Can a pill replace the CPAP machine for sleep apnea?

NCT ID NCT05071612

Completed Disease control Sponsor: Apnimed Source: ClinicalTrials.gov ↗

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This phase 2 trial is testing whether two investigational drugs, AD109 and AD504, taken as a pill at bedtime, can reduce the number of breathing pauses in people with obstructive sleep apnea. The study compares these drugs against atomoxetine (an existing medication) and a placebo. Participants are adults with moderate sleep apnea, and the main goal is to see if the drugs lower the apnea-hypopnea index, a measure of breathing disruptions during sleep.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Combination of investigational drugs AD109 and AD504, compared to atomoxetine and placebo, taken orally at bedtime.
What this could lead to: If successful, this could lead to a new oral medication option for obstructive sleep apnea, potentially offering an alternative to CPAP machines.
What could go wrong: This is an early-phase trial, so the drugs may not prove effective or safe. Possible side effects are not fully known, and results may not generalize to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

obstructive sleep apnea syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OSA - OBSTRUCTIVE SLEEP APNEA

Contacts and locations

Locations

Bogan Sleep Consultants LLC

Columbia, South Carolina, 29201, United States
Brian Abaluck, LLC

Malvern, Pennsylvania, 19355, United States
CTI Clinical Research Center

Cincinnati, Ohio, 45212, United States
Chicago Research Center

Chicago, Illinois, 60634, United States
Clayton Sleep Institute

Maplewood, Missouri, 63143, United States
Clinilabs

New York, New York, 10016, United States
Coastal Carolina Health Care, P.A.

New Bern, North Carolina, 28562, United States
Delta Waves

Colorado Springs, Colorado, 80918, United States
FutureSearch Trials of Neurology

Austin, Texas, 78731, United States
Henry Ford Hospital

Detroit, Michigan, 48377, United States
Intrepid Research

Cincinnati, Ohio, 45245, United States
Minnesota Lung Center / Minnesota Sleep Institute

Woodbury, Minnesota, 55125, United States
NeuroTrials Research, Inc.

Atlanta, Georgia, 30328, United States
Neurocare

Newton, Massachusetts, 02459, United States
Pacific Research Network

San Diego, California, 92103, United States
Research Centers of America -- Hollywood

Hollywood, Florida, 33024, United States
SDS Clinical Trials, Inc.

Santa Ana, California, 92705, United States
Santa Monica Clinical Trials

Los Angeles, California, 90025, United States
Sleep Disorders Centers of the Mid-Atlantic (SDCMA)

Glen Burnie, Maryland, 21061, United States
Sleep Medicine Specialists of South Florida

Miami, Florida, 33176, United States
Sleep and Attention Disorders Institute

Sterling Heights, Michigan, 48314, United States
St. Luke's Hospital Sleep Medicine

Chesterfield, Missouri, 63017, United States
Teradan Clinical Trials

Brandon, Florida, 33511, United States
The Center for Sleep & Wake Disorders

Chevy Chase, Maryland, 20815, United States
Velocity Clinical Research

Greenville, South Carolina, 29615, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.