Beyond the genome: new Multi-Omics approach aims to crack the code of intellectual disability
NCT ID NCT07755098
First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time
Summary
This study tests whether combining several advanced genetic analysis techniques can find the cause of intellectual disability or neurodevelopmental disorders in people who have already had standard genetic testing with no answer. Participants will have their existing genetic data re-analyzed, and if that is not conclusive, they may undergo additional tests like long-read genome sequencing and RNA analysis. The goal is to see if these newer methods can provide a diagnosis where current methods have failed.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Multi-omics diagnostic testing including re-analysis of short-read genome sequencing data, long-read genome sequencing, mRNA sequencing, and optical genome mapping
- What this could lead to
- If successful, this approach could provide answers for families who have been searching for a genetic cause of their child's neurodevelopmental disorder, potentially improving diagnosis and care.
- What could go wrong
- The trial is relatively small and the technologies are complex and costly. It may not find a diagnosis for everyone, and the results may not be widely available in routine practice for some time.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for INTELLECTUAL DISABILITY are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Chu Dijon Bourgogne
Dijon, 21000, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Tiny exercise bursts might sharpen minds in intellectual disability
- Could a Self-Help guide transform parenting stress for families of kids with NDD?
- Brain imaging may unlock early clues to autism in tuberous sclerosis
- Can tracking a rare genetic syndrome unlock its mysteries?
- Can a simple grip test reveal mobility gaps in teens with intellectual disability?
- One-shot gene editor aims to correct a brain disorder at its source