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Hope for ataxia: experimental drug shows promise in Late-Stage trial

NCT ID NCT02960893

Completed Disease control Sponsor: Biohaven Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a drug called troriluzole in 141 adults with spinocerebellar ataxia, a rare disease that affects balance and coordination. Participants took either the drug or a placebo daily for 8 weeks. The main goal was to see if troriluzole could improve symptoms like walking and hand movements, as measured by a standard ataxia rating scale.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

autosomal dominant cerebellar ataxia Machado-Joseph disease Machado-Joseph disease type 3 spinocerebellar ataxia 7 spinocerebellar ataxia type 1 spinocerebellar ataxia type 10 spinocerebellar ataxia type 2 spinocerebellar ataxia type 6 spinocerebellar ataxia type 8 Spinocerebellar Ataxias

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SPINOCEREBELLAR ATAXIA GENOTYPE TYPE 1 SPINOCEREBELLAR ATAXIA GENOTYPE TYPE 10 SPINOCEREBELLAR ATAXIA GENOTYPE TYPE 2 SPINOCEREBELLAR ATAXIA GENOTYPE TYPE 3 SPINOCEREBELLAR ATAXIA GENOTYPE TYPE 6 SPINOCEREBELLAR ATAXIA GENOTYPE TYPE 7 SPINOCEREBELLAR ATAXIA GENOTYPE TYPE 8 SPINOCEREBELLAR ATAXIAS

Contacts and locations

Locations

  • CNS Trial

    Long Beach, California, 90806, United States

  • Columbia University

    New York, New York, 10032, United States

  • Emory University

    Atlanta, Georgia, 30329, United States

  • Harvard University (Beth Israel Deaconess Medical Center)

    Boston, Massachusetts, 02215, United States

  • Harvard University (Massachusetts General Hospital)

    Boston, Massachusetts, 02114, United States

  • Houston Methodist Research Center

    Houston, Texas, 77030, United States

  • Johns Hopkins University

    Baltimore, Maryland, 21287, United States

  • Northwestern University

    Chicago, Illinois, 60611, United States

  • St. Joseph's Hospital and Medical Center

    Phoenix, Arizona, 85013, United States

  • University of California, Los Angeles

    Los Angeles, California, 90095, United States

  • University of California, San Francisco

    San Francisco, California, 94158, United States

  • University of Chicago

    Chicago, Illinois, 60637, United States

  • University of Colorado Denver

    Denver, Colorado, 80045, United States

  • University of Florida

    Gainesville, Florida, 32611, United States

  • University of Michigan

    Ann Arbor, Michigan, 48105, United States

  • University of Rochester Medical Center

    Rochester, New York, 14642, United States

  • University of South Florida

    Tampa, Florida, 33612, United States

  • University of Texas Southwestern

    Dallas, Texas, 75390, United States