerritos, California, 90703, United States
Galderma Investigational Site (Site#8739)

Normal, Illinois, 61761, United States
Galderma Investigational Site (Site#8764)

Tampa, Florida, 33613, United States
Galderma Investigational Site (Site#8777)

Charleston, South Carolina, 29407, United States
Galderma Investigational Site (Site#8786)

Clearwater, Florida, 33765, United States
Galderma Investigational Site (Site#8787)

Plano, Texas, 75093, United States
Galderma Investigational Site (Site#8788)

Orlando, Florida, 32801, United States
Galderma Investigational Site (Site#8791)

Fresno, California, 93720, United States
Galderma Investigational Site (Site#8792)

Doral, Florida, 33122, United States
Galderma Investigational Site (Site#8793)

Towson, Maryland, 21204, United States
Galderma Investigational Site (Site#8795)

Shelby, North Carolina, 28150, United States
Galderma Investigational Site (Site#8812)

Metairie, Louisiana, 70005, United States
Galderma Investigational Site (Site#8813)

Los Angeles, California, 90057, United States
Galderma Investigational Site (Site#8817)

Katy, Texas, 77494, United States
Galderma Investigational Site (Site#8828)

Kew Gardens, New York, 11415, United States
Galderma Investigational Site (Site#8831)

Anaheim, California, 92801, United States
Galderma Investigational Site (Site#8833)

Inglewood, California, 90301, United States
Galderma Investigational Site (Site#8836)

Jacksonville, Florida, 32256, United States
Galderma Investigational Site (Site#8837)

Pomona, California, 91767, United States
Galderma Investigational Site (Site#8839)

Tampa, Florida, 33615, United States
Galderma Investigational Site (Site#8840)

Ocoee, Florida, 34761, United States
Galderma Investigational Site (Site#8841)

Medford, Oregon, 97504, United States
Galderma Investigational Site (Site#8843)

Sweetwater, Florida, 33172, United States
Galderma Investigational Site (Site#8844)

Orem, Utah, 84058, United States
Galderma Investigational Site (Site#8845)

Huntington Beach, California, 92647, United States
Galderma Investigational Site (Site#8846)

Austin, Texas, 78742, United States
Galderma Investigational Site (Site#8847)

Las Vegas, Nevada, 89118, United States
Galderma Investigational Site (Site#8848)

Las Vegas, Nevada, 89144, United States
Galderma Investigational Site (Site#8849)

Troy, Michigan, 48084, United States
Galderma Investigational Site (Site#8850)

Margate, Florida, 33063, United States
Galderma Investigational Site (Site#8851)

Miami, Florida, 33135, United States
Galderma Investigational Site (Site#8854)

Canoga Park, California, 91303, United States
Galderma Investigational Site (Site#8855)

Beaumont, Texas, 77702, United States
Galderma Investigational Site (Site#8856)

Ormond Beach, Florida, 32174, United States
Galderma Investigational Site (Site#8856)

Ormond Beach, Florida, 33174, United States
Galderma Investigational Site (Site#8857)

Oklahoma City, Oklahoma, 73118, United States
Galderma Investigational Site (Site#8858)

Long Beach, California, 90806, United States
Galderma Investigational Site (Site#8868)

Houston, Texas, 77004, United States
Galderma Investigational Site (Site#8873)

Scottsdale, Arizona, 85260, United States
Galderma Investigational Site (Site#8876)

Bridgeton, Missouri, 63044, United States
Galderma Investigational Site (Site#9919)

Raleigh, North Carolina, 27617, United States
Galderma Investigational Site (Site#9921)

Miami Lakes, Florida, 33014, United States
Galderma Investigational Site (Site#9922)

Phoenix, Arizona, 85018, United States
Galderma Investigational Site (Site#9924)

Raritan, New Jersey, 08869, United States
Galderma Investigational Site (Site#9935)

Springville, Utah, 84663, United States
Galderma Investigational Site 2 (Site#8816)

Tampa, Florida, 33613, United States
Galderma Investigational Site 2 (Site#8833)

Inglewood, California, 90301, United States
Galderma Investigational Site 2 (Site#8864)

Las Vegas, Nevada, 89144, United States

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