Scientists hunt for biological clues to severe childhood eczema

NCT ID NCT03849716

Completed Knowledge-focused Sponsor: Sanofi Source: ClinicalTrials.gov ↗

First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time

Summary

This study looks at children with eczema (atopic dermatitis) that is not well controlled by prescription creams or for whom such creams are not advised. Researchers are collecting blood and cheek swab samples to find biological markers (biomarkers) that may be linked to how the disease changes over time, how severe it gets, and how well different treatments work. The goal is to better understand the disease and potentially guide more personalized treatment decisions in the future.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could help identify which children with eczema are most likely to benefit from specific treatments, enabling more personalized care.
What could go wrong: This is an observational study, so it does not test a new treatment. The findings may not lead to immediate changes in clinical practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atopic eczema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DERMATITIS, ATOPIC

Contacts and locations

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Locations

Allergic Disease and Asthma Research Center, PA Site Number : 8400048

Greenville, South Carolina, 29607, United States
Amarillo Center for Clinical Research Site Number : 8400055

Amarillo, Texas, 79124, United States
Amedica Research Institute, Inc. Site Number : 8400067

Hialeah, Florida, 33013, United States
Axis Clinical Trials Site Number : 8400025

Los Angeles, California, 90036, United States
C Squared Research Center Site Number : 8400068

Birmingham, Alabama, 35209, United States
C2 Research Center, LLC Site Number : 8400071

Montgomery, Alabama, 36117, United States
Cahaba Dermatology Site Number : 8400046

Birmingham, Alabama, 35244, United States
Cincinnati Children's Hospital Medical Center Site Number : 8400017

Cincinnati, Ohio, 45229, United States
Clínica de Alergia Martti Antila Site Number : 0760001

Sorocaba, 18040-425, Brazil
Dermatology Associates of Mid-Ohio Site Number : 8400052

Marion, Ohio, 43302, United States
Eastern Research, Inc. Site Number : 8400032

Hialeah, Florida, 33013, United States
Fomat Medical Research, Inc. Site Number : 8400033

Oxnard, California, 93030, United States
Georgia Pollens Clinical Research Centers, Inc. Site Number : 8400057

Albany, Georgia, 31707, United States
HC - UFPR - Hospital de Clínicas da Universidade Federal do Paraná Site Number : 0760004

Curitiba, Paraná, 80060-900, Brazil
HC - UFPR - Hospital de Clínicas da Universidade Federal do Paraná Site Number : 0760005

Curitiba, Paraná, 80060-900, Brazil
Heights Dermatology and Aesthetic Center Site Number : 8400065

Houston, Texas, 77008, United States
Hospital Sao Paulo Site Number : 0760006

SÃ£o Paulo, São Paulo, 04037-002, Brazil
IACT Health Site Number : 8400056

Columbus, Georgia, 31904, United States
Investigational Site Number : 0320001

Ciudad Autonoma Bs As, C1121ABE, Argentina
Investigational Site Number : 0320002

Ciudad Autonoma de Buenos Aires, Buenos Aires, C1181ACH, Argentina
Investigational Site Number : 0320003

Buenos Aires, C1061AAA, Argentina
Investigational Site Number : 0320004

Rosario, Santa Fe Province, S2000DBS, Argentina
Investigational Site Number : 0320006

Ciudad Autonoma de Buenos Aire, Buenos Aires, C1056ABJ, Argentina
Investigational Site Number : 0360001

Westmead, New South Wales, 2145, Australia
Investigational Site Number : 0360003

Melbourne, Victoria, 3010, Australia
Investigational Site Number : 1240005

Winnipeg, Manitoba, R3C 0N2, Canada
Investigational Site Number : 1240006

Montreal, Quebec, H3T 1C5, Canada
Investigational Site Number : 1240007

Calgary, Alberta, T3B 6A8, Canada
Investigational Site Number : 1240008

Toronto, Ontario, M5G 1X8, Canada
Investigational Site Number : 1700001

Bogotá, 110111, Colombia
Investigational Site Number : 1700004

Bogotá, 111211, Colombia
Investigational Site Number : 2500003

Paris, 75743, France
Investigational Site Number : 2500006

Marseille, 13385, France
Investigational Site Number : 4840003

Monterrey, Nuevo León, 64460, Mexico
Investigational Site Number : 4840005

Tlalnepantla, 54055, Mexico
Investigational Site Number : 4840006

México, 06720, Mexico
Investigational Site Number : 5280003

Utrecht, 3508 GA, Netherlands
Investigational Site Number : 5280005

Groningen, 9713 GZ, Netherlands
Irmandade da Santa Casa de Misericórdia de Porto Alegre Site Number : 0760002

Porto Alegre, Rio Grande do Sul, 90020-090, Brazil
MUSC Site Number : 8400013

Charleston, South Carolina, 29425, United States
Madera Family Medical Group Site Number : 8400054

Madera, California, 93637, United States
NorthShore University HealthSystem Site Number : 8400064

Skokie, Illinois, 60077, United States
Northwestern University Feinberg School of Medicine Site Number : 8400001

Chicago, Illinois, 60611, United States
Pediatric & Adult Research Center Site Number : 8400040

Orlando, Florida, 32825, United States
Philip Fried, M.D., PLLC Site Number : 8400029

The Bronx, New York, 10463, United States
Tiga Pediatrics, PC Site Number : 8400037

The Bronx, New York, 10463, United States
Universidade Federal do Paraná Site Number : 0760003

Curitiba, Paraná, 80060-000, Brazil
Vista Health Research, LLC Site Number : 8400034

Miami, Florida, 33176, United States

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