Can targeted brain zaps ease movement problems in a rare ataxia?

NCT ID NCT07743866

First seen Aug 04, 2026 · Last updated Aug 06, 2026 · Updated 2 times

Summary

This trial tests a non-invasive brain stimulation technique called transcranial temporal interference stimulation (tTIS) in people with spinocerebellar ataxia type 3, a genetic condition that affects coordination and balance. The stimulation targets a deep brain region involved in movement control, using personalized head models to guide electrode placement. The study aims to find the best stimulation dose that improves ataxia symptoms while minimizing risks like seizures or skin burns. Participants will receive tTIS over several days, and their symptoms will be measured using a standard ataxia rating scale.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Transcranial temporal interference stimulation (tTIS) - a non-invasive brain stimulation device
What this could lead to
If successful, this could offer a non-invasive treatment to improve coordination and balance in people with spinocerebellar ataxia type 3, potentially easing daily challenges.
What could go wrong
This is an early-stage trial with a small number of participants, so results may not apply broadly. Risks include skin burns, seizures, severe headache, sleep disturbances, or brain changes.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Department of Rehabilitation Medicine, The First Affiliated Hospital of Fujian Medical University

    Fuzhou, Fujian, China

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