Can brain stimulation tame ataxia?
NCT ID NCT07752095
First seen Aug 07, 2026 · Last updated Aug 07, 2026
Summary
This trial tests whether deep brain stimulation (DBS) targeting the cerebellum is safe and feasible for people with spinocerebellar ataxia types 1 and 3, a group of inherited disorders that cause progressive problems with movement and coordination. The study will enroll 12 adults with moderate ataxia and will measure side effects, as well as changes in ataxia severity and brain activity. The goal is to see if this approach could offer a new way to control symptoms.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Deep brain stimulation (DBS) of the deep cerebellar nuclei using the UG3NS140720 system
- What this could lead to
- If successful, this could lead to a new treatment option to improve movement and coordination in people with spinocerebellar ataxia.
- What could go wrong
- This is an early safety and feasibility study with a small number of participants. Risks include bleeding in the brain, infection, and device-related complications. The treatment may not improve symptoms.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Cleveland Clinic
Cleveland, Ohio, 44195, United States
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Columbia University Irving Medical Center
New York, New York, 10032, United States
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