New hope for lung scarring: buloxibutid trial underway

NCT ID NCT06588686

Ongoing Disease control Sponsor: Vicore Pharma AB Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 15, 2026 · Updated 3 times

Summary

This Phase 2 trial tests an oral drug called buloxibutid in 378 people with idiopathic pulmonary fibrosis (IPF), a lung-scarring disease. Over 52 weeks, researchers compare two doses of buloxibutid against a placebo to see if it can slow lung function decline. The study is double-blind, meaning neither participants nor doctors know who gets the real drug.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: buloxibutid
What this could lead to: If successful, buloxibutid could offer a new oral treatment option to slow lung function decline in people with idiopathic pulmonary fibrosis.
What could go wrong: This is a Phase 2 trial, so results are still early. The drug may not prove effective or safe over the long term, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

idiopathic pulmonary fibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IDIOPATHIC PULMONARY FIBROSIS (IPF)

Contacts and locations

Show contact details

Locations

"Sotiria" Chest Diseases Hospital of Athens

Athens, 11527, Greece
Allergology- Pulmunology Outpatient Clinic Alergopneuma, Pulmonology Outpatient Clinic

Świdnik, 21-040, Poland
Asan Medical Center

Seoul, 05505, South Korea
Austin Hospital

Heidelberg, VIC 3084, Australia
Baylor Scott & White Research Institute

Dallas, Texas, 75246, United States
Belgrano Clinical Research Center

Buenos Aires, C1028AAP, Argentina
Breathe Comprehensive Clinical Health

Godoy Cruz, 5501, Argentina
CEMER Medical Center for Respiratory Diseases

Buenos Aires, 1602, Argentina
CINME - Metabolic Research Center

Buenos Aires, C1056ABI, Argentina
China Medical University Hospital

Taichung, 404327, Taiwan
Cleveland Clinic - Cleveland, Department of Pulmonary Medicine

Cleveland, Ohio, 44195, United States
Clinical Research Centre Respiratory Medicine

Frankfurt am Main, Hesse, 60596, Germany
Clinical Research Specialists

Kissimmee, Florida, 34746, United States
Concord Repatriation General Hospital, Department of Respiratory Medicine

Concord, NSW 2139, Australia
Diex Research Trois-Riviere Inc.

Trois-Rivières, Quebec, G9A 4P3, Canada
Dr. Jose Eleuterio Gonzalez Monterrey University Hospital

Monterrey, Nuevo León, 64460, Mexico
El Paso Pulmonary Association

El Paso, Texas, 79902, United States
Emory Saint Joseph's Hospital

Atlanta, Georgia, 30342, United States
Emphysema Foundation, Pneumology

Mar del Plata, 7600, Argentina
Endeavor Health - Evanston Hospital

Evanston, Illinois, 60201, United States
Erasme Hospital

Brussels, 1070, Belgium
Far Eastern Memorial Hospital

New Taipei City, 220, Taiwan
Flinders Medical Centre

Adelaide, SA 5042, Australia
Foundation PTV - Polyclinic Tor Vergata

Roma, 00133, Italy
General Hospital of Chest Diseases "Sotiria" 5th Pulmonology Department

Athens, 11527, Greece
General Hospital of Thessaloniki "G. Papanikolaou", University Department of Pulmonology

Thessaloniki, PC 57010, Greece
Guy's Hospital

London, SE1 9RT, United Kingdom
Hannover Medical School, Center for Internal Medicine

Hanover, Lower Saxony, 30625, Germany
Hanyang University - Myongji Hospital

Goyang-si, 10475, South Korea
Homerton University Hospital

London, E9 6SR, United Kingdom
Hospital Penzing, Department of Respiratory and lung diseases

Vienna, 1140, Austria
IMER Respiratory Medicine Institute

Córdoba, X5003DCE, Argentina
IRCCS Policlinic Hospital San Martino

Genoa, Liguria, 16132, Italy
Ibamedica

Santa Fe, 3000, Argentina
Immenhausen Lung Hospital

Immenhausen, Hesse, 34 376, Germany
InJe University Busan Paik Hospital

Busan, 47392, South Korea
InJe University Haeundae Paik Hospital

Busan, 48108, South Korea
InnovaCiencia

Rosario, S2000, Argentina
Integral Health Medical Unit

San Nicolás de los Garza, Nuevo León, 66465, Mexico
Kaohsiung Chang Gung Memorial Hospital

Kaohsiung City, 833401, Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital

Kaohsiung City, 807377, Taiwan
Keck Medicine of University of Southern California

Los Angeles, California, 90033, United States
Kelowna Respiratory & Allergy Clinic

Kelowna, British Columbia, V1W 1V3, Canada
Kepler University Hospital GmbH, Department of Pulmonology

Linz, Upper Austria, 4021, Austria
Korea University Anam Hospital

Seoul, 02841, South Korea
Local Healthcare Company Papa Giovanni XXIII (ASST Papa Giovanni XXIII)

Bergamo, 24127, Italy
Low Country Lung and Critical Care

North Charleston, South Carolina, 29406, United States
Lung Research Victoria

Footscray, Victoria, 3011, Australia
MICS Medical Centre Bydgoszcz

Bydgoszcz, 85-065, Poland
Massachusetts General Hospital, Pulmonary & Critical Care Medicine

Boston, Massachusetts, 02114, United States
Medical Center Dra. De Salvo

Buenos Aires, C1426ABP, Argentina
National Cheng Kung University Hospital

Tainan, 704302, Taiwan
National Institute of Respiratory Diseases Ismael Cosio Villegas (INER)

Mexico City, Mexico City, 14080, Mexico
National Jewish Medical and Research Center

Denver, Colorado, 80206, United States
National Taiwan University Hospital

Taipei, 100225, Taiwan
Norbert Barlicki University Clinical Hospital in Lodz Departament of Pneumology and Allergy

Lodz, 90-153, Poland
Oaxaca Site Management Organization S.C - (Osmo)

Oaxaca City, 68000, Mexico
Oregon Clinic, Pulmonary, Critical Care & Sleep Medicine East

Portland, Oregon, 97220, United States
Oxford University Hospitals NHS Trust

Oxford, OX3 9DU, United Kingdom
Paradigm Clinical Research

San Diego, California, 92108, United States
Paradigm Clinical Research Centers, Inc.

Redding, California, 96001, United States
Queen Elizabeth Hospital Birmingham

Birmingham, B15 2TH, United Kingdom
Renown Clinical Research

Reno, Nevada, 89502, United States
Research Institute of Respiratory Diseases

San Miguel de Tucumán, Tucumán Province, 4000, Argentina
Royal Brompton Hospital

London, SW3 6NP, United Kingdom
Royal Devon and Exeter Hospital

Exeter, EX2 5DW, United Kingdom
Royal Prince Alfred Hospital

Sydney, NSW 2050, Australia
RuhrlandClinic - Lung Center

Essen, North Rhine-Westphalia, 45122, Germany
Salzburg Regional Hospital, Department of Pneumology/Respiratory Medicine

Salzburg, 5020, Austria
Samsung Medical Center

Seoul, 06351, South Korea
San Gerardo of Tintori IRCCS Foundation

Monza, 20900, Italy
Seoul National University Hospital

Seoul, 03080, South Korea
Severance Hospital, Yonsei University Health System

Seoul, 03722, South Korea
Soon Chun Hyang Central Medical Center

Bucheon-si, 14584, South Korea
Soon Chun Hyang University Hospital Seoul

Seoul, 04401, South Korea
Southeastern Research Center

Winston-Salem, North Carolina, 27103, United States
St Vincent's Hospital, Sydney Ltd.

Darlinghurst, NSW 2010, Australia
StatCare - Bearden

Knoxville, Tennessee, 37919, United States
Stony Brook University

Stony Brook, New York, 11794, United States
Summit Health - Bend

Bend, Oregon, 97201, United States
Taipei Veterans General Hospital

Taipei, 112201, Taiwan
Temple University Hospital

Philadelphia, Pennsylvania, 19140, United States
The Catholic University Of Korea Bucheon St. Mary's Hospital

Bucheon-si, 14647, South Korea
The Prince Charles Hospital

Brisbane, QLD 4032, Australia
The Queen Elizabeth Hospital

Woodville, SA 5011, Australia
Townsville University Hospital

Douglas, QLD 4814, Australia
Twoja Przychodnia Medical Centre of Nowa Sol

Nowa Sól, 67-100, Poland
UAB Hospital, School of Medicine/Lung Health Center

Birmingham, Alabama, 35233, United States
UC Davis Health System

Sacramento, California, 95816, United States
UC San Diego Medical Center - Hillcrest

San Diego, California, 92103, United States
UCL Mont-Godinne University Hospitals

Yvoir, 5530, Belgium
University General Hospital "Attikon", 2nd Pulmonary Department

Athens, PC 12462, Greece
University General Hospital of Heraklion, Pneumonology Clinic

Heraklion, Crete, 715 00, Greece
University General Hospital of Ioannina

Ioannina, 45500, Greece
University General Hospital of Patras

Pátrai, 26504, Greece
University Hospital - Ospedali Riuniti Umberto I - GM Lancisi - G Salesi of Ancona

Ancona, 60126, Italy
University Hospital Center Sart-Tilman

Liège, 4000, Belgium
University Hospital City of Health and Science of Turin - Hospital Molinette

Turin, 10126, Italy
University Hospital Freiburg

Freiburg im Breisgau, Baden-Wurttemberg, 79106, Germany
University Hospital Heidelberg, Clinic of Thoracic Medicine Heidelberg GmbH

Heidelberg, Baden-Wurttemberg, 69126, Germany
University Hospital Tuebingen

Tübingen, Baden-Wurttemberg, 72076, Germany
University Hospitals Saint-Luc

Brussels, 1200, Belgium
University of Florida Health (UF Health)

Gainesville, Florida, 32610, United States
University of Kansas Medical Center

Kansas City, Kansas, 66160, United States
University of Utah, Health Sciences Center

Salt Lake City, Utah, 84108, United States
University of Wisconsin Clinical Science Center

Madison, Wisconsin, 53792, United States
VITAMED Galaj i Cichomski General Partnership

Bydgoszcz, 85-079, Poland
Vistalba Health Center

Mendoza, 5509, Argentina
Vivantes Hospital Neukoelln

Berlin, 12351, Germany
William Beaumont Hospital - Royal Oak

Royal Oak, Michigan, 48073, United States
Wythenshawe Hospital

Manchester, M23 9LT, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.