New pill combo aims to crush bad cholesterol

NCT ID NCT07216482

Ongoing Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tests whether adding enlicitide decanoate to the standard statin rosuvastatin lowers LDL cholesterol more than placebo in 975 adults with high cholesterol. Participants take the drugs or matching placebos for 8 weeks. The main goal is to see the percent change in LDL-C from start to week 8.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: enlicitide decanoate (also called MK-0616) and rosuvastatin
What this could lead to: If it works, this could offer a new combination pill that lowers 'bad' cholesterol more effectively than current treatments.
What could go wrong: This is a late-stage trial, but results may not apply to everyone with high cholesterol. Side effects or lack of added benefit over existing drugs are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hyperlipidemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPERLIPIDEMIA

Contacts and locations

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Locations

Alliance for Multispecialty Research LLC ( Site 0049)

Tempe, Arizona, 85281, United States
Alliance for Multispecialty Research, LLC ( Site 0040)

Fort Myers, Florida, 33912, United States
Alliance for Multispecialty Research, LLC ( Site 0048)

Newton, Kansas, 67114, United States
Alliance for Multispecialty Research, LLC - Norman ( Site 0043)

Norman, Oklahoma, 73069, United States
Australian Clinical Research Network ( Site 0900)

Maroubra, New South Wales, 2035, Australia
Baker - HeartWest ( Site 0902)

Hoppers Crossing, Victoria, 3029, Australia
Barzilai Medical Center ( Site 0504)

Ashkelon, 7830604, Israel
Borbánya Praxis ( Site 1103)

Nyíregyháza, Szabolcs-Szatmár-Bereg, 4405, Hungary
CEMEDIC ( Site 0201)

CABA, Buenos Aires, C1407GTL, Argentina
CIPREC-CIPREC Sede Arenales ( Site 0200)

Buenos Aires, Buenos Aires F.D., C1061AAS, Argentina
Cardiology Consultants of Philadelphia Yardley ( Site 0016)

Yardley, Pennsylvania, 19067, United States
Cardiovascular Associates of the Delaware Valley ( Site 0035)

Elmer, New Jersey, 08318, United States
Care Access - Thunder Bay ( Site 0130)

Thunder Bay, Ontario, P7B 7C7, Canada
Central Research Associates ( Site 0009)

Birmingham, Alabama, 35205, United States
Centricity Research Mirabel Multispecialty ( Site 0107)

Mirabel, Quebec, J7J 2K8, Canada
Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada ( Site 0206)

CABA, C1425AGC, Argentina
Centro de Pesquisa Clinica do Coracao ( Site 0303)

Aracaju, Sergipe, 49055-530, Brazil
Centro de Pesquisas em Diabetes e Doenças Endócrino-Metabólicas ( Site 0306)

Fortaleza, Ceará, 60430-350, Brazil
Centro de Salud Concepcion Arenal ( Site 0603)

Santiago de Compostela, Galicia, 15701, Spain
Chemidox Clinical Trials ( Site 0008)

Lancaster, California, 93534, United States
Clalit Health Services - Sakhnin Community Clinic ( Site 0502)

Sakhnin, 3081000, Israel
Clinical Research Trials of Florida ( Site 0001)

Tampa, Florida, 33607, United States
Clinical Site Partners LLC, dba CSP Orlando ( Site 0014)

Winter Park, Florida, 32789, United States
Clinical Trials Research ( Site 0036)

Sacramento, California, 95821, United States
Clinical Trials of Texas, Inc. ( Site 0010)

San Antonio, Texas, 78229, United States
Conquest Research ( Site 0045)

Vienna, Virginia, 22182, United States
Cotton O'Neil Clinical Research Center ( Site 0006)

Topeka, Kansas, 66606, United States
DRC Gyógyszervizsgáló Központ ( Site 1109)

Balatonfüred, Veszprém megye, 8230, Hungary
Debreceni Egyetem Klinikai Kozpont-Belgyógyászati Klinika (Anyagcsere Tanszék) ( Site 1102)

Debrecen, 4032, Hungary
EAP Sardenya ( Site 0601)

Barcelona, 08025, Spain
EBA Centelles ( Site 0600)

Barcelona, 08540, Spain
East Coast Institute for Research ( Site 0041)

Lake City, Florida, 32055, United States
Ege Universitesi Hastanesi ( Site 0708)

Izmir, 35080, Turkey (Türkiye)
Emeritus Research ( Site 0904)

Camberwell, Victoria, 3124, Australia
Erciyes Universitesi Tıp Fakultesi Hastaneleri ( Site 0701)

Kayseri, 38030, Turkey (Türkiye)
Eskisehir Osmangazi University ( Site 0705)

Eskişehir, 26480, Turkey (Türkiye)
Fundacion Estudios Clinicos ( Site 0203)

Rosario, Santa Fe Province, S2000CVD, Argentina
Fundação Faculdade Regional de Medicina de São José do Rio Preto ( Site 0309)

São José do Rio Preto, São Paulo, 15090-000, Brazil
Fusion Clinical Research ( Site 0901)

Norwood, South Australia, 5067, Australia
G A Research Associates ( Site 0102)

Moncton, New Brunswick, E1G 1A7, Canada
G&L Research ( Site 0024)

Foley, Alabama, 36535, United States
Great Lakes Clinical Trials - Ravenswood ( Site 0018)

Chicago, Illinois, 60640, United States
Hacettepe Universite Hastaneleri ( Site 0700)

Sıhhiye, Ankara, 06230, Turkey (Türkiye)
Health Research of Hampton Roads, Inc. ( Site 0013)

Newport News, Virginia, 23606, United States
Hospital Universitário São Francisco de Assis - Bragança Paulista ( Site 0305)

Bragança Paulista, São Paulo, 12916-542, Brazil
IBPClin - Instituto Brasil de Pesquisa Clínica ( Site 0302)

Rio de Janeiro, 20241-180, Brazil
Inpatient Research Clinic ( Site 0017)

Miami Lakes, Florida, 33014, United States
Institut de Cardiologie de Montreal ( Site 0109)

Montreal, Quebec, H1T 1C8, Canada
Instituto de Cardiología "Juana F. Cabral"-Cardiología ( Site 0205)

Corrientes, W3400AMZ, Argentina
Instituto de Investigaciones Clinicas Rosario ( Site 0204)

Rosario, Santa Fe Province, S2000CVD, Argentina
Instituto de Investigaciones Clínicas Mar del Plata ( Site 0202)

Mar del Plata, Buenos Aires, B7600FZO, Argentina
Istanbul Universitesi - Cerrahpasa Kardiyoloji Enstitusu ( Site 0703)

Istanbul, 34080, Turkey (Türkiye)
Jubilee Clinical Research ( Site 0031)

Las Vegas, Nevada, 89106, United States
Lakeland Clinical Trials Waikato ( Site 1000)

Nawton, Waikato Region, 3200, New Zealand
Lakeland Clinical Trials Wellington ( Site 1002)

Upper Hutt, Wellington Region, 5018, New Zealand
Lakeside Surgery ( Site 0802)

Corby, Northamptonshire, NN17 2UR, United Kingdom
Lausmed Egészségügyi Szolgáltató ( Site 1105)

Baja, Bács-Kiskun county, 6500, Hungary
Legacy Clinical Trials ( Site 0044)

Colorado Springs, Colorado, 80909, United States
LinQ Research ( Site 0025)

Pearland, Texas, 77584, United States
LinQ Research - Tomball ( Site 0047)

Tomball, Texas, 77375, United States
Linn Medical Center ( Site 0503)

Haifa, 3100000, Israel
Manassas Clinical Research Center ( Site 0002)

Manassas, Virginia, 20110, United States
Meir Medical Center. ( Site 0501)

Kfar Saba, 4428164, Israel
Midwest Institute For Clinical Research ( Site 0033)

Indianapolis, Indiana, 46260-5310, United States
Milestone Research Inc. ( Site 0111)

London, Ontario, N5W 6A2, Canada
Momentum Clinical Research Taringa ( Site 0907)

Taringa, Queensland, 4068, Australia
Momentum Darlinghurst ( Site 0906)

Sydney, New South Wales, 2010, Australia
Monroe Biomedical Research ( Site 0004)

Louisville, Kentucky, 40213, United States
National Clinical Research, Inc ( Site 0028)

Richmond, Virginia, 23294, United States
New Mexico Clinical Research & Osteoporosis Center, Inc. ( Site 0027)

Albuquerque, New Mexico, 87106-4725, United States
North York Diagnostic and Cardiac Centre ( Site 0110)

North York, Ontario, M6B 3H7, Canada
Pacific Clinical Research Network - Forte ( Site 1004)

Christchurch, Canterbury, 8013, New Zealand
Pacific Clinical Research Network - Rotorua ( Site 1001)

Rotorua, Bay of Plenty, 3010, New Zealand
Pacific Clinical Research Network - Tasman ( Site 1003)

Nelson, Tasman District, 7011, New Zealand
Permian Research Foundation ( Site 0005)

Odessa, Texas, 79761, United States
Provecta Research Network LLC ( Site 0022)

Houston, Texas, 77027, United States
Rainier Clinical Research ( Site 0023)

Renton, Washington, 98057, United States
Rambam Health Care Campus ( Site 0500)

Haifa, 3109601, Israel
Recherche Clinique Sigma Inc ( Site 0108)

Québec, Quebec, G1G 5X1, Canada
Soffer Health Institute ( Site 0046)

Hollywood, Florida, 33020, United States
Stone Oak, LLC dba Discovery Clinical Trials (DCT) ( Site 0021)

San Antonio, Texas, 78258, United States
Synexus Clinical Research US, Inc. - Phoenix Central ( Site 0030)

Phoenix, Arizona, 85020, United States
Trialmed ( Site 0026)

Chicago, Illinois, 60602, United States
Ufuk University Dr.Ridvan Ege Hospital ( Site 0709)

Ankara, 06520, Turkey (Türkiye)
Velocity Clinical Research Havering ( Site 0804)

London, Havering, RM1 3PJ, United Kingdom
Velocity Clinical Research, Bristol ( Site 0803)

Bristol, Bristol, City of, BS8 2RA, United Kingdom
West Walk Surgery ( Site 0801)

Yate, Gloucestershire, BS37 4AX, United Kingdom
William Harvey Heart Centre ( Site 0800)

London, London, City of, EC1M 6BQ, United Kingdom
İnönü Üniversitesi Turgut Özal Tıp Merkezi ( Site 0702)

Malatya, 44280, Turkey (Türkiye)

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