Disease by developmental or physiological process

This early-phase trial tests whether a bone marrow transplant from a partially matched relative can safely cure chronic granulomatous disease (CGD), a condition that causes severe infections and inflammation. Four people aged 4 to 65 with CGD and no perfect donor will receive che…

This trial tests an experimental gene therapy called MWAV201 in adults with Wilson disease, a genetic condition that causes copper to build up in the body. The treatment uses a harmless virus to deliver a corrected gene, potentially restoring the body's ability to remove copper. …

This early-stage trial is testing a new vaccine called HydroVax-001B WNV to see if it is safe and triggers an immune response against West Nile virus, a mosquito-borne disease. About 30 healthy adults aged 18 to 49 will receive either the vaccine or a placebo. The study will comp…

This Phase 3 trial tests a new meningococcal conjugate vaccine in 660 healthy children aged 2-6 years. The vaccine targets four strains (A, C, Y, W135) that cause meningitis. Participants receive one shot and provide blood samples to compare immune response with a licensed vaccin…

This trial is testing an experimental vaccine made from virus-like particles (VLPs) that mimic polio viruses without causing disease. It aims to see if this vaccine is safe and triggers a strong immune response in healthy infants starting at 6 weeks old and toddlers aged 12-18 mo…

This Phase 2 trial tests an oral drug called buloxibutid in 378 people with idiopathic pulmonary fibrosis (IPF), a lung-scarring disease. Over 52 weeks, researchers compare two doses of buloxibutid against a placebo to see if it can slow lung function decline. The study is double…

This pilot study is testing whether giving children (ages 6-17) newly diagnosed with stage 3 type 1 diabetes free weekly healthy foods and intensive nutrition counseling can help preserve their remaining insulin production. The study will enroll 20 children and measure how feasib…

This early-stage study tests an experimental drug called MK-1403 in people with type 2 diabetes. The main goals are to check if the drug is safe and tolerable, and to see how it behaves in the body. Researchers will also measure its effect on a marker of inflammation (hsCRP). Abo…

This phase 3 trial tests whether rituximab, a cheaper drug, works as well as ocrelizumab for active multiple sclerosis. About 600 adults with relapsing or progressive MS will receive one of the two drugs. The main goal is to see if rituximab can prevent new brain lesions as effec…

This trial is investigating whether adding a short course of targeted radiation to a standard immunotherapy combination (ipilimumab and nivolumab) can improve outcomes for people with metastatic melanoma. Participants will receive the two immunotherapy drugs, and some will also r…

This 12-week study is for people who completed a previous trial of the ketogenic diet for first-episode bipolar disorder. Researchers want to see if the diet can improve symptoms like depression, mania, and psychosis, as well as brain energy metabolism and insulin resistance. Abo…

This study is testing a new knee implant called the Persona SoluTion PPS femur in 200 adults who need total knee replacement. The goal is to see if it safely improves knee function and reduces pain over two years. Participants will have their knee health measured before surgery a…

This pilot study tests whether using a videoscope—a small camera that gives surgeons a magnified, clearer view—during minimally invasive gum surgery improves outcomes for people with severe chronic periodontitis. Participants are randomly assigned to receive surgery with the vide…

This study tests whether a piece of donated aorta (the body's largest artery) can be used as a patch to repair severe windpipe or bronchial defects in children. The surgery is for kids who cannot have standard windpipe repair. Only 5 children will be enrolled, and the main goal i…

This study tests an oral drug called TAK-279 (Zasocitinib) in 207 adults with moderate-to-severe ulcerative colitis. Participants take either the drug or a placebo for 12 weeks, then everyone gets the drug for up to a year. The goal is to see if TAK-279 reduces bowel inflammation…

This study tests whether adding a continuous glucose monitor (CGM) and nutrition counseling to a food-as-medicine program helps adults with type 2 diabetes and food insecurity better manage their blood sugar. Sixty participants will be split into two groups: one gets the standard…

This study tests a device that uses radiofrequency energy to calm overactive kidney nerves, which can drive high blood pressure. About 1,900 adults with uncontrolled hypertension will receive the procedure and be followed for years. The goal is to see if this approach safely and …

This study compares the real-world effectiveness of mirikizumab against standard biologic therapies for adults with ulcerative colitis or Crohn's disease. Researchers will track whether mirikizumab reduces the need for extra medical care, like emergency visits or treatment change…

This study is testing the Persona Ti-Nidium knee implant in 240 people who need total knee replacement due to conditions like osteoarthritis or rheumatoid arthritis. The goal is to see if the implant is safe and improves knee function and pain. Participants will be followed over …

This study tests the long-term safety of the drug tolebrutinib in 2,500 adults with relapsing or progressive multiple sclerosis. Participants previously took part in earlier trials and will continue taking tolebrutinib or a placebo for up to several years. The goal is to see if t…

This study tests whether a diabetes care program using continuous glucose monitors (CGM) and remote patient monitoring can help adults with uncontrolled type 2 diabetes improve their blood sugar levels and reduce diabetes-related distress. Participants will wear a CGM that shows …

This study tests a high-dose stem cell transplant for people with chronic granulomatous disease (CGD), a condition that weakens the immune system. Participants receive donor stem cells along with drugs to prevent rejection and graft-versus-host disease. The goal is to improve tra…

This study tracks 132 people with PNH who are taking Fabhalta to see how safe it is and what side effects occur. Researchers will monitor infections and check for serious red blood cell breakdown if the drug is stopped. The goal is to better understand the drug's risks in everyda…

This early-stage study tests a single intravenous dose of a gene therapy called LY3884961 in 15 adults with Gaucher disease type 1. The goal is to see if it is safe and can reduce or replace the need for ongoing enzyme replacement or substrate reduction therapy. Participants must…

This study tests whether a light-activated dye called rose Bengal, combined with antibiotics and steroids, can improve vision in people with severe bacterial eye infections. About 60 adults with corneal ulcers and vision loss will receive either the dye treatment or a sham proced…

This trial aims to see if there is a difference in how well two cementless total knee replacement implants hold up over time. About 50 people with knee osteoarthritis will be randomly assigned to receive either the Triathlon Tritanium or the GMK Sphere implant. Using CT scans, re…

This study tests a weekly injection called pemvidutide in 100 adults with alcohol-related liver disease. Participants are overweight or obese and have a history of heavy drinking. The goal is to see if the drug can reduce liver stiffness and scarring over 24 to 48 weeks compared …

This study tests a new medicine called ORKA-001 for adults with moderate-to-severe plaque psoriasis, a skin condition causing red, scaly patches. About 160 participants will receive either the drug or a placebo to see if it can completely clear the skin by week 16. The goal is to…

This study tests whether giving people with type 2 diabetes and food insecurity monthly vouchers for fruits and vegetables can improve blood sugar control. Participants receive $100 per month in produce-only gift cards along with dietary education for five months, then switch to …

This study tests a weekly injection called TransCon CNP in children and teens with achondroplasia, the most common form of dwarfism. The goal is to see if it is safe and helps improve growth over several years. Participants who completed a previous TransCon CNP trial can join thi…

This phase II trial tests whether lisinopril, a widely used blood pressure medication, can prevent liver damage from getting worse in people with non-alcoholic fatty liver disease (NAFLD). The study enrolls 45 adults with advanced liver scarring and measures changes in fibrosis m…

This study is testing the long-term safety of a daily pill called OLZ/SAM (olanzapine plus samidorphan) in 236 teenagers with schizophrenia or bipolar I disorder. Participants have already completed a previous study with the same drug. The goal is to see if the drug is safe and t…

This study tests whether mentoring local clinic teams via telehealth can help them start a comprehensive diabetes program for low-income Latino(a)s with type 2 diabetes. The program includes community health workers, help getting medication, and diabetes education. Researchers wi…

This study looks at whether giving an extra dose of the antibiotic cefoxitin during appendix removal surgery can better prevent infections compared to the usual single dose before surgery. Researchers will measure antibiotic levels in blood, fat, and appendix tissue from 46 parti…

This study tests a gene therapy for people with X-linked chronic granulomatous disease (X-CGD), a genetic condition that weakens the immune system and leads to severe infections. Researchers take the patient's own stem cells, add a working copy of the faulty gene, and return the …

This phase 3 trial tests the drug lutikizumab against a placebo in about 1400 adults and teens with moderate to severe hidradenitis suppurativa, a chronic skin condition causing painful lumps and abscesses. Participants receive weekly shots for 16 weeks, then continue on differen…

This study tests an investigational drug called rozanolixizumab in adults with MOG antibody-associated disease (MOGAD), a rare condition where the immune system attacks the brain and spinal cord. The main goal is to see if the drug can prevent or delay relapses (flare-ups) compar…

This phase 3 trial tests sefaxersen, a drug that targets a part of the immune system, in 428 people with IgA nephropathy at high risk of kidney decline. Participants receive either sefaxersen or a placebo as a shot under the skin. The main goal is to see if the drug reduces prote…

This study follows about 772 teenagers and adults with moderate to severe eczema who are taking upadacitinib (Rinvoq) as prescribed by their doctor. Researchers want to see how well the drug controls the disease over two years in everyday medical practice. Participants will have …

This early-stage study tests an experimental drug called ALN-4324 in two groups: healthy overweight volunteers and overweight patients with type 2 diabetes. The goal is to check the drug's safety and how well it controls blood sugar. Participants receive either the drug or a plac…

This Phase 3 trial tests a new injectable drug called IBI306 in 198 Chinese adults with non-familial high cholesterol and mixed high lipids. Participants receive either IBI306 or a placebo every 2 or 4 weeks for 12 weeks. The main goal is to see how much the drug lowers LDL (bad)…

This phase III trial compares the drug pembrolizumab (MK-3475) to the current standard treatments—high-dose interferon or ipilimumab—in 1,301 patients with high-risk melanoma that has been surgically removed. The goal is to see if pembrolizumab is better at preventing the cancer …

This study tests a new medicine called bimekizumab against an existing one (ustekinumab) for children and teens aged 6 to 17 with moderate to severe plaque psoriasis. The goal is to see if bimekizumab works better at clearing skin symptoms. About 168 participants will receive inj…

This trial tests whether adding screws to secure the cup part of a hip replacement makes a difference in how well the implant stays in place. Participants aged 65-80 with hip osteoarthritis will receive a hybrid hip replacement, and half will get screws while the other half won't…

This study looks at whether sending reminders (nudges) to doctors, patients, or both can increase the number of people with HIV who smoke getting help to quit. About 500 patients and their doctors are involved. The goal is to see if these nudges lead to more referrals and partici…

This study tests whether referring Veterans in early recovery from substance use disorder to work-focused programs (like supported employment) helps them stay sober and function better. About 100 Veterans will be randomly assigned to get the work referral or usual treatment alone…

This early-stage trial evaluates an experimental oral drug called VV119, which is being developed for schizophrenia. The study enrolls healthy volunteers to receive a single dose of VV119 or a placebo, with some participants taking it with food to see if meals affect how the drug…

This study tests a daily pill called upadacitinib for people with moderate to severe hidradenitis suppurativa (HS), a painful skin condition causing boils in the armpits, groin, and genital area. The trial includes about 1,328 adults and teens who have not improved with standard …

This phase 2 study tests a combination of two nucleoside drugs, doxecitine and doxribtimine, in 47 people with thymidine kinase 2 (TK2) deficiency, a rare genetic disorder that weakens muscles. Participants already receiving nucleoside therapy continue treatment to see if the dru…

This study compares two conservative methods for treating deep tooth decay that reaches close to the nerve. In one approach, dentists leave softer decayed tissue near the nerve; in the other, they remove more until firmer tissue remains. About 100 patients with deep decay in perm…

This early-stage trial is testing a new treatment called GPC2 CAR T cells for children with neuroblastoma or retinoblastoma that has come back or not responded to standard treatments. The therapy uses a patient's own immune cells, which are modified in a lab to better recognize a…

This early-stage trial is testing a new drug called ABBV-291 in adults with Non-Hodgkin's lymphoma that has come back or stopped responding to treatment. The study will first find the safest dose, then check if the drug can shrink tumors. About 165 participants will take part wor…

This study tests whether a daily probiotic supplement can improve the balance of gut bacteria in children aged 3 to 7 who have autism and digestive issues like constipation or stomach pain. Over 6 months, 60 children will receive either the probiotic or a placebo. The main goal i…

This study tests a treatment made from healthy donor stool (MTP-101-C) for cancer patients whose skin or gut side effects from immunotherapy don't get better with steroids. About 30 participants will take the oral capsules to see if the therapy is safe and can calm these side eff…

This study tests a drug called lutikizumab for people with moderate to severe atopic dermatitis (eczema) that hasn't improved with standard treatments. About 80 participants will receive either the drug or a placebo for 16 weeks, then everyone gets the drug for another 32 weeks. …

This study is testing the long-term safety and effectiveness of bimekizumab, a drug that reduces inflammation, in 508 adults with active axial spondyloarthritis (including ankylosing spondylitis). Participants who completed earlier trials will receive the drug for an extended per…

This study tests a drug called GLM101 for people with PMM2-CDG, a rare inherited disease that affects movement and coordination. About 50 children and adults will receive weekly infusions of either GLM101 or a placebo for 24 weeks, followed by an open-label phase where everyone g…

This trial compares two ways to treat a severely decayed tooth that has caused irreversible pulpitis, a painful condition where the tooth's inner pulp is inflamed. One method uses a standard solution to control bleeding after removing damaged pulp, while the other uses a diode la…

This study tests a new growth hormone medicine called somapacitan, given once a week, in 47 children who are very short due to being born small for gestational age, or having Turner syndrome, Noonan syndrome, or idiopathic short stature. The main goal is to see if it is safe and …

This study tests a drug called selumetinib in adults with neurofibromatosis type 1 (NF1) who have nerve tumors that cannot be removed by surgery. The goal is to see if the drug can shrink these tumors or slow their growth. Participants take the drug twice daily and are monitored …

This phase II trial is testing whether a combination of talimogene laherparepvec (a modified herpes virus that infects and kills cancer cells) and nivolumab (an immunotherapy drug) can shrink tumors in people with rare skin cancers or lymphomas that haven't responded to standard …

This study looks at whether taking omega-3 fatty acid supplements can help lower very high triglyceride levels in pregnant women. High triglycerides during pregnancy can increase the chance of having a large baby. The study involves 40 pregnant women with elevated triglycerides a…

This study offers open/aftercare treatment to adults with obsessive-compulsive disorder (OCD) who have completed an earlier study at Stanford's Rodriguez Lab. Participants receive evidence-based psychotherapy and/or pharmacotherapy from trained professionals. The goal is to see i…

This study looks at whether adding pistachios to the daily diet for 6 months can improve memory, thinking speed, and other brain functions in adults aged 65 to 80. It also checks for changes in blood pressure and overall life satisfaction. About 97 participants who are already in…

This study looks at the long-term safety of relacorilant, a drug for people with Cushing syndrome. It includes 125 adults who previously completed a relacorilant study and may benefit from continued treatment. Researchers will track side effects over time to see if the drug is sa…

This trial tests whether a less invasive dental procedure called pulpotomy can successfully treat baby molars with a severe, painful tooth condition known as irreversible pulpitis. Instead of removing the entire nerve, pulpotomy removes only the top part and places a soothing med…

This study compares two daily pills—fenebrutinib and teriflunomide—in about 746 adults with relapsing multiple sclerosis. The goal is to see which one better reduces relapses and delays worsening disability. Participants take one of the two drugs for several years, with an option…

This phase 2 trial is investigating whether psilocybin, the active compound in magic mushrooms, combined with psychological support, is safe and suitable for military veterans and first responders who have both alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD). …

This early-stage trial is testing a new way to give ocrelizumab (Ocrevus) for multiple sclerosis — as a simple shot under the skin instead of a long IV infusion. About 75 adults with MS will receive increasing doses to see if the new form is safe and tolerable. If it works, it co…

This study compares a targeted drug called selumetinib to standard chemotherapy (carboplatin/vincristine) in children aged 2 to 21 with neurofibromatosis type 1 (NF1) and low-grade glioma, a type of brain tumor. The goal is to see if selumetinib works as well or better at control…

This study is testing a new type of hip resurfacing device made entirely of ceramic, designed for people with hip osteoarthritis, necrosis, or dysplasia. The goal is to see if it is as safe and effective as existing metal-on-metal devices, but without releasing metal ions into th…

This study tests a mobile app called Connections for people living with HIV who also have substance use disorders. The app provides resources, weekly check-ins, discussion rooms, and private messaging with peer mentors and care teams. Researchers want to see if using the app help…

This study tests a new once-weekly growth hormone medicine (somapacitan) against a daily one (Norditropin) in 62 children born small who remain short. The goal is to see if the weekly shot works as well and is safe. Children receive injections either once a week or once a day for…

This trial explores whether adding vitamin D and iron supplements to usual OCD treatment can improve the ability to control impulses. It involves 60 people with OCD who will receive the supplements for 12 weeks. Researchers will use brain scans and behavioral tasks to see if thes…

This study compares two dental procedures for treating severe pulpitis (tooth nerve inflammation) in children's baby molars. One is a standard full root canal treatment (pulpectomy), and the other is a less invasive option that removes only part of the nerve (pulpotomy). The goal…

This phase 3 trial tests whether taking tranexamic acid (TXA) by mouth for an extended period after total knee replacement can improve recovery. TXA is already used during surgery to reduce bleeding, but its benefits when continued afterward are unclear. The study will compare di…

This study tests a vaccine called AADvac1 in 146 people with progressive supranuclear palsy (PSP), a rare brain disorder that affects movement and thinking. The vaccine aims to target a protein linked to the disease and slow its progression. Participants will receive injections o…

This study follows about 200 people with Prader-Willi syndrome who are taking or starting VYKAT XR. Researchers will track side effects and how the drug affects their health over time. The goal is to gather more safety information, not to test if the drug cures the condition.

This study tests a granule (sprinkle) form of the drug selumetinib in children aged 1 to under 7 years who have neurofibromatosis type 1 (NF1) with painful, inoperable tumors. The goal is to find the right dose, check safety, and see if it shrinks tumors. About 36 children will t…

This early-stage trial tests a new weekly injection called NNC0194-0499, alone or with another drug (semaglutide), in 96 adults with type 1 diabetes. The goal is to see if it improves blood sugar levels compared to placebo. All participants continue their usual insulin. The study…

This study tests an experimental daily pill (RO7269162) in 256 people who either have brain plaques but no symptoms, or have mild memory problems due to Alzheimer's. Participants take the pill or a placebo for about 1.5 years, with regular check-ups to monitor safety and brain ch…

This study tests whether a newer drug, benralizumab, works as well as the current standard, mepolizumab, for people with a rare disease called EGPA that inflames blood vessels. About 140 adults with active EGPA will receive either drug for a year, along with their usual steroids.…

This study follows 250 people with severe aortic stenosis who receive the SAPIEN 3 transcatheter heart valve as part of their standard care. The goal is to see how safe and effective the valve is over the long term in everyday clinical practice. Researchers will track how many pa…

This study tests a treatment that uses a patient's own immune cells (T-cells) to fight advanced melanoma. Some participants also receive a dendritic cell vaccine to boost the immune response. The goal is to see if the T-cells last longer and work better against the cancer. The tr…

This study follows people with knee osteoarthritis who receive one of two total knee replacement designs: a cruciate-retaining (CR) or a posterior-stabilized (PS) implant. The goal is to compare how well each design relieves pain, restores function, and holds up over time. Resear…

This study tests whether the drug ixekizumab is safe and effective for children with certain types of juvenile arthritis (enthesitis-related arthritis and juvenile psoriatic arthritis). About 101 children aged 2 to 17 years will receive either ixekizumab or the standard drug adal…

This long-term study tests the safety and effectiveness of bitopertin (DISC-1459) in people with erythropoietic protoporphyria (EPP) or X-linked protoporphyria (XLP), rare conditions that cause severe pain from sunlight exposure. About 230 participants who previously took bitoper…

This study tests a new medicine called ALN-6400 for people with hereditary hemorrhagic telangiectasia (HHT), a condition that causes abnormal blood vessels and frequent nosebleeds. First, healthy volunteers will receive a single dose to check safety. Then, HHT patients will recei…

This early-stage trial tests a personalized cell therapy called ADP-A2M4CD8 in people with certain cancers that have a specific marker (MAGE-A4). The therapy uses a patient's own immune cells, modified to better attack tumors, and is given alone or with standard immunotherapy dru…

This phase 2 trial is testing whether a combination of two drugs, talazoparib and temozolomide, can shrink tumors in people with rare cancers that have spread. The study includes 14 participants with advanced rare solid tumors, such as pheochromocytoma or paraganglioma, who have …

This study looks at whether a daily dose of milk polar lipids (a type of fat found in milk) can improve cholesterol levels, reduce inflammation, and support gut health in adults with high cholesterol and abdominal obesity. Researchers will measure changes in blood fats and other …

This phase 2 trial is testing whether an experimental drug called HTD1801 can improve liver health in adolescents with primary sclerosing cholangitis (PSC), a rare disease that damages the bile ducts. Participants will receive either HTD1801 or the standard treatment, ursodeoxych…

This trial tests whether adjusting diabetes medications to keep blood sugar levels in the normal range can preserve the body's insulin-producing beta-cells and slow the natural worsening of type 2 diabetes. Adults aged 40 to 75 with type 2 diabetes will be assigned to either usua…

This Phase 2 trial tests whether the drug LM11A-31 can slow the progression of Progressive Supranuclear Palsy (PSP), a rare brain disorder that affects movement and balance. About 147 people with early-stage PSP will receive either the drug or a placebo twice daily for several mo…

This trial tests whether giving zinc supplements before and after colonic surgery in children can help protect the gut lining and reduce inflammation. Children aged 1 month to 18 years undergoing colonic surgery with anastomosis will be randomly assigned to receive either routine…

This study tests a drug called sonelokimab in 960 adults with active psoriatic arthritis who have not used biologic treatments before. The goal is to see if it reduces joint pain and swelling better than a placebo. Participants receive injections over several months, and research…

This Phase 3 trial tests whether bitopertin, a daily pill, can help people with erythropoietic protoporphyria (EPP) or X-linked protoporphyria (XLP) spend more time in sunlight without pain. About 183 participants aged 12 and older will take bitopertin or a placebo for 6 months. …

This study offers continued access to the drug mitapivat for adults with pyruvate kinase deficiency who completed an earlier Agios-sponsored trial and cannot get the drug commercially. Only 6 participants are enrolled, and the main goal is to monitor side effects. The study does …

This program provides access to esmethadone (REL-1017), an experimental drug, for people with serious depression who have not responded to standard treatments and cannot join other clinical trials. The goal is to offer a potential treatment option when no satisfactory alternative…

This study is testing a device called KeriFuse® that is implanted into the finger joint to fuse the bones together. It is for people with arthritis in the last joint of the finger or thumb. The goal is to see if it reduces pain and successfully fuses the joint within three months…

This trial tests whether rituximab, an infusion drug that calms certain immune cells, can help people with idiopathic membranous nephropathy and nephrotic syndrome. Participants receive either rituximab or a placebo, and the study tracks how many achieve a significant reduction i…

This study follows about 500 people who already had cataract surgery with a special adjustable lens (RxSight LAL) or a standard lens. Researchers want to see how well the lens works over time, focusing on vision sharpness and correction of astigmatism. Participants just need to c…

This trial tests whether a smartphone app and remote diet/exercise coaching can help people with non-alcoholic fatty liver disease lose weight and reduce liver fat. 120 participants will either get standard lifestyle advice or use the app with daily meal tracking, weekly recipe a…

This trial is testing two different cup designs for total hip replacement, both paired with the same stem, to see which one gives patients better hip function and less pain. About 120 people with hip arthritis or related conditions will be randomly assigned to receive either the …

This study tests a new medicine called zodasiran in people aged 12 and older who have a rare genetic condition that causes extremely high cholesterol (homozygous familial hypercholesterolemia). The goal is to see if the drug can safely lower bad cholesterol levels over 12 months.…

This trial tests whether losartan, a common blood pressure medication, can reduce scarring in the heart's main pumping chamber and improve exercise capacity in adults who had surgery to repair coarctation of the aorta. Participants will take losartan, amlodipine, or a placebo dai…

This pilot trial tests whether the timing of carbohydrates and protein across meals can improve glucose metabolism in people with prediabetes or type 2 diabetes who are overweight or obese. Participants follow two different isocaloric diets—one with a high-protein breakfast and h…

This study tests whether people with relapsing-remitting multiple sclerosis (MS) who have been stable on anti-CD20 therapies can safely switch to a fumarate drug like Tecfidera or Vumerity. The goal is to see if the switch keeps the disease inactive—meaning no relapses, no new br…

This study aims to find better ways to treat depression in people with chronic kidney disease (CKD). About 201 adults with advanced CKD and major depression will receive either behavioral activation teletherapy plus a non-SSRI antidepressant, or the antidepressant plus teletherap…

This study follows 299 people who received the Smith+Nephew Porous Total Knee System, a titanium knee replacement for severe arthritis. The goal is to see if the implant reduces pain, improves movement, and lasts at least two years without needing revision surgery. Participants a…

This trial compares two dental procedures—direct pulp capping and partial pulpotomy—for treating permanent teeth with deep cavities that expose the pulp. Adults with deep caries and reversible pulpitis will be randomly assigned to one of the two procedures. The study will follow …

This study tests a new device that uses freezing (cryotherapy) to treat obstructive sleep apnea in adults who cannot use standard treatments like CPAP machines. About 25 people with moderate to severe sleep apnea will receive the procedure. The main goal is to check safety and se…

This Phase 3 study tests the long-term safety and effectiveness of the drug solriamfetol in 300 adults with binge eating disorder. Participants take a daily pill (75, 150, or 300 mg) and are monitored for side effects and changes in binge eating. The study is open-label, meaning …

This study tests whether a diet rich in prebiotic foods can help the immune system better fight advanced melanoma that no longer responds to standard immunotherapy. Four adults with stage III or IV melanoma will eat a prebiotic-enriched diet while receiving a combination of two i…

This study tests whether intravenous ketamine can help people with moderate to severe methamphetamine use disorder reduce their drug use. Over 12 weeks, 120 adults will receive either ketamine or a mild sedative (midazolam) in six sessions. The main goal is to see if more partici…

This trial compares two types of knee replacement implants: one that keeps the posterior cruciate ligament (CR) and one that does not (PS). Both are implanted using a computer-assisted personalized technique that aims to restore the knee's natural alignment. The study includes 14…

This early-stage study tests the safety of acamprosate, a drug used for alcohol dependence, in 30 adults with ALS who have a specific mutation in the C9orf72 gene. Participants take the pill three times daily for 24 weeks and undergo regular checkups, breathing tests, and spinal …

This study tests whether baricitinib, a daily pill, is safe and works for children aged 1 to under 18 with systemic juvenile idiopathic arthritis (sJIA), a chronic inflammatory disease. About 58 children will receive either baricitinib or a standard injected drug (tocilizumab) to…

This Phase 3 study tests whether a gel containing patidegib can lower the number of new basal cell carcinomas (a type of skin cancer) on the face of adults with Gorlin syndrome. Participants apply the gel or a placebo to their face twice daily for a year. The study will compare h…

This study tests whether the level of a specific inflammatory marker (MMP9) in the dental pulp can predict the success of a full pulpotomy, a procedure that removes the inflamed pulp from the crown of a tooth and seals it with a special material. Adults with deep cavities causing…

This phase 2 study tests two drugs, sunitinib and temsirolimus, in 137 people with advanced rare tumors that have no cure. The goal is to see if these drugs can shrink tumors or slow their growth. Participants take one of the two drugs, and researchers measure how long the cancer…

This Phase 3 trial tests whether a cell therapy called REACT (rilparencel) can slow kidney decline in 685 adults with type 2 diabetes and chronic kidney disease. Participants receive either two injections of their own kidney cells or sham procedures. The study measures changes in…

This study tests whether a lab-made antibody called Tegoprubart can safely prevent the immune system from attacking transplanted islet cells in people with type 1 diabetes who have dangerous low blood sugar. The goal is to help patients stop needing insulin without using standard…

This study tests a combination of three drugs—dabrafenib, trametinib, and navitoclax—in people with BRAF mutant melanoma or other solid tumors that have spread or can't be removed by surgery. The goal is to find the best dose and see how well the drugs shrink tumors. About 75 adu…

This pilot study tests a new surgical procedure for people with anterior shoulder instability, where the shoulder repeatedly dislocates. The procedure uses a semitendinosus tendon graft to create a sling around the subscapular tendon and form a new labrum, aiming to hold the shou…

This study tests whether using a continuous glucose monitor (CGM) helps adults with type 2 diabetes who do not take insulin improve their blood sugar control. Participants are randomly assigned to either use a real-time CGM or receive routine care with occasional blinded CGM wear…

This study tests an experimental drug called CS060380, taken with the weight-loss drug semaglutide, in adults with both fatty liver disease (MASH) and obesity. About 120 participants will be randomly assigned to get either CS060380 or a placebo for 36 weeks, then everyone gets CS…

This Phase 3 trial tests an experimental drug called ALXN2220 in about 1,180 adults with transthyretin amyloid cardiomyopathy (ATTR-CM), a condition where abnormal protein builds up in the heart, causing heart failure. The drug is designed to remove those protein deposits. Partic…

This trial compares two surgical procedures for people with painful thumb base osteoarthritis that hasn't improved with conservative care. One procedure removes the entire trapezium bone, while the other removes only a small portion to create a narrow gap. The study will track pa…

This pilot study tests whether having a pharmacist oversee continuous glucose monitoring (using a FreeStyle Libre device) can improve blood sugar control and health behaviors in people with type 2 diabetes. Forty participants will use the monitor for 12 weeks, and their results w…

This trial investigates whether a long-acting liquid stimulant medication (Quillivant XR) can safely and effectively reduce ADHD symptoms in children with Down syndrome, who are at higher risk for ADHD but often go untreated. The study will compare the medication against a placeb…

This trial tests whether injecting platelet-rich plasma (PRP) into the thumb joint can reduce pain and improve function in people with thumb base osteoarthritis. Participants are randomly assigned to receive either PRP or a saline placebo injection, and neither they nor the resea…

This study tests whether two HIV medications, emtricitabine and Descovy, are safe for people with mild cognitive impairment (MCI), a condition that can lead to Alzheimer's. Researchers think these drugs might slow disease progression by blocking a process linked to Alzheimer's. A…

This early-phase study tests whether a new treatment called KSQ-001EX is safe for people with advanced solid tumors like melanoma, lung cancer, or head and neck cancer. The treatment uses a patient's own immune cells (tumor-infiltrating lymphocytes) that are genetically modified …

This trial compares two surgical approaches for a common type of ankle fracture. Half of the participants will have the posterior bone fragment fixed with a plate or screw, while the other half will not. The goal is to see if fixing this fragment makes the ankle joint stable enou…

This study compares two methods for creating an arteriovenous fistula (AVF) in people with end-stage kidney disease who need dialysis. The newer endovascular method uses a needle through the skin, while the traditional surgical method requires an incision. Researchers will enroll…

This study tests three different non-drug approaches to help older adults in nursing homes manage their type 2 diabetes. One group uses a device that sends mild electrical pulses to the leg muscles, another does supervised exercise, and the third receives health education. The ma…

This Phase 2 trial tests an experimental drug called CT1812 in 540 people with early Alzheimer's disease. Participants receive either the drug or a placebo for 18 months. The goal is to see if CT1812 can slow declines in memory, thinking, and daily function. The study is active b…

This study tests whether polyphenols from muscadine wine, served as a non-alcoholic beverage, can improve cognitive performance, memory, mood, and anxiety in healthy adults over 50. Participants will drink either the polyphenol-rich beverage or a placebo and complete a series of …

This study tests whether taking potassium supplements can slow down kidney function loss in people with moderate-to-severe chronic kidney disease (CKD) and high blood pressure. About 532 adults with CKD stage 3b or 4 will receive potassium or a placebo. The goal is to see if pota…

This study tested two targeted drugs, dabrafenib and trametinib, given before and after surgery in 58 people with stage III melanoma that has a BRAF gene mutation. The goal was to shrink tumors before surgery and kill any remaining cancer cells afterward. The approach aims to imp…

This study tests whether a daily fingolimod capsule works better than a weekly interferon injection to prevent multiple sclerosis relapses in children. About 240 kids with MS will take one of the two treatments for 2 years, followed by a 5-year extension where everyone gets fingo…

This study tests a new 3D-printed implant for adults with hip dysplasia, a condition where the hip socket doesn't fully cover the thigh bone, causing pain and gait problems. Ten participants aged 18-45 will receive the implant to see if it is safe and helps improve hip function a…

This study tests the drug zanubrutinib (Brukinsa) in 18 Chinese adults who have Waldenström macroglobulinemia but have not yet received any treatment. The goal is to see how well the drug controls the disease and to check for side effects. Participants take zanubrutinib by mouth,…

This early-stage trial tests a new treatment called KYV-101 for people with progressive multiple sclerosis (MS) that hasn't improved with standard treatments. KYV-101 is a CAR T-cell therapy made from a patient's own immune cells, designed to attack the cells causing inflammation…

This pilot study is testing whether one 25 mg dose of psilocybin, given alongside psychotherapy, can ease depression in people with bipolar II disorder who haven't responded to at least two prior treatments. Using brain scans (fMRI), researchers will look at how the drug affects …

This study tests whether drinking 15 ml of apple cider vinegar twice a day for two weeks can improve blood sugar stability and cholesterol in adults with type 2 diabetes. Thirty-eight participants will compare the vinegar to plain water using a continuous glucose monitor. It's a …

This study tests a new maintenance dosing schedule for ofatumumab, a drug used to control relapsing multiple sclerosis (MS). Researchers want to see if the new schedule is as safe and effective as the current approved dose. About 196 adults with relapsing MS will take part, and t…

This study tests an injection called AHB-137 in 20 adults with chronic hepatitis B who are already on standard antiviral pills. The goal is to see if the drug can lower or eliminate hepatitis B surface antigen (HBsAg) and viral DNA, potentially leading to a functional cure. Parti…

This trial is testing whether a single injection of micrografts made from a patient's own ear cartilage can improve symptoms and knee function in adults with moderate knee osteoarthritis. The micrografts are prepared from a small ear cartilage sample using a special device, witho…

This study tests a drug called riliprubart in 140 adults with chronic inflammatory demyelinating polyneuropathy (CIDP) that hasn't improved with standard care. Participants receive either riliprubart or a placebo for up to 111 weeks. The main goal is to see if the drug reduces di…

This study tests a new drug called Afimkibart (RO7790121) in 160 adults with moderate to severe atopic dermatitis (eczema). Participants receive either the drug or a placebo as a shot under the skin. The main goal is to see if the drug improves eczema symptoms by at least 75% aft…

This early-phase trial tests a single intravenous dose of LY-M001 gene therapy in 9 children (ages 6 to 17) with type 1 Gaucher disease. The goal is to see if it is safe and can improve key symptoms like liver size and blood markers. Researchers will monitor participants for side…

This trial tests whether transferring vaginal fluid from healthy donors can help people with recurrent bacterial vaginosis (BV) that doesn't respond well to antibiotics. Participants receive either the donor fluid or a placebo (saline) to see if the transplant restores a healthie…

This study tests whether frozen capsules containing processed stool from healthy donors can help people with mild-to-moderate active ulcerative colitis. Participants will take either the real capsules or a placebo for 12 weeks. The goal is to see if the treatment can bring the di…

This study looks at the long-term safety and tolerability of iptacopan in adults with paroxysmal nocturnal hemoglobinuria (PNH) who have already completed earlier phase 2 or 3 studies with the drug. About 208 participants will continue taking iptacopan and be monitored for side e…

This study tests a culturally tailored sleep program for Latino couples where one partner has sleep apnea and is starting CPAP therapy. The program includes three telehealth sessions teaching sleep skills and support strategies. Researchers want to see if it improves CPAP use and…

This trial tests whether an estradiol patch can reduce liver fat and scarring in postmenopausal women with NASH, a progressive form of fatty liver disease. The study enrolls women aged 45-70 with NASH or fatty liver, giving them either a daily estradiol patch or a placebo for a p…

This trial tests whether applying a gel containing hyaluronic acid and chlorhexidine after a minimally invasive deep cleaning can improve gum healing in people with advanced periodontitis (stage III or IV). Participants receive either the deep cleaning alone or the cleaning plus …

This phase 3 trial is testing whether the immunotherapy drug nivolumab (Opdivo) can prevent melanoma from coming back in people who have had their stage IIB/C melanoma completely removed. About 790 adults and children are randomly assigned to receive either nivolumab or a placebo…

This study tests whether adding concentrated platelet-rich fibrin (C-PRF), a gel made from a patient's own blood, to a minimally invasive non-surgical gum treatment can improve healing in people with advanced periodontitis. Thirty adults with severe gum disease and deep bone defe…

This pilot study is testing a new, shortened chemotherapy regimen called N9 for children with high-risk neuroblastoma, a type of cancer. The regimen combines several chemotherapy drugs given in different cycles to see if it is safe and effective. The study includes children under…

This phase 2 trial tests an injectable drug called DII235 in 233 adults with high lipoprotein(a), a genetic condition that raises heart disease and stroke risk. Participants have heart disease or type 2 diabetes. The study compares different doses of DII235 against a placebo to s…

This study tests two different doses of TEV-48574 (duvakitug) given as a shot every 4 weeks to adults with moderate to severe ulcerative colitis or Crohn's disease. Participants who completed a previous 14-week study can join. The goal is to see if the drug can keep the disease u…

This study tests a drug called selumetinib in children and young adults (ages 3-18) with neurofibromatosis type 1 (NF1) who have nerve tumors that cannot be removed by surgery. The goal is to see if the drug can shrink or slow the growth of these tumors. Participants take the dru…

This phase 3 trial tests whether ziltivekimab, a drug that targets inflammation, can reduce swelling in the arteries of 40 people with coronary artery disease. Participants receive either the drug or a placebo, and researchers use advanced imaging and blood tests to measure chang…

This study is testing a procedure called duodenal mucosal resurfacing (DMR) to see if it can safely improve blood sugar control in people with type 2 diabetes who are not on insulin. About 18 adults will be randomly assigned to receive DMR or a sham (fake) procedure. The study wi…

This study tested two drug combinations in 42 people with advanced uveal melanoma, a rare eye cancer that has spread. The goal was to see if adding a second drug (GSK2141795) to trametinib could better slow cancer growth. Participants were randomly assigned to receive either tram…

This early-phase study tests a single IV dose of NGGT002 gene therapy in 15 adults with phenylketonuria (PKU), a genetic disorder that causes harmful buildup of phenylalanine. The main goal is to check safety over one year, with long-term follow-up for five years. Researchers wil…

This early-phase trial is testing a new drug called enzelkitug, alone or with standard immunotherapies, in people with advanced solid tumors that have not responded to other treatments. The main goals are to check safety, find the right dose, and see if the drug shrinks tumors. A…

This trial tests whether sodium butyrate, a short-chain fatty acid, can reduce protein in the urine and slow kidney function decline in people with IgA nephropathy, a kidney disease. Participants receive either sodium butyrate or a placebo for 12 weeks, then switch after a washou…

This trial tests whether an insomnia treatment can improve markers of heart health in adults with insomnia and risk factors for cardiovascular disease. Participants receive either a cognitive-behavioral therapy program for insomnia or a sleep education control. The study measures…

This trial tests whether adjusting the number of non-opioid pain pills or adding gabapentin can reduce opioid use after hand, wrist, or elbow surgery. Participants are randomly assigned to one of three pain medication regimens and report their pain levels and any need for extra p…

This Phase 3 study tests a drug called plozasiran in 311 adults with severe hypertriglyceridemia, a condition where blood fat levels are very high and raise the risk of pancreatitis. Participants receive four injections over a year, either the drug or a placebo. The main goal is …

This study tests a combination of three immunotherapy drugs (INCMGA00012, INCAGN02385, and INCAGN02390) in 12 adults with advanced Merkel cell carcinoma that continued to grow after standard treatment. The drugs are given by IV to help the immune system fight the cancer. The main…

This trial asks whether real-time continuous glucose monitoring (CGM) can improve blood sugar control in adults with type 2 diabetes who do not use insulin. Participants will either use a CGM device or stick to standard self-monitoring with a blood glucose meter. The study tracks…

This study is testing a minimally invasive weight loss procedure called endoscopic sleeve gastroplasty (ESG) in 12 people who have both obesity and ulcerative colitis and are planning or have had colon removal surgery. The procedure uses a suturing device to reduce stomach size b…

This study offers kidney transplant patients with antibody-mediated rejection (AMR) the chance to receive felzartamab for up to 4 more years. AMR occurs when the immune system attacks the new kidney. The main goal is to check long-term safety and monitor kidney health through bio…

This study looks at whether a special dental sealer (bioceramic) helps heal infections and reduces pain after a repeat root canal done in one visit. About 70 adults with failed root canals and silent infections in their back teeth will take part. They will get the new sealer or a…

This early study tests a new drug called ABBV-101 in people with several types of non-Hodgkin lymphoma that have come back or not responded to other treatments. The drug is a pill that targets a protein (BTK) involved in cancer growth. The main goals are to find a safe dose and s…

This trial is testing a new type of heart valve made from a material that the body absorbs over time. It is designed for children and young adults who need surgery to fix a congenital heart defect affecting the passage from the heart to the lungs. The valve is implanted during su…

This study compares two versions of the drug ocrelizumab given as a shot under the skin in people with multiple sclerosis. The goal is to see if the new test version works the same as the current one. About 182 participants with relapsing or primary progressive MS will take part.

This trial tests whether a 12-month aerobic walking program can improve cognitive processing speed and brain connectivity in adults with multiple sclerosis who have slowed thinking. Participants will be randomly assigned to one of two home-based walking programs that differ in in…

This trial tests whether an investigational drug called SHR-1314 can reduce joint pain, swelling, and skin symptoms in adults with active psoriatic arthritis. Participants receive either SHR-1314 or a placebo injection over 24 weeks, with follow-up for safety. The study aims to s…

This trial tests whether offering postpartum checkups in a mobile medical van helps new mothers attend their visits more easily than going to a clinic. About 100 women who gave birth at Women & Infants Hospital will be randomly assigned to receive their standard postpartum care e…

This study looks at whether using a CPAP machine during pregnancy can reduce the chance of developing high blood pressure disorders like preeclampsia. About 1,500 pregnant women with mild to moderate sleep apnea will be randomly assigned to use CPAP or not. The goal is to see if …

This study is a long-term follow-up for people who previously received an injection of RGX-314, a gene therapy, for diabetic retinopathy (with or without diabetic macular edema). The purpose is to monitor the safety and effectiveness of the treatment over a total of five years af…

This study tests a device called ReCET that delivers gentle electric pulses to the first part of the small intestine. The goal is to trigger cell regeneration and improve blood sugar control in people with type 2 diabetes who are not on insulin. Participants are randomly assigned…

This phase 1 trial is testing a new treatment called GD2CART for children and young adults with osteosarcoma or neuroblastoma that has returned or does not respond to standard treatments. GD2CART is made by taking a patient's own T cells (a type of immune cell), adding a new gene…

This early-stage study tests a new drug called AZD1705 in adults with high cholesterol (dyslipidemia). The main goal is to check if the drug is safe and how the body processes it. About 98 participants will receive either the drug or a placebo. This research helps determine if th…

This trial tests whether providing monthly food vouchers for farmers markets and mailed food stock boxes, alongside diabetes education, can help African American adults with type 2 diabetes and food insecurity achieve better blood sugar control. Participants are randomly assigned…

This study tests a new medicine, crovalimab, for paroxysmal nocturnal hemoglobinuria (PNH), a rare blood disease that destroys red blood cells. It involves healthy volunteers and people with PNH to check safety and how well the drug works. The goal is to control the disease, not …

This study compares two community-based programs designed to reduce heart disease risk factors—like high blood pressure and obesity—in Black women after pregnancy. About 432 Black or African American women who are early in pregnancy and have obesity or high blood pressure will ta…

This trial tests whether proglumide, an older drug that blocks a specific receptor, can safely reduce pain and slow or reverse the scarring seen in chronic pancreatitis. The study includes adults with confirmed chronic pancreatitis and compares proglumide against a placebo over 1…

This early-stage trial tests a new treatment called P-CD19CD20-ALLO1, a type of CAR-T cell therapy, for people with severe lupus that hasn't improved with standard treatments. The study will enroll 162 participants and aims to check if the therapy is safe and tolerable. It also l…

This study tests whether taking dexamethasone pills twice a week for 3 months can stop active vitiligo from spreading in children aged 4 to 9. Researchers will also monitor side effects, especially on growth and bone health. The goal is to control the disease, not cure it.

This trial investigates whether combining atezolizumab (a drug that boosts the immune system) with bevacizumab (a drug that blocks blood vessel growth) can shrink tumors in people with advanced melanoma that cannot be removed by surgery or has spread. The study focuses on patient…

This phase 3 trial tests whether adding enlicitide decanoate to the standard statin rosuvastatin lowers LDL cholesterol more than placebo in 975 adults with high cholesterol. Participants take the drugs or matching placebos for 8 weeks. The main goal is to see the percent change …

This study explores whether a very high-powered microscope can help diagnose acid reflux disease (GERD) in children by examining tiny gaps between cells in the esophagus. Researchers will compare biopsy samples from children with GERD, those with a related condition called eosino…

This Mayo Clinic study tests a new 3D MRI sequence called oZTEo, enhanced with deep learning, to detect bone erosions in the hands of people with inflammatory arthritis. The goal is to see if this advanced scan finds erosions better than standard MRI or X-rays. The study will enr…

This trial tests whether a blood-based test called KidneyIntelX can help doctors better manage patients with type 2 diabetes and early-stage chronic kidney disease. The test estimates the risk of rapid kidney function decline over five years. Researchers will see if using this te…

This trial is testing whether a diagnostic test called KidneyIntelX can help doctors better manage patients with type 2 diabetes and early-stage chronic kidney disease. The test predicts the risk of rapid kidney function decline over five years. Researchers will see if using this…

This trial tests whether a blood-based test called KidneyIntelX can help doctors better manage type 2 diabetes patients with early to moderate chronic kidney disease. The test estimates the risk of rapid kidney function decline over five years. Researchers will see if using this …

This study investigates whether a combination of skin biopsies, speech analysis, and ultra-high field 7T MRI can detect early signs of Parkinson's disease and dementia with Lewy bodies. It focuses on people with a specific type of REM sleep behavior disorder triggered by serotone…

This trial is testing a new imaging tracer called FLT, which is used with a PET scan to measure how fast tumors are growing. The study includes people with various cancers or those awaiting a biopsy for a suspicious mass. The goal is to see if FLT PET imaging can help find and di…

This study enrolls about 4,000 adults aged 60 and older with heart failure who are at high risk for ATTR amyloidosis, a rare disease that stiffens the heart. Doctors receive special training on how to spot and diagnose the condition using standard tests. The goal is to see if thi…

This study compares a self-administered oral glucose tolerance test (OGTT) at home using a continuous glucose monitor (CGM) with the standard clinic-based OGTT. 75 adults with prediabetes will undergo both tests to see if the home version accurately diagnoses blood sugar problems…

This trial tests an online program to help women who had gestational diabetes get the recommended diabetes screening and lifestyle programs after giving birth. The program includes standard health information plus optional interactive components like values reflection and persona…

This study tests a 24-week program called CoMPASS that uses rewards (contingency management) and extra support to help people who inject drugs take PrEP consistently for HIV prevention. About 526 participants with opioid use disorder will be enrolled. Those who don't stick with P…

This study will test a telehealth group prenatal care program called Centering HER in 72 low-income, predominantly Black pregnant women in Kansas who are at moderate or high risk for preeclampsia. Participants will receive routine care plus seven doula-led virtual group sessions,…

This study looks at whether long-term, high-intensity indoor cycling can slow or delay Alzheimer's-related brain changes in healthy older adults (ages 65-80) who carry the APOE ε4 gene, a known risk factor. Participants, who are currently inactive, will use a Peloton bike at home…

This study tests whether metformin, a drug used for diabetes, can prevent Alzheimer's dementia in people with mild cognitive impairment (MCI). Over 18 months, 326 overweight adults aged 55-90 with MCI will receive either metformin or a placebo. Researchers will track memory, brai…

This pilot study will test whether providing Mediterranean diet groceries plus virtual nutrition classes helps overweight adults at risk for type 2 diabetes improve their diet and lose weight. Forty participants in the US South will be randomly assigned to receive either weekly g…

This study tests whether an app-based early intervention can help reduce alcohol use and posttraumatic stress symptoms in people who have recently experienced sexual assault. Participants are randomly assigned to receive different versions of the THRIVE app, which includes activi…

This study tests whether a virtual group program called Mothers and Babies can prevent postpartum depression in immigrant Latinas who are at risk. About 300 pregnant women and new mothers will either join the program via Zoom or receive usual support services. Researchers will tr…

This study tests a co-created antenatal care program designed for busy urban clinics in Dar es Salaam, Tanzania, where climate risks like heat, flooding, and pollution add to pregnancy challenges. The program includes guidance for pregnant women and their families, provider train…

This study tests a 12-session program called Forging Hopeful Futures, designed to reduce violence among teens ages 13-19. The program uses group discussions and activities to help youth understand how racism, gender inequality, and economic injustice can lead to violence, and tea…

This study tests whether giving the antibiotic azithromycin to pregnant women and their babies during routine care can prevent stillbirths and infant deaths in Mali, a country with very high infant mortality. Over 99,000 participants are involved in this large, placebo-controlled…

This study explores whether a community-based cooking program can help African-American adults at risk for heart disease cook and eat healthier. About 43 participants from Washington, D.C. will take surveys, attend cooking classes led by a chef, and track their eating habits. The…

This trial is testing whether taking daily vitamin D3 and fish oil supplements can reduce the risk of lung problems like COPD flare-ups, asthma attacks, and pneumonia in older adults. It involves over 25,000 men and women aged 50 and older who do not have a history of cancer or h…

This trial tests whether an educational program on sustainable diet and breastfeeding, given before delivery, can increase the number of mothers who exclusively breastfeed for up to six months. The study includes 429 pregnant women and also measures the environmental impact of di…

This trial tests a stepped-care intervention for mothers of young children enrolled in Head Start. The program aims to prevent depression in those with mild symptoms and help those with more severe symptoms connect to mental health services. Researchers will measure changes in de…

This trial tests whether giving women who had gestational diabetes a continuous glucose monitor and a FitBit can help them adopt healthier habits and prevent type 2 diabetes. Participants will wear the sensor for up to 14 days and use the tracker to monitor their activity. The st…

This trial tests whether a comprehensive lifestyle program, called HELMS, can improve the health of overweight women and their children. The program starts before conception and continues through pregnancy and the first 18 months of the child's life, including health screenings, …

This trial tests whether adding recreational basketball to the standard National Diabetes Prevention Program (NDPP) helps adults aged 18-44 with prediabetes lose more weight, lower blood sugar, and become more active. Participants are randomly assigned to either the standard prog…

This study tests whether combining aerobic exercise with cognitive training, delivered via interactive 'exergames' at home, can help prevent Alzheimer's in older adults who have memory concerns but no diagnosed dementia. Participants will be randomly assigned to either an exergam…

This pilot study tests a family-based program called Modified Family Talk, designed to help prevent substance use in teenagers aged 12-18 whose parents are in recovery from substance use disorder. The program consists of six sessions over 12 weeks, aiming to strengthen family res…

This trial asks whether the type of pain relief a woman receives during labor can influence her risk of developing postnatal depression. About 10-15% of new mothers experience postnatal depression, and this study compares epidural analgesia with non-epidural options like laughing…

This study tests whether a dedicated care coordinator can help people with psoriasis or psoriatic arthritis reduce their risk of heart disease. About 520 adults aged 40-75 who do not already take cholesterol medication will receive support to manage risk factors like high cholest…

This phase 3 trial tests a single oral dose of VQW-765 versus placebo for quickly reducing acute anxiety in adults with social anxiety disorder. About 500 participants will take the drug as needed before anxiety-provoking situations. The study measures distress levels during and …

This study tests whether a daily capsule containing a heat-killed probiotic (LDL557) can improve joint discomfort and inflammation in 100 older adults with early knee or hip arthritis. Participants take either the probiotic or a placebo for a period, and researchers measure chang…

This study tests whether a virtual reality (VR) platform can help in-home dementia caregivers feel more connected and less stressed. Thirty caregivers will use the VR system to join group activities and access support with peers. The goal is to see if the platform is easy to use …

This study tests whether doing specific mouth and tongue exercises can help people with obstructive sleep apnea who cannot use a CPAP machine. Forty-five adults will be randomly assigned to real exercises, sham exercises, or unsupervised exercises for 10 weeks. The main goal is t…

This study is an extension of an earlier trial, testing the safety and tolerability of SPT-300 in 360 adults with major depressive disorder, with or without anxious distress. Participants who completed the prior study will receive SPT-300 for 6 weeks. The goal is to monitor side …

This study tests a smartphone app called StandUPTV that alerts adults after 30 minutes of evening screen time, encouraging them to stand or move. Researchers want to see if this can reduce total sitting time and improve physical activity, sleep quality, and blood sugar levels. Th…

This study tests a telemedicine program called FOCUS that helps advanced cancer patients manage common symptoms like trouble sleeping, worry, tiredness, and low mood. The program uses counseling techniques delivered through a phone app. Researchers will enroll 120 adults with adv…

This study tests a multi-family therapy program for teens aged 11–18 with anorexia nervosa and their families. The therapy brings several families together to share support and learn skills for meal support and emotional regulation. Researchers will track weight, eating disorder …

This study tests a mobile telehealth app called Brain CareNotes designed to help unpaid Hispanic caregivers manage challenging behaviors in people with Alzheimer's or related dementias. The app offers coaching and tools to handle symptoms like agitation or wandering. Researchers …

This phase 2 trial tests whether adding oxytocin nasal spray to standard psychosocial treatment can improve social skills and reduce symptoms in adults with schizophrenia spectrum disorders. Participants receive either oxytocin or a placebo spray alongside their usual therapy. Th…

This study tests a digital tool that helps parents of young children with developmental delays or disabilities organize and share their priorities with early intervention professionals. The tool, called PEM+, is designed to make family-centered care more practical by guiding fami…

This trial tests whether tocilizumab, an anti-inflammatory drug used for arthritis, can reduce pain and improve quality of life in people with chronic pancreatitis. Participants receive either tocilizumab or a placebo every four weeks for 24 weeks. The study measures changes in p…

This study tests whether a simple ear acupressure technique, called auricular point sticking therapy, can reduce anxiety and improve sleep in women undergoing IVF. 178 women aged 20-45 with anxiety or insomnia will either receive standard IVF care or standard care plus ear acupre…

This study tests a personalized workplace intervention for 124 Dutch workers with Parkinson's disease, cerebellar ataxia, hereditary spastic paraparesis, or slowly progressive neuromuscular/mitochondrial disorders. A trained facilitator helps employees and their managers identify…

This trial tests whether Written Exposure Therapy (WET), a brief six-session therapy involving guided writing about a traumatic event, can reduce PTSD symptoms in adults receiving care at Federally Qualified Health Centers. The study enrolls 720 English- or Spanish-speaking adult…

This Phase 3 trial tests whether two easy tests—measuring blood pressure changes when standing and eye reactions to light—can predict which veterans with PTSD will respond to the drug prazosin. The study involves 87 veterans and compares prazosin to a placebo. The goal is to pers…

This trial tests whether heart rate variability biofeedback—a non-invasive technique that teaches people to control their heart rhythm—can ease symptoms of functional neurological disorders (FND), a condition where the brain and nervous system don't function properly despite no s…

This trial tests whether spending time in nature can reduce anxiety in children aged 9-12 who have experienced adverse childhood events. Participants are assigned to either group nature outings, family outings, or a waitlist. The goal is to see if these nature-based activities im…

This study tests a shortened, 4-week version of dialectical behavior therapy (DBT) for 12 teens aged 14-18 who have recently harmed themselves or attempted suicide. The goal is to see if this intensive program is practical and helps reduce self-harm, suicide attempts, and depress…

This study tests whether a non-invasive magnetic brain stimulation treatment (rTMS) can improve sleep in people with chronic insomnia. About 70 adults aged 18 to 85 will receive six 25-minute sessions over two weeks. The goal is to see if insomnia severity and sleep patterns impr…

This trial tests whether blood flow restriction (BFR) training—exercising with a cuff that partially limits blood flow—can improve blood sugar control, nerve function, pain, and quality of life in people with type 2 diabetes and peripheral neuropathy. Participants will be randoml…

This study tests a program called REAL-Fam, designed to help families in rural areas manage a child's type 1 diabetes. About 16 families will either receive 12 telehealth sessions focused on diabetes routines and family participation, or just 3 basic check-in meetings. The goal i…

This study tests whether using a hand extension rubber during IV insertion can reduce pain, anxiety, and improve satisfaction. Researchers will enroll 114 adults who need an IV and randomly assign them to use the rubber or not. The goal is to see if this simple, low-cost distract…

This study explores whether Child-Parent Psychotherapy (CPP) is a practical and helpful treatment for children aged 0-6 who are in foster care and have experienced traumatic events. The therapy involves the child and their caregiver working together to reduce trauma symptoms and …

This study tests a cream called tapinarof on babies and toddlers aged 3 to 23 months with eczema (atopic dermatitis). The goal is to see if it can clear or nearly clear their skin rash. About 180 children will take part, and the cream is compared to a placebo (inactive cream) for…

This study looks at whether offering yoga or physical therapy at opioid treatment programs can help people with chronic back pain and opioid use disorder feel better and use fewer opioids. About 180 adults will be randomly assigned to 12 weeks of yoga, physical therapy, or their …

This study tests a group version of the Feeling Safe Programme, a type of cognitive behavioral therapy for people with schizophrenia or schizoaffective disorder. The goal is to reduce distressing symptoms like paranoia and hallucinations and improve quality of life. Fifty partici…

This small study tests a new treatment called TEST for people with depression that hasn't improved with standard treatments. TEST uses a lower electric current than standard electroconvulsive therapy (ECT), aiming to avoid memory and thinking problems. Eight adults aged 25-64 wil…

This trial tests whether a brief program called CALM, delivered by school nurses, can reduce excessive anxiety in children aged 5 to 12. The program teaches relaxation, facing fears, and changing anxious thoughts over eight weeks. It is compared to a relaxation-only approach and …

This trial tests a counseling program called Mpata Yathu ('Our Space') for adolescent girls and young women in Zambia who have experienced gender-based violence and may be living with or at risk for HIV. The program uses problem-solving therapy delivered by trained lay counselors…

This study is tracking 150 adults with chronic rhinitis (long-term runny nose and congestion) who are receiving treatment with the NEUROMARK device. The device uses radiofrequency energy to disrupt nerves in the nose, aiming to reduce symptoms. Researchers are collecting real-wor…

This trial tests whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can improve symptoms of functional movement disorder (FMD), a condition causing involuntary movements without a known neurological cause. Adults aged 18 to 80 with a…

This study tests two physical therapy techniques for frozen shoulder (adhesive capsulitis). About 42 adults aged 40-60 will receive either Gong's mobilization alone or with an added scapular lift. The goal is to see which method better improves shoulder movement, reduces pain, an…

This study tests an experimental oral drug called CYB003 in 220 adults with major depressive disorder. Participants receive either CYB003 or a placebo alongside their usual treatment. The goal is to see if CYB003 safely reduces depression symptoms better than placebo.

This study compares two internet-based cognitive behavioral therapies for people with generalized anxiety disorder. 400 adults will receive one of two 10-week online programs, guided by a psychologist. The goal is to see which therapy reduces anxiety more and whether they work by…

This study tests whether a 10-week program called Positive Minds, Strong Joints is feasible for Black adults aged 50 and older with knee osteoarthritis. The program combines recommended exercise with mental health strategies to address pain, depression, and anxiety. Researchers w…

This study tests a personal health app called MS FIT that lets people with multiple sclerosis log falls and near-falls, view their health data, and share it with their doctor. The goal is to improve communication about fall risks and provide educational tips. About 100 participan…

This study tests an experimental drug called barzolvolimab in adults with moderate to severe atopic dermatitis (eczema). The goal is to see if it can reduce itching and improve skin condition compared to a placebo. About 131 participants will receive either a low dose, high dose,…

This study tests whether using a special augmented reality (AR) game called Little NIRVANA, along with numbing cream, can help children ages 2 to 8 feel less pain and anxiety when getting an IV in the emergency room. About 130 kids will be randomly assigned to get either the AR g…

This study tests whether atorvastatin, a drug typically used for cholesterol, can reduce bile acid production and improve symptoms in people with bile acid diarrhoea (BAD). Twenty adults with moderate-to-severe BAD will receive atorvastatin and a placebo in random order, each for…

This phase 2 trial is testing whether a dissolvable film containing dexmedetomidine (BXCL501) can safely and effectively reduce agitation in adult ICU patients who have delirium. The study will compare four different starting doses of the drug against a placebo to find the best b…

This study tests whether an 8-week arts-based storytelling workshop can improve social connection, identity, and emotional well-being in adolescents and young adults with diabetes. Ten participants aged 16-25 will attend weekly sessions involving writing, drawing, and group discu…

This study tests an experimental drug called RAP-219 for people with bipolar I disorder who are currently experiencing a manic episode. About 250 participants will receive either RAP-219 or a placebo daily for 21 days. Researchers will measure changes in manic symptoms using a st…

This study explores whether a type of improvised music, designed with calming sound parameters, can reduce anxiety in people with Alzheimer's disease and in healthy adults. Researchers will measure changes in anxiety scores, blood pressure, and heart rate before and after listeni…

This study tests a remote education program called REST, designed to help adults aged 65 and older with insulin-treated diabetes start and keep using continuous glucose monitors (CGMs). The goal is to reduce dangerous low blood sugar episodes and improve overall glucose control. …

This study tests whether a nerve block given before surgery (TAP block) works as well as numbing medicine injected into the wound by the surgeon for controlling pain after gynecologic cancer surgery. About 80 women having surgery through a vertical belly cut will take part. The g…

This study is testing whether two dietary supplements, urolithin A and fisetin, can improve sleep quality and reduce signs of aging in middle-aged and older adults. Eighty participants aged 30-75 with poor sleep will take one of the supplements, a combination, or a placebo daily …

This study is testing whether an online course can help people with multiple sclerosis, long COVID, fibromyalgia, or cancer-related fatigue adopt healthier diets and self-care habits. Researchers will measure changes in quality of life, fatigue, and mental health. The goal is to …

This study tested a school-based program called Proud & Empowered, designed to help LGBTQ students cope with minority stress and improve mental health. About 228 high school students took part. The program was led by school counselors and social workers. The study was terminated …

This study tests whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can improve memory in older adults with mild cognitive impairment or subjective memory complaints. About 70 participants will be randomly assigned to receive either …

This study is testing whether a smartphone app, combined with nicotine patches, can help people reduce or quit smoking. The app guides users to smoke on a schedule and tracks their progress. The study involves 56 adult smokers who smoke at least 10 cigarettes a day. The goal is t…

This study tests an oral medication called MM120 against a placebo in adults with major depressive disorder. The trial has two parts: a 12-week blinded phase followed by a 40-week open-label extension where everyone gets MM120. The main goal is to see if MM120 reduces depression …

This study tests an oral medication called MM120 against a placebo in 245 adults with generalized anxiety disorder. Participants take the drug or placebo for 12 weeks, and those who complete may join a 40-week follow-up where everyone gets the active drug. The goal is to see if M…

This trial tests whether a virtual reality (VR) educational video can reduce anxiety and improve satisfaction in adults starting their first course of external beam radiotherapy for cancer. Half of the 122 participants will watch a VR video through a headset before treatment, whi…

This trial tests whether listening to music for 30 minutes before and after surgery can reduce pain, anxiety, and the need for painkillers in women undergoing gynecologic surgery. Participants will choose from several music genres and report their pain, anxiety, and satisfaction …

This study tests an online pathway called iPath*D that guides cancer patients who report depression symptoms from screening to treatment options. The goal is to see if the tool is acceptable and easy to use for adults starting cancer treatment. Researchers will measure usability,…

This trial tests whether nurse-guided breathing exercises can reduce shortness of breath and anxiety in people with advanced heart failure who come to the emergency department. Participants are randomly assigned to receive either standard care plus guided diaphragmatic and pursed…

This trial tests whether using virtual reality (VR) relaxation before and after gynecologic surgery can reduce anxiety and pain. About 220 women undergoing day or inpatient gynecologic procedures will either use a VR headset with calming scenes or receive standard care. Researche…

This study tests whether a 10-week internet-based cognitive behavioral therapy program can improve quality of life and reduce ADHD symptoms in adults. Two hundred adults in Sweden who have been diagnosed with ADHD and are working or studying will be randomly assigned to either th…

This trial tests whether giving older adults with diabetes and other chronic conditions audio recordings of their clinic visits helps them take a more active role in their own care. Participants either receive these recordings for a year or standard after-visit summaries. The stu…

This study tests whether a treatment called IVIG (intravenous immunoglobulin) can help with ongoing neurological symptoms after COVID-19, like dizziness, trouble walking, or memory problems. About 45 adults who had COVID-19 at least 12 weeks ago will receive either IVIG or a plac…

This study tests whether a 12-week mobile app program can improve thinking skills and motivation in people with early psychosis. About 400 participants already receiving coordinated specialty care will either use the app or continue standard care. Researchers will track changes i…

This study is testing the long-term safety of a drug called ML007C-MA for people with Alzheimer's disease who also have hallucinations and delusions. About 210 adults who completed a previous study will take the drug twice daily for up to 52 weeks. The goal is to see if the drug …

This study tests whether mild electrical stimulation of the ear, combined with physical and speech therapy, can improve symptoms like voice problems, swallowing, and balance in people with Parkinson's disease. 46 participants will receive either active or sham stimulation during …

This study tests new versions of Clareon Vivity Pro intraocular lenses (IOLs) to see if they improve vision better than current lenses. About 231 adults with cataracts in both eyes will receive one new lens and one current lens to compare results. The main goal is to measure how …

This early-stage study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can safely help autistic adults with depression that hasn't improved with other treatments. Twenty participants will receive two doses of psilocybin along with ab…

This study tests whether two simple, drug-free techniques can ease the pain, fear, and crying that 9-month-old babies often experience during routine vaccinations. One method uses a small bee-shaped device called Buzzy, which vibrates and cools the skin near the injection site. T…

This study is testing whether a daily practice of Tao Calligraphy meditation and drinking so-called 'energized water' can improve symptoms of unipolar depression in adults. Fifty participants will be split into two groups to compare the effects over 12 weeks. The goal is to see i…

This study tests two treatments for tennis elbow (lateral epicondylitis) in 60 adults aged 18-65. One group gets ultrasound-guided dry needling, the other gets shock wave therapy, both once a week for five weeks. Everyone also does a home exercise program. The goal is to see whic…

This study tests whether a special hat with built-in goggles can make phototherapy more comfortable for full-term newborns with jaundice, compared to standard eye patches. Researchers will measure the babies' comfort levels, bilirubin changes, treatment duration, and parental sat…

This study tests whether a non-invasive magnetic brain stimulation technique, called rTMS, can help ease depression in people with Parkinson's disease. Fifty adults with mild to moderate depression will be randomly assigned to receive either real rTMS or a sham (fake) treatment f…

This study tests whether a smartphone app called AIM+ can help juvenile justice officers and other professionals who work with youth in the legal system manage chronic stress, anxiety, and burnout. Over 30 days, participants use the app for short guided meditations and videos. Th…

This study looks at whether a digital version of the classic clock-drawing test can help identify older adults at higher risk for confusion or memory issues after surgery. Researchers will analyze data from thousands of patients aged 65 and older who take the test before an opera…

This study looks at the genetic and molecular factors behind type 2 diabetes, obesity, and related complications like kidney disease. Researchers will collect health information, blood and urine samples, and perform tests like eye exams and ultrasounds from over 2,300 adults, foc…

This study is testing whether a blood test that looks for tumor DNA can help doctors decide when to safely stop immunotherapy in people with advanced melanoma or non-small cell lung cancer. About 39 patients who have been on immunotherapy for at least a year and show no signs of …

This study from the University of Pittsburgh is looking at how well people recover after total knee replacement surgery. It compares two types of surgery: one done with a robot's help and one done by hand. Researchers will follow 30 people who are already scheduled for knee repla…

This study tests a smartphone app designed to help adults taking GLP-1 medications for obesity or type 2 diabetes eat better. About 50 participants will use the app for 6 weeks to track their diet and learn about nutrition. The goal is to see if the app is helpful and easy to use…

This study looks at whether taking extra random biopsies during a colonoscopy helps find precancerous growths in people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. About 1,600 participants will be randomly assigned to one of two biopsy…

This study tracks 80 adults with different smell disorders (like total loss, partial loss, or distorted smell) plus healthy volunteers over one year. Researchers use brain scans, smell tests, and questionnaires to see how the brain changes and how smell loss impacts mood and dail…

This study collects and analyzes blood, DNA, and tissue samples from 315 adults with pulmonary fibrosis, their relatives, and healthy volunteers. The goal is to learn more about the disease's causes, not to test a new treatment. Researchers hope the findings will guide future the…

This study follows up to 500 people with acute or chronic inflammatory disorders, such as infections or immune problems, over time. Researchers will monitor participants with standard tests and may screen them for other studies. The goal is to better understand these conditions a…

This study follows over 64,000 adults who grew up on farms to see if early exposure to pesticides and other agricultural factors is linked to cancer. Participants fill out an online questionnaire and may provide biological samples. Researchers will track their health over many ye…

This study tests a new interview tool called the Opioid Timeline Follow-Back (OpiTLFB) to better track nonmedical opioid use, including fentanyl. Thirty adults who use opioids at least once a week will fill out a calendar and answer questions about their drug use over the past 30…

This study investigates the link between autism and physical symptoms like gastrointestinal issues, autoimmune diseases, and heart problems. Researchers will compare autistic individuals, people with anxiety or depression, and healthy controls to understand how these symptoms are…

This study looks at whether transcranial magnetic stimulation (TMS) can change how people with opioid use disorder and healthy volunteers make risky or uncertain decisions. Participants will have MRI scans and computer tasks, and some will receive real or sham TMS. The goal is to…

This study follows 46 people with gyrate atrophy, a rare genetic condition that causes vision loss, over 4 years. Researchers measure ornithine levels in the blood and track changes in the retina using eye scans and photos. The goal is to learn how the disease progresses under st…

This study uses MRI scans to look at the brains of children and adults with conditions like ADHD, autism, schizophrenia, and endocrine disorders, as well as healthy volunteers. Researchers aim to compare brain anatomy and function across different groups and ages. The goal is to …

This study tests a program called Individual Placement and Support for Autism (IPS-AUT) to help autistic adults ages 18-40 find and keep competitive jobs. Researchers will work with employment agencies to train staff and track job outcomes, satisfaction, and thinking skills. The …

This study looks at people and families who have a high risk of cancer to learn what genes and environmental factors might increase that risk. Over 5,000 participants are followed over time with questionnaires, medical records, and optional genetic testing. No treatment is given,…

This study aims to test a new assessment tool called the ANA, which uses surveys and computer tasks to measure three key brain functions related to addiction. Researchers will study 1,400 adults with alcohol use disorder to see how these brain functions relate to drinking behavio…

This study looks at whether measuring the arm or finger can help choose the right blood pressure cuff size for pregnant women. Accurate blood pressure readings are vital during pregnancy and childbirth, but the current method of sizing cuffs may not always be correct. Researchers…

This study follows 1,000 adults aged 50 and older to see how the health of their heart and blood vessels relates to early signs of Alzheimer's disease and brain aging. Researchers will use brain scans, memory tests, and blood or spinal fluid samples to look for connections betwee…

This study follows children from kindergarten through first grade to understand how brain networks involved in reading, math, and executive function (thinking skills like attention and planning) interact to predict academic outcomes. Researchers will also see if these brain and c…

This program collects brain and other tissue samples from adults, including healthy individuals and those with memory disorders, to support research on Alzheimer's disease. Participants are typically enrolled in affiliated studies or approved on a case-by-case basis. The goal is …

This study investigates whether children with Wilson's disease, who appear to have normal heart function, may actually have subtle heart problems. Using advanced echocardiography, ECG, and a blood test for a heart stress marker, researchers will compare these children to healthy …

This study follows 1,500 volunteers with normal memory, mild cognitive impairment, or Alzheimer's over several years. Researchers use brain scans, memory tests, and blood samples to track how the disease progresses. The goal is to find better ways to diagnose and treat Alzheimer'…

This study looks at a program called the Collaborative Behavioral Health Program (CBHP) for treating depression in primary care. The program brings together primary care doctors, behavioral health managers, and psychiatrists to work as a team. Researchers will track how well the …

This study looks back at dental implant cases to see if bone-related conditions—like vitamin D deficiency, calcium problems, or kidney disease—make implant failure more likely. Researchers will compare 192 failed implants with successful ones from similar patients. The goal is to…

This study tests a new program called M-HARP that helps new mothers get health screenings and referrals during their baby's regular doctor visits. About 150 women in the Dominican Republic will take part. The goal is to see if this approach makes it easier for moms to get postpar…

This study investigates whether people with type 2 diabetes who have or are at risk for chronic kidney disease produce too much aldosterone, a hormone that regulates salt and blood pressure. Participants undergo several suppression tests—including oral sodium, saline infusion, an…

This study follows 25 people with spinocerebellar ataxia type 7 (SCA7) for up to 5 years to learn how the disease changes vision, coordination, and thinking. Participants will have yearly eye exams, brain scans, and neurological tests. No treatment is given; the goal is to gather…

This study looks at health records from over 780,000 people with type 2 diabetes to compare four common second-line medications: SGLT2 inhibitors, GLP-1 receptor agonists, DPP-4 inhibitors, and sulfonylureas. The goal is to see which drug class is most effective at preventing hea…

This long-term study looks at people and families with a higher chance of developing blood or lymph node cancers like leukemia or lymphoma. Researchers collect medical histories, genetic samples, and sometimes perform exams to find inherited genes or environmental triggers. The g…

This study aims to understand why some women get recurrent vaginal yeast infections (vulvovaginal candidiasis) and others don't. Researchers will compare the vaginal microbiome, immune markers, and metabolic profiles of women with and without the infection. By identifying key dif…

This registry study follows 500 adults with obstructive sleep apnea who are prescribed a mandibular advancement device (MAD) — a dental appliance worn at night to keep the airway open. Researchers will track how the device is prescribed, how often patients actually use it, and wh…

This study follows 121 adults who have been cured of chronic hepatitis C to understand why some still develop liver complications like scarring or cancer. Participants are monitored for up to 10 years with regular tests, scans, and occasional liver biopsies. The goal is to learn …

This study collects white blood cells and tumor cells from cancer patients, and white blood cells from healthy volunteers, to help researchers grow anti-cancer cells in the lab. The goal is to create experimental cell therapies for future use. Up to 7,000 participants will provid…

This study is screening 115 underserved children and adults who are at risk for type 1 diabetes or celiac disease. Researchers will use blood tests to find early signs of these conditions, aiming to improve how we detect them. The goal is to catch these diseases sooner, especiall…

This observational study is looking at a protein called neurofilament light chain (NfL) in the blood of people who carry a gene variant for hereditary ATTR amyloidosis, both those without symptoms and those with nerve damage. Researchers want to see if NfL levels can help detect …

This study looks at how much of the multiple sclerosis drug ofatumumab gets into breast milk. About 24 women with relapsing MS who are breastfeeding and starting or restarting ofatumumab will provide milk samples. The goal is to measure drug concentrations, which may help guide f…

This study aims to find out how many pregnant women in Slovenia use alcohol or cannabis by testing their newborns' first stool (meconium) and asking mothers to fill out a survey. Researchers will also compare the gut bacteria of babies exposed to these substances with those who w…

This study watches how people with eosinophilic esophagitis (EoE) use the medicine Dupixent in everyday care. Researchers will collect information from about 350 patients to learn more about the disease and how treatment affects symptoms and quality of life. No new treatments are…

This study explores whether people with plantar fasciitis—a common cause of heel pain—show differences in spinal posture, balance, and core muscle endurance compared to healthy individuals. Researchers will measure these factors in adults aged 18 to 50 with and without the condit…

This study follows 100 adults who drink alcohol at least weekly and have some interest in cutting back. Researchers want to see how alcohol use, suicidal thoughts, and decision-making are linked. Participants get access to a self-guided online cognitive behavioral therapy program…

This study looks at how social media and AI-generated beauty standards influence anxiety about appearance in people planning cosmetic surgery. Researchers will survey 145 adults before their procedure to measure social media habits, attitudes toward AI beauty ideals, and social a…

This study aims to find out how often cancer patients treated with opioids for pain are at risk of misusing these medications. Researchers will use two screening questionnaires to assess misuse risk in 200 adult outpatients receiving opioids for cancer-related pain. The findings …

This study analyzes health records from over 547,000 people in France who started taking SGLT2 inhibitors for type 2 diabetes between 2020 and 2024. Researchers will describe patient characteristics, prescription patterns, and track the occurrence of heart attacks, strokes, heart…

This pilot study tests whether daily, at-home stimulation of a nerve in the ear can change brain activity in people with inflammatory bowel disease (IBD) who are in remission. Fifteen adults with Crohn's disease or ulcerative colitis will use a small device for 28 days and underg…

This study follows people diagnosed with uveal melanoma, a rare eye cancer, over time to document the disease's natural course. Researchers will collect data on how the cancer progresses, including survival rates and whether it spreads. The goal is to build a detailed registry th…

This study follows 60 adults getting hip or knee replacement to track their sleep before and up to 6 months after surgery. Participants use a special device and app to measure sleep quality, pain, and recovery. The goal is to learn when sleep returns to normal so doctors can give…

This study uses PET imaging to measure two key proteins in the brain—amyloid and tau—that are hallmarks of Alzheimer's disease. Researchers will follow 120 participants over five years, including people with normal aging, mild cognitive impairment, and dementia, to see how these …

This study tests whether seeing a picture of a supportive friend or family member helps people with social anxiety unlearn fear more effectively. Researchers will compare fear responses in 100 participants (50 with social anxiety, 50 healthy) after pairing threatening cues with e…

This study follows about 2,200 mothers and their children in Cox's Bazar, Bangladesh, including Rohingya refugees and local families. Researchers want to understand how growing up in conflict and displacement affects child development and mental health. They are also looking at w…

This study looks at how parents of autistic young people (ages 12-18) with anorexia nervosa make sense of a group intervention designed for them. Researchers want to understand how parents interpret the concepts from the group and apply them to daily family life, and how they see…

This study looks at whether seeing a picture of a supportive person can help people with social anxiety feel less afraid. Researchers will compare 50 healthy adults and 50 adults with social anxiety disorder. Participants will learn to associate a neutral image with a mild electr…

This study looks at how dupilumab changes the way the nose and blood respond to house dust mites in adults with allergic asthma. Participants will be exposed to dust mites in a special chamber and receive either dupilumab or a placebo. The goal is to understand the drug's effects…

This study tests a video-based mobile app designed to reduce mental health stigma and medical mistrust among Black adults with moderate to severe depression or anxiety. Participants watch personal stories from others with similar experiences. The goal is to see if this approach i…

This study tests whether a standard nutrition screening tool, called PYMS, can accurately identify children with Crohn's disease or ulcerative colitis who are at risk of malnutrition. Researchers will use the tool on 2,000 children aged 4–18 with IBD in outpatient and inpatient c…

This observational study follows about 2,400 people with relapsing-remitting multiple sclerosis (MS) across Germany for up to six years. It asks whether loss of volume in the thalamus—a deep brain region—tracks with worsening disability, measured by the EDSS scale. Using standard…

This study looks at whether improving sleep can help overweight or obese African Americans who don't get enough exercise become more active. About 28 people will try a sleep program either before or after a physical activity program. The goal is to see if this approach is practic…

This study investigates whether people with neurodegenerative diseases—like Alzheimer's, Parkinson's, or ALS—show changes in behavior, social circumstances, or health before and after their diagnosis. Researchers will compare the records of over 61,000 patients with those of matc…

This study tests whether coaching or communication classes for primary care clinicians can improve patient satisfaction scores and reduce clinician burnout. About 45 Mayo Clinic providers will take part, filling out questionnaires before, right after, and two months after the tra…

This study follows 2,000 adults aged 45-75 in Pennsylvania to better understand why some groups have higher heart disease risk. About 800 participants at higher risk will receive either usual care or a personalized program with nutrition, exercise, and stress management advice. T…

This study tests a new imaging tracer called [18F]fluortriopride to see if it can clearly show D3 dopamine receptors in the brain. Researchers will compare brain scans from healthy volunteers and people with cocaine dependence, and also check how consistent the tracer's signals a…

This observational study explores whether levels of a protein called soluble CD163 in blood or urine can reflect how active IgA nephropathy is and how it might progress. Researchers will compare these levels among people with IgA nephropathy, those with a similar kidney condition…

This study looks at how people use their sense of hearing versus physical feeling when they speak. Healthy adults aged 18 to 45 will do speech tasks with altered audio feedback, sometimes with a visual display. Researchers will use a computer model to see if individual difference…

This study looks at how continuous positive airway pressure (CPAP) therapy affects body signals like oxygen levels, heart rate, and breathing in adults with obstructive sleep apnea. Researchers will analyze data from 160 people who completed a previous trial, comparing signals be…

This study follows 1,000 patients in China who are already receiving faricimab for diabetic macular edema, retinal vein occlusion, or wet age-related macular degeneration. Researchers will collect data from routine clinic visits over one year to see how well the drug works and ho…

This observational study follows 367 adults with relapsing multiple sclerosis who are taking cladribine tablets (Mavenclad) in routine care. Researchers want to find out which patient characteristics predict how long people stay on the drug and how well it works. The goal is to h…

This study looks at balance and movement problems in people with stroke, Parkinson's disease, or multiple sclerosis. Researchers will use special devices to measure how well participants can keep their balance and walk. The goal is to learn more about these issues so that rehabil…

This study tests a program called SHIFT2 that helps teens and young adults with type 1 diabetes prepare for the switch from pediatric to adult medical care. Participants work with a transition coach and receive messages to encourage self-management. The goal is to see if this sup…

This study looks at whether long (over 5 days) or compulsory psychiatric hospital stays affect self-harm and suicide in people with borderline personality disorder. Researchers will compare clinics across Sweden that use these practices more or less often, tracking outcomes like …

This study is looking at why some people develop persistent pain after breast cancer surgery while others do not. Researchers will follow 220 adults undergoing breast cancer surgery, using questionnaires and a pain sensitivity test to identify risk factors. The goal is to find re…

This study is testing a new physical therapy protocol for people over 50 who have had arthroscopic rotator cuff surgery. Researchers will track shoulder function, pain levels, and sleep quality over the recovery period. The goal is to gather better evidence on what helps patients…

This study looks back at data from nearly 49,000 births to see if epidural or spinal pain relief during labor is linked to infections in mothers or newborns. Researchers will compare women who had this type of pain relief with those who didn't, checking for fevers, chorioamnionit…

This observational study follows about 198 patients in Spain who are already taking inclisiran (Leqvio) for high cholesterol linked to heart disease or a genetic condition. Researchers will check if patients reach their LDL cholesterol goals after 6 and 12 months. The goal is to …

This study evaluates a sensor-based version of the Timed Up and Go test (QTUG) for measuring balance and predicting fall risk in older adults with dizziness (vestibulopathy). Researchers will compare QTUG results with other balance tests, track whether a six-month vestibular reha…

This study follows children aged 6 to 17 with active juvenile enthesitis-related or psoriatic arthritis who are being treated with secukinumab. Researchers will track how long children stay on the drug, how much their symptoms improve, and whether they achieve remission. The goal…

This study aims to understand how genes affect obesity, diabetes, and heart disease in people of African ancestry. Researchers will collect blood samples and health information from 1,100 adults, including African Americans, Afro-Caribbeans, and migrants from sub-Saharan Africa. …

This study follows thousands of medical interns through their first year of residency—a time of intense, predictable stress—to see how genes and stress together might trigger depression. By tracking mood and genetic markers over 12 months, researchers hope to untangle why some pe…

This study is testing a new video game designed to help teenagers with congenital heart disease learn how to manage their own healthcare. The game teaches skills like talking to doctors, understanding medical information, and keeping track of appointments and medications. About 1…

This study follows about 955 people aged 12 and older who are starting treatment with Dupixent (dupilumab) for atopic dermatitis, commonly known as eczema. The goal is to see how the drug performs in everyday clinical practice, not just in controlled trials. Researchers will trac…

This study tracks 585 patients with familial or regular high cholesterol who are already prescribed Leqvio. Researchers will monitor side effects and cholesterol levels over time to see how safe and effective the drug is in everyday use. No new treatment is given—it's purely obse…

This study follows people with Phelan-McDermid syndrome, a rare genetic condition linked to autism and intellectual disability, to map how the syndrome unfolds over two years. Researchers will measure changes in thinking, behavior, language, and motor skills, and use brain imagin…

This study will use brain scans to see how cannabis affects inflammation and brain activity in up to 100 U.S. military veterans with PTSD and suicidal thoughts. Participants will take cannabis for 12 weeks and have PET and MRI scans before and after. The goal is to link brain cha…

This study collects tissue and blood samples from 1,200 adults with known or suspected cancer. The samples are taken during standard surgeries or biopsies, with no extra procedures. Researchers will compare cancerous and normal tissues to identify differences that could lead to n…

This study investigates whether certain progesterone receptors in the placenta are linked to gestational diabetes, a type of diabetes that develops during pregnancy. Researchers will compare placental tissue from women with gestational diabetes to tissue from healthy pregnant wom…

This study uses stem cell technology to create brain cells from people with anorexia nervosa and compare them to cells from healthy individuals. The goal is to understand how specific brain cells, called hypothalamic neurons and microglia, function differently in anorexia. By pro…

This study aims to improve how doctors communicate with patients facing serious illnesses like cancer, heart failure, COPD, or dementia. Researchers will give doctors detailed feedback on their conversations about goals of care. The goal is to help patients receive care that matc…

This study is not testing a new treatment. Instead, it follows people who already received experimental cell therapies (like growing immune cells from their tumors or blood) in earlier NCI Surgery Branch trials. The goal is to monitor their health for up to 15 years, as required …

This study explores whether a brief, moderate-intensity walk can alter brain function and blood flow in people with multiple sclerosis. Participants will undergo MRI scans before and after either treadmill or overground walking at a brisk pace. The goal is to see if even a single…

This study follows individuals with autism who carry a PTEN gene mutation, along with comparison groups, to track changes in thinking, language, and behavior over time. Researchers will also collect blood samples and medical data to build a large database for future studies. The …

This study investigates whether advanced brain imaging and electrical recordings can predict the presence and severity of autism spectrum disorder (ASD) and intellectual disability (ID) in people with tuberous sclerosis complex (TSC). Researchers will follow participants over tim…

This study tested a program that screens older adults (60+) for memory and thinking problems after they leave the intensive care unit (ICU). The goal was to see if it's possible to identify issues like mild cognitive impairment or dementia early. 109 people took part, and the stu…

This study looks back at medical records of 50 adults who had a shingles virus infection in their brain or spinal cord. Researchers want to find out what makes some people more likely to get these serious infections and what leads to long-term problems like memory loss or seizure…

This study looks at how physical, psychological, and movement-related factors work together in adults with chronic knee pain. By tracking these factors over time, researchers hope to understand why pain experiences differ between people. The goal is to develop practical tools tha…

This study aims to understand how insulin deprivation and high blood sugar affect protein synthesis in muscles and blood of people with type 1 diabetes. Researchers will use muscle biopsies and special amino acid labels to track protein production. The study involves 70 participa…

This study investigates why some people are more susceptible to melanoma, a type of skin cancer. Researchers will compare the genes and sun exposure histories of people who have had multiple melanomas, those with a single melanoma, and similar people without melanoma. By analyzin…

This study looks at how what people eat relates to heart health, gut bacteria, sleep quality, and thinking skills in Singapore adults aged 21 to 80. Participants will keep a food diary and provide blood and stool samples to measure things like blood pressure, cholesterol, blood s…

This study looks at how doctors trust artificial intelligence (AI) when it estimates a baby's weight during pregnancy. Over 300 clinicians will review ultrasound cases and choose between AI-based or traditional weight estimates. Some doctors will also see how reliable the AI is. …

This study is testing whether functional MRI brain scans can predict and track how well children and teens with obsessive-compulsive disorder (OCD) respond to a type of therapy called Exposure and Response Prevention (ERP). Thirty participants aged 10 to 17 will receive 14 weekly…