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Scientists hunt for biological clues to severe childhood eczema

NCT ID NCT03849716

Knowledge-focused Sponsor: Sanofi Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time

Summary

This study looks at children with eczema (atopic dermatitis) that is not well controlled by prescription creams or for whom such creams are not advised. Researchers are collecting blood and cheek swab samples to find biological markers (biomarkers) that may be linked to how the disease changes over time, how severe it gets, and how well different treatments work. The goal is to better understand the disease and potentially guide more personalized treatment decisions in the future.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help identify which children with eczema are most likely to benefit from specific treatments, enabling more personalized care.
What could go wrong
This is an observational study, so it does not test a new treatment. The findings may not lead to immediate changes in clinical practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

266 people

The number who actually took part.

Started

Apr 2019

Finished

Apr 2026

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Pediatric patients with moderate to severe AD whose disease is not adequately controlled with topical therapies or when those therapies are not medically advisable, who are included in observational study OBS15333 and consent to enter this companion study LPS15496.

Ages

0 to 11 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: * Participation in the OBS15333 pediatric atopic dermatitis (AD) registry. * Signed informed consent by the parent/legally acceptable representative and assent by the participant appropriate to the participant's age. Exclusion criteria: Not applicable. The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.

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Conditions

The condition(s) this trial relates to.

atopic eczema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dermatitis, atopic

Contacts and locations

Locations

  • Allergic Disease and Asthma Research Center, PA Site Number : 8400048

    Greenville, South Carolina, 29607, United States

  • Amarillo Center for Clinical Research Site Number : 8400055

    Amarillo, Texas, 79124, United States

  • Amedica Research Institute, Inc. Site Number : 8400067

    Hialeah, Florida, 33013, United States

  • Axis Clinical Trials Site Number : 8400025

    Los Angeles, California, 90036, United States

  • C Squared Research Center Site Number : 8400068

    Birmingham, Alabama, 35209, United States

  • C2 Research Center, LLC Site Number : 8400071

    Montgomery, Alabama, 36117, United States

  • Cahaba Dermatology Site Number : 8400046

    Birmingham, Alabama, 35244, United States

  • Cincinnati Children's Hospital Medical Center Site Number : 8400017

    Cincinnati, Ohio, 45229, United States

  • Clínica de Alergia Martti Antila Site Number : 0760001

    Sorocaba, 18040-425, Brazil

  • Dermatology Associates of Mid-Ohio Site Number : 8400052

    Marion, Ohio, 43302, United States

  • Eastern Research, Inc. Site Number : 8400032

    Hialeah, Florida, 33013, United States

  • Fomat Medical Research, Inc. Site Number : 8400033

    Oxnard, California, 93030, United States

  • Georgia Pollens Clinical Research Centers, Inc. Site Number : 8400057

    Albany, Georgia, 31707, United States

  • HC - UFPR - Hospital de Clínicas da Universidade Federal do Paraná Site Number : 0760004

    Curitiba, Paraná, 80060-900, Brazil

  • HC - UFPR - Hospital de Clínicas da Universidade Federal do Paraná Site Number : 0760005

    Curitiba, Paraná, 80060-900, Brazil

  • Heights Dermatology and Aesthetic Center Site Number : 8400065

    Houston, Texas, 77008, United States

  • Hospital Sao Paulo Site Number : 0760006

    São Paulo, São Paulo, 04037-002, Brazil

  • IACT Health Site Number : 8400056

    Columbus, Georgia, 31904, United States

  • Investigational Site Number : 0320001

    Ciudad Autonoma Bs As, C1121ABE, Argentina

  • Investigational Site Number : 0320002

    Ciudad Autonoma de Buenos Aires, Buenos Aires, C1181ACH, Argentina

  • Investigational Site Number : 0320003

    Buenos Aires, C1061AAA, Argentina

  • Investigational Site Number : 0320004

    Rosario, Santa Fe Province, S2000DBS, Argentina

  • Investigational Site Number : 0320006

    Ciudad Autonoma de Buenos Aire, Buenos Aires, C1056ABJ, Argentina

  • Investigational Site Number : 0360001

    Westmead, New South Wales, 2145, Australia

  • Investigational Site Number : 0360003

    Melbourne, Victoria, 3010, Australia

  • Investigational Site Number : 1240005

    Winnipeg, Manitoba, R3C 0N2, Canada

  • Investigational Site Number : 1240006

    Montreal, Quebec, H3T 1C5, Canada

  • Investigational Site Number : 1240007

    Calgary, Alberta, T3B 6A8, Canada

  • Investigational Site Number : 1240008

    Toronto, Ontario, M5G 1X8, Canada

  • Investigational Site Number : 1700001

    Bogotá, 110111, Colombia

  • Investigational Site Number : 1700004

    Bogotá, 111211, Colombia

  • Investigational Site Number : 2500003

    Paris, 75743, France

  • Investigational Site Number : 2500006

    Marseille, 13385, France

  • Investigational Site Number : 4840003

    Monterrey, Nuevo León, 64460, Mexico

  • Investigational Site Number : 4840005

    Tlalnepantla, 54055, Mexico

  • Investigational Site Number : 4840006

    México, 06720, Mexico

  • Investigational Site Number : 5280003

    Utrecht, 3508 GA, Netherlands

  • Investigational Site Number : 5280005

    Groningen, 9713 GZ, Netherlands

  • Irmandade da Santa Casa de Misericórdia de Porto Alegre Site Number : 0760002

    Porto Alegre, Rio Grande do Sul, 90020-090, Brazil

  • MUSC Site Number : 8400013

    Charleston, South Carolina, 29425, United States

  • Madera Family Medical Group Site Number : 8400054

    Madera, California, 93637, United States

  • NorthShore University HealthSystem Site Number : 8400064

    Skokie, Illinois, 60077, United States

  • Northwestern University Feinberg School of Medicine Site Number : 8400001

    Chicago, Illinois, 60611, United States

  • Pediatric & Adult Research Center Site Number : 8400040

    Orlando, Florida, 32825, United States

  • Philip Fried, M.D., PLLC Site Number : 8400029

    The Bronx, New York, 10463, United States

  • Tiga Pediatrics, PC Site Number : 8400037

    The Bronx, New York, 10463, United States

  • Universidade Federal do Paraná Site Number : 0760003

    Curitiba, Paraná, 80060-000, Brazil

  • Vista Health Research, LLC Site Number : 8400034

    Miami, Florida, 33176, United States

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