DIABETES (DM)

This study aims to understand how a class of drugs called SGLT2 inhibitors affects the long-term health of people who have both chronic kidney disease and a specific type of heart failure (HFpEF). Researchers will observe 200 patients, some taking the drug and some not, to see if…

This study tests whether regular follow-up with a dietitian-nutritionist works as well as traditional day hospital visits for improving blood sugar control in people with type 2 diabetes. It will involve 140 adults whose diabetes is not well controlled, and who are on insulin. Th…

This study is looking at whether newer types of diabetes medications might help delay or prevent diabetic retinopathy, a serious eye complication. Researchers will compare people taking newer drugs (like SGLT2 or DPP-4 inhibitors) to those taking older drugs (like metformin) to s…

This study is testing whether trained female community health volunteers can help people in Nepal better manage high blood pressure and diabetes together. About 400 adults with these conditions will either receive standard clinic care or extra support from volunteers, who will pr…

This study is testing whether a single dose of a natural amino acid called arginine can help people recover faster from diabetic ketoacidosis (DKA), a serious complication of diabetes. Sixty adults arriving at Detroit-area emergency rooms with DKA will receive either arginine or …

This study is testing if adding simple electronic reminders to doctors' computer systems helps prevent people with prediabetes from developing full diabetes. It involves 6000 adults in Singapore and compares clinics that use the reminders with those that don't. The main goal is t…

This study aims to find out how many patients in intensive care have undiagnosed diabetes or prediabetes, which current hospital records often miss. Researchers will measure a long-term blood sugar marker (HbA1c) in 4395 adult ICU patients to get a more accurate picture. The goal…

This study is testing a new, detailed type of heart scan to see if it can better identify dangerous, fatty buildups (plaques) in the arteries of people with diabetes and heart disease. Researchers will follow about 1,500 participants for two years to see if the scan results can p…

This study aims to understand how different hormone-producing cells in the pancreas communicate to control blood sugar. Researchers will test 30 healthy volunteers and people with obesity using detailed glucose and insulin measurements. The goal is to gather basic knowledge about…

This study aims to understand why the heart muscle weakens at higher heart rates in people with heart failure and diabetes. Researchers will collect small samples of fat, muscle, and blood from 160 patients during their scheduled pacemaker or defibrillator surgery. By analyzing t…

This study aims to better understand the link between mental health and blood sugar control in people with diabetes. Researchers will follow about 1,800 participants for several years, collecting data on their mood, stress, and glucose levels to create 'digital twin' computer mod…