Can a single eye injection shrink melanoma and save sight?

This early-phase trial is testing an investigational drug called RBP-01 (sotrastaurin), given as an injection into the eye, for people with primary uveal melanoma—a rare cancer of the eye. The study aims to see if the drug is safe and whether it can shrink the tumor enough to avoid eye removal (enucleation) or reduce the risk of vision loss from standard radiation therapy. Participants will receive the injection before their planned standard treatment, and researchers will monitor for side effects and measure tumor response.