New drug aims to slow kidney failure in IgA nephropathy patients
NCT ID NCT05797610
First seen Jun 25, 2026 · Last updated Aug 14, 2026 · Updated 2 times
Summary
This phase 3 trial tests sefaxersen, a drug that targets a part of the immune system, in 428 people with IgA nephropathy at high risk of kidney decline. Participants receive either sefaxersen or a placebo as a shot under the skin. The main goal is to see if the drug reduces protein in the urine, a sign of kidney damage, over 37 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- sefaxersen
- What this could lead to
- If it works, this could slow kidney damage and delay the need for dialysis or transplant in people with IgA nephropathy.
- What could go wrong
- This is a phase 3 trial, but results are not guaranteed. The drug may not work better than placebo, and side effects from the injection or immune suppression are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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4. Wojskowy Szpital Kliniczny z Poliklinika SP ZOZ
Wroclaw, Lower Silesian Voivodeship, 53-114, Poland
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Academic Medical Research Institute - Los Angeles
Los Angeles, California, 90022, United States
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Addenbrookes Hospital
Cambridge, CB2 0QQ, United Kingdom
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Affiliated Hospital of Jiangsu University
Zhenjiang, 212001, China
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Ajou University Hospital
Gyeonggi-do, 443-380, South Korea
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Azienda Ospedaliera Universitaria Federico II
Naples, Campania, 80131, Italy
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Azienda Ospedaliero Universitaria Consorziale Policlinico di Bari
Bari, Apulia, 70124, Italy
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Azienda Ospedaliero Universitaria Di Bologna - Policlinico S Orsola Malpighi-Via Massarenti
Bologna, Emilia-Romagna, 40138, Italy
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Beijing Friendship Hospital, Capital Medical University - PPDS
Beijing, Beijing Municipality, 000000, China
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C.H. Regional Reina Sofia - PPDS
Córdoba, 14004, Spain
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CHA Bundang Medical Center, CHA University
Seongnam-si, 13496, South Korea
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CHU Boulogne sur Mer
Boulogne-sur-Mer, 62200, France
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Cangzhou Central Hospital
Cangzhou Shi, Hebei, 060001, China
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Cape Breton Regional Hospital
Sydney, Nova Scotia, B1P 1P3, Canada
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Care Institute Idaho Kidney Institute
Idaho Falls, Idaho, 83402, United States
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Central Florida Kidney Specialists
Orlando, Florida, 32806, United States
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Centre Hospitalier
Annonay, 07103, France
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Centre Hospitalier Universitaire de Quebec
Québec, G1R 2J6, Canada
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Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada
Ciudad Autonoma Buenos Aires, C1425AGC, Argentina
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Centro de Investigacion Clinica Chapultepec S. A. de C. V.
Morelia, Michoacán, 58260, Mexico
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Chang Gung Medical Foundation
Kaohsiung City, 83301, Taiwan
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Chang Gung Memorial Hospital, Linkou
Taoyuan City, 333, Taiwan
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Changhua Christian Hospital
Changhua, 500, Taiwan
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Changi General Hospital
Singapore, 529889, Singapore
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Changzhou First People's Hospital
Changzhou, 213003, China
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Charite Universitaetsmedizin Berlin - Campus Charite Mitte
Berlin, 10117, Germany
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China Medical University Hospital
Taichung, 40447, Taiwan
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Chungbuk National University Hospital
Cheongju-si, 28644, South Korea
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Churchill Hospital
Oxford, OX3 7LE, United Kingdom
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Clinica San Cosme
Fracc Lomas Del Campestre, Aguascalientes, 20129, Mexico
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Consultorios Médicos Dr. Doreski
Ciudad Autonoma Buenos Aires, C1426ABP, Argentina
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Cowry Medical Group LLC
Acworth, Georgia, 30101, United States
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Faculdade de Medicina da Universidade de Sao Paulo
São Paulo, São Paulo, 01246, Brazil
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Fakultni nemocnice Hradec Kralove
Hradec Králové, 500 05, Czechia
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Far Eastern Memorial Hospital
Taipei, 220, Taiwan
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Fondazione Policlinico Universitario A Gemelli
Rome, Lazio, 00168, Italy
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Freire Pesquisa Clinica
Belo Horizonte, Minas Gerais, 30150, Brazil
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Fujita Health University Hospital
Aichi, 470-1192, Japan
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Gangdong Kyung Hee University Hospital
Seoul, 05278, South Korea
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General Hospital of Ningxia Medical University
Yinchuan, 750004, China
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Guangdong Provincial People's Hospital
Guangzhou, 510080, China
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Guys and St Thomas Hospital
London, SE1 9RT, United Kingdom
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Hallym University Sacred Heart Hospital
Anyang-si, 14068, South Korea
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Hirosaki University Hospital
Aomori, 036-8563, Japan
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Hiroshima University Hospital
Hiroshima, 734-8551, Japan
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Hokkaido University Hospital
Hokkaido, 060-8648, Japan
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Hopital Bichat - Claude Bernard AP-HP
Paris, 75877, France
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Hopital Henri Mondor
Créteil, 94000, France
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Hopital Tenon
Paris, 75020, France
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Hospital Ampang
Ampang, 68000, Malaysia
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Hospital Do Rim E Hipertensao Fundacao Oswaldo Ramos
São Paulo, São Paulo, 04038-002, Brazil
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Hospital Kuala Lumpur
Kuala Lumpur, FED. Territory of Kuala Lumpur, 50586, Malaysia
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Hospital Ribera Polusa
Lugo, 27004, Spain
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Hospital Seri Manjung
Seri Manjong, Pahang, 32040, Malaysia
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Hospital Sibu
Sibu, Sarawak, 96000, Malaysia
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Hospital Tengku Ampuan Afzan
Kuantan, Pahang, 25100, Malaysia
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Hospital Universitari Arnau de Vilanova
Lleida, Lerida, 25198, Spain
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Hospital Universitario 12 De Octubre
Madrid, 28041, Spain
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Hospital Universitario La Paz - PPDS
Madrid, 28046, Spain
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Hospital Universitario Vall d'Hebron - PPDS
Barcelona, 08035, Spain
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Hospital Universitario Virgen del Rocio - PPDS
Seville, 41013, Spain
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Hospital de Clinicas de Porto Alegre HCPA PPDS
Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
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Hyogo Prefectural Nishinomiya General Medical Center
Hyōgo, 663-8241, Japan
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Hôpital de Rangueil
Toulouse, 31059, France
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IRCCS Pavia - Istituti Clinici Scientifici Maugeri Spa ? Società Benefit
Pavia, Lombardy, 27100, Italy
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Instituto D?Or Pesquisa e Ensino - Hospital Gloria D?Or
Rio de Janeiro, 22281, Brazil
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Instituto Medico de la Fundacion Estudios Clinicos
Rosario, S2013DTC, Argentina
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Instituto Mexicano de Trasplantes
Cuernavaca, Morelos, 62448, Mexico
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Iwate Medical University Hospital
Numakunai, 028-3695, Japan
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Japanese Red Cross Fukuoka Hospital
Fukuoka, 815-8555, Japan
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Jichi Medical University Hospital
Tochigi, 329-0498, Japan
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Juntendo University Hospital
Tokyo, 113-8431, Japan
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Juntendo University Nerima Hospital, department of renal and hypertension
Tokyo, 177-8521, Japan
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Juntendo University Urayasu Hospital
Chiba, 279-0021, Japan
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Kanazawa Medical University Hospital
Ishikawa, 920-0293, Japan
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Kidney Disease Medical Group Inc-1505 Wilson Ter
Glendale, California, 91206-4032, United States
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Kings College Hospital
London, SE5 9RS, United Kingdom
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Klinikum Koln-Merheim
Cologne, 51109, Germany
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Konkuk University Medical Center
Seoul, 05030, South Korea
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Kumamoto University Hospital
Kumamoto, 860-8556, Japan
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Kyoto City Hospital
Nakagyo-ku, 604-8845, Japan
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L&C Professional Medical Research Institute
West Miami, Florida, 33144, United States
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Leicester General Hospital
Leicester, LE5 4PW, United Kingdom
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Liverpool Hospital
Liverpool, New South Wales, 2170, Australia
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London Health Sciences Centre · Victoria Hospital
London, Ontario, N6A 5W9, Canada
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Mackay Memorial Hospital-Taipei branch
Zhongshan Dist., 10449, Taiwan
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Massachussets General Hospital
Boston, Massachusetts, 02114, United States
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Matsuyama Red Cross Hospital
Ehime, 790-8524, Japan
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Medizinische Hochschule Hannover
Hanover, 30625, Germany
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Miri Hospital
Miri, 98000, Malaysia
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Montreal General Hospital
Montreal, Quebec, H3G 1A4, Canada
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Nara Medical University Hospital
Kashihara, 634-8522, Japan
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Nara Prefecture General Medical Center
Nara, 630-8054, Japan
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National Hospital Organization Okayama Medical Center
Okayama, 701-1192, Japan
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National University Hospital
Singapore, 119074, Singapore
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Nepean Hospital
Kingswood, New South Wales, 02747, Australia
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Nephrologisches Zentrum Villingen-Schwenningen
Villingen-Schwenningen, 78052, Germany
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Nephrology Associates of Northern Illinois
Hinsdale, Illinois, 60521, United States
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Nephrology Associates of Northern Virginia Inc
Fairfax, Virginia, 22033, United States
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Ningbo No.2 Hospital
Ningbo, 315000, China
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North America Research Institute-San Dimas
San Dimas, California, 91773, United States
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North Carolina Nephrology, PA
Raleigh, North Carolina, 27609, United States
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Okayama University Hospital
Okayama-Shi Kita-Ku, 700-0914, Japan
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Osaka University Hospital
Suita, 565-0871, Japan
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Ospedale Policlinico San Martino
Genoa, Liguria, 16132, Italy
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Ospedale San Giovanni Bosco
Turin, Piedmont, 10154, Italy
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Peking University First Hospital
Beijing, 100034, China
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Peking University People's Hospital
Beijing, 100044, China
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Pioneer Research Solutions
Houston, Texas, 077099, United States
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Princess Alexandra Hospital
Woolloongabba, Queensland, 4102, Australia
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Prolato Clinical Research Center
Houston, Texas, 77054, United States
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Queen Mary Hospital
Hong Kong, 999077, Hong Kong
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R & H Clinical Research
Katy, Texas, 77449, United States
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Renmin Hospital of Wuhan University
Wuhan, 430060, China
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Revival Research Institute - McKinney
McKinney, Texas, 75071, United States
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Robert-Bosch-Krankenhaus
Stuttgart, 70376, Germany
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Royal Adelaide Hospital
Adelaide, South Australia, SA5000, Australia
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Royal Melbourne Hospital
Parkville, Victoria, 3050, Australia
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Ruijin Hospital Shanghai Jiaotong University School of Medicine
Shanghai, 200025, China
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SCM Clinic - Prywatny Szpital Specjalistyczny
Krakow, 31-559, Poland
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SMG-SNU Boramae Medical Center
Seoul, 156-707, South Korea
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SPZOZ Centralny Szpital Klin
Lodz, 92-213, Poland
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Saitama Medical University Hospital
Saitama, 350-0451, Japan
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Salford Royal Hospital
Salford, M6 8HD, United Kingdom
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Samsung Medical Center
Seoul, 06351, South Korea
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Sanatorio Allende
Córdoba, X5000JHQ, Argentina
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Sanatorio Mayo Privado
Córdoba, 5000, Argentina
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Santa Casa de Misericordia de Belo Horizonte - PPDS
Belo Horizonte, Minas Gerais, 30150-221, Brazil
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Seoul National University Bundang Hospital
Seongnam-si, 13620, South Korea
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Seoul National University Hospital
Seoul, 03080, South Korea
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Shenzhen People's Hospital
Shenzhen, 518020, China
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Sichuan Academy of Medical Sciences and Sichuan Provincial Peoples Hospital
Chengdu, 610072, China
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Sierra Nevada Nephrology Consultants
Reno, Nevada, 89511, United States
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Singapore General Hospital
Singapore, 169608, Singapore
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Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University
Hangzhou, 310016, China
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Soon Chun Hyang University Hospital Bucheon
Bucheon-si, 420-767, South Korea
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St George Hospital
Kogarah, New South Wales, 2217, Australia
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St. Joseph-Krankenhaus
Berlin, 12101, Germany
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Sunnybrook Health Sciences Centre
Toronto, Ontario, M4N 3M5, Canada
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Sunshine Hospital
St Albans, Victoria, 3021, Australia
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Szpital Kliniczny Dzieciatka Jezus
Warsaw, 02-006, Poland
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Taichung Veterans General Hospital
Xitun Dist., 40705, Taiwan
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Taiping Hospital
Taiping, Perak, 34000, Malaysia
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Tan Tock Seng Hospital
Singapore, 308433, Singapore
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Texas Kidney Institute - Dallas
Dallas, Texas, 75231, United States
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The First Affiliated Hospital of Nanchang University
Nanchang, 330000, China
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The First Affiliated Hospital of Xian Jiao Tong University
Xi'an, 710061, China
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The First Hospital of Hebei Medical University
Shijiazhuang, Hebei, 050031, China
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The Jikei University Hospital
Tokyo, 105-8471, Japan
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The Second Affiliated Hospital of Nanjing Medical University
Nanjing, 210003, China
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The Second Affiliated Hospital of Soochow University
Suzhou, 215004, China
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The University of Hong Kong - Shenzhen Hospital
Shenzhen, 518053, China
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Tohoku University Hospital
Miyagi, 980-8574, Japan
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Tokushima University Hospital
Tokushima, 770-8503, Japan
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Tokyo Medical University Ibaraki Medical Center
Inashiki-Gun, 300-0395, Japan
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Tokyo Women's Medical University Hospital
Tokyo, 162-8666, Japan
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UAB Nephrology Research Clinic
Birmingham, Alabama, 35233, United States
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Universitatsklinikum der RWTH Aachen
Aachen, 52074, Germany
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University General Hospital of Heraklion
Heraklion, 71110, Greece
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University General Hospital of Patras
Pátrai, 265 04, Greece
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University Malaya Medical Centre
Kuala Lumpur, FED. Territory of Kuala Lumpur, 59100, Malaysia
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University of California, Los Angeles (UCLA) - Hematology/Oncology Santa Monica
Los Angeles, California, 90025-4837, United States
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University of Tsukuba Hospital
Tsukuba, 305-8576, Japan
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University of Yamanashi Hospital
Chūō, 409-3821, Japan
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University of the Ryukyus Hospital
Okinawa, 903-0125, Japan
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Universitätsklinikum Leipzig
Leipzig, Saxony, 04103, Germany
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Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Mainz, 55101, Germany
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Uniwersytecki Szpital Kliniczny w Opolu
Opole, 45401, Poland
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Uniwersytecki Szpital Kliniczny w Poznaniu - Przybyszewskiego 49
Poznan, 60-355, Poland
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Vancouver General Hospital
Vancouver, British Columbia, V5Z 1M9, Canada
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Venizeleio General Hospital of Heraklion
Heraklion, 714 09, Greece
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Virginia Commonwealth University
Richmond, Virginia, 23298, United States
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Vseobecna fakultni nemocnice v Praze
Prague, 12808, Czechia
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West China Hospital, Sichuan University
Chengdu, 610041, China
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Wuxi People's Hospital
Wuxi, Jiangsu, 214023, China
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Xinhua Hospital Affiliated To Shanghai Jiaotong University School of Medicine
Shanghai, China
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Yamaguchi University Hospital
Ube, 755-8505, Japan
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Zhejiang Provincial People?s Hospital
Hangzhou, 310014, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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