Disease by developmental or physiological process

This trial is testing an experimental therapy called FKC289 for people with a type of kidney disease called primary membranous nephropathy that has come back or not responded to standard treatment. FKC289 uses the patient's own immune cells, which are modified in the lab to recog…

This trial is testing an experimental treatment called FKC289 for people with primary AL amyloidosis that has relapsed or not responded to standard care. FKC289 uses a patient's own immune cells, engineered to recognize and attack the abnormal plasma cells that produce the harmfu…

This trial tests an experimental therapy called PM577a, which uses prime editing to correct a common genetic mutation that causes Wilson disease. The treatment is given as a single intravenous infusion and aims to restore the liver's ability to remove excess copper. The study inc…

This early-stage trial is testing whether a personalized cell therapy called Eque-cel can safely and effectively treat people with refractory immune-mediated necrotizing myopathy (IMNM), a severe autoimmune condition that causes muscle weakness and damage. The therapy involves re…

This trial is testing whether an experimental mRNA vaccine can safely reduce moderate-to-severe acne in adolescents aged 12 to 17. Participants receive either the vaccine at different dose levels or a placebo, and researchers monitor safety and changes in facial acne lesions. The…

This clinical trial is testing whether a faster, more intensive schedule of a brain stimulation treatment called intermittent theta burst stimulation (iTBS) works better than the standard schedule for adults with major depressive disorder. Participants will be randomly assigned t…

This trial tests whether combining eye movements with different ways of reactivating a memory can reduce the frequency and distress of intrusive trauma memories in people with PTSD. Participants are randomly assigned to one of three procedures: unconscious trauma reactivation, ac…

This trial is testing an experimental procedure called pulsENDO therapy for adults with type 2 diabetes whose blood sugar is not well controlled with current medications. The procedure uses a thin tube to deliver gentle electric pulses to the lining of the small intestine, aiming…

This trial tests whether adding Hebenrun, a functional food made from natural grain bran, to standard metformin treatment helps people with type 2 diabetes achieve better blood sugar control. About 110 adults with type 2 diabetes will be randomly assigned to take either metformin…

This trial is testing an experimental drug called 611 in children aged 2 to 12 with moderate-to-severe atopic dermatitis, a common skin condition that causes itchy, inflamed skin. The drug is designed to block a specific immune signal that drives the inflammation behind eczema. T…

This trial tests whether a smartphone app can enhance parent management training (PMT) for children aged 8 to 13 with disruptive behavior disorders, such as conduct disorder or ADHD. Parents receive 12 weekly PMT sessions, and half also use a digital tool with videos, a resource …

This trial is testing an experimental oral medication called THB335 in adults with chronic spontaneous urticaria (CSU), a condition marked by persistent hives and itching that standard antihistamines don't fully control. Participants will take THB335 or a placebo alongside their …

This trial compares two treatment approaches for moderate to severe pemphigus vulgaris, a rare autoimmune disease causing painful blisters on skin and mucous membranes. One group receives rituximab (a biologic that targets immune B-cells) plus corticosteroids, while the other get…

This early-stage trial is testing an experimental oral drug called E2511 in people with early Alzheimer's disease, including those with mild cognitive impairment or mild dementia. The study aims to see if E2511 affects a specific brain signal measured by PET scans, and to check i…

This trial tests whether mazdutide, a weekly injection, can help people with type 2 diabetes achieve normal blood sugar levels—a state called remission. Participants are adults with type 2 diabetes who are not well controlled on diet, exercise, or a single medication. They receiv…

This phase 3 trial is testing whether an investigational drug called UBT251 can reduce the severity of obstructive sleep apnea in people who are obese and do not use positive airway pressure (PAP) therapy. Participants will receive weekly injections of UBT251 or a placebo for 52 …

This study tests whether a light-activated treatment called Rose Bengal photodynamic therapy can help people with a severe fungal eye infection called Fusarium keratitis. The infection can cause vision loss, and standard treatments may not always work. Participants receive either…

This trial tests whether combining traditional Ayurvedic treatments with standard medical care can better ease knee osteoarthritis symptoms than either approach alone. It enrolls 300 adults aged 30-65 with mild to moderate knee osteoarthritis, randomly assigning them to receive s…

This early trial is testing whether a new investigational drug called HX15001, given as an injection, can be safely combined with an existing pill (etrasimod) to treat moderate-to-severe ulcerative colitis. The study will include about 32 adults with the condition and will focus …

This clinical trial is testing an experimental oral medication called AC-101 in adults with moderately to severely active ulcerative colitis (UC), a chronic inflammatory bowel disease. The study aims to see if AC-101 can help achieve clinical remission—meaning fewer symptoms and …

This phase 3 trial is testing whether adding the drug obinutuzumab to the standard treatment (mycophenolate mofetil and corticosteroids) can improve outcomes for people with active lupus nephritis, a serious kidney complication of lupus. The study will enroll 70 adults aged 18-65…

This study tests whether a procedure called full pulpotomy can successfully treat permanent teeth with irreversible pulpitis and apical periodontitis. Instead of removing the entire nerve like a root canal, full pulpotomy removes only the inflamed pulp from the crown, preserving …

This trial tests whether an oral drug called HRS-5346 can safely lower elevated lipoprotein(a) — a genetic risk factor for heart attacks and strokes — in adults at high cardiovascular risk. Participants will take one of two doses of the drug or a placebo for 12 weeks, and researc…

This trial is testing whether a minimally invasive technique for robotic knee replacement, which uses a smaller incision and less tissue disruption, can improve scar appearance and recovery compared to the standard approach. The study will involve 100 adults with knee osteoarthri…

This phase 3 trial is testing whether a radioactive drug called iopofosine I 131 can keep Waldenstrom macroglobulinemia (a rare blood cancer) from getting worse for longer than the standard combination of rituximab, cyclophosphamide, and dexamethasone (R-CD). The study enrolls ab…

This study will see if a program led by community health workers (CHWs) can help people with type 2 diabetes in rural and low-income clinics. About 200 Spanish-speaking Hispanic adults will attend monthly diabetes classes and get weekly check-ins from CHWs. The goal is to see if …

This trial tests whether an oral medication called zasocitinib (TAK-279) can reduce the redness, thickening, scaling, and painful cracks of palmoplantar psoriasis, a type of psoriasis that affects the palms and soles. Adults with moderate-to-severe non-pustular palmoplantar psori…

This trial tests a new laparoscopic procedure called SIBS, which combines sleeve gastrectomy with a side-to-side connection between the duodenum and ileum, without cutting the duodenum. The goal is to see if the surgery is safe and technically feasible in adults with obesity and …

This phase 2 trial is testing whether combining two immunotherapy drugs—vilastobart and retifanlimab—can shrink tumors in people with metastatic pancreatic cancer that has a BRCA1, BRCA2, or PALB2 gene mutation. Participants receive both drugs by IV infusion over several months. …

This study tests a drug called inebilizumab in 180 adults with autoimmune hepatitis, a condition where the immune system attacks the liver. The goal is to see if the drug can reduce liver inflammation and allow patients to take lower doses of steroids. Participants will receive e…

This phase 2 trial tests whether an investigational medicine called SPY072 can improve hidradenitis suppurativa (HS), a chronic skin condition causing painful lumps and tunnels. About 150 adults with moderate-to-severe HS who are already receiving standard care will be randomly a…

This study looks at the long-term safety of a drug called admilparant in people with pulmonary fibrosis (lung scarring). About 2,277 adults who finished earlier studies will take the drug and be monitored for side effects. The goal is to see if the drug is safe to use over time, …

This early-stage trial tests an oral capsule containing a genetically modified probiotic yeast designed to neutralize toxins produced by C. diff bacteria. The study first evaluates safety in healthy adults, then in people at risk for recurrent C. diff infection. Participants take…

This study follows about 1,020 people who receive the oneKNEE total knee prosthesis during knee replacement surgery. Researchers track safety and how well the implant works by measuring changes in knee pain and function using the Oxford Knee Score two years after surgery. The goa…

This phase 2 trial is testing whether an experimental oral drug called HS-20118 can improve moderate to severe plaque psoriasis, a condition that causes thick, scaly patches on the skin. About 120 adults with the condition will receive either HS-20118 or a placebo once a week for…

This phase 2 trial tests whether indapamide, a common diuretic, can slow the worsening of walking ability in people with progressive multiple sclerosis (MS). Participants take one tablet daily for 12 months, with walking speed measured regularly. The study aims to see if the drug…

This study tests whether taking ibuprofen after a platelet-rich plasma (PRP) injection changes pain relief and knee function in adults with knee osteoarthritis. Participants receive one ultrasound-guided PRP injection and then take either ibuprofen or acetaminophen for five days.…

This study tests whether an investigational drug called tilrekimig, given as injections alongside medicated creams or ointments, can improve moderate-to-severe eczema (atopic dermatitis) in people aged 12 and older. Participants will be randomly assigned to receive either tilreki…

This trial is testing whether a personalized form of brain stimulation, called accelerated intermittent theta-burst stimulation (iTBS), can improve symptoms of depression and anxiety in people with treatment-resistant depression. The approach uses brain imaging to target specific…

This trial compares two types of clear retainers worn after braces to see if the way they are made affects gum health. One retainer is created from a digital scan of the teeth, while the other uses a traditional plaster mold. About 52 people who recently finished braces will wear…

This study is following people who receive a Tornier Perform™ Reversed MonoPost shoulder replacement to see how well it works and how safe it is. The implant is designed for patients with severe shoulder damage, such as from arthritis, fractures, or failed previous surgeries. Res…

This study is testing a new approach for young adults (ages 18-26) with posttraumatic stress disorder (PTSD) who have experienced childhood trauma. The treatment combines the substance MDMA with talk therapy sessions, known as MDMA-assisted therapy. The main goals are to see if t…

This trial investigates whether combining two behavioral therapies can help people with non-fluent aphasia—a condition where stroke damages the brain's language centers, making speech difficult. The approach uses Melodic Intonation Therapy (MIT), which uses singing-like intonatio…

This study tests whether a specially developed high-protein, low-glycemic index rice can improve blood sugar control in adults with prediabetes. Participants will eat both this special rice and conventional rice in a crossover design, allowing each person to serve as their own co…

This trial asks whether a minimally invasive root canal procedure can match the success of the traditional approach in treating lower molars with dead nerves and an infected root tip. Sixty adults aged 20 to 50 with such molars will be randomly assigned to receive either a conser…

This trial tests whether adding silver nanoparticles to a standard antibiotic paste used inside root canals can better reduce pain and inflammation in people with symptomatic apical periodontitis, a painful infection at the tooth root. Half of the 50 adult participants receive th…

This trial tests a six-session peer-led program called Gwan Enjoy Life for sexual minority men living with HIV in Jamaica. The program aims to reduce depression, anxiety, and loneliness while helping participants stay engaged in HIV care and take their medications. Sixty men will…

This Phase 2 trial is testing an experimental oral drug called ABI-6250 in about 80 people with chronic hepatitis D, a serious liver infection. Participants take the pill once daily for 48 weeks. The study aims to see if the drug is safe, how it moves through the body, and whethe…

This trial tests whether icosapent ethyl, a purified form of fish oil, can stabilize high-risk coronary plaques in people with heart disease. Participants have plaques that narrow a major heart artery by 30–70% and show at least one high-risk feature on a CT scan. Half will take …

This clinical trial is testing whether the drug nemolizumab can help treat moderate-to-severe atopic dermatitis (a common type of eczema) in Chinese patients aged 12 and older. Participants will receive either nemolizumab or a placebo (a look-alike with no active drug) every four…

This phase II trial is testing whether a combination of selinexor, daratumumab, and dexamethasone (called XDd) can help people with advanced light-chain cardiac amyloidosis, a condition where abnormal proteins build up in the heart. The study aims to see if the regimen can achiev…

This study tests whether a personalized diet plan, guided by a continuous glucose monitor (CGM), can help Chinese and Vietnamese Americans with type 2 diabetes better control their blood sugar. 120 participants will either receive the adaptive diet program or standard care for 12…

This phase II trial tests whether an experimental oral drug called TLL-018 can reduce itching and hives in adults with moderate-to-severe chronic spontaneous urticaria (CSU) that hasn't responded to standard antihistamines. Participants will take either a low or high dose of TLL-…

This study compares three treatments for obstructive sleep apnea: positive airway pressure (CPAP), a dental device that moves the jaw forward, and a combination of two medications (atomoxetine and oxybutynin). About 2,400 adults with sleep apnea will be randomly assigned to one o…

This early-stage trial tests an experimental gene therapy called VY1706 in people with early Alzheimer's disease. The goal is to see if it is safe and tolerable, and whether it can reduce tau protein buildup in the brain, a hallmark of the disease. Participants receive one of thr…

This trial tests whether a calcium-rich food chew, made from milk-derived minerals, is easier for women to take daily than a standard calcium carbonate pill. Women aged 40 to 90 at increased risk for osteoporosis will be randomly assigned to one of the two forms for four weeks. T…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can help people with severe alcohol use disorder reduce heavy drinking. Thirty-six adults who recently completed detox will receive either a high or low dose of psilocybin du…

This study tests whether a machine-learning system called iAST® can improve how doctors choose antibiotics for patients with pneumonia, urinary tract infections, or sepsis. The AI predicts which antibiotics are likely to work before standard lab results are available. Researchers…

This study tests whether a new drug called Bmab1700 works the same as the approved immunotherapy Opdivo in people with melanoma who have had their tumors surgically removed. The trial will involve 120 adults with stage IIB to IV melanoma. Researchers will compare how the drugs mo…

This trial tests an experimental oral drug called resmetirom in children aged 6 to 17 with metabolic dysfunction-associated steatohepatitis (MASH) and liver fibrosis. The study aims to evaluate the drug's safety, how the body processes it, and its effects on the liver. Participan…

This early-phase trial tests whether immune cells (CD8+ T cells) given through a spinal tap are safe for people with melanoma that has spread to the lining of the brain. Only 8 participants will receive the treatment. The main goal is to check for side effects, not to cure the di…

This study will test whether providing acute hospital care at home, instead of in a traditional hospital, can help people with moderate to severe dementia spend more days at home after an acute illness. Researchers will randomly assign 200 participants to either receive home-base…

This trial tests whether combining fractional carbon dioxide laser treatment with a topical metformin cream works better than laser alone for acanthosis nigricans—dark, velvety patches on the neck. About 34 adults with this condition will have one side of their neck treated with …

This study tests a 6-month program where patients work with a pharmacist and their primary care doctor to make shared decisions about medications and lifestyle. The goal is to see if this team-based approach improves heart and kidney health scores and medication adherence. The st…

This trial tests whether replacing some of the usual diet with navy beans — without changing total calories — is a practical and acceptable way to help manage metabolic dysfunction-associated steatotic liver disease (MASLD) in adults with intermediate-stage liver fibrosis. Forty …

This trial tests whether a low-sodium diet can improve blood pressure control in people who had a hypertensive disorder of pregnancy. Participants receive either a provided diet with less than 2000 mg of sodium per day or a standard diet with no salt restrictions for the first we…

This study will test whether living in a self-contained, AI-managed community (called a Microcity) can improve mental health and reduce addiction in adults with conditions like autism, ADHD, substance use disorders, and behavioral addictions. Up to 1 million participants will liv…

This study looks at whether switching to a higher-dose eye injection called aflibercept 8 mg can allow people with neovascular age-related macular degeneration (nAMD) or diabetic macular oedema (DME) to go longer between treatments. It follows adults in Portugal who have already …

This study tests whether a natural molecule called oleoylethanolamide (OEA) can reduce inflammation, improve thinking, and lower alcohol use in young adults aged 18–25 with alcohol use disorder. Participants will take OEA or a placebo daily for 6 weeks and provide blood, saliva, …

This trial is testing whether an experimental medication called centanafadine, taken once daily as extended-release capsules, can help adults with attention-deficit/hyperactivity disorder (ADHD) who also experience emotional dysregulation—difficulty managing emotions like irritab…

This study follows people with bone loss caused by long-term steroid use to compare two treatment approaches. One group received romosozumab for the first year and then switched to denosumab, while the other group took denosumab throughout. After six years, researchers will measu…

This study tests whether a traditional Chinese herb called Polygonatum sibiricum, or Huangjing, can help reduce visceral fat—the deep belly fat around organs that raises risks for diabetes, fatty liver, and heart disease. Adults with visceral obesity will receive either the herb …

This trial is testing an investigational drug called brenipatide in adults with moderate-to-severe COPD. Participants will receive either brenipatide or a placebo for about a year, alongside standard care. The goal is to see if brenipatide improves lung function and reduces the n…

This phase 3 trial is testing the long-term safety of an oral drug called HS-10380 in Chinese adults with schizophrenia. Over about a year, 500 participants will take the medication daily, with doses adjusted to an optimal level. The study tracks side effects, serious adverse eve…

This trial tests whether simple reminders—sent to patients' phones and to their care teams—can increase the use of alcohol screening and brief counseling (SBIRT) during cancer care. About 315 adults with cancer across four clinics will take part, with some clinics using the remin…

This phase 2 trial tests whether adding a combination of deferiprone (an iron-chelating drug) and N-acetylcysteine (an antioxidant) to standard antipsychotic treatment can reduce the negative symptoms of schizophrenia, such as apathy, lack of motivation, and social withdrawal. Ab…

This early-stage trial is testing an experimental oral medication called HRS-7085 in adults with moderate to severe ulcerative colitis, a chronic inflammatory bowel disease. The main goal is to see if the drug is safe and tolerable, and to understand how it moves through the body…

This trial tests whether a daily supplement of calcium-HMB plus vitamin D3 can help adults aged 65 to 85 with type 2 diabetes keep their muscle mass and metabolism while starting semaglutide, a common weight-loss and diabetes medication. Participants take the supplement or a plac…

This study tests a combination of two immunotherapy drugs, nivolumab and relatlimab, in people with advanced melanoma that hasn't been treated before. The goal is to see if the combination is safe and helps shrink tumors. About 30 adults and teens (ages 12 and up) in India will t…

This trial tests whether nicotinamide riboside (NR), a form of vitamin B3, can slow the progression of early Alzheimer's disease. About 270 adults with early-stage Alzheimer's will take NR or a placebo daily for two years. Researchers will measure changes in memory, thinking, and…

This study tests whether oral valganciclovir or ganciclovir eye drops can reduce the virus causing eye inflammation and prevent flare-ups. About 117 adults with CMV anterior uveitis will receive either antiviral treatment or placebo for 7 days, then some continue for 12 months. T…

This study tests whether screening for elder neglect in primary care, combined with a caregiver support app, can reduce neglect in older adults with dementia. Researchers will compare three groups: one receiving screening alone, one receiving screening plus the SIRENS app, and on…

This trial tests whether photodynamic therapy (PDT) can clear toenail fungus. People with a confirmed fungal nail infection will have a special gel applied to the affected nail, then exposed to red light. The study will check if the nail looks healthy and if the fungus is gone at…

This study tests the long-term safety and tolerability of acoramidis, an oral medication that stabilizes the transthyretin protein, in people newly diagnosed with transthyretin amyloid cardiomyopathy (ATTR-CM), a condition that can lead to heart failure. Participants who complete…

This pilot study explores whether a gentle manual therapy applied to the hip bone, in addition to standard treatment with a Pavlik harness, can improve hip joint coverage in infants with developmental dysplasia of the hip (DDH). Thirty infants aged 1 to 5 months with moderate to …

This pilot trial tests whether a 4-week group education program that blends Chinese medicine concepts—like body constitution, dietary therapy, and acupressure—with standard diabetes self-management training is feasible and acceptable for adults with type 2 diabetes in Hong Kong. …

This phase II trial is testing an investigational drug called SHR-1139 in adults with plaque psoriasis who have not responded well to at least one biologic treatment. Participants will receive either SHR-1139 or a placebo via subcutaneous injection over a 52-week treatment period…

This study tests whether eating a daily serving of pecans for 12 weeks can improve cholesterol levels and other markers of heart-disease risk. Adults aged 25–75 who are overweight or have borderline-high cholesterol will either add pecans to their diet or stick with their usual e…

This trial tests whether applying a platelet-rich fibrin (PRF) membrane during hypospadias repair surgery improves healing and reduces complications like fistulas. PRF is made from the patient's own blood and is thought to support tissue repair. The study will include 80 boys wit…

This trial is testing whether taking a daily Ceylon cinnamon supplement, combined with a structured educational program, can improve blood sugar control, cholesterol levels, and nerve pain in adults with type 2 diabetes and painful diabetic peripheral neuropathy. About 900 partic…

This early-stage trial is testing an experimental drug called DNL921 to see if it is safe and tolerable for people. It will involve healthy volunteers and people with Alzheimer's disease, who will receive either the drug or a placebo. The main goal is to gather safety data and un…

Steroid injections for knee arthritis can temporarily raise blood sugar in people with type 2 diabetes. This trial tests whether giving a short course of NPH insulin right after the injection can prevent those high blood sugar episodes. Adults with type 2 diabetes and knee osteoa…

This trial explores whether a single dose of psilocybin, combined with motivational support therapy, can help people with HIV who have moderate-to-severe methamphetamine use disorder reduce or stop their meth use. Participants will be randomly assigned to receive either a higher …

This trial tests whether a culturally tailored, Spanish-language onboarding and support program helps Latino youth aged 10–20 with type 1 diabetes adopt and consistently use the Medtronic MiniMed 780G automated insulin delivery system. Participants receive one-on-one nutrition su…

This trial investigates the long-term safety of buntanetap, an experimental daily pill, in people with Alzheimer's disease who have already taken the drug in a previous study. About 400 participants will receive buntanetap 30 mg daily, with researchers tracking side effects and s…

This trial tests whether a counseling method called motivational interviewing, based on the Transtheoretical Model, can help nursing students who smoke to change their smoking habits and quit. Participants will receive two to six face-to-face sessions tailored to their readiness …

This trial tests whether open-source automated insulin delivery (AID) systems can control blood sugar as well as commercial systems in adults with type 1 diabetes, even when meals are not announced. Participants will use both types of systems for four weeks each, with a focus on …

This trial tests whether a daily routine of tummy time and careful positioning can help correct cranial asymmetry—a flattened head shape—in premature newborns. About 300 babies born before 37 weeks who are in the neonatal ICU or intermediate care unit will be split into two group…

This trial tests whether a structured group therapy, blending EMDR and sensorimotor techniques, can help adults with trauma-related symptoms in a primary care setting. Participants are randomly assigned to either this group intervention or usual care. The study measures changes i…

This study looks at whether a newer opioid painkiller, oliceridine, is less likely than the standard sufentanil to cause breathing problems after surgery in people at high risk of obstructive sleep apnea. About 851 adults with known or suspected sleep apnea will receive one of th…

This trial tests whether combining nurse-delivered care with text message check-ins and support can help adults with uncontrolled high blood pressure lower their blood pressure and improve diabetes management. Participants receive either usual care or the enhanced support, which …

This trial tests whether a single day of accelerated transcranial magnetic stimulation (TMS) can reduce depressive symptoms in adults with treatment-resistant depression. Participants are randomly assigned to receive one of two active TMS protocols—targeting the precuneus or the …

This trial tests whether applying a gel containing either metformin or zoledronate under the gums can improve healing of bone defects caused by periodontitis in people with well-controlled type 2 diabetes. Participants receive standard deep-cleaning treatment, and some also get o…

This early-stage trial is testing an experimental drug called SHR-7590 to see if it is safe and tolerable when given by injection under the skin or into a vein. It involves healthy volunteers and people with moderate-to-severe ulcerative colitis, a condition that causes inflammat…

This trial tests whether a device delivering synchronized 40-Hz light and sound stimulation can safely improve cognitive function in people with early Alzheimer's disease. Sixty participants with mild cognitive impairment or mild dementia due to Alzheimer's will receive either ac…

This study explores whether robot-guided repetitive transcranial magnetic stimulation (rTMS) can effectively treat postpartum depression (PPD). Researchers will compare brain activity, heart signals, blood markers, and body awareness in women with PPD versus healthy controls. Par…

This trial tests whether a minimally invasive deep-cleaning technique (MINST) works better than the usual scaling and root planing for severe periodontitis in back teeth. Adults aged 18–35 with stage III/IV gum disease will have one molar treated with standard cleaning and anothe…

This phase 2 trial explores whether fecal microbiota transplantation (FMT) is safe, tolerable, and practical for adolescents aged 13–17 with ADHD. Participants receive oral FMT capsules after bowel prep, alongside antibiotics, to see if changing gut bacteria can influence ADHD sy…

This phase II trial is testing whether an experimental oral medication, DA-302168S, can help people with type 2 diabetes control their blood sugar. The study will compare the drug against a placebo in about 272 adults who are already taking metformin. Researchers will measure cha…

This Phase 2 trial tests efgartigimod PH20 SC, a drug that lowers harmful antibodies, in 170 adults and teens with autoimmune encephalitis (AIE). Participants receive either the drug or a placebo, and researchers measure changes in disability and symptoms over up to 3 years. The …

This trial tests an experimental therapy called SYS6020 for people with relapsing or progressive multiple sclerosis that hasn't responded well to standard treatments. SYS6020 uses a patient's own immune cells, engineered to target and potentially reduce harmful B cells involved i…

This phase 2 trial will test two drugs, finerenone and sotagliflozin, in 57 people with type 1 diabetes who are at risk for heart and kidney problems. The goal is to see if matching the right drug to each person's specific diabetes subtype can improve early signs of heart and kid…

This phase 2 trial tests whether injecting botulinum toxin (Botox) into skin affected by hidradenitis suppurativa (HS) can reduce the number of painful abscesses, nodules, and draining tunnels, and ease pain. About 40 people with HS will receive either Botox or a saline placebo i…

This study compares how adult smokers experience IQOS heated tobacco products versus their usual cigarettes. Participants use both products and rate them on appeal, taste, harshness, and satisfaction. Researchers also measure puffing behavior and nicotine withdrawal symptoms. The…

This pilot study will test whether deep brain stimulation (DBS) can help people with schizophrenia who still hear voices and have delusions despite trying multiple medications. Fifteen adults will have electrodes placed in a brain region linked to schizophrenia symptoms. The goal…

This early-stage trial is testing whether a single infusion of universal STAR-T cells—a type of engineered immune cell that targets both CD19 and BCMA—can safely and effectively treat two autoimmune kidney diseases: IgA nephropathy and primary membranous nephropathy. The study wi…

This phase 3 trial asks whether survodutide, an investigational weekly injection, can help adults with type 2 diabetes lower their blood sugar more than a placebo. Around 600 participants, who also follow diet and exercise or take standard diabetes medications (including insulin)…

This trial tests whether a toothpaste containing arginine can alter the bacteria living below the gumline in people with gum disease who are already receiving ongoing dental care. Participants will brush twice daily for six months with either an arginine toothpaste or a standard …

This trial tests whether different intermittent fasting schedules—5:2, alternate-day, and time-restricted eating—can improve blood sugar, cholesterol, inflammation, and body composition in adults with prediabetes. Participants will be randomly assigned to one of three fasting pla…

This phase 2 trial is testing whether pirfenidone, a drug already used for lung scarring, can help people with chronic pancreatitis—a long-term inflammation of the pancreas that causes severe pain. The study will enroll 60 adults with chronic pancreatitis and moderate-to-severe p…

This trial tests whether switching to cigarettes with very low nicotine content can reduce how much people smoke and their nicotine exposure. Adult daily smokers in South Korea will be randomly assigned to either very low nicotine or normal nicotine cigarettes for 12 weeks. Resea…

This trial is testing whether an experimental biologic called IBI3027 works as well as the approved drug dupilumab for people with moderate-to-severe atopic dermatitis (eczema). About 520 adults will be randomly assigned to receive either IBI3027 or dupilumab as a subcutaneous in…

This study compares two ways to manage diabetes after hospital discharge: using a continuous glucose monitor (CGM) versus standard fingerstick checks. About 64 adults with type 2 or steroid-induced diabetes who need insulin after leaving the hospital will wear a sensor for 28 day…

This study tests a 6-month digital program that combines appetite awareness training with behavioral weight loss techniques, delivered remotely via Zoom. It aims to help Black women with obesity who binge eat at least once a week relearn hunger cues and prevent weight gain. The t…

This clinical trial is investigating whether a traditional Chinese medicine formula called Qingxin Jiaotai Decoction (QXJTD) can help adults who have both insomnia and obesity. Participants will receive either the herbal granules or a placebo, along with personalized diet and exe…

This trial asks whether adding intranasal insulin or empagliflozin to standard anti-amyloid therapy can improve outcomes for people with mild cognitive impairment or early Alzheimer's disease. Participants will receive one of the two study drugs or a placebo, alongside their pres…

This study follows people with moderate to severe pulmonary regurgitation or stenosis who receive the PULSTA transcatheter pulmonary valve, a less invasive option for replacing a faulty heart valve. Researchers will track how well the valve works over time, measuring improvements…

This trial tests whether taking a GLP-1 medication (semaglutide) for at least six months before hip or knee replacement surgery can improve recovery and reduce complications in patients with obesity. Participants will be randomly assigned to receive either the medication plus beh…

This study tests NeoMayor, a smartphone app that gives personalized advice on exercise, diet, sleep, and mood to improve heart health. Researchers will enroll 240 adults aged 55 to 75 in Chile who are at risk for heart problems. Participants use the app for 4 months, and some als…

This trial tests whether extending a 6-month exercise coaching program to 12 months helps people with type 2 diabetes maintain a healthier activity level. Participants will be randomly assigned to either the standard 6-month program or an extended version with sessions every two …

This trial is testing whether a probiotic supplement called Colipral, which contains a specific strain of E. coli bacteria, can improve gut health in people with ulcerative colitis who are in remission but still have digestive issues. Participants will take either the supplement …

This study tests whether eating one avocado daily for 12 weeks can improve blood flow to the brain and support heart and blood vessel health in adults with prediabetes and overweight or obesity. Researchers will measure brain blood flow using MRI, along with markers of blood vess…

This trial tests whether deep brain stimulation (DBS) targeting the cerebellum is safe and feasible for people with spinocerebellar ataxia types 1 and 3, a group of inherited disorders that cause progressive problems with movement and coordination. The study will enroll 12 adults…

This first-in-human trial evaluates BYN-001, an antibody designed to block IL-25, a protein linked to atopic dermatitis (eczema). The study first tests the drug in healthy volunteers to assess safety and how it moves through the body, then in people with moderate to severe eczema…

This study is testing whether guselkumab, a biologic drug, can help people with moderate-to-severe ulcerative colitis achieve remission. Participants receive IV infusions followed by maintenance injections. The trial tracks clinical, endoscopic, and histological healing over 48 w…

This phase 3 trial is testing whether giving men with metastatic prostate cancer half the standard dose of certain hormone therapies (called ARPIs) can be just as effective as the full dose, while causing less fatigue and fewer treatment stoppages. About 1,500 men with prostate c…

This trial tests whether a topical gel called GM-XANTHO can reduce the severity of psoriasis, a chronic skin condition that causes red, scaly patches. About 65 adults with plaque psoriasis will apply the gel or a placebo daily for 28 days. Researchers will measure changes in skin…

This trial tests whether extra follow-up—via phone calls, digital messages, or both—helps people recover better after a tooth extraction. Adults having a tooth pulled will get standard instructions, and some will also receive structured phone or digital check-ins during the first…

This Phase 3 trial will test whether a combination of three cholesterol-lowering drugs—bempedoic acid, ezetimibe, and a high-intensity statin—can reduce and stabilize plaque buildup in the coronary arteries. The study enrolls 103 adults with coronary atherosclerosis who have neve…

This trial is testing an experimental oral drug called PTT-621 in adults aged 18-70 with moderate-to-severe ulcerative colitis who haven't responded well to standard treatments. Participants will take PTT-621 tablets for 12 weeks. The main goal is to see if the drug can improve t…

This trial tests whether faricimab, an eye injection, can improve vision and reduce swelling in South Asian patients with diabetic macular edema (DMO), a complication of diabetes that can lead to blindness. Previous studies mostly included Caucasian or East Asian participants, le…

This study will test whether having a pharmacist review a patient's genetic test results can improve treatment for major depression. 220 adults in Pennsylvania who are starting or changing antidepressant medication will be randomly assigned to either receive this specialized medi…

This study tests whether a new auto-adjusting positive airway pressure (APAP) device with a feature called Kairos PAP (KPAP) works better than a standard APAP device with expiratory pressure relief (EPR) for people with obstructive sleep apnea. Participants, who already use PAP t…

This trial is testing whether adding the nerve pain medication pregabalin to a structured educational and behavioral program can better ease the symptoms of bladder pain syndrome (also called interstitial cystitis) than the program alone. Adults with this condition will be random…

This trial tests whether adding inspiratory muscle training (IMT) — breathing exercises using a resistance device — to usual care can improve cardiopulmonary endurance and functional mobility in people with knee osteoarthritis. Adults aged 40-65 with bilateral knee osteoarthritis…

This phase 2 trial is testing an investigational drug called QLS4131 in people newly diagnosed with AL amyloidosis, a condition where abnormal proteins build up in organs and cause damage. QLS4131 is a trispecific antibody designed to target and eliminate the plasma cells produci…

This trial tests a blended caregiver-led intervention for autistic toddlers under 3, combining social-communication strategies with social-emotional support. Caregivers are coached over 12 weekly sessions to embed these techniques into daily routines and play. The study aims to s…

This trial tests whether a single injection of a new gel, called 2107, can relieve pain and improve function in people with mild-to-moderate knee osteoarthritis. About 286 adults aged 40–80 will receive either 2107 or an existing hyaluronic acid injection (DUROLANE) directly into…

This study tests whether a special clinic where heart, kidney, diabetes, and liver doctors work together can help people with type 2 diabetes and heart disease get better control of their blood pressure and cholesterol. About 150 adults will be randomly assigned to either usual c…

This early-stage trial evaluates an investigational oral drug called ONO-6414 in healthy adults and in people with active ulcerative colitis. The main goals are to assess the drug's safety, tolerability, and how the body processes it. The study includes single and multiple doses,…

This Phase 3 trial tests whether a disc made from donated human amnion membrane can help people with moderate to severe dry eye disease. The disc is placed on the eye and compared to standard care like lubricating drops and a bandage lens. The study will enroll 40 adults who have…

This trial is testing an experimental drug called TLL-018 in adults with moderate-to-severe rheumatoid arthritis who haven't responded well to or couldn't tolerate standard treatments. Participants will receive either TLL-018 or a placebo for a period, and the study will measure …

This early-stage trial is testing an investigational drug called RO7845860, given as an injection under the skin, in people with relapsing multiple sclerosis (MS). The main goals are to check the drug's safety, how the body handles it, and its effects on immune cells. The study w…

This study tests the long-term safety and effectiveness of an experimental oral drug called S-606001 in adults with late-onset Pompe disease, a genetic condition that causes progressive muscle weakness. Participants who completed a prior S-606001 study can join, and they will rec…

This study tests a drug called ocrelizumab in children and teens aged 10 to 17 with relapsing-remitting multiple sclerosis (MS). The goal is to see how the drug moves through the body, if it is safe, and how it affects the immune system. Participants will receive the drug as a sh…

This study tests a new type of artificial lens for cataract surgery that may adjust focus like a natural lens. About 100 adults needing cataract surgery will get this lens in one eye and a standard lens in the other. Researchers will check for complications and measure vision imp…

This study tests whether personalized ventilator settings can reduce lung injury in adults with severe respiratory failure who are on ECMO (a heart-lung machine). Researchers will use esophageal manometry or electrical impedance tomography to tailor the ventilator's positive pres…

This study tests whether a short couples therapy, called MERA-C, can help reduce intimate partner violence and improve emotional health in veteran couples. The therapy involves four weekly sessions with both partners, focusing on managing emotions to prevent aggression. Researche…

This trial tests whether a text message-based program called Text2Quit-Kenya can help current tobacco users who visit the emergency department at Kenyatta National Hospital in Kenya quit smoking. Participants receive automated, interactive texts timed around their quit date to tr…

This early-stage trial is testing an investigational injection called GT802 in people with relapsing or refractory multiple sclerosis (MS) — meaning their disease is active despite standard treatments. The study aims to check whether GT802 is safe and to get a first look at wheth…

This trial tests whether a one-time injection of a person's own concentrated fat can reduce pain and improve function in adults with chronic tendinopathy—tendon pain lasting more than three months that hasn't improved with usual treatments. Participants undergo a same-day procedu…

This phase 2 trial is testing whether an investigational drug called arumakimig can improve symptoms of VEXAS syndrome, a rare genetic autoinflammatory condition. The study will compare arumakimig against a placebo in about 120 adults with VEXAS, with the goal of seeing if the dr…

This study is testing whether an experimental drug called FXS6837 can safely reduce protein in the urine and help preserve kidney function in people with IgA nephropathy, a disease that can lead to kidney failure. About 60 patients who previously completed a shorter study of FXS6…

This study tests whether doulas can successfully deliver an 8-week program called YouMatter to new or expecting mothers at risk for postpartum depression. The program combines mental health support, parenting tips, and self-care. Forty mothers with mild depression symptoms will p…

This early-stage trial is testing an experimental drug called SNC116 in people with refractory systemic lupus erythematosus (SLE), a form of lupus that hasn't improved with standard treatments. The study aims to see if a single intravenous infusion of SNC116 is safe and tolerable…

This trial tests whether antiplatelet medications, specifically clopidogrel and aspirin, can reduce inflammation in the blood vessels of people with psoriasis or psoriatic arthritis. Participants take each drug or a placebo for four weeks, and researchers measure changes in infla…

This trial tests a non-invasive brain stimulation technique called transcranial temporal interference stimulation (tTIS) in people with spinocerebellar ataxia type 3, a genetic condition that affects coordination and balance. The stimulation targets a deep brain region involved i…

This trial is testing whether a combination of drugs—inavolisib plus fulvestrant, with or without palbociclib—is safe for people with a specific type of advanced breast cancer (HR+, HER2-negative) that has a PIK3CA mutation, and who also have type 2 diabetes. The main focus is on…

This observational study tracks how long patients with moderate-to-severe Crohn's disease or ulcerative colitis continue taking guselkumab, a biologic treatment, in everyday clinical practice. Researchers will measure time until treatment discontinuation and early responses like …

This study tests an experimental drug called elranatamab in people newly diagnosed with AL amyloidosis who have not yet had treatment. The drug helps the body's immune cells find and destroy the abnormal cells causing the disease. Researchers want to see if it can produce deep re…

This early-stage trial is testing whether a drug called aletekitug is safe and tolerable for people with moderate to severe ulcerative colitis, a chronic inflammatory bowel disease. The drug works by blocking a protein called IL-18, which may play a role in the inflammation that …

This early-phase trial is testing an investigational drug called RBP-01 (sotrastaurin), given as an injection into the eye, for people with primary uveal melanoma—a rare cancer of the eye. The study aims to see if the drug is safe and whether it can shrink the tumor enough to avo…

This study will test whether a diet rich in protein and fiber can reduce harmful gas-producing bacteria in the gut of people with ulcerative colitis. Forty adults with mild to moderate disease will eat specially prepared frozen meals for two separate week-long periods. Researcher…

This trial tests whether a personalized, context-guided form of brain stimulation works better than the standard approach for adults with major depressive disorder. Participants receive either standard intermittent theta burst stimulation (iTBS) or a version where the stimulation…

This trial tests whether taking coenzyme Q10 (CoQ10) for 12 weeks can reduce fat buildup in the liver of people with mitochondrial diabetes, a rare form of diabetes caused by mitochondrial dysfunction. Participants with the m.3243A>G mutation will take 300 mg of CoQ10 daily, and …

This trial tests whether treating high blood pressure in pregnancy to a stricter target (below 140/90) is better than the usual approach (below 160/110) for women with gestational hypertension or preeclampsia without severe features. About 4,120 pregnant women will be randomly as…

This phase 3 trial is testing whether lumateperone (Caplyta), taken alone, can reduce symptoms of major depressive disorder (MDD) compared to a placebo. About 585 adults with MDD will receive one of two doses of lumateperone or a placebo for six weeks, followed by a long-term ext…

This trial tests a modified jaw surgery technique, called low sagittal medial ramus osteotomy, for people with severe bite misalignment (skeletal Class II or III malocclusion). The procedure aims to reposition the jaw with fewer complications than the standard surgery, particular…

This trial tests a medical device that has not yet been approved by the U.S. FDA. The goal is to see if it can help control a specific disease. Participants will use the device as directed, and researchers will monitor its effects on symptoms and disease progression.

This trial tests a program called ROOTS that places substance use counselors and peer recovery specialists directly in rural schools. The goal is to see if this approach helps teens who are referred or seek help on their own to engage in treatment and reduce their substance use. …

This pilot trial tests whether a digital inhaler cap, which gives real-time guidance on inhaler technique, can help adolescents with intellectual and developmental disabilities (IDD) manage their asthma at home. The study will compare active use of the smart inhaler to passive us…

This trial asks whether daily caffeine intake can improve recovery after standard gum disease treatment. About 90 adults with periodontitis will receive non-surgical treatment and then be randomly assigned to avoid caffeine or consume low or moderate amounts for 6 months. Researc…

This phase 2 trial is investigating whether giving immunotherapy before surgery for advanced melanoma (stage IIIB to IV M1a) can maintain survival while allowing patients to skip the usual adjuvant therapy after surgery. Participants are randomly assigned to receive either two in…

This early trial is testing an experimental biologic drug called aletekitug in adults with moderate to severe ulcerative colitis. The main goal is to see if the drug is safe and tolerable when given repeatedly. Researchers will monitor side effects and changes in lab tests, vital…

This trial is testing an experimental oral medication called TQF3250 in people with type 2 diabetes who are also overweight or obese. The drug is designed to mimic a natural hormone that helps control blood sugar and appetite. The study aims to see if the drug is safe, tolerable,…

This Phase 3 trial compares a new once-daily formulation of trientine tetrahydrochloride (TETA 4HCl) to the standard drug D-penicillamine for people newly diagnosed with Wilson's disease. About 38 adults and children (ages 8 and up, weighing at least 55 lbs) will be randomly assi…

This trial tests whether an online training for preschool teachers, called WE PLAY, can increase physical activity among young children with autism. About 150 teacher-child pairs will be randomly assigned to either the WE PLAY training or a control training. The study measures ch…

This trial tests different ways to start once-weekly insulin icodec in adults with type 2 diabetes who haven't used insulin recently. Participants are randomly assigned to one of three starting-dose methods: a fixed dose, a dose based on their fasting blood sugar, or a dose based…

This trial compares an experimental oral drug, FXS6837, to the standard infusion eculizumab in people with paroxysmal nocturnal hemoglobinuria (PNH), a rare blood disorder that causes red blood cells to break apart. About 90 adults who have not previously used complement inhibito…

This trial tests whether taking a daily cocoa flavanol supplement for 4 to 8 weeks can improve blood vessel function and reduce inflammation in healthy men aged 30 to 75. Half the participants will receive the flavanol supplement, while the other half gets a low-flavanol control …

This trial is testing a robotic exoskeleton called ABLE Kids to see if it is safe and practical for children who have trouble walking due to conditions like cerebral palsy, spinal cord injury, or muscle weakness. Fifteen children will use the device in up to ten one-hour training…

This trial explores whether personalized brain imaging can predict who responds best to three rapid-acting treatments for suicidal ideation in people with depression or PTSD. Participants receive either real-time brain feedback (neurofeedback), a form of magnetic brain stimulatio…

This study tests whether using ultrasound to push propolis (a natural bee product) into the skin can help heal diabetic foot ulcers faster. Eighty adults with diabetes and foot ulcers will either get propolis plus ultrasound or standard wound care for 4 weeks. The goal is to see …

This trial investigates whether a sensitive blood test (Signatera) can detect when it is safe to pause immunotherapy in people with advanced solid tumors like lung cancer, melanoma, and colorectal cancer. Participants are randomly assigned to either continuous standard immunother…

This phase 3 trial tests whether an experimental oral drug called engasertib can reduce the number of nosebleeds in adults with moderate to severe hereditary hemorrhagic telangiectasia (HHT), a genetic condition that causes abnormal blood vessels and frequent bleeding. About 240 …

This phase 2 trial is testing whether the combination of avutometinib and defactinib can stop or shrink malignant peripheral nerve sheath tumors (MPNST) that have returned or cannot be removed with surgery. The study enrolls people over 12 years old with relapsed, refractory, met…

This early-stage trial is testing an experimental oral medication called Alpha-0261 in about 10 adults with moderate to severe ulcerative colitis. The main goal is to check the drug's safety and tolerability, while also looking at whether it can help reduce symptoms and lead to c…

This trial compares two methods for closing the main artery in the leg after a TAVI procedure, which replaces a heart valve without open surgery. Half of the participants will have the artery closed with a single suture device, while the other half will receive a hybrid approach …

This study evaluates whether a French version of the HELP score can more accurately diagnose hyperemesis gravidarum (HG), a severe form of nausea and vomiting in pregnancy, compared to the standard PUQE score. Researchers will enroll 300 pregnant women experiencing nausea or vomi…

This trial tests whether an AI-guided handheld ultrasound, used during routine primary care or geriatrics visits, can detect serious heart valve disease and weak heart muscle in adults aged 65 to 85 who have no known heart problems. Half of the participants will receive this quic…

This study looks at whether two simple calculations, called Cancer Ratio and Cancer Ratio Plus, can help doctors tell the difference between fluid around the lungs caused by cancer and fluid caused by tuberculosis. These calculations use results from routine blood and fluid tests…

This study tests whether an eye-tracking device can help detect autism in toddlers born prematurely (before 37 weeks). Children aged 14-48 months referred for autism evaluation will use the device, and researchers will see if the eye-tracking data points to autism. The goal is to…

This study tests whether expired patch test allergens can still accurately diagnose allergic contact dermatitis, a common skin condition. Adults referred for patch testing will receive both expired and non-expired allergens on their skin at the same time. The researchers will com…

This study asks whether levels of uromodulin, a protein in the blood, can indicate the severity of kidney damage in people with lupus nephritis. Researchers will compare uromodulin levels with kidney biopsy results from 90 participants, including those with different classes of l…

This study investigates whether levels of a protein called RNASE1 in the blood can serve as a biomarker for lupus nephritis, a serious kidney complication of systemic lupus erythematosus (SLE). Researchers will compare RNASE1 levels in 128 adults with SLE, some with lupus nephrit…

This early-phase study tests whether a special ultrasound with a targeted contrast agent (Sonazoid) can quickly diagnose heart inflammation caused by immune checkpoint inhibitor cancer drugs. About 30 adults who recently received these drugs and show signs of heart inflammation w…

This trial is testing whether a new ultrasound scoring system can accurately predict the severity of placenta accreta spectrum (PAS), a condition where the placenta grows too deeply into the uterine wall. The study will enroll 50 pregnant women with placenta previa and a history …

This study tests whether combining several advanced genetic analysis techniques can find the cause of intellectual disability or neurodevelopmental disorders in people who have already had standard genetic testing with no answer. Participants will have their existing genetic data…

This study checks if a cheap thermal camera (about 200 euros) works as well as a professional one for spotting early signs of foot problems in people with diabetes. 130 adults with diabetes will have both cameras take pictures of the bottom of their feet. The goal is to see if th…

This study tests whether two advanced MRI techniques, called Double Inversion Recovery (DIR) and Diffusion Tensor Imaging (DTI), can improve the assessment of optic neuritis—inflammation of the optic nerve that can affect vision. Researchers will compare MRI measurements of the a…

This trial tests whether performing a sleep study at home through primary care is more cost-effective than the standard hospital-based approach for diagnosing obstructive sleep apnea. Adults with suspected apnea will be randomly assigned to either home testing via their local hea…

This trial tests whether a lifestyle program that includes the partner can help women who had gestational diabetes improve their weight and blood sugar control. Participants receive three months of health education on diet, physical activity, and stress management, with one group…

This study tests whether sending fentanyl test strips by mail and providing online education can reduce opioid overdoses. Researchers will enroll 100 adults who use opioids or stimulants and live in states where test strips are legal. The goal is to find the most effective and lo…

This trial tests whether two natural supplements—quercetin (from foods like apples and onions) and coenzyme Q10 (a substance your body makes)—can reduce inflammation and improve metabolic health in older adults. Over 12 weeks, participants aged 50 to 75 who are sedentary will tak…

This trial tests a program designed to help adolescent girls in Tanzania avoid unplanned pregnancies by improving access to contraception and reproductive health information. Participants receive educational text messages and interactive voice responses on their phones, plus supp…

This trial tests whether higher doses of nicotine replacement therapy (NRT) can help adults who use both cigarettes and e-cigarettes quit both products. Participants are randomly assigned to receive either standard-dose NRT, augmented-dose NRT, or no NRT, with all groups getting …

This study tests whether leaving the white, creamy coating (vernix caseosa) on a newborn's skin for at least 24 hours after birth can prevent eczema (atopic dermatitis) during the first year of life. Over 1,300 mother-infant pairs in Chile will be randomly assigned to either keep…

This pilot study tests a lifestyle intervention called BASIC-S, which uses coaching, text messages, and video check-ins to help people improve blood pressure, activity, sleep, social connection, nutrition, and support. The goal is to see if this approach is feasible and acceptabl…

This trial tests whether a brief psychological intervention—combining education, mindfulness, and acceptance-based strategies—can help people who have had a musculoskeletal injury reduce their opioid use and avoid developing chronic pain. The study enrolls adults admitted to the …

This trial tests a program called HADAS, designed to prevent eating disorders and body image dissatisfaction in adolescent female athletes aged 12 to 16 who compete in aesthetic sports like gymnastics and figure skating. The program works with athletes, their coaches, and their f…

This study compares three types of therapy for children aged 8 to 16.5 with severe irritability. Participants will receive either exposure-based cognitive behavioral therapy, parent management training, or supportive psychoeducation over 12 sessions. The goal is to see which appr…

This early-phase trial tests a new drug called TLL-018 in 36 adults with moderate-to-severe chronic spontaneous urticaria (hives) that standard antihistamines can't control. The goal is to see how quickly TLL-018 reduces itching and hives after the first dose. Participants will r…

This trial tests whether light therapy glasses can reduce depression in people with end-stage kidney disease who undergo hemodialysis three times a week. Participants wear either active glasses (1000 lux) or a sham device (50 lux) for 30 minutes each session over five weeks. The …

This study tests a telephone program where older adults in rural areas share life memories three times a week. Researchers want to see if it reduces loneliness and improves mental well-being, social support, and life satisfaction for both older adults and their informal caregiver…

This study tests if a phone-based therapy called Acceptance and Commitment Therapy (ACT) can help young adults aged 18-35 who drink heavily to quit or reduce alcohol use. Participants will receive weekly phone sessions for 6 weeks and track their drinking. The study compares ACT …

This study tests whether a brain-training technique called neurofeedback can help people with opioid use disorder who are on methadone feel more pleasure and recall positive memories. Participants learn to control their brain activity using real-time fMRI scans, a method that has…

This study will test whether a wearable device called Apollo Neuro is practical and acceptable for autistic children aged 6 to 14 who hurt themselves. The device delivers low-intensity vibrations through the skin. For about a month, 18 children will wear it at least 3 hours a day…

This trial tests whether cognitive behavioural therapy for insomnia (CBT-I), with or without bright light therapy, can improve sleep and other outcomes in adolescents with ADHD who also have insomnia and a late sleep schedule. Participants aged 10-24 will receive CBT-I plus eithe…

This trial tests whether giving patients a prescription for haloperidol to use as needed at home can help control symptoms of cannabinoid hyperemesis syndrome — a condition marked by severe nausea, vomiting, and abdominal pain from heavy cannabis use. The goal is to see if having…

This trial tests whether wearing a light-blocking eye mask at night can improve sleep quality and reduce delirium in patients recovering from coronary artery bypass graft (CABG) surgery. About 100 adults scheduled for elective CABG will wear the mask during nighttime sleep, and t…

This trial investigates whether a traditional Chinese medicine formula, Xingqi Daozhi Decoction, can relieve constipation that often occurs as a side effect of antipsychotic medications in people with schizophrenia. The study will enroll 46 adults with schizophrenia who have deve…

This study compares two types of virtual reality (VR) during common ear, nose, and throat (ENT) procedures. One group will watch calming scenery, while the other plays an interactive puzzle game. Researchers want to see which better reduces pain and anxiety. The study will includ…

This study tests whether an 8-week mobile app program, based on Transition Theory, can help first-time expectant fathers reduce anxiety, strengthen their bond with the unborn baby, and improve marital adjustment. About 96 fathers whose partners are 26-28 weeks pregnant will be ra…

This trial tests whether giving a combination of dexmedetomidine and esketamine during and after laparoscopic ureteral reconstruction can reduce depressive symptoms and anxiety in patients. The study enrolls 658 adults with ureteral stricture who are scheduled for this surgery. P…

This trial tests whether using a virtual reality headset during regional anesthesia can lower patients' anxiety and pain. Adults aged 18 to 64 having elective surgery with regional anesthesia will either receive VR distraction or standard care. Researchers will measure anxiety an…

This trial tests a wearable vest that uses heat, massage, and vibration to stimulate milk flow in mothers who have had a cesarean delivery and whose babies are in the NICU. Participants use the vest three times daily for 10 days, alongside standard lactation care. The study measu…

This pilot study tests whether N-acetylcysteine (NAC), an antioxidant supplement, can reduce repetitive and self-injurious behaviors in people with Cornelia de Lange syndrome (CdLS). Ten participants aged 13–35 will receive both NAC and a placebo in random order over 18 weeks. Th…

This study tests whether a six-session online program that helps young adults explore meaning in life can reduce symptoms of depression and anxiety. Participants are randomly assigned to either the program or a waitlist. The goal is to see if building a sense of purpose improves …

This trial tests whether a new hand rehabilitation program, called SMART-HAND, can improve hand function, joint position sense, pain, and dexterity in people with rheumatoid arthritis. The program combines sensory training, massage, joint approximation, range-of-motion exercises,…

This trial investigates whether the Healthy Minds Program, a mobile meditation training app, can reduce symptoms of depression in adults. About 1,500 participants with elevated depressive symptoms will complete a 4-week well-being program using the app. Researchers will measure c…

This study tests whether textured shoe insoles can improve balance, walking, and foot sensation in adults with plantar fasciopathy, a common cause of heel pain. Participants will wear both textured and smooth insoles while researchers measure their postural control, gait, and pla…

This study explores whether a short, evidence-based therapy called Written Exposure Therapy (WET) can help pregnant and postpartum women who have PTSD and a history of substance misuse. Participants receive five weekly telehealth sessions where they write about a traumatic experi…

This trial tests whether a wearable device emitting near-infrared light during sleep can improve sleep quality and reduce the need for sedative-hypnotic medications in adults with chronic insomnia. Sixty adults who use sleeping pills at least four nights a week will use either th…

This study looks at whether using AI-made videos to show patients what happens during knee replacement surgery can lower their anxiety and fear of moving after the operation. About 150 adults aged 55 and older who are scheduled for knee replacement will take part. Half will get s…

This trial tests whether adding pain neuroscience education and graded motor imagery to standard physiotherapy can improve pain, movement, and fear of movement in people with type 2 diabetes and frozen shoulder. Fifty adults aged 40-65 with diabetic adhesive capsulitis will recei…

This trial tests whether a structured 12-week physiotherapy exercise program can improve balance, posture, and reduce fall risk in people with osteoporosis. Participants, aged 50 and older, will be randomly assigned to either the exercise program or a control group. The program f…

This study tests if giving a short course of steroids (methylprednisolone) for 7 days can help adults with heart failure who are in cardiogenic shock, a serious condition where the heart can't pump enough blood. The goal is to reduce harmful inflammation and help patients recover…

This study tests whether taking dronabinol (a cannabis-derived medication) before bed can help people with obstructive sleep apnea use their CPAP machine more consistently. Researchers will also check if combining CPAP with dronabinol improves sleep quality and blood pressure. Th…

This trial tests whether a structured self-care education program can reduce joint stiffness and improve functional ability in people with rheumatoid arthritis. Participants are split into two groups: one receives the education program alongside usual care, while the other gets u…

This study tests whether adults with chronic, stable mental health conditions will actively engage in a 4-month musical immersion program called Résonance(s), which includes rehearsals with a professional orchestra, listening sessions, and a final public concert. The main questio…

This pilot study tests a new preservative-free eye drop called NOX-01 in people with mild to moderate dry eye who are having cataract surgery. The drop is designed to lubricate and protect the eye surface, potentially reducing the dry eye symptoms that often occur after surgery. …

This study tests whether AI-based cognitive training, using the Lumosity app, combined with a tailored physical-therapy program can improve sleep and quality of life in people with multiple sclerosis. Participants aged 25-40 with mild to moderate disability will undergo the train…

This trial tests whether an AI-based system can provide preoperative counseling for elective cesarean delivery as effectively as a physician. Women scheduled for a C-section will be randomly assigned to receive either standard doctor-led counseling or AI-delivered counseling with…

This study tests whether a 12-week program of dance, yoga, and mindful movement can improve the lives of adults aged 18 to 35 with autism spectrum disorder (ASD). Researchers want to see if the program can enhance social skills, communication, quality of life, and overall well-be…

This pilot study tests a new model of mental health support for siblings aged 10-17 of children with medical complexity. The model uses screening and assessments by social workers, who can provide talk therapy or refer to a child psychiatrist for diagnosis and treatment. The goal…

This study will compare two sedative drugs, remimazolam and dexmedetomidine, in 60 adults with obstructive sleep apnea undergoing drug-induced sleep endoscopy. The goal is to see which drug provides more stable sedation, fewer side effects like low heart rate or low blood pressur…

This study tests whether a single injection of concentrated bone marrow cells can reduce pain and improve function in people with hip osteoarthritis better than a standard steroid injection. One hundred adults with moderate to severe hip arthritis will be randomly assigned to rec…

This study tests a new group program designed for young people at clinical high risk for psychosis who also have suicidal thoughts or behaviors. The program, led by a clinician and a peer with lived experience, focuses on building hope, setting recovery goals, and strengthening s…

This trial tests whether brief behavioral sleep therapy and mindfulness, alone or combined, can reduce how often older women wake up at night to urinate. Women aged 65 and older with frequent nocturia and poor sleep will be randomly assigned to one of four groups: sleep therapy, …

This trial tests whether duloxetine, an FDA-approved osteoarthritis drug, can improve walking ability and physical activity in people with chronic knee osteoarthritis pain. Participants take duloxetine or a placebo for six weeks, then complete surveys, physical tasks, brain imagi…

This pilot study tests a software tool called NEXT that gives personalized advice on insulin and carbohydrate adjustments before and after exercise for adults with type 1 diabetes. Twenty participants will try three different approaches to managing their blood sugar around exerci…

This study tests whether adding manual lymphatic drainage massage to therapeutic exercises and compression garments helps reduce lower limb swelling in pregnant women during their third trimester. Sixty women aged 25-35 with mild-to-moderate swelling will be split into two groups…

This trial tests whether Yanlishuang buccal dropping pills, a traditional Miao medicine, can relieve the sore throat and pain of acute pharyngitis. About 400 adults with a sore throat that started within the last 48 hours will be randomly assigned to take either the herbal drops …

This trial tests whether a special laser, called UltraClear, can safely improve skin laxity and provide a lifting effect on the lower face, under the chin, and neck. Up to 50 adults aged 35 to 65 will receive two laser treatments about seven weeks apart. Researchers will check re…

This study tests four different supplement formulas, called Qualia Sleep A, B, C, and D, to see if any can improve sleep quality and satisfaction in adults who report poor sleep. About 100 healthy adults will take one of the four formulas as capsules each night for 28 days. Parti…

This trial tests whether a non-wearable audiovisual display, like a mobile screen showing calming content, can reduce anxiety in children aged 6 to 12 during emergency department procedures such as blood draws or stitches. Participants are randomly assigned to either use the dist…

This trial tests whether wearing lavender-sandalwood aromatherapy tabs for 24 hours can improve mood, reduce pain, and increase satisfaction in women recovering from a scheduled cesarean section. Participants wear the scented tabs on their hospital gown and complete mood and pain…

This trial asks whether adding structured exposure exercises to response prevention—a core part of exposure therapy—makes a meaningful difference for people who are highly bothered by persistent physical symptoms. About 360 adults with high symptom burden will be randomly assigne…

This study tests whether a wearable device that delivers mild electrical stimulation to the brain, called transcranial direct current stimulation (tDCS), can reduce appetite and binge eating. Adults with binge eating tendencies will use the device at home twice daily for four wee…

This study explores whether a 6-week creative writing program can help 10 teens and young adults (ages 16-25) with anorexia nervosa express themselves, reflect on their experiences, and build resilience. Participants will attend weekly workshops involving reading, writing, and gr…

Many cancer patients feel anxious before radiotherapy, partly due to unfamiliar equipment and procedures. This trial tests whether adding a simulation-based education session — a virtual preview of the treatment environment — before standard education can reduce that anxiety and …

This study tests whether inhaling high-THC cannabis can safely reduce PTSD symptoms in 320 veterans. Participants will either receive active cannabis or a placebo with almost no THC. The goal is to see if cannabis helps with PTSD severity and daily functioning, providing real-wor…

This trial tests whether a non-invasive brain stimulation method called transcranial temporal interference stimulation (tTIS) can improve sleep in people with chronic insomnia. Participants will be randomly assigned to receive either active tTIS or a sham (inactive) version, with…

This trial is testing whether a specially adapted form of cognitive behavioral therapy, called CBT-DAY, can reduce depressive symptoms in autistic youth aged 11 to 17. Participants will be randomly assigned to receive either CBT-DAY or standard care, and researchers will compare …

This trial tests whether a 12-week Latin dance program—featuring Rumba, Cha-cha, and Jive—can improve psychological health in primary school children aged 6 to 12. Participants are randomly assigned to either the dance program or regular physical education classes. Researchers wi…

This study tests a brief psychological program designed to help people who have been hospitalized with a musculoskeletal injury and prescribed opioids. The program includes education about long-term opioid use and mindfulness-based strategies, delivered through a computer session…

This trial tests whether a set of self-help booklets, based on cognitive behavioural therapy for insomnia (CBT-I), can improve sleep quality in adults with pulmonary hypertension (PH). Participants will be randomly assigned to receive the booklets during the study or after a wait…

This study tests whether taking creatine supplements before surgery can help protect thinking, memory, and attention in older adults. Creatine is widely used for muscle performance, but may also support brain health. Researchers will give creatine to 80 older adults scheduled for…

This study tests whether a daily fermented soy product, Haelan 951, can help ease hot flashes and improve sleep in women going through menopause. About 25 peri- and postmenopausal women aged 45-65 will take the product for 45 days and track their symptoms. The goal is to see if t…

This study tests whether a six-week program of automated text or email messages can help reduce stress and burden for people caring for a loved one with dementia. Twenty care partners who previously took part in an observational study will receive educational tips, stress managem…

This trial tests whether inhaling bitter orange oil before bed can improve sleep quality and reduce fatigue in adults with type 2 diabetes. One hundred participants will be randomly assigned to inhale either bitter orange oil or plain water for three nights. On the fourth morning…

This trial tests whether a magnesium-based supplement taken before bed can improve sleep quality and speed up recovery after intense exercise. Healthy, recreationally active adults aged 18-40 will take the supplement or a placebo for two weeks each, then complete a leg exercise p…

This pilot trial tests a structured cognitive rehabilitation program called CanCOG® for cancer survivors who experience thinking difficulties—often called 'chemo brain'—after treatment for cancers outside the brain. Sixty adult survivors will be randomly assigned to either the si…

This study tests whether a combination of two sedatives, esketamine and dexmedetomidine, can better control agitation and shorten delirium in intensive care unit (ICU) patients who are on non-invasive breathing support. The trial will enroll 388 adults with hyperactive delirium a…

This study compares two types of brain stimulation—accelerated theta burst and high-frequency TMS—against a sham (fake) treatment to see if they can improve cognitive problems like memory and attention in people with treatment-resistant schizophrenia. Ninety adults on clozapine w…

This study tests whether a nurse-led program delivered via WhatsApp, using a digital booklet on sleep hygiene and relaxation, can improve sleep in older adults who feel lonely and have insomnia. Participants are randomly assigned to either the WISE program or usual care. The tria…

This study tests whether a daily probiotic supplement, Bifidobacterium longum 1714™, can improve wellbeing in adolescents aged 15-17 who report mild-to-moderate anxiety. Over 8 weeks, participants take one capsule daily and report changes in anxiety, sleep, fatigue, and cognitive…

This Phase 2 trial tests whether combining psilocybin—a compound from certain mushrooms—with daily cognitive training can enhance brain plasticity in adults aged 65 and older. Participants include healthy older adults and those with mild cognitive impairment or early-stage Alzhei…

This trial tests whether taking a daily capsule of Nepalese pepper extract (Zanthoxylum armatum) for 42 days can improve cognitive speed, reduce mental fatigue, and enhance gaming performance in healthy young action video gamers aged 16 to 39. Participants will take either the pe…

This study tests whether LEGO®-Based Play Therapy can help children with autism spectrum disorder improve their social and play skills. Children aged 6 to 12 will participate in weekly group sessions for 12 weeks, working together to build LEGO models while taking on roles like E…

This pilot trial tests a digital program called Together in Parenting (TIP) designed to help fathers who are experiencing symptoms of depression or anxiety after their child is born. The program includes short podcasts and educational materials based on interpersonal therapy. The…

This large citizen-science trial is testing whether two prebiotic products can reduce feelings of anxiety and improve related outcomes like sleep in adults. Around 1,000 participants will be randomly assigned to take either an active prebiotic or a placebo for 12 weeks, without k…

This study tests whether a gentle, non-invasive brain stimulation technique called transcranial alternating current stimulation (tACS) can improve sleep and reduce anxiety in adults over 60 who have chronic insomnia. Sixty participants will receive tACS sessions, and researchers …

This study tests whether a 12-week program of adaptive computerized cognitive training—brain exercises that automatically adjust to each person's performance—can improve memory, attention, and other thinking skills in older adults with mild cognitive impairment. Participants, age…

This trial tests whether a daily conversation platform powered by artificial intelligence can support cognitive health in older adults at high risk of dementia. Participants engage in voice-based conversations tailored to their interests, designed to exercise memory, attention, l…

This study tests whether adding a ketogenic (low-carb) diet to a non-invasive brain stimulation treatment called iTBS helps people with treatment-resistant depression feel better. Sixty adults will follow either a keto diet or a standard healthy diet for three weeks, then receive…

This early-stage trial will give a single 10 mg dose of psilocybin to 70 adults recovering from trauma surgery who also have opioid use disorder. Researchers want to see if it's safe and practical to give psilocybin in the hospital, and how it affects pain, mood, and opioid use o…

This study tests whether a smartphone app with AI can help adolescents aged 14-20 quit e-cigarettes. Participants use the app to set goals, track progress, and get real-time support during cravings. Researchers compare an immediate-use group with a delayed-start group to see if t…

This study will test a new multilingual chatbot called LIFT-UP designed to help people living in poverty quit smoking. Researchers will interview 22 adults who smoke at least 3 cigarettes daily and are motivated to quit. The goal is to see if the chatbot is easy to use and helpfu…

This study tests a 4-month personalized digital program (PASS) to help people with obstructive sleep apnea start and continue using positive airway pressure (PAP) therapy. Sixty overweight, inactive adults newly diagnosed with sleep apnea will be randomly assigned to either the P…

This pilot study tests whether photobiomodulation therapy—using a special laser device—can reduce pain in people who go home the same day as their total knee replacement surgery. Participants receive the light therapy as part of their post-operative pain plan, and their pain leve…

This study tests a personalized, non-invasive brain stimulation device for 10 people with mild cognitive impairment (MCI). The device uses AI to tailor electrical stimulation to each person's brain patterns while they do memory exercises. The goal is to see if this approach can i…

This trial tests whether a type of talk therapy called Acceptance and Commitment Therapy (ACT) can help cancer survivors and their spouses cope with the fear that cancer might return. It compares ACT to a more traditional therapy, Cognitive Behavioural Therapy (CBT), in a two-arm…

This trial tests a 12-week, physiotherapist-led online exercise program called POSH-Ex for women who recently gave birth. The program combines pelvic floor training, breathing exercises, and whole-body movements to improve sexual function and overall well-being. Researchers will …

This trial asks whether keeping the knee slightly bent for a few hours after knee replacement surgery improves recovery compared to the usual straight position. About 150 adults scheduled for a knee replacement will be randomly assigned to either have their knee positioned at a 6…

This study tests whether using a virtual reality headset at home can help adults with chronic pancreatitis manage their pain. Twenty participants will use either a gut-directed VR therapy or a distraction-based VR for 8 weeks. The main goal is to see if people can stick with the …

This trial tests whether Snoezelen therapy—a calming, multisensory experience using lights, sounds, and textures—can improve health in adults with schizophrenia (including those needing institutional care) and women with alcohol dependence. Participants will attend 30-minute sess…

This trial tests whether Narrative Enhancement and Cognitive Therapy (NECT), a 12-session group program, can help adults with severe mental health disorders — including substance use disorders — overcome self-stigma and promote personal recovery. About 106 participants receiving …

This pilot trial tests whether a brief, culturally adapted support message sent to a smartphone during moments of high stress can reduce the urge to smoke, vape, or eat in response to stress. About 115 gender and sexual minority adults in Dhaka will receive up to five check-ins p…

This study tests whether a structured cognitive training program can improve memory, attention, and other thinking skills in older adults who have type 2 diabetes and mild cognitive impairment. Participants will be randomly assigned to either the cognitive intervention or a contr…

This trial tests whether a structured, culturally adapted home-based exercise program helps Afghan women with mild to moderate depression stay active compared to routine exercise advice. About 60 women aged 18-50 will be randomly assigned to either the exercise program or usual c…

This trial tests whether box breathing — a technique of inhaling, holding, exhaling, and holding for 4 seconds each — can reduce anxiety, pain, and improve lung function in people undergoing colonoscopy. Half of the 68 participants will practice the breathing exercise before the …

This trial tests whether giving the sedative dexmedetomidine during hip replacement surgery can dampen the body's stress and inflammatory response to the operation. Researchers will compare two doses of the drug against a placebo in 90 adults aged 50-90 undergoing total hip arthr…

This trial tests whether a procedure called genicular artery embolization can reduce pain and improve function in people with knee osteoarthritis who have not responded to standard treatments. Doctors insert a thin tube into an artery in the groin, guide it to blood vessels aroun…

This study tests two different CPAP devices for people newly diagnosed with obstructive sleep apnea. One device uses a feature called KPAP, the other uses EPR. Researchers will compare how well each device controls breathing pauses during sleep and how patients feel about their s…

This pilot study tests a short brain training program called EEG neurofeedback in adults with alcohol use disorder. Over about one week, participants complete three sessions where scalp sensors record brain activity and provide real-time feedback to help them lower alpha brain wa…

This study tests whether a self-paced online program called WeACT can help family caregivers of people with dementia feel better mentally and emotionally. About 40 adult caregivers with mild to moderate depression will use the program for six weeks. Researchers will check if care…

This study looks at brain activity in teenagers aged 10 to 17 with ADHD, OCD, or no diagnosis. Researchers will use EEG, MRI, and MEG to measure brain signals while participants do computer tasks. The goal is to understand how the brain controls thinking and behavior, which may h…

This study tests whether structured toolkits—including staff education, referral plans, and billing guidance—can help pediatric diabetes clinics deliver a behavioral intervention called Diabetes Coaching to more families of teens with type 1 diabetes. Researchers will ask whether…

This study tests whether an AI-driven mobile app, paired with a Fitbit, can deliver personalized exercise plans that older adults find feasible and acceptable. Over 8 weeks, participants aged 65 and older will receive daily and weekly exercise prescriptions tailored to their acti…

This study looks at how HIV and substance use disorder (SUD) affect the sense of smell and decision-making. Researchers will test 120 adults aged 18–65, including people with HIV, SUD, both, or neither. Participants will complete smell tests and computer tasks over two visits, an…

This study asks whether swapping a beef burger for a plant-based pea burger changes how the body handles fats and sugar after a meal. Ten adults with metabolic syndrome (and a BMI of 25 or higher) will eat both types of burgers on separate occasions in a crossover design. Researc…

This study compares sleep quality between adolescents with idiopathic scoliosis and healthy peers of similar age and sex. Researchers will use questionnaires to assess sleep, and in the scoliosis group, they will also look at curve severity, pain, body image, and brace use. The g…

This study looks at the medical records of 300 people treated for meningitis at a hospital in Sohag, Egypt, to understand what factors influence their chances of recovery. Researchers will review past cases and follow new patients for a year, tracking who survives, who recovers f…

This study will follow 1,000 people aged 8 to 65 who are overweight, have high blood sugar, or have metabolic issues. Researchers will collect blood, saliva, urine, and stool samples during routine clinic visits, along with questionnaires about diet, sleep, and mood. The goal is …

This study explores whether brain activity and sleep patterns can predict how well people with PTSD respond to Written Exposure Therapy, a brief therapy involving structured writing about a traumatic event. About 200 adults with PTSD will be randomly assigned to either this thera…

This study will follow 100 adults with Crohn's disease, ulcerative colitis, or other IBD, plus their healthy relatives, for up to 3 years. Researchers will collect blood, stool, tissue samples, and imaging to track how immune cells and genetics change over time. The goal is to fi…

This study looks at how stress from being a refugee—like trauma, discrimination, and adjusting to a new culture—affects sleep in Bhutanese refugees living in Ohio. Researchers will hold focus groups and interviews with 70 adults to understand their sleep problems and coping strat…

This study is a large international registry that will look back at the medical records of about 1,000 adults who were treated with the AngioVac system, a device that uses suction to remove blood clots, infected tissue, or other unwanted material from the heart and major blood ve…

This natural history study will explore how life experiences and environmental factors affect heart health and metabolism among 50 Bhutanese adults living in the US. Participants will complete a survey and discuss their views on providing biological samples. The goal is to identi…

This study tests whether continuous glucose monitors (CGMs) like the Dexcom G7 can be safely and effectively used in intensive care units. The monitors provide real-time blood sugar readings and alarms for dangerously high or low levels, potentially reducing the need for frequent…

This study evaluates whether an investigational eye imaging device, UNITY DX, can measure the thickness of the cornea and its epithelial layer as accurately and consistently as a commercially available device. About 110 participants with normal or abnormal corneas will undergo mu…

This trial tests a website called Heart2Heart, created for teens living with congenital heart disease. The site provides health information and interactive tools to help them stay healthy. Researchers want to see if teens will use and enjoy the site, and whether it changes their …

This study screens up to 1,000 people with personal or family histories of certain cancers to see if they qualify for ongoing genetics research at the National Cancer Institute. Participants fill out a 15-20 minute online survey about their health and family history. No treatment…

This early-stage study tests a new form of transcranial magnetic stimulation (TMS) called high-density theta burst stimulation (hdTBS) in 35 healthy adults aged 22 to 60. The goal is to check if hdTBS is safe and to compare its effects on the brain to standard TMS. Participants w…

This study aims to adapt the Menstrual Cycle Knowledge Questionnaire (MCKQ) into Turkish and check whether it is a valid and reliable tool for female athletes. Researchers will ask 120 women aged 16 to 35 who are licensed athletes to fill out the questionnaire, along with other s…

This study will give a single dose of oral methamphetamine to 20 people with HIV who are on effective antiretroviral therapy and have undetectable virus levels. The goal is to see if the drug can temporarily wake up dormant HIV hiding in cells, which could help researchers find n…

This study investigates whether tiny particles called extracellular vesicles, released by brain cells into the blood, can serve as reliable markers of nerve damage in people with multiple sclerosis or stroke. Researchers will measure these particles in blood samples from 60 parti…

This study investigates how eating three high-fat meals in a row changes vitamin E levels in the blood. Researchers will compare people with normal blood fats to those with high blood fats (hyperlipidemia). The goal is to understand whether fats in the blood can trap vitamin E, p…

This study looks at how eating a high-fat or high-carb breakfast changes fat levels in the blood over 8 hours. Researchers will compare results among people with conditions like diabetes, fatty liver, or kidney disease, as well as healthy volunteers. Participants will have two ov…

This study looks at whether a structured surveillance program using regular ultrasound and a blood test (alpha-fetoprotein) can detect liver cancer at an earlier, more treatable stage in people at high risk. About 300 adults with liver cirrhosis, chronic hepatitis B, or advanced …

This study aims to understand how a quick, non-invasive brain stimulation treatment called iTBS works in people with depression. Researchers will measure brain activity before and after stimulation in 100 participants (healthy volunteers and those with depression) using EEG and M…

This study looks at how different doses of THC (the active ingredient in cannabis) affect eye movements and attention. Researchers will test 40 adults—some who use cannabis often and some who use it rarely—to see if eye-tracking can reliably detect impairment. The goal is to deve…

This study aims to classify the different types of chronic pain experienced by people with multiple sclerosis (MS). Researchers will use a detailed clinical assessment to categorize pain as nociceptive, neuropathic, nociplastic, or mixed. The goal is to see if different pain type…

This trial tests whether a brief educational video about sleep can help college students sleep better and think more clearly. About 300 undergraduate students will be randomly assigned to watch the sleep lecture either right away or after a waiting period. Researchers will compar…

This study looks at whether a digital tool called Luscii is practical and acceptable for people with a rare heart condition called ATTR-CM. About 60 adults in Austria, Germany, and Italy will use a smartphone app and home devices to share health information with their care team. …

This study aims to develop and validate a new questionnaire to measure opioid withdrawal symptoms. Researchers will work with people who have experienced opioid withdrawal to identify all possible symptoms and refine the tool through interviews and testing. The goal is to create …

This study evaluates whether several sleepiness questionnaires are reliable for children and adolescents aged 6 to 17. It includes three groups: children from the general population, those with sleep disorders or conditions like narcolepsy or ADHD, and healthy volunteers. The goa…

This study looks at stroke survivors who have mild aphasia—a condition causing language difficulties. Researchers want to see if these individuals also struggle with 'executive control' of language, which helps us manage and switch between words and ideas. By testing 30 participa…

This study follows 400 adults with generalized anxiety disorder (GAD) to understand how symptoms and health change over time. Researchers will collect clinical assessments, blood samples, and brain measurements at multiple visits. The goal is to identify factors that may predict …

This registry study follows 400 Alzheimer's patients in Canada who are prescribed LEQEMBI, a medication for the disease. The goal is to track the frequency and severity of known side effects, such as brain swelling (ARIA-E), microbleeds (ARIA-H), and larger brain hemorrhages, dur…

This study investigates whether the thickness of fat over the shin bone, measured on a standard knee X-ray, is a better predictor of infection after total knee replacement than Body Mass Index (BMI). Researchers will review data from 400 adults who had knee replacement surgery, c…

This study follows 180 people with early relapsing-remitting multiple sclerosis (MS) to understand why some experience disability progression even without relapses. Researchers will use MRI scans, eye tests, and blood biomarkers to see if they can predict this type of progression…

This observational study is investigating whether certain blood markers and gut microorganisms can help identify people with chronic pancreatitis who are at higher risk of developing pancreatic cancer. Researchers will compare healthy individuals, those with chronic pancreatitis,…

This study looks at how using nicotine vapes before or after THC vapes changes the amount of THC that enters the bloodstream. Researchers will compare THC levels and effects in 60 adults who regularly use both products. The goal is to understand safety and how these products work…

This study is a registry that will collect health information from 1,000 people who carry the gene for hereditary amyloidosis, including those with and without symptoms. Researchers will track who develops the disease and how it progresses, including the need for heart transplant…

This study looks at whether a specific type of stroke called branch atheromatous disease (BAD) is linked to cognitive decline. Researchers will follow 60 adults aged 18-80 who had this stroke, tracking their thinking and memory over a year. They will also examine if early neurolo…

This study compares screening for postpartum depression at 2 weeks after birth versus the usual 6-8 weeks. Researchers will randomly assign 428 new mothers to either early or routine screening using a simple questionnaire. The goal is to see if earlier screening helps identify de…

This early-stage trial is testing an experimental oral drug called TUL321 in healthy adults to see if it is safe and tolerable. The study will also measure how the drug moves through the body and whether food affects its absorption. TUL321 is being developed as a potential treatm…

This study investigates how the brain processes social decisions like trust and cooperation. Participants play a modified trust game, either in an MRI scanner or online, where their choices affect monetary gains or losses. The goal is to link brain activity and behavior to person…

This study looks at how bariatric surgery affects the liver's energy processing in people with obesity and fatty liver disease. Researchers will use safe, non-radioactive tracer infusions and MRI scans before, during, and six months after surgery to measure changes in liver metab…

This study measures specific substances (metabolites) in the breath and blood of people with inherited metabolic disorders, those on a special ketogenic diet for epilepsy, and healthy volunteers. The goal is to see if a simple breath test can reliably track these metabolites, pot…

This study tracks blood sugar changes after an epidural steroid injection for back or leg pain. Researchers will compare 36 adults with and without type 2 diabetes using a continuous glucose monitor worn for 15 days. The goal is to see if the injection causes higher or longer-las…

This study looks at whether teaching East Asian American adults about alcohol flushing and offering them a genetic test for it is practical and helpful. About 100 people who flush when they drink or have a family history of flushing will take part. Half will get education only, a…

This study will compare custom 3D printed splints made at the hospital with those made by outside companies for jaw surgery. The splints help surgeons align the teeth and jaws correctly during the operation. Researchers want to see if the in-house splints are faster to get, cheap…

This pilot study explores whether a structured approach called shared decision-making can be successfully implemented in a methadone treatment program. Shared decision-making involves clients and healthcare professionals working together to make treatment choices. The study will …

This study looks at whether the ratio of the second to fourth finger (2D:4D) is linked to anxiety and work stress in anesthesiology residents. Researchers will measure finger lengths and use a questionnaire to assess worry and anxiety in about 116 residents aged 20-35. The goal i…

This trial tests whether taking tyrosol, a compound found in olive oil, together with creatine can improve endurance, strength, and thinking in healthy, active adults. Over eight weeks, participants take either creatine alone, creatine plus tyrosol, or a placebo, and complete cyc…

This study will gather information from hospitals across the country about pregnant women who are critically ill and need a cesarean delivery, especially when it happens outside a standard operating room. The goal is to better understand the risks and outcomes for both the mother…

This study investigates how often muscle relaxants used during general anesthesia remain in the body after surgery, a condition called residual neuromuscular blockade. It will follow 160 adults aged 18-90 who are scheduled for post-anesthesia care unit admission after elective su…

This study investigates whether playing soft sounds during deep sleep can help researchers understand and possibly influence episodes of sleepwalking, sleep terrors, and confusional arousals—conditions known as disorders of arousal. Participants with these conditions will spend t…

This study is building a biobank of blood samples and imaging data from 300 people with suspected inflammatory heart or autoimmune rheumatic diseases. Researchers aim to identify immune biomarkers that could predict major heart events like heart failure, stroke, or atrial fibrill…

This study looks at adults with acute pancreatitis, a sudden inflammation of the pancreas, to understand the different ways it presents and what happens to patients. Researchers will track 100 participants to identify patterns and potential predictors of outcomes. The goal is to …

This study looks at how muscle cells send tiny packages called extracellular vesicles to fat cells during exercise, which may affect how the body processes sugar and fat. Researchers will compare 40 adults—some with prediabetes and some healthy—to understand why some people's fat…

This study uses a non-invasive brain stimulation technique called TMS to temporarily change activity in a brain region linked to anxiety. Researchers will use fMRI scans to see how this affects brain connections and anxiety-related startle responses. 140 adults with anxiety will …

This study looks at how blood test results change after delivery in people with severe preeclampsia. Participants are randomly assigned to receive magnesium for either 12 or 24 hours after birth. The goal is to see if a shorter treatment is safe and effective, and to understand h…

This study is testing a program called Mothers and Babies for Down Syndrome (MBDS) to help prevent depression in new and expectant parents of infants with Down syndrome. About 72 parents will take part in a small pilot study to see if the program helps with feelings of grief and …

This study looks at how anticipated stigma and illness identity affect quality of life in men with hypogonadism (low testosterone). It compares these men to those with other chronic endocrine conditions like diabetes, hypothyroidism, or hypertension. The goal is to see if these p…

This study tests a training program called Project ECHO to help rural jails start or increase use of medications (methadone, buprenorphine, naltrexone) for opioid use disorder. Staff from 40 jails will attend online sessions with experts and peers over 18 months. Researchers will…

This Phase 1 trial is testing two different formulations of an experimental drug called HRS-5346 in healthy adults aged 18 to 45. The goal is to compare how well the body absorbs each version, which helps guide future development. Participants receive both formulations in a cross…

This study looks at whether levels of a protein called 15-PGDH in the blood and joint fluid are linked to the severity of osteoarthritis and ankylosing spondylitis. Researchers will measure 15-PGDH in about 51 adults with these conditions and compare it with ultrasound images and…

This early-stage study looks at how a new drug called ABBV-932 moves through the body when taken with another drug, itraconazole. Twenty healthy adults will take both drugs and have their blood levels measured. The goal is to check for side effects and see if itraconazole changes…

This study looks at how common fatty liver disease (MASLD) is in adults with type 1 diabetes. Researchers will check 250 adults with type 1 diabetes for signs of liver fat and scarring, using non-invasive tests. The goal is to understand if type 1 diabetes raises the risk of live…

This study looks at how beta-cells (which make insulin) respond to growth hormone in people with prediabetes. Researchers will measure insulin release in 10 adults with impaired fasting glucose or impaired glucose tolerance. The goal is to better understand what raises the risk o…

This trial investigates whether taking lithium for a week changes how the eyes and brain respond to light in healthy adults aged 18 to 40. Participants will undergo light exposure sessions with and without lithium, while researchers measure melatonin suppression, alertness, mood,…

This study looks at whether two blood markers—DEL-1, an anti-inflammatory protein, and thromboxane A2, a sign of platelet activity—are linked to diabetic nephropathy, a common kidney complication of diabetes. Researchers will measure these markers in 80 adults, including patients…

This study will examine 108 adults aged 30-65 to see if a gene called Klotho, certain mouth bacteria, and viruses are linked to gum disease and acute coronary syndrome (a type of heart attack). Researchers will measure gum health and collect samples to look for these markers. The…

This study uses an online questionnaire to gather information from 15,000 Spanish-speaking adults about their sexual health, behaviors, and any experiences of altered consciousness during orgasm. The goal is to better understand the range of sexual function and pleasure, and to e…

This study asks whether routine medical data can predict which survivors of an emergency intensive care unit (EICU) stay will develop post-traumatic stress disorder (PTSD) one month after leaving the hospital. Researchers will follow about 800 adult patients, collecting details f…

This study aims to develop and test an AI system that uses smartphone photos with a color card to measure redness in psoriasis lesions. Fifty adults with psoriasis will take weekly photos at home and have clinic photos taken. The goal is to see if this simple, low-cost method mat…

This study will test 70 healthy adults aged 21-55 to see how cannabis products labeled as indica, sativa, or generic affect thinking, driving, and feelings. Participants will complete memory tasks, driving simulations, and questionnaires after using cannabis. The goal is to under…

This study looks at how the hormone glucagon works with insulin in the liver to manage blood sugar. Researchers want to understand glucagon's multiple, sometimes opposite, roles to create better diabetes medicines. Forty healthy adults aged 18-45 will have two 5-hour sessions whe…

This study tests whether a non-invasive brain stimulation technique called theta burst stimulation (TBS) can change how people remember the order of emotional movie clips. Researchers will compare active TBS to a sham (fake) version in 120 healthy adults. The goal is to understan…

This trial tests whether a scenario-based simulation training session can reduce anxiety, boost self-confidence, and improve clinical skills in nursing students when counseling pregnant women about nutrition. Half of the participants will take part in a 20-minute simulated counse…

This study explores how financial insecurity—such as trouble paying for housing, food, or healthcare—affects the mental health of university students and whether it keeps them from seeking help. Researchers will conduct in-depth interviews with 30 students from two French univers…

This study investigates how often older adults in China experience anxiety and depression before undergoing major non-cardiac surgery. Researchers will use standard questionnaires to screen 8,000 patients aged 65 and older across multiple hospitals. The goal is to better understa…

This study follows 200 children and teens aged 7-17 who are at higher risk for depression, anxiety, or obsessive-compulsive disorder (OCD) due to family history or early symptoms. Over two years, researchers will use interviews, questionnaires, brain scans (EEG and MRI), and biol…

This study looks at whether certain proteins in the blood, which signal brain injury, can predict memory and thinking problems in people who survive sepsis or septic shock. Researchers will measure these biomarkers in 210 adults admitted to intensive care and check their cognitiv…

This study explores whether short, AI-generated videos from a virtual doctor can help people with psoriasis stick to their topical medication routine. Fifteen adults will be split into three groups: weekly AI videos, weekly human doctor videos, or standard care (one follow-up vis…

This study compares two ways of giving the same experimental biosimilar drug, DRL_AB, which is designed to work like abatacept for autoimmune conditions. Healthy male volunteers receive a single dose either through an autoinjector or a prefilled syringe. Researchers measure how m…