New shot aims to slash sky-high cholesterol in rare genetic disease
NCT ID NCT07037771
First seen Oct 31, 2025 · Last updated May 13, 2026 · Updated 25 times
Summary
This study tests a new medicine called zodasiran in people aged 12 and older with homozygous familial hypercholesterolemia (HoFH), a rare genetic condition causing extremely high cholesterol. The goal is to see if the drug safely lowers bad cholesterol levels over 12 months. Participants receive either zodasiran or a placebo, and after the main study, everyone can choose to receive the active drug in an open-label extension.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Research Site 1
RECRUITINGCincinnati, Ohio, 45227, United States
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Research Site 10
RECRUITINGJerusalem, 9112001, Israel
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Research Site 11
RECRUITINGParktown, Johannesburg, 2193, South Africa
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Research Site 12
RECRUITINGChristchurch, 8011, New Zealand
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Research Site 13
RECRUITINGCamperdown, New South Wales, 2050, Australia
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Research Site 14
RECRUITINGPittsburgh, Pennsylvania, 15213, United States
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Research Site 15
RECRUITINGTel Litwinsky, 5265601, Israel
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Research Site 16
RECRUITINGOkayama, 700-8558, Japan
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Research Site 17
RECRUITINGTbilisi, 0159, Georgia
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Research Site 18
RECRUITINGTbilisi, 160, Georgia
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Research Site 19
RECRUITINGTbilisi, 186, Georgia
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Research Site 2
RECRUITINGNew York, New York, 10029, United States
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Research Site 20
RECRUITINGFukushima, 960-1295, Japan
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Research Site 21
RECRUITINGHeidelberg, Victoria, 3084, Australia
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Research Site 22
RECRUITINGSaitama, 350-0495, Japan
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Research Site 23
RECRUITINGParis, 75013, France
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Research Site 24
RECRUITINGCerqueira César, São Paulo, CEP-05403-000, Brazil
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Research Site 25
RECRUITINGTokyo, 113-8510, Japan
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Research Site 26
RECRUITINGKanazawa, Ishikawa-ken, 920-8641, Japan
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Research Site 27
RECRUITINGSuita, Osaka, 564-8565, Japan
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Research Site 28
RECRUITINGCórdoba, 14004, Spain
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Research Site 29
RECRUITINGMadrid, 28041, Spain
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Research Site 3
RECRUITINGNedlands, Western Australia, 6009, Australia
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Research Site 30
RECRUITINGHradec Králové, General E3 500 0, Czechia
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Research Site 31
RECRUITINGRiyadh, 12713, Saudi Arabia
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Research Site 32
RECRUITINGGothenburg, 413 46, Sweden
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Research Site 33
RECRUITINGLa Louvière, 7100, Belgium
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Research Site 34
RECRUITINGLeuven, 3000, Belgium
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Research Site 35
RECRUITINGBerlin, 13353, Germany
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Research Site 4
RECRUITINGQuébec, G1V 4W2, Canada
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Research Site 5
RECRUITINGVancouver, British Columbia, V6Z 2H2, Canada
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Research Site 6
RECRUITINGChicoutimi, Quebec, G7H 7K9, Canada
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Research Site 7
RECRUITINGPark Ridge, Illinois, 60068, United States
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Research Site 8
RECRUITINGCape Town, 7925, South Africa
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Research Site 9
RECRUITINGSaint Leonards, New South Wales, 2065, Australia
Conditions
Explore the condition pages connected to this study.