Electric pulse therapy in the gut: a new hope for type 2 diabetes?

NCT ID NCT07768631

NEW Not yet recruiting Disease control Sponsor: Endogenex, Inc. Source: ClinicalTrials.gov ↗

First seen Aug 17, 2026 · Last updated Aug 17, 2026

Summary

This trial is testing an experimental procedure called pulsENDO therapy for adults with type 2 diabetes whose blood sugar is not well controlled with current medications. The procedure uses a thin tube to deliver gentle electric pulses to the lining of the small intestine, aiming to encourage healthy regeneration of the tissue and improve the body's ability to manage blood sugar. The study will compare the effects of this procedure against a sham (placebo) procedure in 320 participants, measuring changes in HbA1c levels over six months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: pulsENDO therapy, a catheter-based endoscopic procedure using pulsed electric fields to target cells in the small intestine
What this could lead to: If successful, this could offer a new, non-drug option to help people with type 2 diabetes achieve better blood sugar control, potentially reducing the need for medications.
What could go wrong: This is an early-stage trial, and the procedure's effects on blood sugar are not yet proven. There are risks associated with any endoscopic procedure, and results may not be consistent across all participants.

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Conditions

The condition(s) this trial relates to.

Body Weight Changes diabetes mellitus type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETES DIABETES (DM) DIABETES TYPE 2 GLYCEMIC CONTROL GLYCEMIC CONTROL FOR DIABETES MELLITUS WEIGHT CHANGE

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