DIABETES (DM)

This study offers a free 3-month diabetes education program at a local faith-based organization for adults with diabetes or prediabetes in Jefferson County, Alabama. Participants attend group sessions on diet, exercise, and coping, and are paired with a community health worker fo…

This study tests whether trained female community health volunteers can help people in Nepal better manage high blood pressure and diabetes. The health workers will lead group meetings, provide health education, and coordinate care with local clinics. About 398 adults with both c…

This study tests whether a single infusion of arginine hydrochloride, a natural amino acid, can help people with type 2 diabetes recover faster from diabetic ketoacidosis (DKA), a serious complication. Sixty adults arriving at emergency rooms with DKA will receive either arginine…

This study tests whether newer diabetes drugs (SGLT2 inhibitors and DPP-4 inhibitors) can delay or prevent diabetic retinopathy, an eye disease that can lead to vision loss. Researchers will compare these newer drugs to older treatments in 70 people with type 2 diabetes. The goal…

This study looks at two ways to help people with type 2 diabetes who have trouble controlling their blood sugar. One group gets care at a day hospital, while the other works closely with a dietitian-nutritionist. The goal is to see which approach lowers HbA1c (a key blood sugar m…

This study tests whether adding reminders to electronic medical records helps doctors better manage pre-diabetes. About 6000 adults with pre-diabetes will take part. Some clinics will use the reminders, others won't. The goal is to see if the prompts lead to more blood tests, ref…

This study looks at whether sulfasalazine, a drug for inflammatory arthritis, makes the standard diabetes blood test (HbA1c) falsely low. That could mean diabetes goes undiagnosed or is undertreated in these patients. Researchers will use continuous glucose monitors and fasting b…

This study looks at how false or misleading health information found online affects the way people with chronic illnesses like diabetes and high blood pressure take their medications and make treatment decisions. Researchers will survey 300 adults who use social media at least on…

This study will use a special camera (NIRS-OCT) to look inside the heart arteries of 1,516 people with diabetes. The goal is to find fatty plaques that might rupture and cause heart attacks. Researchers hope to create a new way to identify these dangerous plaques early, so doctor…

This early-phase study looks at how alpha cells in the pancreas communicate with beta cells to control blood sugar. Researchers will give healthy volunteers exendin-9 (a GLP-1 blocker) and dexamethasone to see how insulin secretion changes. The goal is to better understand diabet…

This study looks at how heart rate affects metabolism in people with heart failure and diabetes. Researchers will take small samples of fat, muscle, and blood during pacemaker surgery to understand the link. The goal is to find new ways to treat heart failure by targeting metabol…

This study aims to identify subgroups of people with diabetes who share similar patterns between their blood sugar levels and mental health. By using smartphone surveys and continuous glucose monitors, researchers will create 'digital twins'—virtual models that can predict how me…

This observational study follows 200 adults with chronic kidney disease and a type of heart failure (HFpEF), some taking SGLT2 inhibitors (flozins) and some not. Researchers will measure arterial stiffness, heart function, and kidney decline over time to see if flozins are linked…